Cyclodextrins as potential gene therapy vectors
Cyclodextrins (CDs)-based techniques of delivering nucleic acid have considerable potential in gene therapy. A clinical study using a CD-based delivery technique to distribute siRNA to patients with solid tumors was done. The ribonucleotide reductase (RRM2)-related siRNA utilized in that work was designed to reduce cancer. Besides melanoma research, CD-like delivery systems were examined as therapeutic techniques for hepatoma, glioma, breast cancer, and cardiovascular diseases. Preclinical and clinical studies that have been linked have shown a tremendous amount of therapeutic promise. Several difficulties remain before clinical studies may employ CD-based nucleic acid delivery methods. In addition, easy modification techniques should be researched to ensure the security of the delivery systems. CD's intrinsic advantages, including its exceptional biological properties and unique structure, enable the sensible design of a wide range of distribution systems. CDs are anticipated to be used for clinical gene therapy transformation with the progress of relevant research and ongoing materials science and biology development. The research focuses on cancer therapy, but other hereditary diseases may benefit from increased attention.