LIPOPHYLIC COMPOUNDS OF PARSLEY CHERVIL ANTHRISCUS SYLVESTRIS (L.) HOFFM. ROOTS

2018 ◽  
Vol 4 (3) ◽  
pp. 75-79
Author(s):  
Ya.P. Lebedev ◽  
◽  
R.M. Bashirova ◽  
R.G. Farkhutdinov ◽  
◽  
...  
Keyword(s):  
Anthriscus Sylvestris

Derivatives of Deoxypodophyllotoxin Induce Apoptosis Through Bcl-2/Bax Proteins Expression

2020 ◽  
Vol 20 ◽  
Author(s):  
Ya-Nan Li ◽  
Ni Ning ◽  
Lei Song ◽  
Yun Geng ◽  
Jun-Ting Fan ◽  
...  
Keyword(s):  
Annexin V ◽  
Mtt Method ◽  
Anthriscus Sylvestris ◽  
Anti Tumor Activity ◽  
Derivatives Of ◽  
Toxicity In Vitro ◽  
Ht 29 ◽  
Mcf 7

Background: Deoxypodophyllotoxin, isolated from theTraditional Chinese Medicine Anthriscus sylvestris, is well-known because of its significant antitumor activity with strong toxicity in vitro and in vivo. Objective: In this article, we synthesized a series of deoxypodophyllotoxin derivatives, and evaluated their antitumor effectiveness.Methods:The anti tumor activity of deoxypodophyllotoxin derivatives was investigated by the MTT method. Apoptosis percentage was measured by flow cytometer analysis using Annexin-V-FITC. Results: The derivatives revealed obvious cytotoxicity in the MTT assay by decreasing the number of late cancer cells. The decrease of Bcl-2/Bax could be observed in MCF-7, HepG2, HT-29 andMG-63 using Annexin V-FITC. The ratio of Bcl-2/Bax in the administration group was decreased, which was determined by the ELISA kit. Conclusion: The derivatives of deoxypodophyllotoxin could induce apoptosis in tumor cell lines by influencing Bcl-2/Bax.

Sur l'organisation phytochimique de formations prairiales permanentes

2001 ◽  
Vol 79 (4) ◽  
pp. 510-519 ◽  
Author(s):  
Philippe Lebreton ◽  
Bernard Jeangros ◽  
Christiane Gallet ◽  
Jan Scehovic
Keyword(s):  
Cell Wall ◽  
Multivariate Analysis ◽  
Plant Communities ◽  
Nutrient Pool ◽  
Grassland Species ◽  
Anthriscus Sylvestris ◽  
Cool Environment ◽  
Mineral Components ◽  
Herbaceous Community ◽  
Food Value

Organic and mineral components have been analysed on 18 dicotyledonous species of permanent grassland communities. Multivariate analysis revealed an opposition between a macromolecular pool (cellulose and lignin) and a nutrient pool (potassium and phosphorus, nitrogen). The first pole is characterized by Tragopogon pratensis L. (Compositae) and Galium mollugo L. (Rubiaceae), the second by Anthriscus sylvestris (L.) Hoffm. (Umbelliferae) and Geranium sylvaticum L. (Geraniaceae). The most thermo-helio-xerophilous species (Knautia arvensis (L.) Coult and Tragopogon pratensis) belong to the first group, whereas the second group includes the cool-environment species (like Alchemilla xanthochlora Roth.), which reveals an ecophysiological determinism. Moreover, correlations between the biochemical and ecological structure, and other interrelated parameters, including sclerophylly, have been shown. Compared to lignous and sempervirent plant communities, the grassland species have lower phenolic and lignin contents but higher glucide and nutrient (potassium and phosphorus) contents, which is in accordance with their food value. For this herbaceous community, the C/N ratio indicates the same general equilibrium between cell-wall macromolecules and nitrogen than for two other plant communities (mainly ligneous) previously studied, with some differences revealing distinct trends from the same general metabolic sheme.Key words: dicotyledonous plant communities, biochemical organization, C/N ratio, ecophysiology.

scholarly journals Ethnomedicinal, Phytochemical and Pharmacological Profile of Anthriscus sylvestris as an Alternative Source for Anticancer Lignans

Molecules ◽  
2015 ◽  
Vol 20 (8) ◽  
pp. 15003-15022 ◽  
Author(s):  
Octavian Olaru ◽  
George Niţulescu ◽  
Alina Orțan ◽  
Cristina Dinu-Pîrvu
Keyword(s):  
Pharmacological Profile ◽  
Alternative Source ◽  
Anthriscus Sylvestris

Anthriscus cerefolium (L.) Hoffm. Anthriscus sylvestris (L.) Hoffm. Apiaceae

2020 ◽  
pp. 107-112
Author(s):  
Rainer W. Bussmann ◽  
Ketevan Batsatsashvili ◽  
Zaal Kikvidze ◽  
Narel Y. Paniagua-Zambrana ◽  
Manana Khutsishvili ◽  
...  
Keyword(s):  
Anthriscus Sylvestris

scholarly journals On the use of fungicides in ecological seed burial studies

2009 ◽  
Vol 19 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Nadine Mitschunas ◽  
Juliane Filser ◽  
Markus Wagner
Keyword(s):  
Organic Matter ◽  
Organic Matter Content ◽  
Matter Content ◽  
Potential Influence ◽  
Seed Burial ◽  
Fungicide Treatment ◽  
Anthriscus Sylvestris ◽  
Seed Mortality ◽  
Buried Seed ◽  
Seed Demography

AbstractEvidence for effects of saprophytic fungi on buried seed demography is usually obtained from studies involving the simultaneous burial of fungicide-treated seeds and of untreated seeds. However, any potential influence of fungicide treatment on seed dormancy levels is generally ignored in these studies. Also, some studies assume that a combination of several fungicidal compounds provides better protection against a broader range of fungi, ignoring chemical interactions that may potentially occur between different compounds. To investigate these issues, we carried out a 6-month burial experiment using seeds ofAnthriscus sylvestris(L.) Hoffm.,Centaurea nigraL. andDaucus carotaL., and three substrates differing in organic matter content. Three fungicidal compounds, captan, iprodione and mancozeb, were applied alone and in combination, including an untreated control. All fungicidal compounds and combinations thereof provided protection against fungal-induced seed mortality and, except for a low efficacy of iprodione in protecting seeds ofAnthriscus, there were no pronounced differences in seed mortality between different fungicide treatments. Captan temporarily inhibited germination inCentaurea, whereas a similar inhibition inDaucusseeds caused by mancozeb was more long lasting, suggesting an induction of secondary dormancy. Organic matter content had only a negligible influence on these results. Our results suggest that the basic conclusions from most seed burial studies are robust with respect to their choice of fungicide. We conclude by discussing further implications of our findings for the design and interpretation of seed burial studies.

Comprehensive study of Anthriscus sylvestris lignans

2021 ◽  
Vol 192 ◽  
pp. 112958
Author(s):  
Dejan Orčić ◽  
Sanja Berežni ◽  
Dušan Škorić ◽  
Neda Mimica-Dukić
Keyword(s):  
Anthriscus Sylvestris ◽  
Comprehensive Study

Carrot mottle virus. [Distribution map].

2008 ◽  
Author(s):  
Keyword(s):  
New South ◽  
South Australia ◽  
Mottle Virus ◽  
Petroselinum Crispum ◽  
Distribution Map ◽  
Anthriscus Sylvestris ◽  
South Wales ◽  
Carrot Mottle Virus ◽  
Virus Distribution ◽  
Distribution In Europe

Abstract A new distribution map is provided for Carrot mottle virus. Virus: Umbravirus. Hosts: carrot (Daucus carota); parsley (Petroselinum crispum), cow parsley (Anthriscus sylvestris) and other wild hosts. Information is given on the geographical distribution in Europe (Belgium, Denmark, France, Germany, the Netherlands, UK, England and Wales, Scotland), Asia (Japan), Africa (Morocco), North America (Canada, British Columbia, USA, California, Pennsylvania, Washington, Wisconsin), South America (Brazil, Minas Gerais, Sao Paulo), Oceania (Australia, New South Wales, South Australia, Tasmania, Victoria, Western Australia, New Zealand).

scholarly journals Deoxypodophyllotoxin, a Lignan from Anthriscus sylvestris, Induces Apoptosis and Cell Cycle Arrest by Inhibiting the EGFR Signaling Pathways in Esophageal Squamous Cell Carcinoma Cells

2020 ◽  
Vol 21 (18) ◽  
pp. 6854
Author(s):  
Ah-Won Kwak ◽  
Mee-Hyun Lee ◽  
Goo Yoon ◽  
Seung-Sik Cho ◽  
Joon-Seok Choi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Reactive Oxygen Species Generation ◽  
Direct Interaction ◽  
Cyclin B1 ◽  
Dependent Manner ◽  
Anthriscus Sylvestris

Deoxypodophyllotoxin (DPT) derived from Anthriscus sylvestris (L.) Hoffm has attracted considerable interest in recent years because of its anti-inflammatory, antitumor, and antiviral activity. However, the mechanisms underlying DPT mediated antitumor activity have yet to be fully elucidated in esophageal squamous cell carcinoma (ESCC). We show here that DPT inhibited the kinase activity of epidermal growth factor receptor (EGFR) directly, as well as phosphorylation of its downstream signaling kinases, AKT, GSK-3β, and ERK. We confirmed a direct interaction between DPT and EGFR by pull-down assay using DPT-beads. DPT treatment suppressed ESCC cell viability and colony formation in a time- and dose-dependent manner, as shown by MTT analysis and soft agar assay. DPT also down-regulated cyclin B1 and cdc2 expression to induce G2/M phase arrest of the cell cycle and upregulated p21 and p27 expression. DPT treatment of ESCC cells triggered the release of cytochrome c via loss of mitochondrial membrane potential, thereby inducing apoptosis by upregulation of related proteins. In addition, treatment of KYSE 30 and KYSE 450 cells with DPT increased endoplasmic reticulum stress, reactive oxygen species generation, and multi-caspase activation. Consequently, our results suggest that DPT has the potential to become a new anticancer therapeutic by inhibiting EGFR mediated AKT/ERK signaling pathway in ESCC.

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