Surfactant markers - the place in the early diagnosis of occupational chronic obstructive pulmonary disease

2020 ◽  
pp. 765-765
Author(s):  
L. A. Strizhakov ◽  
M. V. Lebedeva ◽  
V. D. Beketov
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pilot Study ◽  
Pulmonary Fibrosis ◽  
Early Diagnosis ◽  
Clinical Studies ◽  
Surfactant Proteins ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Occupational Copd

The results of a pilot study of the clinical significance of the determination of surfactant proteins A and D in patients with occupational COPD are presented. The need for further clinical studies to identify diagnostically reliable values of surfactant proteins to determine the stages of inflammation and progressive pulmonary fibrosis has been shown.

scholarly journals Determination of Diagnostic Value of FEV3/FEV6 Spirometric Index in Early Diagnosis of Chronic Obstructive Pulmonary Disease

2019 ◽  
Vol 4 (2) ◽  
pp. 81-87
Author(s):  
Seyed Mehdi Talebzadeh ◽  
Vahan Moradianc ◽  
Rozbeh Naghshin ◽  
Maryam Hamidzad Sangachin ◽  
◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Early Diagnosis ◽  
Pulmonary Disease ◽  
Diagnostic Value ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

Flavonoids and Reduction of Cardiovascular Disease (CVD) in Chronic Obstructive Pulmonary Disease (COPD)

2019 ◽  
Vol 26 (39) ◽  
pp. 7048-7058 ◽  
Author(s):  
Patrizia Russo ◽  
Giulia Prinzi ◽  
Palma Lamonaca ◽  
Vittorio Cardaci ◽  
Massimo Fini
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Clinical Studies ◽  
Risk Prevention ◽  
Chronic Obstructive ◽  
Low Molecular Weight ◽  
Important Class ◽  
Cvd Risk ◽  
Obstructive Pulmonary Disease ◽  
Convincing Data

Background: Chronic Obstructive Pulmonary Disease (COPD) and Cardiovascular Diseases (CV) Often Coexist. COPD and CVD are complex diseases characterized by a strict interaction between environment and genetic. The mechanisms linking these two diseases are complex, multifactorial and not entirely understood, influencing the therapeutic approach. COPD is characterized by several comorbidities, it hypothesized the treatment of cardiovascular co-morbidities that may reduce morbidity and mortality. Flavonoids are an important class of plant low molecular weight Secondary Metabolites (SMs). Convincing data from laboratory, epidemiological, and human clinical studies point the important effects on CVD risk prevention. Objective: This review aims to provide up-to-date information on the ability of Flavonoids to reduce the CVD risk. Conclusion: Current studies support the potential of Flavonoids to prevent the risk of CVD. Well-designed clinical studies are suggested to evaluate advantages and limits of Flavonoids for managing CVD comorbidity in COPD.

Oxidized low-density lipoproteins and its connection with dyslipidemia, inflammatory markers, and oxidative stress in patients with occupational chronic obstructive pulmonary disease

2021 ◽  
Vol 31 (4) ◽  
pp. 456-462
Author(s):  
I. A. Umnyagina ◽  
L. A. Strakhova ◽  
T. V. Blinova ◽  
V. V. Troshin ◽  
V. D. Fedotov
Keyword(s):  
Oxidative Stress ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Comparison Group ◽  
Serum Levels ◽  
Low Density Lipoproteins ◽  
Chronic Obstructive ◽  
Low Density ◽  
Obstructive Pulmonary Disease ◽  
Occupational Copd

The role of low-density oxidized lipoproteins (OxLDL) in the pathogenesis of occupational chronic obstructive pulmonary disease (COPD) is not understood well enough.The study aims to determine the serum levels of oxidized low-density lipoproteins and their relationship with lipid profile, the level of oxidative stress and level C-reactive protein in patients with occupational chronic obstructive pulmonary disease.Methods. 116 patients diagnosed with occupational COPD and 25 patients with no respiratory diseases (comparison group) were examined. Serum levels of OxLDL was determined by solid phase enzyme-linked immunosorbent assay (ELISA) using the commercial reagent kit MDA-oxLDL from Biomedica Gruppe, Austria.Results. Circulating OxLDL was detected in serum in a significant proportion of patients with stable occupational COPD. In most of the patients, the concentration of OxLDL was within the values observed in the comparison group or exceeded them by no more than two times. In the minority of patients with occupational COPD (16.5%), the concentration of OxLDL was high and 4 – 10 times higher than its average value in the comparison group. It can be assumed that the revealed differences in the concentration of OxLDL are due to the different degree and intensity of oxidation of low-density lipoproteins. The relationships between OxLDL and lipid metabolism, oxidative stress (OS), the antioxidant capacity of serum (AOS), and serum levels of C-reactive protein were described.Conclusion. Serum OxLDL levels in patients with occupational COPD, the relationship between OxLDL and lipid metabolism, oxidative stress, and inflammation will provide an expanded view of the pathogenetic aspects of occupational COPD.

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