scholarly journals Guality eradication anti-helicobacter therapy increases the effectiveness of treatment of patients with stable angina pectoris

2021 ◽  
pp. 41-46
Author(s):  
M. N. Prikhodko ◽  
Zh. G. Simonova ◽  
E. P. Kolevatykh
Keyword(s):  
Chronic Gastritis ◽  
Clinical Status ◽  
Eradication Therapy ◽  
Antibiotic Sensitivity ◽  
Prospective Clinical Study ◽  
Group I ◽  
Group Ii ◽  
H Pylori ◽  
Gastroduodenal Zone ◽  
Endoscopic Picture

Aim. On the basis of the complex analysis, to evaluate the efficiency of eradication therapy at patients with stable stenocardia with a combination of chronic gastritis. Material and methods. 46 patients with stable stenocardia with a combination of chronic H. pylori-associated gastritis were included in the open prospective clinical study. Two groups of patients were formed during the study. Patients of group I (n = 25) received eradication therapy in accordance with antibiotic sensitivity of H. pylori strains, patients of group II (n = 21) - without antibiotic sensitivity. In all patients before and after treatment were performed: evaluation of clinical status, laboratory indicators, EGDS with biopsy sampling, diagnosis of H. pylori. Results. The effectiveness of eradication therapy was 86.9%, at the same time, 96% -in group I and 76.2% - in group II. It is established: stabilization of clinical status of patients, improvement of morphological and endoscopic picture of gastroduodenal zone, improvement of laboratory indices. Conclusions. The inclusion of antibiotic-sensitive erication therapy in the algorithm of treatment of patients with stable stenocardia in combination with chronic gastritis allows to achieve high effectiveness of killing the infection Helicobacter pylori. At the same time stabilizes clinical status of patients, laboratory indices, has a positive effect on morphological and endoscopic picture of gastroduodenal zone, preventing progression of metaplastic changes.

CHRONIC GASTRITIS AND OLD AGE: A PROBLEM OR NOT?

2020 ◽  
pp. 30-39
Author(s):  
Zh.G. Simonova ◽  
M.N. Prikhod'ko ◽  
E.M. Shul'gina
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Elderly Patients ◽  
Old Age ◽  
Chronic Gastritis ◽  
Morphological Changes ◽  
Eradication Therapy ◽  
Prospective Clinical Study ◽  
H Pylori ◽  
Endoscopic Picture

The objective of the paper is to study the clinical and functional characteristics of chronic H. pylori-associated gastritis in the elderly patients. Materials and Methods. A group of elderly patients (n=116) (aged 69.5±3.2) with chronic H. pylori-associated gastritis was formed during a prospective clinical study. All patients underwent esophagogastroduodenoscopy with biopsy. OLGA staging system was used for histological assessment. The dyspeptic index (DI) was used to measure dyspepsia. The patients were followed up for 48 weeks. Results. Dyspepsia was found only in 41.3 % of patients, while 58.7 % of patients had asymptomatic disease progression. Atrophic changes in the gastric mucosa were found in 30.1 % of the trial subjects. The efficacy of the eradication therapy was 88.7 %. During the study, the endoscopic picture of the gastroduodenal zone improved. There was no progression of atrophic and metaplastic changes in the gastric mucosa. Conclusion. Thus, in elderly patients, chronic H. pylori-associated gastritis is often asymptomatic. Eradication of H. pylori infection promotes disease remission and prevents morphological changes in the gastric mucosa. Keywords: chronic gastritis, Helicobacter pylori, atrophic gastritis, dyspepsia, old age, eradication therapy. Цель – изучить клинико-функциональные особенности течения хронического H. pylori-ассоциированного гастрита у лиц пожилого возраста. Материалы и методы. В процессе проспективного клинического исследования была сформирована группа больных (n=116) пожилого возраста (69,5±3,2 года) с хроническим H. pylori-ассоциированным гастритом. Всем больным была выполнена эзофагогастродуоденоскопия с биопсией. Для гистологической оценки применяли классификацию OLGA. Для оценки диспепсического синдрома использовали диспепсический индекс (ДИ). Длительность наблюдения больных составила 48 нед. Результаты. Наличие диспепсического синдрома было установлено у 41,3 % больных, 58,7 % пациентов имели бессимптомное течение заболевания. У 30,1 % обследуемых выявлены атрофические изменения слизистой оболочки желудка. Эффективность проведенной эрадикационной терапии составила 88,7 %. В процессе исследования установлено улучшение эндоскопической картины гастродуоденальной зоны. Отмечено отсутствие прогрессирования атрофических и метапластических изменений слизистой оболочки желудка. Выводы. У больных пожилого возраста течение хронического H. pylori-ассоциированного гастрита чаще имеет бессимптомный характер. Эрадикация инфекции H. pylori способствует ремиссии заболевания и предотвращает морфологические преобразования слизистой оболочки желудка. Ключевые слова: хронический гастрит, Helicobacter pylori, атрофический гастрит, синдром диспепсии, пожилой возраст, эрадикационная терапия.

CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF H. PYLORI-ASSOCIATED GASTRODUODENAL ZONE DISEASES: AGE-RELATED ASPECTS

2021 ◽  
pp. 89-99
Author(s):  
E.M. Shul'gina ◽  
Zh.G. Simonova
Keyword(s):  
Helicobacter Pylori ◽  
Clinical Picture ◽  
Average Length ◽  
Eradication Therapy ◽  
Young Patients ◽  
Morphological Characteristics ◽  
Prospective Clinical Study ◽  
Age Related ◽  
H Pylori ◽  
Gastroduodenal Zone

The aim of the paper is to study the clinical and morphological characteristics of H. pylori-associated gastroduodenal zone diseases, depending on patients’ age. Materials and Methods. Three groups of patients of various ages with H. pylori-associated gastroduodenal zone diseases were formed in the course of a prospective clinical study. We studied the clinical picture, and morphological characteristics of the gastroduodenal zone before and after eradication therapy. Average length of the observation period was 172 days. All patients underwent esophagogastroduodenoscopy with biopsy. Results. Severe dyspeptic disorders were diagnosed in all young patients belonging to group 1 (100 %). The dyspeptic index corresponded to a high degree of severity. Morphological changes in the gastric mucosa were more significant in patients with a less pronounced clinical picture (Groups 2 and 3). In group 3, atrophic transformations of the gastric corpus were found in 30.5 %, atrophic transformations of the pylorus – in 11 %, and intestinal metaplasia – in 2.8 % of patients. Unlike young and middle-aged patients with pronounced dyspeptic syndrome, elderly patients were characterized by a low-symptom clinical picture, which was accompanied by morphological gastroduodenal zone transformations with the possible progression. Conclusions. Effective eradication therapy contributes to clinical, endoscopic and morphological remission of the gastroduodenal zone and prevents the progression of the inflammatory cascade. Key words: Helicobacter pylori, gastroduodenal diseases, eradication therapy, age characteristics. Цель исследования – изучить клинико-морфологические особенности H. рylori-ассоциированных заболеваний гастродуоденальной зоны в зависимости от возраста пациентов. Материалы и методы. В процессе проспективного клинического исследования были сформированы три группы пациентов разного возраста, имеющих H. pylori-ассоциированные заболевания гастродуоденальной зоны. Изучали клиническую картину, морфологические особенности гастродуоденальной зоны до и после эрадикационной терапии. Период наблюдения больных составил в среднем 172 дня. Всем пациентам выполнялась ззофагогастродуоденоскопия с биопсией. Результаты. У 100 % пациентов молодого возраста (I группа) установлены выраженные диспепсические расстройства. Диспепсический индекс соответствовал высокой степени тяжести. Для пациентов II и Ш групп при менее выраженной клинической картине морфологические изменения слизистой оболочки желудка оказались более существенны. В старшей группе (Ш группа) атрофические преобразования тела желудка выявлены у 30,5 % пациентов, привратника желудка – у 11 %, кишечная метаплазия – у 2,8 %. В отличие от пациентов молодого и среднего возраста, имеющих выраженный диспепсический синдром, для пациентов пожилого возраста характерна малосимптомная клиническая картина, которая сопровождалась морфологическими преобразованиями гастродуоденальной зоны с возможностью прогрессирования. Выводы. Эффективная эрадикационная терапия способствует достижению клинико-эндоскопической и морфологической ремиссии состояния гастродуоденальной зоны и создает условия для предотвращения прогрессирования воспалительного каскада. Ключевые слова: Helicobacter pylori, заболевания гастродуоденальной зоны, эрадикационная терапия, возрастные особенности.

scholarly journals Helicobacter pylori genotypes in patients with stable angina combined with chronic gastritis

2021 ◽  
pp. 119-124
Author(s):  
M. N. Prikhodko ◽  
Zh. G. Simonova
Keyword(s):  
Helicobacter Pylori ◽  
Chronic Gastritis ◽  
Stable Angina ◽  
Antibiotic Sensitivity ◽  
Dilution Method ◽  
Prospective Clinical Study ◽  
Serological Method ◽  
Pcr Diagnosis ◽  
Serial Dilution Method ◽  
H Pylori

Research objective. То study the genotypes of Helicobacter pylori and their antibiotic sensitivity in patients with stable angina in combination with chronic gastritis. Material and methods. 46 patients with stable angina with a combination of chronic H. pylori-associated gastritis were included in the open prospective clinical study. To diagnose H. pylori, serological method of detection of antibodies in blood serum was used, PCR - diagnosis of H. pylori genes. Antibiotic sensitivity of H. pylori strains was studied by serial dilution method. Results. In the patients (n = 46) stable angina in combination with chronic gastritis in the endoscopic study by the EGDS method, gastrobioptates were obtained and further investigated. Chronic neatrophic gastritis was diagnosed in 54.3% of patients, atrophic gastritis - in 45.7%. It was found that the genotypes of H. pylori VacA had 8.7% of patients, CagA - 34.7%, HopQ - 13.1%, Oip - 30.4% of patients. Only 13.1% of patients had non-toxic genotypes. The absence of antibiotic resistance of the first line of erication therapy - clarithromycin and amoxicillin - was revealed. 45.7% of patients showed resistance, 39.1% showed weak sensitivity of H. pylori isolates to metronidazole. Conclusions. In patients with stable angina with a combination of chronic gastritis, H. pylori strains with toxigenic genotypes: CagA, Oip, Vac A, HopQ predominate. Resistance of H. pylori isolates to metronidazole was determined in 45.7% of patients.

scholarly journals Can probiotics improve efficiency and safety profile of triple Helicobacter pylori eradication therapy? A prospective randomized study

2016 ◽  
Vol 73 (11) ◽  
pp. 1044-1049 ◽  
Author(s):  
Sasa Grgov ◽  
Tomislav Tasic ◽  
Biljana Radovanovic-Dinic ◽  
Daniela Benedeto-Stojanov
Keyword(s):  
Helicobacter Pylori ◽  
Randomized Study ◽  
Eradication Therapy ◽  
Saccharomyces Boulardii ◽  
Rapid Urease Test ◽  
Group I ◽  
Urease Test ◽  
Probiotic Strains ◽  
The Difference ◽  
H Pylori

Background/Aim. Some studies suggest the benefit of applying different probiotic strains in combination with antibiotics in the eradication of Helicobacter pylori (H. pylori) infection. The aim of this study was to evaluate the effect of co-administration of multiple probiotic strains with triple H. pylori eradication therapy. Methods. This prospective study included 167 patients with dyspeptic symptoms and chronic gastritis who were diagnosed with H. pylori infection and randomized into two groups. The group I of 77 patients underwent triple eradication therapy, for 7 days, with lansoprazole, 2 ? 30 mg half an hour before the meal, amoxicillin 2 ? 1.000 mg per 12 hours and clarithromycin 2 ? 500 mg per 12 hours. After the 7th day of the therapy, lansoprazole continued at a dose of 30 mg for half an hour before breakfast for 4 weeks. The group II of 90 patients received the same treatment as the patients of the group I, with the addition of the probiotic cultures in the form of a capsule comprising Lactobacillus Rosell-52, Lactobacillus Rosell-11, Bifidobacterium Rosell-1755 and Saccharomyces boulardii, since the beginning of eradication for 4 weeks. Eradication of H. pylori infection control was performed 8 weeks after the therapy by rapid urease test and histopathologic evaluation of endoscopic biopsies or by stool antigen test for H. pylori. Results. Eradication of H. pylori infection was achieved in 93.3% of the patients who received probiotics with eradication therapy and in 81.8% of patients who were only on eradication therapy without probiotics. The difference in eradication success was statistically significant, (p < 0.05). The incidence of adverse effects of eradication therapy was higher in the group of patients who were not on probiotic (28.6%) than in the group that received probiotic (17.7%), but the difference was not statistically significant. Conclusion. Multiple probiotic strains addition to triple eradication therapy of H. pylori achieves a significantly better eradication success, with fewer side effects of antibiotics.

scholarly journals Neuron-specific blood enolase in children with Helicobacter pylori-associated chronic gastroduodenitis

2019 ◽  
Vol 16 (2) ◽  
pp. 151-155
Author(s):  
S. Kh. Dombayan ◽  
I. V. Panova ◽  
G. M. Letifov
Keyword(s):  
Mucous Membrane ◽  
Inflammatory Process ◽  
Neuron Specific Enolase ◽  
Control Group ◽  
Healthy Children ◽  
Serological Tests ◽  
Group I ◽  
Group Ii ◽  
Severity Of The Disease ◽  
Gastroduodenal Zone

The aim of the study was to assess the level of blood neuron specific enolase (NSE) in children with chronic gastroduodenitis (CGD) depending on Hеlicobacter pylori (HP), the severity of the inflammatory process, sex. The study involved 73 children with CGD. Group I– children with CGD associated with HP (HP CGD+); group II – with CGD not associated with HP (CGD, HP–). The control group (GK) – 28 healthy children. In the diagnosis of the disease, the endoscopic and morphological methods were used; the urease, microscopy, molecular biological and serological tests were performed to verify HP. The elevated levels of NSE were revealed in children groups I and II compared with GK (p < 0.01, p < 0.01). High levels of NSE in serum were observed in boys with CGD HP+ compared with girls with CGD HP+ (p < 0.01). Similar changes related to the gender were identified in group II (p < 0.01). In group I the highest values of NSE were identified with erosive gastroduodenitis (p < 0.01). In group II the opposite direction of enzyme changes was revealed and depended on the severity of the disease. Тhe increase of NSE in the blood of children with CGD HP+ and HP-indicates the presence of enzyme in the mechanisms of the inflammatory process in the mucous membrane gastroduodenal area outside the continuum of HP-infection. A multidirectional character of NSE changes depending on the characteristics of lesions mucous membrane gastroduodenal zone in groups I and II does not exclude the NSE involvement into the mechanisms of formation of the severity of the disease. Higher levels of NSE in boys as in CGD, HP+ and HP – do not exclude the relations of NSE and sex hormones.

scholarly journals The usefulness of melatonin supplementation in postmenopausal women with Helicobacter pylori-associated dyspepsia

2020 ◽  
Author(s):  
Cezary Chojnacki ◽  
Marta Mędrek-Socha ◽  
Paulina Konrad ◽  
Jan Chojnacki ◽  
Aleksandra Błońska
Keyword(s):  
Serum Level ◽  
Postmenopausal Women ◽  
Epigastric Pain ◽  
Serum Levels ◽  
Duodenal Mucosa ◽  
Urinary Concentration ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
H Pylori

Abstract Background Dyspeptic syndrome in the form of epigastric pain are particularly frequent in postmenopausal women. The aim of the study was to assess the role of melatonin in chronic dyspepsia in this group of women, with consideration of Helicobacter infection.Methods The study comprised 152 subjects Including 30 healthy women (group I), 60 women with asymptomatic H.pylori infection (group II), and 64 women H. pylori infected with chronic dyspepsia (group III). Endoscopic examination, histological assessment of gastric end duodenal mucosa, urease breath test (UBT-13C), and serum levels of 17-β-estradiol, follicle stimulating hormone, melatonin and urinary concentration of 6-sulfatoxymelatonin were determined by immunoenzymatic method. In group III – 14-day antibacterial treatment was introduced with pantoprazole, amoxicillin and levofloxacin. Afterward, in 32 women was administered placebo(group IIIa), and in 32 women (group IIIb) melatonin at a dose 1 m/morning and 3 mg/at bedtime, for six months.Results No significant differences were assessed between serum level of female hormone. Serum level of melatonin in group I and in group II was similar – 12,5 ± 2,72pg/ml and 10,5±3,73 pg/ml (p>0,05), whereas in group III was lesser – 5,72±1,42 pg/ml (p<0,001). Eradication of H.pylori was obtained in 75,0% women in group IIIa, and in 84,3% in group IIIb (p>0,05). After 6 months dyspeptic symptoms resolved in 43,7% patients in group IIIa and in 84,3% in group IIIb (p<0,001). Conclusion Melatonin supplementation is useful to complex therapy of H. pylori-associated dyspepsia, particularly in postmenopausal women at whom secretion of this hormone is decreased.

CHRONIC HELICOBACTER PYLORI GASTRITIS: THE ERADICATION EFFICACY&NBSP;OF THE&NBSP;BISMUTH-CONTAINING QUADRUPLE REGIMEN (EBMT)

2016 ◽  
pp. 149-158
Author(s):  
Ngoc Quy Hue Dang ◽  
Van Huy Tran ◽  
Thanh Hai Nguyen
Keyword(s):  
Helicobacter Pylori ◽  
Side Effects ◽  
Chronic Gastritis ◽  
Medication Compliance ◽  
Compliance Rate ◽  
Eradication Therapy ◽  
Rapid Urease Test ◽  
Urease Test ◽  
H Pylori ◽  
Helicobacter Pylori Gastritis

Background: there has not been yet any research on the effectiveness of H. pylori eradication of bismuth-containing quadruple regimen on chronic gastritis patients in our country. Objective: to evaluate H. pylori eradication rate of bismuth-containing quadruple regimen according to intention to treat (ITT), per protocol (PP) analysis, the rate of side effects and medication compliance. Subjects and Methods: from March 2014 to January 2016 we used bismuth-containing quadruple regimen (EBMT) 10 days for H. pylori eradication therapy for 166 chronic gastritis patients diagnosed based on clinical, endoscopic, rapid urease test, histology and culture. Patients were evaluated side effects and medication compliance at the end of treatment (day 11-14). To assess the eradication, repeating endoscopy with both rapid urease test and histological examination were performed at 4 to 8 weeks after stopping treatment course. Results: H. pylori eradication rates on ITT and PP analysis overall, for naïve patients, after one and more two eradication failures were respectively: 80.72-89.33%, 79.51-90.65%, 91.67-91.67% and 75.00-78.95%. Medication adherence rate was 96.99%. The rates of patients experiencing moderate, severe and very severe side effects were: 19.88%, 0.60% and 1.81%. Conclusion: the EBMT 10-day regimen attained high eradication rates in chronic gastritis patients with rare serious side effects and the high compliance rate. We should apply bismuth-containing quadruple regimen in H. pylori eradication therapy for naïve patients or after one eradication failure. Key words: bismuth-containing quadruple regimen, EBMT, eradication, chronic Helicobacter pylori gastritis

scholarly journals The value of melatonin supplementation in postmenopausal women with Helicobacter pylori-associated dyspepsia

2020 ◽  
Author(s):  
Cezary Chojnacki ◽  
Marta Mędrek-Socha ◽  
Paulina Konrad ◽  
Jan Chojnacki ◽  
Aleksandra Błońska
Keyword(s):  
Postmenopausal Women ◽  
Epigastric Pain ◽  
Duodenal Mucosa ◽  
Endoscopic Examination ◽  
Female Hormone ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
H Pylori

Abstract Background Dyspeptic syndrome is particularly common in postmenopausal women in the form of epigastric pain. The aim of the study was to assess the role of melatonin in chronic dyspepsia in this group of women, and examine the role of Helicobacter infection.Methods The study comprised 152 subjects including 30 healthy women (Group I), 60 women with asymptomatic H.pylori infection (Group II), and 64 women with H. pylori infection with chronic dyspepsia (Group III). Endoscopic examination was performed, as well as histological assessment of gastric end duodenal mucosa, urease breath test (UBT-13C), and immunoenzymatic assessment of serum 17-β-estradiol, follicle stimulating hormone and melatonin, and urinary 6-sulfatoxymelatonin. In Group III, 14-day antibacterial treatment was introduced with pantoprazole, amoxicillin and levofloxacin followed a six-month treatment with placebo in 32 women (Group IIIa), and melatonin 1 mg/morning and 3 mg/at bedtime in the other 32 women (Group IIIb).Results No significant differences were found between serum level of female hormone. Serum melatonin levels were similar between Group I (12.5 ± 2.72pg/ml) and Group II (10.5±3.73 pg/ml; p>0,05). The level was significantly lower in Group III (5.72±1.42 pg/ml; p<0.001). Eradication of H.pylori was obtained in 75.0% women in Group IIIa, and in 84.3% in Group IIIb (p>0.05). After six months, dyspeptic symptoms resolved in 43.7% patients in Group IIIa and 84.3% in Group IIIb (p<0.001).Conclusion Melatonin supplementation is useful in treating H. pylori-associated dyspepsia, particularly in postmenopausal women with lower levels of this hormone.Trial registration: NCT04352062, date of registration: 15.04.2020.

scholarly journals THE LEVELS OF IL-4 AND IL-8 IN SERUM OF PATIENTS WITH CHRONIC GASTRITIS AND ULCERATIVE DISEASE OF STOMACH AND DUODENUM

2019 ◽  
Vol 24 (1) ◽  
pp. 4-10
Author(s):  
Olga Fedorovna Belaia ◽  
D. C. Gutkin ◽  
E. V. Volchkova ◽  
A. N. Sundukova ◽  
E. N. Kareva ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Chronic Gastritis ◽  
Eradication Therapy ◽  
Serum Levels ◽  
The Body ◽  
Angiogenic Factor ◽  
Number Of Patients ◽  
Anti Inflammatory ◽  
H Pylori ◽  
Inflammatory Effect

Local inflammation in H. pylori infection is characterized by infiltration of the gastric mucosa by neutrophils and specific lymphocytes, an increase in the production of immunoregulatory, pro- and anti-inflammatory cytokines. IL-4 is the most important regulatory cytokine that plays a role in a huge number of immune and non-immune functions. IL-8 is a potent angiogenic factor and chemoattractant, its presence in the circulation can have a systemic pro-inflammatory effect on the body. IL-4 and IL-8 in H. pylori infection has been studied insufficiently. The goal is to establish serum levels of IL-4 and IL-8 in patients with chronic gastritis and peptic ulcer and duodenal ulcer. Materials and methods. 95 patients of the gastroenterological department were examined, of them 37 men and 58 women (mean age 59 years): 53 patients diagnosed with chronic active gastritis (CAG, including erosive gastroduodenitis) and 42 patients diagnosed with peptic ulcer (PU). Patients were conditionally divided into 4 subgroups: PU (without confirming the presence in patients with Hp according to generally accepted methods), PU + Hp (patients with the presence of Hp), CAG and CAG + Hp. Results. An increase in serum IL-4 levels (above 10 pg / ml) was observed in only 50.7% of patients, with approximately the same frequency in patients with CAG and PU, and an increase in serum IL-8 levels (above 0.062 ng / ml) - in most patients (90%), and the highest levels of IL8 were detected in patients with PU + Hp. In the first analysis, 31% of patients had elevated levels of IL-8 in the absence of IL-4, while in the second analysis - already 62% of patients (p ≤ 0.01). This indicated a sharp twofold decrease in the production of IL-4 in just a few days between the two analyzes. Conclusion. Considering that an increase in serum levels of IL-8 is found in a larger number of patients than IL-4, which, moreover, ceases to be detected in serum, it can be assumed that the production and anti-inflammatory effect of IL-4 are insufficient in some patients with gastritis and peptic ulcer disease. Against this background, elevated levels of IL-8 can help maintain inflammation in a significant number of patients, as well as reduce the effectiveness of eradication therapy.

scholarly journals CHRONIC GASTRITIS CLINICAL FEATURES AND STOMACH FUNCTIONAL STATE DURING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS ADMINISTRATION IN PATIENTS WITH OSTEOARTHRITIS

2016 ◽  
Vol 5 ◽  
pp. 17-22
Author(s):  
Maxim Zak ◽  
Lyudmila Pasiyeshvili
Keyword(s):  
Protective Factors ◽  
Atrophic Gastritis ◽  
Clinical Features ◽  
Chronic Gastritis ◽  
Group Iii ◽  
Group I ◽  
Gastric Contents ◽  
Inflammatory Drugs ◽  
Group Ii ◽  
Selective Nsaid

Aim. Determination of chronic gastritis clinical features and stomach functional state during nonsteroidal anti-inflammatory drugs (NSAID) administration in patients with osteoarthritis (OA). Materials and methods. 122 patients with OA and verified chronic gastritis (CG) (50 males and 72 females) aged 42 to 64 years (mean age – 49.65±3.51) were observed. Depending on gastritis morphological form, patients were divided into 2 groups: 54 patients with OA in combination with non-atrophic gastritis (NAG) were included into the group I, 68 patients with OA in combination with atrophic gastritis (AG) – into group II. 40 patients with OA without concomitant gastroduodenal pathology in anamnesis were included into the group III. All patients obtained selective NSAID for OA treatment: Meloxicam 15 mg daily or Nimesulide 200 mg daily. The control group was formed by 20 persons, which were found to be healthy after a complex examination. Stomach acid-forming function was investigated using esophageal pH monitoring. In the gastric contents, which obtained by aspiration, concentration of sialic acids glycoproteins, fucose, and hexosamines was determined. Results. Clinical picture of NSAID gastropathy at NAG characterized by abdominal pain of varying intensity and not associated with eating, but in patients with AG severity and discomfort symptoms dominated over weakly expressed pain syndrome. As a result of NSAID, in the group I dyspepsia developed in 31 (57.4 %), and erosive gastropathy developed in 9 (16.7 %) patients. In the group II, erosive gastropathy and dyspepsia were observed in 15 (22.1%) and in 35 (51.5 %) patients, respectively. In the group III, erosive gastropathy was observed 3.3 times (c2=84.33; р=0.009) and 4.4 times (c2=36.78; р=0.002) less than in groups I and II, respectively. In 25% patients of the group I after NSAID therapy intragastric pH increased from normacid to hyperacid status. In the group II, NSAID administration led to stomach mucosal (SM) protective factors depletion, which was observed in 73.3 % and in 28.6 % of patients with erosive gastropathy and NSAID-associated dyspepsia, respectively. At AG with erosive gastropathy, unlike NAG, several protective factors simultaneous reduction was observed. Coonclusion. In anamnesis, CG factor at selective NSAID administration (Meloxicam and Nimesulide) in relation to OA significantly increases the risk of erosive gastropathy, compared with patients without CG in anamnesis. At OA NSAID administration in patients with NAG led to gastric contents acidification and in patients with AG – to SM protective factors depletion (glycoprotein, fucose, and hexosamine).

Sign in / Sign up

Export Citation Format

Share Document