scholarly journals The need for accessibility to chloride to solubilize insoluble salts may underlie some cases of hypertension

2021 ◽  
Author(s):  
Lipeng Liao ◽  
Tao Gan ◽  
Yuhan Lin ◽  
Chanyuk Lam David ◽  
Jess Lan Ouyang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Calcium Oxalate ◽  
The Body ◽  
Increase Blood Pressure ◽  
Calcium Salts ◽  
Widespread Distribution ◽  
Defensive Mechanism

Hypertension is the greatest risk factor for stroke. It is the most common comorbidity of COVID-19, and may be partly caused by the widespread distribution of insoluble and stiff calcium salts such as calcium oxalate. As an intrinsic defensive mechanism, tissues in hypertensive individuals increase blood pressure to pump NaCl to inaccessible parts of the body, and chloride, as a strong anion can solubilize insoluble and rigid salts which are stressful to cells.

scholarly journals Psychosocial Distress and Blood Pressure among Young Adults: Role of Cortisol as Mediator

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Wan Fatein Wan Omar ◽  
Ramli Musa ◽  
Jamalludin A. Rahman ◽  
Azarisman Shah Mohd Shah ◽  
Norlelawati A. Talib ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Young Adults ◽  
Risk Factor ◽  
Stress Test ◽  
Fasting Blood Glucose ◽  
Serum Cortisol ◽  
Psychosocial Distress ◽  
The Body ◽  
Mediating Role

Introduction: Hypertension is the most prevalent risk factor of cardiovascular diseases in Malaysia. 17.3% of hypertension cases in Malaysia is attributed to adults aged 18 to 39 years. Psychosocial distress is a possible risk factor for elevated blood pressure in young adults, and cortisol could be the mediating factor. The aim of this study is to evaluate the mediating role of cortisol in hypertension and psychosocial distress in young adults. Materials and Methods: A comparative crosssectional study was conducted in 240 young adults aged 45 years or less. The body mass index, waist circumference and blood pressure parameters were recorded. Serum cortisol, creatinine, fasting blood glucose and lipid profile were measured following acute mental stress test. Psychosocial distress was assessed using the DASS-21 questionnaire. Results: Mean (standard deviation) values for SBP, DBP and MAP were 126.0 (16.3), 84.1 (12.2) and 98.1 (13.1) mmHg respectively. Anxiety was significantly associated with systolic blood pressure (β = 0.644), diastolic blood pressure (β = 0.454) and mean arterial pressure (β = 0.516) after adjusting to sex, age and cortisol. However, it was not mediated by cortisol. Depression and stress were not found to have any effect on blood pressure of the young adults studied. Conclusion: The data suggest that there is no elevated risk for psychosocial distress and hypertension that cortisol poses in young adults.

scholarly journals An Innovative Data-Driven Computational Model to Predict High Blood Pressure Based on AAA++

2018 ◽  
Vol 7 (3.3) ◽  
pp. 114 ◽  
Author(s):  
Satyanarayana Nimmala ◽  
Y Ramadevi ◽  
B Ashwin Kumar
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Computational Model ◽  
High Blood Pressure ◽  
Experimental Analysis ◽  
The Body ◽  
Data Driven ◽  
Blood Cholesterol ◽  
Proposed Model ◽  
The Impact

Every tissue of human body needs energy and oxygen for its livelihood. In order to supply energy and oxygen, the heart pumps the blood around the body. When heart pushes the blood against the walls of arteries, it creates some pressure inside the arteries, called as blood pressure. If this pressure is more than the certain level we treat it as high blood pressure (HBP). Nowadays HBP is a silent killer of many across the globe. So here we proposed a new data-driven computational model to predict HBP. Blood Pressure (BP) may be elevated because of many changes such as physical and emotional. In the proposed model we have considered AAA++ (age, anger level, anxiety level, obesity (+), blood cholesterol (+)), for experimental analysis. Our model initially calculates the correlation coefficient (CC) between each risk factor and class label attribute. Then based on the impact of each risk factor value and CC, it assigns the corresponding weight to it. Then proposed model uses risk factor value and its weight to predict whether person becomes a victim of HBP or not. We have used real-time data set for experimental analysis. It consists of 1000 records, which are collected from Doctor C, a Medical Diagnostic center, Hyderabad, India. 

Abstract 134: Does Low-Level Cumulative Lead Play a Role in Resistant-Hypertension?

2018 ◽  
Vol 11 (suppl_1) ◽  
Author(s):  
Alex Zheutlin ◽  
Howard Hu ◽  
Marc Weisskopf ◽  
David Sparrow ◽  
Pantel Vokonas ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
The Body ◽  
Mitigation Strategies ◽  
Future Research ◽  
Continuous Variables ◽  
Bone Lead ◽  
Confounding Variables ◽  
Lead Levels

Purpose: Deposition of lead into bone offers a better method over conventional blood lead measurement to discern long-term lead exposure and its insidious accumulation within the body. Bone lead deposition has been identified as an independent risk factor for hypertension (HTN). Yet, little is known how bone lead as a risk factor for HTN can be translated into clinical utility. We examined the association between bone lead levels and resistant-HTN. Methods: All subjects were males, participating in the Veterans Affairs Normative Aging Study (NAS) with an age variation of 48-93 years old. Participants were included if there was complete data on HTN (systolic blood pressure, diastolic blood pressure, and anti-HTN medication), lead (blood, bone-patella, bone-tibia), as well as demographic and confounding variables. Cases of resistant-HTN were identified by meeting criteria for a) inadequate SBP (≥140 mmHg) or DBP (≥90 mmHg) on 3 medications or b) requiring ≥ 4 medications for blood pressure control. Resistant-HTN was categorized as a dichotomous variable, based upon meeting the noted criteria, while tibia and patella bone lead were treated as continuous variables. The data was analyzed using a binomial logistic regression, accounting for demographic and confounding variables. Results: Of the 871 total study participants, 111 cases of resistant-HTN (12.7%) were identified. Amongst the cases of resistant-HTN, the mean tibia and patella lead levels were 23.1 μg/g and 31.5 μg/g, respectively. Both mean levels were higher than those among the participants without resistant-HTN (21.5 μg/g and 30.9 μg/g, respectively). Tibia lead levels demonstrated a significant association with resistant-HTN (OR=1.27 (95% CI, 1.01-1.59) per one IQR increase in tibia lead (15μg/g), p=0.04) after adjusting for age, BMI, cigarette pack-year burden, income, education, and ethnicity. A weak, non-significant association was observed between patella lead and resistant-HTN (OR = 1.16 (95% CI, 0.92-1.46) per one IQR increase in patella lead (21μg/g), p=0.21). Conclusion: Lead has been long-studied for its effect on blood pressure. Yet, lead has not previously been assessed for the role it plays in clinical outcomes. Difficulty in attaining goal blood pressure may be influenced by environmental exposures. Our study demonstrates an increased association between tibia lead and resistant-HTN status, with an OR of 1.27 per one IQR increase in tibia lead. Tibia lead represents a novel risk factor for resistant-HTN. Future research should consider screening and mitigation strategies for populations with resistant-HTN exposed to long-term low-levels of lead.

scholarly journals Obesity as a risk factor linked to high blood pressure in ecuadorian labor population

2019 ◽  
Vol 3 (27) ◽  
pp. 171
Author(s):  
Ciro Gabriel Espinel Robles ◽  
Marlene Sánchez Mata ◽  
Junes Lady Robles-Amaya
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
High Blood Pressure ◽  
Public Health Problem ◽  
Overweight And Obesity ◽  
The Body ◽  
Public Institution ◽  
Cross Sectional ◽  
Research Participants ◽  
Important Relationship

Introduction Studies have shown that obesity and high blood pressure are related and constitute a public health problem due to the burden on health worldwide and Ecuador is no exception. Objective: The objective of this study is to determine obesity as a risk factor linked to high blood pressure in employees of a public institution in Ecuador. Methods: This is a descriptive cross-sectional study, with a population of 18 to 72 years of age, carried out from December 2016 to March 2017, in a local government of Guayas province. The variables studied were sociodemographic, anthropometric to determine the body mass index, measurement of blood pressure. After the informed consent, a control-card was applied. Results: Obesity contributes as a risk factor for high blood pressure with 42.7%, with a predominance in the group of 28 to 37 years of age of the population studied; and obesity grade 1, grade 2 and grade 3, represents 37.3%. People with high blood pressure corresponded to 36.4%, with dominance in the population from 18 to 57 years of age and similarly distributed in these age groups. Discussion overweight and obesity are health problems that are increasing and may present complications related to other diseases such as hypertension. Conclusions: The study concludes that there is an important relationship between obesity and high blood pressure in the research participants. Conclusions: The study concludes that there is an important percentage relationship between obesity and high blood pressure in research participants.

scholarly journals Psychosocial Distress and Blood Pressure among Young Adults: Role of Cortisol as Mediator

2020 ◽  
Vol 18 (2) ◽  
Author(s):  
Wan Fatein Nabeila W.O. ◽  
Azarisman S.M.S ◽  
Jamalludin A.R. ◽  
Norlelawati A.T. ◽  
Ramli M. ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Young Adults ◽  
Risk Factor ◽  
Stress Test ◽  
Fasting Blood Glucose ◽  
Serum Cortisol ◽  
Psychosocial Distress ◽  
The Body ◽  
Cross Sectional

Introduction: Hypertension is the most prevalent risk factor of cardiovascular diseases in Malaysia. 17.3% of hypertension cases in Malaysia is attributed to adults aged 18 to 39 years. Psychosocial distress is a possible risk factor for elevated blood pressure in young adults, and cortisol could be the mediating factor. The aim of this study is to evaluate the mediating role of cortisol in hypertension and psychosocial distress in young adults. Methods and materials: A comparative cross-sectional study was conducted in 240 young adults aged 18 to 45 years. The body mass index, waist circumference and blood pressure parameters were recorded. Serum cortisol, creatinine, fasting blood glucose and lipid profile were measured following acute mental stress test. Psychosocial distress was assessed using the DASS-21 questionnaire. Results: Mean (standard deviation) values for SBP, DBP, MAP were 126.0(16.3), 84.1(12.2) and 98.1(13.1) mmHg respectively. Anxiety was significantly associated with systolic blood pressure (β=0.644), diastolic blood pressure (β=0.454) and mean arterial pressure (β=0.516) after adjusting for sex, age and cortisol. However, it was not mediated by cortisol. Depression and stress were not found to have any effect on blood pressure of the young adults studied. Conclusion: The data suggest that there is no elevated risk for psychosocial distress and hypertension that cortisol poses in young adults.

scholarly journals Cross-talk between ANGPTL4 gene SNP Rs1044250 and weight management is a risk factor of metabolic syndrome

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Zhoujie Tong ◽  
Jie Peng ◽  
Hongtao Lan ◽  
Wenwen Sai ◽  
Yulin Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Risk Factor ◽  
Waist Circumference ◽  
Weight Management ◽  
Independent Risk Factor ◽  
The Body ◽  
Elevated Blood Pressure ◽  
Elevated Blood

Abstract Background The prevalence of metabolic syndrome (Mets) is closely related to an increased incidence of cardiovascular events. Angiopoietin-like protein 4 (ANGPTL4) is contributory to the regulation of lipid metabolism, herein, may provide a target for gene-aimed therapy of Mets. This observational case control study was designed to elucidate the relationship between ANGPTL4 gene single nucleotide polymorphism (SNP) rs1044250 and the onset of Mets, and to explore the interaction between SNP rs1044250 and weight management on Mets. Methods We have recruited 1018 Mets cases and 1029 controls in this study. The SNP rs1044250 was genotyped with blood samples, base-line information and Mets-related indicators were collected. A 5-year follow-up survey was carried out to track the lifestyle interventions and changes in Mets-related indicators. Results ANGPTL4 gene SNP rs1044250 is an independent risk factor for increased waist circumference (OR 1.618, 95% CI [1.119–2.340]; p = 0.011), elevated blood pressure (OR 1.323, 95% CI [1.002–1.747]; p = 0.048), and Mets (OR 1.875, 95% CI [1.363–2.580]; p < 0.001). The follow-up survey shows that rs1044250 CC genotype patients with weight gain have an increased number of Mets components (M [Q1, Q3]: CC 1 (0, 1), CT + TT 0 [− 1, 1]; p = 0.021); The interaction between SNP rs1044250 and weight management is a risk factor for increased systolic blood pressure (β = 0.075, p < 0.001) and increased diastolic blood pressure (β = 0.097, p < 0.001), the synergistic effect of weight management and SNP rs1044250 is negative (S < 1). Conclusion ANGPTL4 gene SNP rs1044250 is an independent risk factor for increased waist circumference and elevated blood pressure, therefore, for Mets. However, patients with wild type SNP 1044250 are more likely to have Mets when the body weight is increased, mainly due to elevated blood pressure.

scholarly journals Assessment of the functional state of the pilot organism during the simulated flight on the simulator

2020 ◽  
pp. 17-30
Author(s):  
Василий Васильевич Сериков ◽  
Ольга Игоревна Юшкова ◽  
Валентина Евгеньевна Богданова ◽  
Евгений Владимирович Зибарев ◽  
Агния Юрьевна Форверц
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Risk Factor ◽  
Arterial Hypertension ◽  
Functional State ◽  
Continuous Monitoring ◽  
Flight Time ◽  
The Body ◽  
Physiological Cost

В статье обсуждаются проблемы динамики функционального состояния организма летчиков в условиях продолжительного полета и во время смоделированного полета на тренажере. По результатам данных непрерывного мониторирования артериального давления и частоты сердечных сокращений установлено, что высоконапряженная работа пилотов является фактором риска развития общесоматической патологии. Чем больше времени находится пилот воздушного судна в полете, тем выше физиологическая «стоимость» работы, что указывает на высочайшую степень их загруженности даже во время тренировочного полета. По мере увеличения длительности рабочей нагрузки наблюдаются признаки развития артериальной гипертензии The article discusses the problems of the dynamics of the functional state of the body of pilots in the conditions of a long flight and during a simulated flight on a simulator. The results of continuous monitoring of blood pressure and heart rate revealed that the highly stressed work of pilots is a risk factor for the development of somatic pathology. The longer the flight time of an aircraft pilot, the higher the physiological “cost” of work, which indicates the highest degree of their workload even during a training flight. As the duration of the workload increases, signs of the development of arterial hypertension are observed.

B-Vitamins, Methylenetetrahydrofolate Reductase (MTHFR) and Hypertension

2011 ◽  
Vol 81 (4) ◽  
pp. 240-244 ◽  
Author(s):  
Mary Ward ◽  
Carol P Wilson ◽  
J J Strain ◽  
Geraldine Horigan ◽  
John M. Scott ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Low Dose ◽  
Methylenetetrahydrofolate Reductase ◽  
Genetic Determinant ◽  
Gene Encoding ◽  
Homocysteine Concentration ◽  
Homozygous Mutant ◽  
B Vitamin

Hypertension is a leading risk factor for cardiovascular disease (CVD) and stroke. A common polymorphism in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR), previously identified as the main genetic determinant of elevated homocysteine concentration and also recognized as a risk factor for CVD, appears to be independently associated with hypertension. The B-vitamin riboflavin is required as a cofactor by MTHFR and recent evidence suggests it may have a role in modulating blood pressure, specifically in those with the homozygous mutant MTHFR 677 TT genotype. If studies confirm that this genetic predisposition to hypertension is correctable by low-dose riboflavin, the findings could have important implications for the management of hypertension given that the frequency of this polymorphism ranges from 3 to 32 % worldwide.

Burnout of the Mind – Burnout of the Body?

2018 ◽  
Vol 32 (1) ◽  
pp. 30-42 ◽  
Author(s):  
Claudia Traunmüller ◽  
Kerstin Gaisbachgrabner ◽  
Helmut Karl Lackner ◽  
Andreas R. Schwerdtfeger
Keyword(s):  
Blood Pressure ◽  
Allostatic Load ◽  
Maslach Burnout Inventory ◽  
The Body ◽  
Lower Percentage ◽  
Control Group ◽  
Urinary Catecholamines ◽  
Morning Cortisol ◽  
The Mind ◽  
Cortisol Increase

Abstract. In the present paper we investigate whether patients with a clinical diagnosis of burnout show physiological signs of burden across multiple physiological systems referred to as allostatic load (AL). Measures of the sympathetic-adrenergic-medullary (SAM) axis and the hypothalamic-pituitary-adrenal (HPA) axis were assessed. We examined patients who had been diagnosed with burnout by their physicians (n = 32) and were also identified as burnout patients based on their score in the Maslach Burnout Inventory-General Survey (MBI-GS) and compared them with a nonclinical control group (n = 19) with regard to indicators of allostatic load (i.e., ambulatory ECG, nocturnal urinary catecholamines, salivary morning cortisol secretion, blood pressure, and waist-to-hip ratio [WHR]). Contrary to expectations, a higher AL index suggesting elevated load in several of the parameters of the HPA and SAM axes was found in the control group but not in the burnout group. The control group showed higher norepinephrine values, higher blood pressure, higher WHR, higher sympathovagal balance, and lower percentage of cortisol increase within the first hour after awakening as compared to the patient group. Burnout was not associated with AL. Results seem to indicate a discrepancy between self-reported burnout symptoms and psychobiological load.

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