scholarly journals The role of materiality in numerical cognition

2021 ◽  
Author(s):  
Karenleigh A. Overmann
Keyword(s):  
Numerical Cognition ◽  
Middle Stone Age ◽  
Upper Palaeolithic ◽  
Cultural Complexity ◽  
Engagement Theory ◽  
Cognitive Archaeology ◽  
Finger Counting ◽  
New Perspective ◽  
Blombos Cave

Numerical elaboration and the extension of numbers to non-tangible domains such as time have been linked to cultural complexity in several studies. However, the reasons for this phenomenon remain insufficiently explored. In the present analysis, Material Engagement Theory, an emerging perspective in cognitive archaeology, provides a new perspective from which to reinterpret the cultural nexus in which quantification develops. These insights are then applied to representative Neolithic, Upper Palaeolithic, and Middle Stone Age artifacts used for quantification: clay tokens from Neolithic Mesopotamia, notched tallies from the European Upper Palaeolithic, hand stencils with possible finger-counting patterns as documented at Cosquer and Gargas, and stringed beads from Blombos Cave in South Africa.

scholarly journals Type and Token in the Prehistoric Origins of Numbers

2020 ◽  
Vol 30 (4) ◽  
pp. 629-646
Author(s):  
Oliver Schlaudt
Keyword(s):  
Cultural Practices ◽  
Mathematical Thinking ◽  
Philosophy Of Mathematics ◽  
Cultural Resources ◽  
Upper Palaeolithic ◽  
Cognitive Archaeology ◽  
Original Meaning ◽  
Thought Patterns ◽  
Analytical Tools

The type–token distinction and the notion of ‘tokenization’ are proposed as analytical tools that may help us understand better the emergence of numbers and mathematical thinking from the non-mathematical cultural practices of the Upper Palaeolithic such as painting, decorating portable objects, or making ornaments from beads, as described in recent studies in cognitive archaeology. While the type–token distinction has been a salient element in recent debates in the philosophy of mathematics, it seems not yet to have been registered in those areas of cognitive archaeology concerned with numbers—and yet it may help to identify the circumstances under which the conceptual potential of cultural artefacts develops. The concept of tokenization permits us to identify a plausible link between non-numerical cultural resources and the emergence of numerical thought patterns. This approach offers a way of appreciating the role of artefacts without raising the notoriously difficult question of their original ‘meaning’.

Faunal Exploitation Strategies During the Later Pleistocene in Southern Africa

2021 ◽  
Author(s):  
G. L. Dusseldorp ◽  
J.P. Reynard
Keyword(s):  
Southern Africa ◽  
Modern Human ◽  
Middle Stone Age ◽  
Faunal Remains ◽  
Large Herbivores ◽  
Subsistence Economies ◽  
Wide Range ◽  
Key Sites ◽  
Blombos Cave

The Late Pleistocene in southern Africa shows important developments in human subsistence economies. Zooarchaeological research indicates that early modern humans exploited a wide range of faunal species during the Middle Stone Age. Southern African societies developed flexible animal exploitation strategies that increased their resilience against the backdrop of drastic Pleistocene climatic changes. While megafauna are virtually absent, very large herbivores such as giant buffalo and dangerous prey such as suids were targeted with regularity. The study of faunal remains of such key sites as Border Cave, Blombos Cave, Klasies River, and Sibudu also played an important role in the development of overarching theories of the role of subsistence in the development of modern human behaviors through landmark studies by Richard Klein, Lewis Binford, and Curtis Marean, among others.

Is a snake scarier than a gun? The ontogenetic–phylogenetic dispute from a new perspective: The role of arousal.

Emotion ◽  
2019 ◽  
Vol 19 (4) ◽  
pp. 726-732 ◽  
Author(s):  
Andras Norbert Zsido ◽  
Anita Deak ◽  
Laszlo Bernath
Keyword(s):  
New Perspective

Epilogue

2018 ◽  
Author(s):  
Bruno and
Keyword(s):  
Sensory Processing ◽  
Multisensory Processing ◽  
Multisensory Perception ◽  
Future Directions ◽  
Life Problems ◽  
Multisensory Interactions ◽  
Contemporary Work ◽  
New Perspective

Multisensory interactions in perception are pervasive and fundamental, as we have documented throughout this book. In this final chapter, we propose that contemporary work on multisensory processing is a paradigm shift in perception science, calling for a radical reconsideration of empirical and theoretical questions within an entirely new perspective. In making our case, we emphasize that multisensory perception is the norm, not the exception, and we remark that multisensory interactions can occur early in sensory processing. We reiterate the key notions that multisensory interactions come in different kinds and that principles of multisensory processing must be considered when tackling multisensory daily-life problems. We discuss the role of unisensory processing in a multisensory world, and we conclude by suggesting future directions for the multisensory field.

Shifting Concepts

2020 ◽  
Keyword(s):  
Experimental Philosophy ◽  
Central Area ◽  
Linguistic Meaning ◽  
Human Cognition ◽  
Important Work ◽  
Linguistic Communication ◽  
New Perspective ◽  
Semantic Properties ◽  
Conceptual Variation

Concepts stand at the centre of human cognition. We use concepts in categorizing objects and events in the world, in reasoning and action, and in social interaction. It is therefore not surprising that the study of concepts constitutes a central area of research in philosophy and psychology. Since the 1970s, psychologists have carried out intriguing experiments testing the role of concepts in categorizing and reasoning, and have found a great deal of variation in categorization behaviour across individuals and cultures. During the same period, philosophers of language and mind did important work on the semantic properties of concepts, and on how concepts are related to linguistic meaning and linguistic communication. An important motivation behind this was the idea that concepts must be shared, across individuals and cultures. However, there was little interaction between these two research programs until recently. With the dawn of experimental philosophy, the proposal that the experimental data from psychology lacks relevance to semantics is increasingly difficult to defend. Moreover, in the last decade, philosophers have approached questions about the tension between conceptual variation and shared concepts in communication from a new perspective: that of ameliorating concepts for theoretical or for social and political purposes. The volume brings together leading psychologists and philosophers working on concepts who come from these different research traditions.

scholarly journals Exosomes: a new perspective in EGFR-mutated lung cancer

2021 ◽  
Author(s):  
Amina Jouida ◽  
Cormac McCarthy ◽  
Aurelie Fabre ◽  
Michael P. Keane
Keyword(s):  
Lung Cancer ◽  
Cell Communication ◽  
Egfr Mutations ◽  
Functional Effect ◽  
Prognosis And Prediction ◽  
Novel Biomarkers ◽  
New Perspective ◽  
Source Of Information ◽  
Egfr Mutated

AbstractExosomes are major contributors in cell to cell communication due to their ability to transfer biological material such as protein, RNA, DNA, and miRNA. Additionally, they play a role in tumor initiation, promotion, and progression, and recently, they have emerged as a potential source of information on tumor detection and may be useful as diagnostic, prognostic, and predictive tools. This review focuses on exosomes from lung cancer with a focus on EGFR mutations. Here, we outline the role of exosomes and their functional effect in carcinogenesis, tumor progression, and metastasis. Finally, we discuss the possibility of exosomes as novel biomarkers in early detection, diagnosis, assessment of prognosis, and prediction of therapeutic response in EGFR-mutated lung cancer.

scholarly journals From Exosome Glycobiology to Exosome Glycotechnology, the Role of Natural Occurring Polysaccharides

2021 ◽  
Vol 2 (2) ◽  
pp. 311-338
Author(s):  
Giulia Della Rosa ◽  
Clarissa Ruggeri ◽  
Alessandra Aloisi
Keyword(s):  
State Of The Art ◽  
Cell Communication ◽  
Pathological Conditions ◽  
New Findings ◽  
Cell Type Specific ◽  
New Perspective ◽  
And Function ◽  
And Personalized Medicine ◽  
Innate Ability

Exosomes (EXOs) are nano-sized informative shuttles acting as endogenous mediators of cell-to-cell communication. Their innate ability to target specific cells and deliver functional cargo is recently claimed as a promising theranostic strategy. The glycan profile, actively involved in the EXO biogenesis, release, sorting and function, is highly cell type-specific and frequently altered in pathological conditions. Therefore, the modulation of EXO glyco-composition has recently been considered an attractive tool in the design of novel therapeutics. In addition to the available approaches involving conventional glyco-engineering, soft technology is becoming more and more attractive for better exploiting EXO glycan tasks and optimizing EXO delivery platforms. This review, first, explores the main functions of EXO glycans and associates the potential implications of the reported new findings across the nanomedicine applications. The state-of-the-art of the last decade concerning the role of natural polysaccharides—as targeting molecules and in 3D soft structure manufacture matrices—is then analysed and highlighted, as an advancing EXO biofunction toolkit. The promising results, integrating the biopolymers area to the EXO-based bio-nanofabrication and bio-nanotechnology field, lay the foundation for further investigation and offer a new perspective in drug delivery and personalized medicine progress.

scholarly journals Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 377
Author(s):  
Yunna Lee ◽  
Eunok Im
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
Natural Antioxidants ◽  
Sirtuin 1 ◽  
Potential Benefits ◽  
New Perspective ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Cardiovascular diseases (CVDs) are the most common cause of morbidity and mortality worldwide. The potential benefits of natural antioxidants derived from supplemental nutrients against CVDs are well known. Remarkably, natural antioxidants exert cardioprotective effects by reducing oxidative stress, increasing vasodilation, and normalizing endothelial dysfunction. Recently, considerable evidence has highlighted an important role played by the synergistic interaction between endothelial nitric oxide synthase (eNOS) and sirtuin 1 (SIRT1) in the maintenance of endothelial function. To provide a new perspective on the role of natural antioxidants against CVDs, we focused on microRNAs (miRNAs), which are important posttranscriptional modulators in human diseases. Several miRNAs are regulated via the consumption of natural antioxidants and are related to the regulation of oxidative stress by targeting eNOS and/or SIRT1. In this review, we have discussed the specific molecular regulation of eNOS/SIRT1-related endothelial dysfunction and its contribution to CVD pathologies; furthermore, we selected nine different miRNAs that target the expression of eNOS and SIRT1 in CVDs. Additionally, we have summarized the alteration of miRNA expression and regulation of activities of miRNA through natural antioxidant consumption.

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