Arqueas y virus en la enfermedad periodontal. Revisión de la literatura

Rodolfo Javier Gutiérrez Flores; Mercedes Elvira Marval Figueroa; Carmen Peña Farías; María Gabriela Ramírez; Geraldine Xiomary Tapias Urbáez; Gabriela Mercedes Zambrano Rodríguez

doi:10.30972/rfo.1425766

Arqueas y virus en la enfermedad periodontal. Revisión de la literatura

Revista de la Facultad de Odontología ◽

10.30972/rfo.1425766 ◽

2021 ◽

Vol 14 (2) ◽

pp. 20

Author(s):

Rodolfo Javier Gutiérrez Flores ◽

Mercedes Elvira Marval Figueroa ◽

Carmen Peña Farías ◽

María Gabriela Ramírez ◽

Geraldine Xiomary Tapias Urbáez ◽

...

Keyword(s):

Cochrane Library ◽

Epstein Barr

<p>La cavidad bucal posee la segunda microbiota más compleja del cuerpo humano, precedida por la perteneciente al colón. Alberga diversos microorganismos (arqueas, hongos, bacterias y virus) y su disbiosis podría estar relacionada con enfermedades como periodontitis. El objetivo de esta revisión de la literatura fue analizar la relación existente entre la enfermedad periodontal y microorganismos como arqueas y virus. Se realizó un estudio retrospectivo de corte transversal mediante una exploración electrónica para la selección de información científica detallada en PubMed a través del NCBI, Biblioteca Virtual en Salud y en las bases de datos Scielo, Redalyc, Dialnet, Latindex, Cochrane Library y LILACS, en inglés y español. Las arqueas son microorganismos productores de metano, asociados al grupo de bacterias que se presentan en periodontitis. Realizan interacciones simbióticas con bacterias fermentativas que se encuentran en ambientes anaeróbicos naturales y constituyen sólo una parte menor de la microbiota bucal y la cantidad de especies es limitada en pacientes sanos. El origen de la enfermedad periodontal puede ser viral, causado por virus de la familia Herpesviridae, como el virus Epstein-Barr (VEB), Citomegalovirus (CMV), Herpes Simple tipo 1 (VHS-1), Herpes Simple tipo 2 (VHS-2) y Varicela-zoster (VVZ). Originan un efecto citopático directo células de defensa debilitando así la respuesta inflamatoria del hospedero e iniciando el proceso destructivo propio de la enfermedad periodontal.</p>

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Epstein-Barr Virus Infection and Increased Sporadic Breast Carcinoma Risk: A Meta-Analysis

Medical Principles and Practice ◽

10.1159/000502131 ◽

2019 ◽

Vol 29 (2) ◽

pp. 195-200

Author(s):

Qing’e Jin ◽

Jianrong Su ◽

Donghui Yan ◽

Shanna Wu

Keyword(s):

Breast Carcinoma ◽

Publication Bias ◽

Subgroup Analysis ◽

Epstein Barr Virus ◽

Meta Analysis ◽

Tissue Type ◽

Cochrane Library ◽

Barr Virus ◽

Ebv Infection ◽

Epstein Barr

Objective: An association of Epstein-Barr virus (EBV) infection with breast carcinoma (BC) risk has so far been disputed in the literature. Therefore, we performed a meta-analysis to clarify this relationship. Materials and Methods: An electronic database search for eligible case-control studies was performed using PubMed, Embase, Web of Science, the Cochrane Library, CNKI, and Wanfang Data until May 17, 2018. The pooled OR and 95% CI were used to estimate the relationship between EBV infection and BC risk using a fixed or random-effects model depending on heterogeneity. Subgroup analysis and meta-regression were used to explore the heterogeneity. Publication bias was assessed using Egger’s and Harbord’s tests. Results: A total of 16 studies with 1,279 patients and 814 controls were reviewed based on our inclusion and exclusion criteria. Compared with the control group, EBV infection had a significant association with BC risk (OR 4.75, 95% CI 2.53–8.92, p < 0.01) with significant heterogeneity observed (I2 = 65.3%). The subgroup analysis revealed that region and tissue type might explain potential sources of heterogeneity. The sensitivity analyses yielded stable results. No significant publication bias was observed. Conclusion: The current results suggest that EBV infection is significantly associated with increased risk of BC.

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Multiple Sclerosis and Epstein-Barr Virus

Canadian Journal of Infectious Diseases ◽

10.1155/2002/745764 ◽

2002 ◽

Vol 13 (2) ◽

pp. 111-118 ◽

Cited By ~ 6

Author(s):

Ruth Ann Marrie ◽

Christina Wolfson

Keyword(s):

Multiple Sclerosis ◽

Epstein Barr Virus ◽

Data Extraction ◽

Cochrane Library ◽

Historical Cohort ◽

Barr Virus ◽

Relative Risks ◽

Etiological Role ◽

Epstein Barr ◽

Incident Cases

OBJECTIVE: To evaluate the epidemiological evidence for an etiological role of Epstein-Barr virus in multiple sclerosis (MS).DATA SOURCES: MEDLINE and Cochrane Library searches of the medical literature identified 24 studies.DATA EXTRACTION: Studies were categorized as seroepidemiological, case-control or historical cohort, and were then classified within each group according to methodological rigour using criteria derived from published guidelines for the epidemiological study of MS.DATA SYNTHESIS: There was significant variability in the quality of evidence, and while two well-designed cohort studies found increased relative risks of MS in subjects with infectious mononucleosis, results from other studies were unconvincing.CONCLUSIONS: The evidence was insufficient to accept or reject the hypothesis that Epstein-Barr virus has an etiological role in MS. Further study, ideally using large samples of incident cases with blinded, trained interviewers using confirmatory sources for recalled data, is needed.

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The role of Epstein-Barr viral infection and hepatitis B and C in liver pathology

Voprosy Virusologii ◽

10.36233/0507-4088-2019-64-5-215-220 ◽

2019 ◽

Vol 64 (5) ◽

pp. 215-220 ◽

Cited By ~ 1

Author(s):

T. V. Solomay ◽

T. A. Semenenko ◽

M. Yu. Ivanova

Keyword(s):

Hepatitis B ◽

Viral Infection ◽

Liver Diseases ◽

Epstein Barr Virus ◽

Scientific Literature ◽

Wide Distribution ◽

Cochrane Library ◽

Barr Virus ◽

Epstein Barr

A review of scientific literature data on clinical and epidemiological characterization of viral hepatitis B, C and Epstein-Barr viral infection is presented. Scopus, Web of Science, MedLine, The Cochrane Library, PubMed, CyberLeninka, RSCI databases were used to find the necessary literature. It was shown that Epstein-Barr virus along with hepatitis B and C viruses plays a significant role in the development of virus-mediated autoimmune liver diseases, as well as other organs (intestine, heart, kidneys, thyroid gland, etc.). The similarity of these nosologies is also evident in the nature of the course of the disease: the presence of a primary infection in a manifest or latent form, with possible subsequent chronization of the process and its periodic reactivation. Wide distribution of pathogens in the human population determines the possibility of mixed infections with Epstein-Barr virus and hepatitis B and C viruses, however, this problem has not been adequately described in the scientific literature. The review suggests that the role of Epstein-Barr virus in the development of liver diseases and extrahepatic pathology should not be ignored, and the combination of this pathogen with hepatitis B and C viruses required further in-depth studies.

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Measures aimed at preventing in medical institutions the transmission of Epstein–Barr virus infection (review)

Hygiene and Sanitation ◽

10.47470/0016-9900-2021-100-1-36-41 ◽

2021 ◽

Vol 100 (1) ◽

pp. 36-41

Author(s):

Tatiana V. Solomay ◽

Tatiana A. Semenenko

Keyword(s):

Epstein Barr Virus ◽

Assisted Reproductive Technologies ◽

Clinical Manifestations ◽

Reproductive Technologies ◽

Cochrane Library ◽

Epstein Barr Virus Infection ◽

Barr Virus ◽

Ebv Infection ◽

Medical Institutions ◽

Epstein Barr

To systematize the existing methods, techniques, and means of non-specific prevention transmission of the Epstein-Barr virus (EBV) in medical institutions, the authors perform a comprehensive analysis of data from domestic and foreign literature. Information was collected using Scopus, Web of Science, MedLine, the Cochrane Library, PubMed, RSCI, Cyberleninka. The analysis revealed data confirming the relevance of EBV infection for different areas of clinical medicine. Researchers do not classify EBV as a causative agent of diseases associated with medical care. Measures aimed at preventing transmission of EBV infection similar to those of other illnesses should consider the existing mechanisms of the transmission and the pathogen’s characteristics. The lifetime persistence of EBV in the human body, the presence of the pathogen in various organs and tissues during the active infection, the polymorphism of clinical manifestations of the disease, along with errors in compliance with disinfection and sterilization regimes, create a risk of cross-infection in medical institutions of various profiles. Intensive introduction into medical practice of modern including invasive methods of diagnosis and treatment assisted reproductive technologies; medical equipment contributes to the emergence of new factors of transmission of EBV infection and requires the development of standard protocols for their disinfection and sterilization. To improve medical staff’s competence it is necessary to introduce more widely training activities on preventive and anti-epidemic measures in the system of continuing medical education.

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(EB) Virus: Latency and Expression in Transplanted and Cultured Human Cells

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100065882 ◽

1971 ◽

Vol 29 ◽

pp. 368-369

Author(s):

B. G. Uzman ◽

M. M. Kasac ◽

H. Saito ◽

A. Krishan

Keyword(s):

Cell Lines ◽

Primary Cultures ◽

Virus Particles ◽

Barr Virus ◽

Virus Latency ◽

Virus Surveillance ◽

Cultured Human Cells ◽

Epstein Barr ◽

Serial Transplantation ◽

Tubular Arrays

In conjunction with the cultivation and transplantation of cells from human tumors by the Programs of Microbiology and Immunogenetics, virus surveillance by electron microscopy has been routinely employed. Of particular interest in this regard have been 3 cell lines cultured from lymph nodes or spleen of 2 patients with Hodgkin's disease and 1 patient with Letterer-Siwe's disease. Each of these cell lines when transplanted in Syrian hamster neonates conditioned with anti-lymphocyte serum grew as serially transplantable tumors; from such transplants of the 3 cell lines cell cultures were retrieved.Herpes type virus particles (Figs. 1, 2, 3) were found in the primary cultures of all three lines, in frozen thawed aliquots of same, and in cultures retrieved from their tumors growing by serial transplantation in hamsters. No virus was detected in sections of 25 of the serially transplanted tumors. However, in 10 such tumors there were repeated instances of tubular arrays in the cisternae of the endoplasmic reticulum (Fig. 4). On serologic examination the herpes virus was shown to be the Epstein-Barr virus.

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A Quantitative Ultrastructural Study of Peripheral Blood Lymphocytes Containing Parallel Tubular Arrays in Epstein-Barr Virus and Cytomegalo-Virus Mononucleosis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100098769 ◽

1981 ◽

Vol 39 ◽

pp. 454-455

Author(s):

C. M. Payne ◽

P. M. Tennican

Keyword(s):

Peripheral Blood ◽

Lymphocyte Count ◽

Epstein Barr Virus ◽

Absolute Lymphocyte Count ◽

Peripheral Blood Lymphocytes ◽

Clinical State ◽

Barr Virus ◽

The Absolute ◽

Epstein Barr ◽

Tubular Arrays

In the normal peripheral circulation there exists a sub-population of lymphocytes which is ultrastructurally distinct. This lymphocyte is identified under the electron microscope by the presence of cytoplasmic microtubular-like inclusions called parallel tubular arrays (PTA) (Figure 1), and contains Fc-receptors for cytophilic antibody. In this study, lymphocytes containing PTA (PTA-lymphocytes) were quantitated from serial peripheral blood specimens obtained from two patients with Epstein -Barr Virus mononucleosis and two patients with cytomegalovirus mononucleosis. This data was then correlated with the clinical state of the patient.It was determined that both the percentage and absolute number of PTA- lymphocytes was highest during the acute phase of the illness. In follow-up specimens, three of the four patients' absolute lymphocyte count fell to within normal limits before the absolute PTA-lymphocyte count.In one patient who was followed for almost a year, the absolute PTA- lymphocyte count was consistently elevated (Figure 2). The estimation of absolute PTA-lymphocyte counts was determined to be valid after a morphometric analysis of the cellular areas occupied by PTA during the acute and convalescent phases of the disease revealed no statistical differences.

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Studies of Epstein-Barr Virus Antigens Using Immunoperoxidase and Immunofluorescence Techniques

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010011533x ◽

1975 ◽

Vol 33 ◽

pp. 342-343

Author(s):

R. Stephens ◽

K. Traul ◽

D. Woolf ◽

P. Gaudreau

Keyword(s):

Electron Microscopy ◽

Nasopharyngeal Carcinoma ◽

Epstein Barr Virus ◽

Barr Virus ◽

If Technique ◽

Infected Cells ◽

Virus Antigens ◽

Epstein Barr ◽

Virus Capsid Antigen ◽

Antigen Reactivity

A number of antigens have been found associated with persistent EBV infections of lymphoblastoid cells. Identification and localization of these antigens were principally by immunofluorescence (IF) techniques using sera from patients with nasopharyngeal carcinoma (NPC), Burkitt lymphoma (BL), and infectious mononucleosis (IM). Our study was mainly with three of the EBV related antigens, a) virus capsid antigen (VCA), b) membrane antigen (MA), and c) early antigens (EA) using immunoperoxidase (IP) techniques with electron microscopy (EM) to elucidate the sites of reactivity with EBV and EBV infected cells.Prior to labeling with horseradish peroxidase (HRP), sera from NPC, IM, and BL cases were characterized for various reactivities by the indirect IF technique. Modifications of the direct IP procedure described by Shabo and the indirect IP procedure of Leduc were made to enhance penetration of the cells and preservation of antigen reactivity.

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Characteristics of the Frequency-Following Response to Speech in Neonates and Potential Applicability in Clinical Practice: A Systematic Review

Journal of Speech Language and Hearing Research ◽

10.1044/2020_jslhr-19-00322 ◽

2020 ◽

Vol 63 (5) ◽

pp. 1618-1635

Author(s):

Céline Richard ◽

Mary Lauren Neel ◽

Arnaud Jeanvoine ◽

Sharon Mc Connell ◽

Alison Gehred ◽

...

Keyword(s):

Systematic Review ◽

Cochrane Library ◽

Neurodevelopmental Outcomes ◽

Frequency Following Response ◽

Ovid Medline ◽

Published Evidence ◽

Mesh Terms ◽

Potential Applicability ◽

Clinical Potential

Purpose We sought to critically analyze and evaluate published evidence regarding feasibility and clinical potential for predicting neurodevelopmental outcomes of the frequency-following responses (FFRs) to speech recordings in neonates (birth to 28 days). Method A systematic search of MeSH terms in the Cumulative Index to Nursing and Allied HealthLiterature, Embase, Google Scholar, Ovid Medline (R) and E-Pub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily, Web of Science, SCOPUS, COCHRANE Library, and ClinicalTrials.gov was performed. Manual review of all items identified in the search was performed by two independent reviewers. Articles were evaluated based on the level of methodological quality and evidence according to the RTI item bank. Results Seven articles met inclusion criteria. None of the included studies reported neurodevelopmental outcomes past 3 months of age. Quality of the evidence ranged from moderate to high. Protocol variations were frequent. Conclusions Based on this systematic review, the FFR to speech can capture both temporal and spectral acoustic features in neonates. It can accurately be recorded in a fast and easy manner at the infant's bedside. However, at this time, further studies are needed to identify and validate which FFR features could be incorporated as an addition to standard evaluation of infant sound processing evaluation in subcortico-cortical networks. This review identifies the need for further research focused on identifying specific features of the neonatal FFRs, those with predictive value for early childhood outcomes to help guide targeted early speech and hearing interventions.

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