scholarly journals High Performance in Screening for Colorectal Cancer: A Practice Partner Research Network (PPRNet) Case Study

2009 ◽  
Vol 22 (2) ◽  
pp. 141-146 ◽  
Author(s):  
L. S. Nemeth ◽  
P. J. Nietert ◽  
S. M. Ornstein
Keyword(s):  
Colorectal Cancer ◽  
High Performance ◽  
Research Network ◽  
Partner Research

THE USE OF CASE STUDY METHOD IN TEACHING THE TERMINOLOGY IN THE FIELD OF AGRICULTURAL MACHINERY

2019 ◽  
pp. 123-130
Keyword(s):  
Case Studies ◽  
High Performance ◽  
Mechanical Engineering ◽  
The United States ◽  
Machine Building ◽  
Soil Tillage ◽  
Case Study Method ◽  
Agricultural Machine ◽  
Manufacturing Machine

The scientific research works concerning the field of mechanical engineering such as, manufacturing machine slate, soil tillage, sowing and harvesting based on the requirements for the implementation of agrotechnical measures for the cultivation of plants in its transportation, through the development of mastering new types of high-performance and energy-saving machines in manufacturing machine slate, creation of multifunctional machines, allowing simultaneous soil cultivation, by means of several planting operations, integration of agricultural machine designs are taken into account in manufacturing of the local universal tractor designed basing on high ergonomic indicators. For this reason, this article explores the use of case studies in teaching agricultural terminology by means analyzing the researches in machine building. Case study method was firstly used in 1870 in Harvard University of Law School in the United States. Also in the article, we give the examples of agricultural machine-building terms, teaching terminology and case methods, case study process and case studies method itself. The research works in the field of mechanical engineering and the use of case studies in teaching terminology have also been analyzed. In addition, the requirements for the development of case study tasks are given in their practical didactic nature. We also give case study models that allow us analyzing and evaluating students' activities.

scholarly journals Neighborhood Energy Modeling and Monitoring: A Case Study

Energies ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3716
Author(s):  
Francesco Causone ◽  
Rossano Scoccia ◽  
Martina Pelle ◽  
Paola Colombo ◽  
Mario Motta ◽  
...  
Keyword(s):  
High Performance ◽  
High Efficiency ◽  
Early Stage ◽  
Energy Performance ◽  
Monitoring Plan ◽  
Performance Targets ◽  
Carrier Energy ◽  
Zero Carbon ◽  
Energy Grid

Cities and nations worldwide are pledging to energy and carbon neutral objectives that imply a huge contribution from buildings. High-performance targets, either zero energy or zero carbon, are typically difficult to be reached by single buildings, but groups of properly-managed buildings might reach these ambitious goals. For this purpose we need tools and experiences to model, monitor, manage and optimize buildings and their neighborhood-level systems. The paper describes the activities pursued for the deployment of an advanced energy management system for a multi-carrier energy grid of an existing neighborhood in the area of Milan. The activities included: (i) development of a detailed monitoring plan, (ii) deployment of the monitoring plan, (iii) development of a virtual model of the neighborhood and simulation of the energy performance. Comparisons against early-stage energy monitoring data proved promising and the generation system showed high efficiency (EER equal to 5.84), to be further exploited.

Hardware Accelerator Integration Tradeoffs for High-Performance Computing: A Case Study of GEMM Acceleration in N-Body Methods

2021 ◽  
Vol 32 (8) ◽  
pp. 2035-2048
Author(s):  
Mochamad Asri ◽  
Dhairya Malhotra ◽  
Jiajun Wang ◽  
George Biros ◽  
Lizy K. John ◽  
...  
Keyword(s):  
High Performance Computing ◽  
High Performance ◽  
Hardware Accelerator ◽  
Performance Computing

scholarly journals A mixed methods multiple case study to evaluate the implementation of a care pathway for colorectal cancer surgery using extended normalization process theory

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
R. van Zelm ◽  
E. Coeckelberghs ◽  
W. Sermeus ◽  
A. Wolthuis ◽  
L. Bruyneel ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Healthcare Professionals ◽  
Care Pathway ◽  
Implementation Process ◽  
Colorectal Cancer Surgery ◽  
Protocol Adherence ◽  
Multiple Case ◽  
Specific Factors ◽  
Normalization Process

Abstract Background Specific factors that facilitate or prevent the implementation of enhanced recovery protocols for colorectal cancer surgery have been described in previous qualitative studies. This study aims to perform a concurrent qualitative and quantitative evaluation of factors associated with successful implementation of a care pathway (CP) for patients undergoing surgery for colorectal cancer. Methods This comparative mixed methods multiple case study was based on a sample of 10 hospitals in 4 European countries that implemented a specific CP and performed pre- and post-implementation measurements. In-depth post-implementation interviews were conducted with healthcare professionals who were directly involved. Primary outcomes included protocol adherence and improvement rate. Secondary outcomes included length of stay (LOS) and self-rated protocol adherence. The hospitals were ranked based on these quantitative findings, and those with the highest and lowest scores were included in this study. Qualitative data were summarized on a per-case basis using extended Normalization Process Theory (eNPT) as theoretical framework. The data were then combined and analyzed using joint display methodology. Results Data from 381 patients and 30 healthcare professionals were included. Mean protocol adherence rate increased from 56 to 62% and mean LOS decreased by 2.1 days. Both measures varied greatly between hospitals. The two highest-ranking hospitals and the three lowest-ranking hospitals were included as cases. Factors which could explain the differences in pre- and post-implementation performance included the degree to which the CP was integrated into daily practice, the level of experience and support for CP methodology provided to the improvement team, the intrinsic motivation of the team, shared goals and the degree of management support, alignment of CP development and hospital strategy, and participation of relevant disciplines, most notably, physicians. Conclusions Overall improvement was achieved but was highly variable among the 5 hospitals evaluated. Specific factors involved in the implementation process that may be contributing to these differences were conceptualized using eNPT. Multidisciplinary teams intending to implement a CP should invest in shared goals and teamwork and focus on integration of the CP into daily processes. Support from hospital management directed specifically at quality improvement including audit may likewise facilitate the implementation process. Trial registration NCT02965794. US National Library of Medicine, ClinicalTrials.gov. Registered 4 August 2014.

scholarly journals ctDNA Clearance and Radiographic Resolution of Disease in Response to Dual Checkpoint Inhibition in Metastatic Microsatellite Stable Colorectal Cancer with a High Tumor Mutation Burden

2021 ◽  
pp. 849-853
Author(s):  
Charles J. Schneider ◽  
Michael Krainock ◽  
Allyson Koyen Malashevich ◽  
Meenakshi Malhotra ◽  
Perry Olshan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Ct Scan ◽  
Circulating Tumor Dna ◽  
Therapeutic Benefit ◽  
Tumor Mutation Burden ◽  
Early Treatment Response ◽  
Mutation Burden ◽  
Disease Present

Immunotherapy (IO) has increasingly been demonstrated to provide therapeutic benefit to patients with metastatic colorectal cancer (mCRC). However, only a subset of mCRC tumors respond to IO. Monitoring response with tumor biomarkers like carcinoembryonic antigen (CEA) has been challenging in patients with microsatellite stable (MSS) mCRC due to low expression of CEA (CEA/lo). Noninvasive blood-based biomarkers such as circulating tumor DNA (ctDNA) can inform early treatment response and augment radiographic monitoring. We describe a case study of a patient with chemotherapy-refractory CEA/lo MSS mCRC, with metastatic disease present in a cardiophrenic lymph node. The patient was given 2 cycles of combination IO (ipilimumab/nivolumab). Response was monitored by ctDNA using a multiplex PCR next-generation sequencing assay, CEA, and CT scan. After IO administration, ctDNA levels rapidly declined, becoming undetectable. This was concurrent with radiographic resolution of the lymph node metastasis. Serial monitoring of CEA during this same period was uninformative, with no significant changes observed. Significant decline in ctDNA identified metastatic response to IO in a patient with CEA/lo, MSS mCRC and was concurrently validated by CT scan. This case study provides evidence that ctDNA can be used as a prospective surrogate for radiographic tumor response.

scholarly journals To separate or not to separate: what is necessary and enough for a green and sustainable extraction of bioactive compounds from Brazilian citrus waste

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Vânia G. Zuin ◽  
Luize Z. Ramin ◽  
Mateus L. Segatto ◽  
Aylon M. Stahl ◽  
Karine Zanotti ◽  
...  
Keyword(s):  
High Performance ◽  
Orange Peel ◽  
Solvent Ratio ◽  
Biomass Waste ◽  
Chemical Profiles ◽  
Orange Waste ◽  
Sustainable Materials ◽  
Citrus Waste ◽  
Sustainable Extraction

AbstractIncreasing demands to obtain chemicals via greener and more sustainable materials and processes introduces concepts that should be considered and applied from lab to larger scales. Obtaining bioactive chemicals from agro-industrial non-food biomass waste can combine benign techniques and bio-circular economy to reach this goal. After extraction, evaluating profitability and environmental impacts to decide whether separation – and to what extent – is necessary or not is indispensable. This could be integrated into an approach known as sufficiency, as an important criterion for sustainability. From this perspective, Brazil’s annual generation of 8 million tons of orange waste is relevant, since citrus waste has large amounts of high-value compounds, such as pectin, d-limonene and flavonoids. This case study aimed at developing and comparing green and sustainable analytical methods to obtain flavonoids from orange peel. Homogenizer, ultrasound and microwave-assisted extractions were employed using chemometric tools, considering time, sample/solvent ratio, temperature and ethanol concentration as variables to obtain extracts containing hesperidin, naringenin, hesperetin and nobiletin. The bioactive flavonoids were determined by high-performance liquid chromatography (HPLC-UV). Microwave extraction was the most efficient method for obtaining the majority of flavonoids studied, six times more for hesperidin. Moreover, orange waste from different farming models showed diverse chemical profiles showing the importance of this alternative in natural product resources.

SURVEILLANCE OF DIABETES PREVALENCE RATE THROUGH THE DEVELOPMENT OF A MARKOV-BASED CONTROL CHART

2012 ◽  
Vol 12 (04) ◽  
pp. 1250083
Author(s):  
PERSHANG DOKOUHAKI ◽  
RASSOUL NOOROSSANA
Keyword(s):  
Control Chart ◽  
Control Charts ◽  
High Performance ◽  
Discrete Data ◽  
Correlated Data ◽  
Statistical Process ◽  
Control Charting ◽  
Attribute Quality ◽  
Related Process

In the field of statistical process control (SPC), usually two issues are addressed; the variables and the attribute quality characteristics control charting. Focusing on discrete data generated from a process to be monitored, attributes control charts would be useful. The discrete data could be classified into two categories; the independent and auto-correlated data. Regarding the independence in the sequence of discrete data, the typical Shewhart-based control charts, such as p-chart and np-chart would be effective enough to monitor the related process. But considering auto-correlation in the sequence of the data, such control charts would not workanymore. In this paper, considering the auto-correlated sequence of X1, X2,…, Xt,… as the sequence of zeros or ones, we have developed a control chart based on a two-state Markov model. This control chart is compared with the previously developed charts in terms of the average number of observations (ANOS) measure. In addition, a case study related to the diabetic people is investigated to demonstrate the applicability and high performance of the developed chart.

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