scholarly journals Histopathological Study of Endometrium in Patients of Perimenopausal Age Group in a tertiary care Hospital in West Bengal

2021 ◽  
Vol 12 (9) ◽  
pp. 84-87
Author(s):  
Nabanita Chakraborty ◽  
Rajasri Chunder ◽  
Barnali Mukherjee ◽  
Soham Chakraborty
Keyword(s):  
Tertiary Care ◽  
Abnormal Uterine Bleeding ◽  
Histological Change ◽  
Endometrial Biopsy ◽  
Uterine Bleeding ◽  
Histopathological Study ◽  
Care Hospital ◽  
Age Group ◽  
Histological Changes ◽  
Reproductive Life

Background: Menopause is an important event in women’s life and it marks the end of a woman`s reproductive life. Perimenopause is the interval in which a woman`s body makes a natural shift from regular cycles of ovulation & menstruation to irregular cycles and various forms of abnormal uterine bleeding. Dysfunctional uterine bleeding (DUB) is a very frequent complaint from women in the perimenopausal age group. The histological diagnosis of DUB and its proper management is very essential in this age group. Aims and Objective: Primary aim of our study was to identify the spectrum of histological changes that occur in the endometrium in perimenopausal age group and to identify the demographic pattern of each histological change. Materials and Methods: Fifty-two specimens of endometrial biopsy obtained from the patients in the perimenopausal age group of 40-50 years attending the Gynaecology and Obstetrics department were studied. Results: 71.15% cases of DUB was diagnosed amongst the 52 endometrial biopsy specimens in perimenopausal age group and Secretory endometrium is most common histological pattern. Conclusion: This study reflects a spectrum of endometrial histology present during perimenopausal age. This study has  also highlighted the correlation of endometrial histology with final diagnoses of the patients, and this may help in diagnosis and treatment of gynaecological diseases of this specific age group in future.

HISTOPATHOLOGICAL STUDY OF ENDOMETRIUM IN WOMEN WITH ABNORMAL UTERINE BLEEDING

2021 ◽  
pp. 30-33
Author(s):  
Bhakti D Deshmukh ◽  
Anuradha Malpani ◽  
Alka V Gosavi ◽  
Kalpana R Sulhyan ◽  
Rucha M Pimpalkhute
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Abnormal Uterine Bleeding ◽  
Intraepithelial Neoplasia ◽  
Mucinous Carcinoma ◽  
Uterine Bleeding ◽  
Serous Carcinoma ◽  
Histopathological Study ◽  
Care Hospital ◽  
Age Group

BACKGROUND –Abnormal uterine bleeding (AUB) is dened as a bleeding pattern that differs in frequency, duration and amount from a pattern observed during a normal menstrual cycle. The term dysfunctional uterine bleeding (DUB) is used to describe abnormal uterine bleeding for which no specic cause has been found. AUB is one of the most common gynaecological problems. This study was done to evaluate histological patterns of endometrium in women with abnormal uterine bleeding. AIMS AND OBJECTIVE – To study various histological patterns of endometrium in abnormal uterine bleeding and correlate it with age, parity and symptoms. MATERIAL AND METHODS –This is a retrospective study, conducted in the Department of Pathology, in a tertiary care hospital from 1st July 2016 to 30th June 2019. Total 718 specimens with AUB were included in the study from the age group of 21 to 95 years. The specimens received were hysterectomy (74.65 %), endometrial biopsies (21.45%), dilatation and curettage (2.79 %) and transcervical resection of endometrium (1.11 %). RESULTS –The patients with AUB were mainly from the age group 41-50 years with menorrhagia as the chief complaint. Most of the women with AUB were multiparous (84.54%). The most common pattern observed on histopathological examination was proliferative endometrium (49.86%) followed by atrophic endometrium (10.31%). Malignancy was found in 2.23% (Endometrioid carcinoma – 1.81%, serous carcinoma - 0.14% and mucinous carcinoma – 0.28%). Endometrial hyperplasia without atypia (23 cases, 3.20%) was more common than endometrial atypical hyperplasia (EAH) / endometrioid intraepithelial neoplasia {EIN} (4 cases, 0.56 %). Various other patterns of endometrium on histopathology were endometritis (6.82 %) followed by endometrial polyp (4.46 %). CONCLUSION – Histopathological examination of endometrium should be done generously in women presenting with abnormal uterine bleeding especially after the age of 40 years to rule out malignant pathology.

scholarly journals Histopathological evaluation of Endometrium hyperplasia and it’s correlation with the clinical parameters in a tertiary care hospital

2021 ◽  
Vol 6 (3) ◽  
pp. 187-190
Author(s):  
Tina Rai ◽  
Upasana Uniya ◽  
Archana Shrivastava ◽  
G.S Rai
Keyword(s):  
Endometrial Hyperplasia ◽  
Tertiary Care ◽  
Abnormal Uterine Bleeding ◽  
Clinical History ◽  
Underlying Disease ◽  
Uterine Bleeding ◽  
Clinical Parameters ◽  
Care Hospital ◽  
Age Group ◽  
Proper Management

: Abnormal uterine bleeding is a common clinical presentation in the perimenopausal age group its biopsy serves as an excellent clue to the underlying disease. The presentation may vary according to the type of endometrial hyperplasia and their correlation helps in the proper management of the patients complain.: To analyze the histopathological patterns of endometrial hyperplasia as well as to correlate endometrial hyperplasia with the clinical parameters.: It is a retrospective study and included one year data. A total of 125 cases that underwent hysterectomies or endometrial biopsies for abnormal uterine bleeding were recorded with their clinical history. For all cases the histopathology slides were re-evaluated and results were recorded. Epidemiological variables were analyzed by cross tabulation to assess their relationship. Out of 125 cases 53 cases had endometrial hyperplasia, 24 cases were having simple hyperplasia followed by 14 cases with simple hyperplasia without atypia, 9 cases with complex hyperplasia with atypia followed by 6 cases with complex hyperplasia without atypia. 30 to 50 years age group commonly had endometrial hyperplasia & menorrhagia was the common clinical complain in our patients.: In all the females coming to OPD with abnormal uterine bleeding clinical correlation should be properly made with biopsy report of the patient for the proper management of the condition, which avoids landing up of the patient into further complication.

scholarly journals Histopathological study of endometrium in dysfunctional uterine bleeding

2018 ◽  
Vol 7 (9) ◽  
pp. 3497
Author(s):  
Malarvizhi Loganathan ◽  
Meera Krishnakumar
Keyword(s):  
Abnormal Uterine Bleeding ◽  
Histological Change ◽  
Uterine Bleeding ◽  
Histopathological Study ◽  
Age Group ◽  
Dysfunctional Uterine Bleeding ◽  
Medical College ◽  
Histopathological Studies ◽  
The Right ◽  
Secretory Endometrium

Background: This study was undertaken to study the endometrial histology in patients presenting with abnormal uterine bleeding in the absence of palpable pelvic pathology, which helps in choosing the right modality of treatment in a particular age group with a specific histological change. The study of endometrium in dysfunctional uterine bleeding was undertaken to correlate clinical presentations with histopathological studies and to correlate the distribution of histopathological findings in various age groups.Methods: The present study was conducted in the Department of Obstetrics and Gynaecology at Govt. Dharmapuri Medical College and Hospital during the period 01.07.2017 to 31.05.2018. Patients presenting to Govt. Dharmapuri Medical College and Hospital with abnormal uterine bleeding form the material of this study. Cases have been selected by using purposive sampling technique.Results: An ovulatory cycles were more common than ovulatory cycles in all age group. However, in patients with menorrhagia and polymenorrhagia majority had secretory endometrium (ovulatory cycles).Conclusions: Majority of the patients were found in the reproduction age group with the maximum percentage in multiparous women. Menorrhagia was the commonest mode of presentation in all age group. Most of the patients with proliferative and secretory endometrium had normal sized uterus and normal looking endometrium.

scholarly journals Study of endometrial histopathology in women with abnormal uterine bleeding

2017 ◽  
Vol 6 (3) ◽  
pp. 824
Author(s):  
Ushadevi Gopalan ◽  
Sathiyakala Rajendiran ◽  
Karnaboopathy Ranganathan
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Abnormal Uterine Bleeding ◽  
Endometrial Biopsy ◽  
Uterine Bleeding ◽  
Age Group ◽  
Dilatation And Curettage ◽  
Proliferative Endometrium ◽  
A Prospective Study ◽  
Secretory Endometrium

Background: Abnormal uterine bleeding is a major gynaecological problem accounting for 33% of Gynaec outpatients. The cause of the bleeding is established in only 50-60% of the cases. The aim of this study was to evaluate the various histopathological patterns in the endometrial biopsy of patients presenting with abnormal uterine bleeding and to determine the specific pathology in the different age groups.Methods: This was a prospective study done in a tertiary care teaching hospital for a period of 2 years. Total of 905 patients with abnormal uterine bleeding were included in the study and they were subjected to a Dilatation and Curettage. Histopathological examination of the endometrial biopsy was done and the various histopathological patterns identified and classified.Results: The age of patients ranged from 24-74 years. 54.7% were in the age group 40-49 years followed by 23.4% in the age group 30-39 years. The most frequent findings were proliferative findings in 47.3% followed by secretory endometrium in 16.1 % patients. Proliferative endometrium was more common in the age group 40-49 years as also disordered proliferation, secretory endometrium, cystoglandular hyperplasia and endometrial hyperplasia.Conclusions: Endometrial curettings and biopsy is an important diagnostic procedure for assessing all cases of abnormal uterine bleeding and to plan for successful management.

scholarly journals Pipelle Endometrial Biopsy vs Dilatation and Curettage to Diagnose Endometrial Diseases in Abnormal Uterine Bleeding

2017 ◽  
Vol 5 (2) ◽  
pp. 123-128
Author(s):  
Nikhitha Chandrashekar ◽  
Jyothi GS ◽  
Prasanna Shetty
Keyword(s):  
Predictive Value ◽  
Endometrial Hyperplasia ◽  
Tertiary Care ◽  
Abnormal Uterine Bleeding ◽  
Endometrial Biopsy ◽  
Uterine Bleeding ◽  
Histopathological Analysis ◽  
Care Hospital ◽  
Dilatation And Curettage ◽  
Risk Of Cancer

ABSTRACT Aim The objective of this study was to assess the adequacy of the sample aspirated in order to make a definite diagnosis of endometrial disease in abnormal uterine bleeding (AUB) and to draw comparisons between the histopathological findings of Pipelle endometrial aspiration biopsy and dilatation and curettage (D&C). Materials and methods Pipelle endometrial biopsy and D&C samples were collected from 100 patients with AUB in the Department of the Obstetrics and Gynecology and sent to the Department of Pathology of a tertiary care hospital for adequacy of the sample and for histopathological analysis. Results The Pipelle sample was adequate in 73% of the cases and inadequate in 27% compared with D&C, which showed 85% and 15%, respectively. About 53% of cases were comparable between D&C and Pipelle and 37% were discordant. For endometrial hyperplasia using Pipelle aspirator, the sensitivity was 58.8%, specificity was 91.6%, positive predictive value (PPV) was 58.8%, negative predictive value (NPV) was 91.6%, and concordance was 86%. For detection of endometrial carcinoma using Pipelle, the sensitivity was 50%, specificity was 99%, PPV was 50%, NPV was 99%, and concordance rate was 98%. Conclusion It is more convenient and cost-effective for patients to undergo pipelle biopsy to confirm normalcy and rule out endometrial hyperplasia rather than undergoing D&C initially. Out of the 27% of inadequate samples, 14.8% had fibroids and 11.1% had polyps, thus showing that tumors localized to a polyp or a small area of endometrium went undetected with Pipelle. Clinical significance Due to the high specificity and NPV and low sensitivity and PPV in diagnosing endometrial lesions and carcinomas, pipelle is suitable for women with a low risk of cancer. In cases where the diagnosis is hyperplasia on Pipelle, the patients are advised to undergo hysteroscopic-guided D&C following pipelle to confirm the diagnosis. This is also applicable for cases of polyps and fibroids. How to cite this article Chandrashekar N, Jyothi GS, Shetty P. Pipelle Endometrial Biopsy vs Dilatation and Curettage to Diagnose Endometrial Diseases in Abnormal Uterine Bleeding. J South Asian Feder Menopause Soc 2017;5(2):123-128.

scholarly journals Histopathological evaluation of endometrial tissue in patients of abnormal uterine bleeding

2021 ◽  
Vol 11 (1) ◽  
pp. 69
Author(s):  
Zothansangi . ◽  
Vanremmawii . ◽  
Naveen P.
Keyword(s):  
Abnormal Uterine Bleeding ◽  
Endometrial Biopsy ◽  
Uterine Bleeding ◽  
Endometrial Tissue ◽  
Histopathological Study ◽  
Age Group ◽  
North East ◽  
The North ◽  
Resource Setting ◽  
A Prospective Study

Background: Abnormal uterine bleeding (AUB) is one of the commonest complaints in the gynecology OPD. It is also one of the most common reason for hysterectomy among Mizo women. Endometrial biopsy is a gold standard and first step for diagnosis of AUB in a low resource setting like the North-east states of India. The aim of the study was to evaluate the histopathology of endometrium for proper management of AUB cases.Methods: This was a prospective study done to evaluate the histopathology of all the cases of AUB who attended gynaecology OPD, from the year 2018 to 2020. This study comprised of 668 AUB cases and material of the study was endometrial tissue of the cases of Abnormal uterine bleeding collected by dilatation and curettage, and sent for histopathological study to the department of pathology.Results: Most of the abnormal uterine bleeding patients was in the age group of 40 to 49 years, and the most common histopathological finding was proliferative endometrium, 35.5% followed by disordered proliferation, 21%. 14 cases of carcinoma endometrium were found among the age group above 40 years.Conclusions: The research evident that all the women above 40 years old need to undergo screening, keeping in mind the higher risk of carcinoma in the older age group of women.

scholarly journals Histo-pathological pattern of endometrial biopsy in females with abnormal uterine bleeding: a retrospective study in tertiary care hospital of Haryana

2020 ◽  
Vol 9 (10) ◽  
pp. 4068
Author(s):  
Gagan Lata ◽  
Susmita Sharma ◽  
Sukhbir Pal Kaur ◽  
Sandhya Panjeta Gulia
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Abnormal Uterine Bleeding ◽  
Endometrial Biopsy ◽  
Care Hospital ◽  
Age Group ◽  
Normal Endometrium ◽  
Biopsy Specimens ◽  
Standard Procedures ◽  
Malignant Changes

Background: This study aimed to know the various histo-pathological patterns of endometrial biopsy and their incidence in patients of AUB.Methods: Patients in the age group between 21-75 years who had presented with AUB and underwent endometrial biopsy from 1st January 2017 to 31st December 2019 were included. The endometrial biopsy specimens which were already taken from patients with AUB were scrutinized for histopathological pattern. Various patterns of histo-pathology of endometrial biopsy were noted and studied.Results: Most common age group which was affected was between 36-40 years. The endometrial biopsies and curetting’s on histopathology revealed various patterns ranging from normal endometrium to malignancy. Patterns of normal cyclical endometrium (proliferative and secretory phases) were the most common patterns.Conclusions: Evaluation of women with AUB is important around the perimenopausal age group to detect any atypical and malignant changes and intervene early. Histopathological examination in correlation to radiological findings remain the standard procedures for diagnosis.

scholarly journals Study on abnormal uterine bleeding among adult women in a tertiary care hospital in Bihar, India

2018 ◽  
Vol 7 (8) ◽  
pp. 3136
Author(s):  
Kajal Sinha ◽  
Prajnanika Gurung ◽  
Hemali H. Sinha ◽  
Punam P. Bhadani
Keyword(s):  
Tertiary Care ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Adult Women ◽  
Care Hospital ◽  
Age Group ◽  
Successful Management ◽  
Age Group Classification ◽  
Rule Out

Background: Abnormal uterine bleeding (AUB) is the most common problem among patients coming to gynaecology outpatient department. There are various pathologies which can lead to AUB. History, blood investigations, ultrasonography, hysteroscopy and endometrial aspiration are the methods to rule out different causes. Later on, they are classified as per PALM-COEIN classification. It helps in better and successful management of AUB patients.Methods: It was a retrospective study done in Obstetrics and Gynaecology Department of AIIMS Patna from March 2014 to March 2016. A total of 272 cases were selected and data were collected in structured proforma on excel sheet.Results: The most common age-group presenting with AUB was 40 to 49 years of age (58%) and the most common histological pattern was secretory (47.7%).  Menorrhagia was found to be the most common problem in AUB patients (58.45%). As per PALM- COEIN classification, the most common type in our study was found to be AUB-E (26.8%). In a sub-set of patients, who underwent hysterectomy, histopathological samples were compared to endometrial samples which were similar in 81.6% cases.Conclusions: Incidence and pattern of AUB varies according to the age of the patient. It is more common in perimenopausal age-group. Classification of AUB as per PALM-COEIN helps in better understanding of disease and successful management of patients. 

Histopathological Study of Myometrial Lesions of Uterus in a Tertiary Care Hospital of South India

2021 ◽  
Vol 8 (06) ◽  
pp. 293-297
Author(s):  
Gayathri B.N ◽  
Mallikarjun A. Pattanashetti ◽  
Priyadarshini M.M
Keyword(s):  
Histopathological Examination ◽  
Tertiary Care ◽  
Abnormal Uterine Bleeding ◽  
Cross Sectional Study ◽  
Histopathological Study ◽  
Care Hospital ◽  
Age Group ◽  
Cross Sectional ◽  
Microscopic Pathology ◽  
Age Range

BACKGROUND The most commonly done gynaecological surgery worldwide is hysterectomy. Myometrial lesions contribute to majority of cases with abnormal uterine bleeding. Leiomyoma and adenomyosis are most common lesions seen in the myometrium. The present study was undertaken to identify the various types of myometrial pathologies in hysterectomy samples. METHODS This is a two-year retrospective cross-sectional study done from January 2017 to December 2018, in the Department of Pathology, Kodagu Institute of Medical Sciences, Madikeri. All the patients who underwent hysterectomy and myomectomy for myometrial lesions of uterus were included in the study. Hysterectomy specimens showing secondaries, gross infection, massive haemorrhage and necrosis were excluded from the study. Gross appearance and microscopic pathology were noted and results were analysed. RESULTS In this study, 148 specimens were included. Age range was from 20 years to 65 years. Histopathological examination revealed that 58.25 % of myometrial lesions were present in the age group of 41 to 50 years followed by age group of 31 to 40 years. Histopathological examination done showed the following diagnosis in patients - leiomyoma (85.13 %), adenomyosis (8.79 %) and leiomyoma with adenomyosis (6.08 %). CONCLUSIONS The commonest histopathological lesion in myometrium was leiomyoma (85.13 %) followed by adenomyosis (8.79 %). It is mandatory to examine the hysterectomy specimens adequately to diagnose myometrial lesions. KEYWORDS Myometrium, Leiomyoma, Adenomyosis

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