scholarly journals Biochemical changes in some trace elements, antioxidant vitamins and their therapeutic importance in prostate cancer patients

2014 ◽  
Vol 6 (1) ◽  
pp. 95-97 ◽  
Author(s):  
Bridget Obiageli Onyema-iloh ◽  
Samuel C Meludu ◽  
Emmanuel Iloh ◽  
Johnkennedy Nnodim ◽  
Onyema Onyegbule ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Trace Elements ◽  
Vitamin A ◽  
Cancer Patients ◽  
High Performance ◽  
Serum Levels ◽  
Serum Copper ◽  
Antioxidant Vitamins ◽  
Copper Level ◽  
Antioxidant Vitamin

Aim: This study was conducted to evaluate the serum levels of some trace-elements (zinc, copper and selenium) and antioxidant vitamins (vitamin A, C and E) in prostate cancer patients. Method: A total of 50 prostate cancer patients aged 50-70 years with PSA > 4.0 ng/dl were recruited for the study while 50 apparently healthy individual were used as control subjects. Zinc, copper and selenium were determined using atomic absorption spectrophotometer while vitamin A, C and E were determined using high performance liquid chromatography. Result: The result showed that the mean levels of Se (0.77±0.26), Zn(147.75±42.05) were significantly lower (p <0.05) when compared with the control (1.47±0.13) and (168.78±59.80) respectively. The serum copper level (187. 76±66.05) was significantly higher (p<0.05) when compared with control (126.40±31.24).The antioxidant vitamin A (0.42±0.19), vitamin C (3.62±1.81) and vitamin E (0.39±0.13) were Significantly lower p(<0.05) when compared with the control (0.68±0.32)(12.16±4.07) and (1.40±0.16) respectively. Concusion: The decreased trace elements and antioxidant vitamins may be associated with high free radicals generated due to oxidative stress in prostate cancer patient. DOI: http://dx.doi.org/10.3126/ajms.v6i1.10799 Asian Journal of Medical Sciences Vol.6(1) 2015 95-97

scholarly journals Serum Levels of Selenium, Zinc, Copper, Manganese, and Iron in Prostate Cancer Patients

2020 ◽  
Vol 14 (1) ◽  
pp. 44-49 ◽  
Author(s):  
Saleh A.K. Saleh ◽  
Heba M. Adly ◽  
Altaf A. Abdelkhaliq ◽  
Anmar M. Nassir
Keyword(s):  
Prostate Cancer ◽  
Trace Elements ◽  
Cancer Patients ◽  
Serum Levels ◽  
Cellular Growth ◽  
Control Groups ◽  
Icp Ms ◽  
Copper Manganese ◽  
Trace Element Contents ◽  
Serum Trace Elements

Backgrounds: Variations of trace element contents may be associated with several diseases including metabolic disorders, cellular growth disturbance, mutation and tumorigenesis. Prostate cancer is the second most common male cancer worldwide and stand fifth most common male cancer in Saudi Arabia. Objective: In the present study, Serum levels of selenium, zinc, copper, manganese, and iron were measured in patients with BPH and prostate cancer aiming to explore the association between these elements and prostate cancer. Patients and Methods: The study included 40 newly diagnosed prostate cancer patients, 22 patients with BPH and 30 healthy male subjects. All participant groups had similar socio-economic levels. Fasting blood samples were collected from all subjects and before any intervention for the patients. Serum PSA concentrations were analyzed by ELIZA and trace elements Se, Zn, Cu, Mn and Fe were measured by ICP-MS. Results: Serum Se, Zn, and Mn levels of prostate cancer patients were significantly decreased compared to control groups. The levels of serum Cu and Fe were significantly higher in prostate cancer patients than in control groups. Conclusion: In the present study, an association was noticed between serum trace elements disturbance and prostate cancer. The decreased levels of Se, Zn, and Mn, and increased Cu and Fe levels may play significant roles in the initiation of prostate cancer. However, future prospective studies on the causes of trace elements alteration in prostate cancer patients are needed as well as to illustrate the relation between different prostate cancer stages and trace elements concentrations.

scholarly journals SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER

2015 ◽  
Vol 57 (4) ◽  
pp. 315-320 ◽  
Author(s):  
Rajendiran SOUNDRAVALLY ◽  
Jacob SHERIN ◽  
Balakrishna Pillai AGIESHKUMAR ◽  
Mariya Samadanam DAISY ◽  
Cherupanakkal CLEETUS ◽  
...  
Keyword(s):  
Trace Elements ◽  
Dengue Fever ◽  
Serum Levels ◽  
Serum Copper ◽  
Warning Signs ◽  
The Other ◽  
Severe Dengue ◽  
Copper Level ◽  
Iron Level

SUMMARY The role of trace elements in dengue virulence is not yet known. The present study assessed the serum levels of two micronutrients, copper and iron, in cases of dengue fever. The study involved 96 patients of whom 48 had either severe or non-severe forms of dengue (with and without warning signs), and the remaining 48 were patients with other febrile illnesses (OFI), used as controls. Serum levels of copper and iron were evaluated at admission and by the time of defervescence using commercially available kits. At admission, no difference in the level of serum copper was observed between cases and controls. In the group of dengue cases, the copper level was found to be significantly decreased in severe and non-severe cases with warning signs, compared to non-severe cases without warning signs. In contrast, by the time of defervescence the copper level was found to be increased in all dengue cases compared to OFI controls, but no difference was observed among dengue cases. Unlike OFI controls, dengue cases showed an increasing pattern of copper levels from admission until defervescence. On the other hand, no such significant differences were observed in the serum level of iron in the clinical groups, except for a decreased iron level found in severe cases, compared to non-severe dengue without warning signs. The results show that copper is associated with dengue severity and this finding emphasizes the need to investigate the involvement of trace elements in disease severity so as to improve the prognosis of dengue.

scholarly journals A correlative study of copper, iron, zinc and haematological parameters in oral cancer patients

2021 ◽  
Vol 19 (2) ◽  
pp. 22-25
Author(s):  
Joel Sabu ◽  
Keyword(s):  
Trace Elements ◽  
Oral Cancer ◽  
Serum Level ◽  
Cancer Patients ◽  
Serum Levels ◽  
Haematological Parameters ◽  
Oral Carcinogenesis ◽  
Group I ◽  
Iron And Zinc ◽  
Oral Cancer Patients

Background: Alteration in levels of copper, iron and zinc variate the enzymatic actions in our body and thereby play a major role in etiopathogenesis of oral carcinogenesis. Aim of the study: The present study was mainly aimed to estimate, compare and correlate the serum levels of copper, iron and zinc with haematological parameters in oral cancer patients in comparison to normal controls. Methods: The collected serum of cases and controls were analyzed by using standard spectrophotometric methods in spectrophotometer analyzer and the data obtained was analysed and represented as Mean ± SD, mean difference was analyzed by Student’s T-test and Chi- square test for significance and strength of association by Karl Pearson’s correlation using SPSSv23 software. Results: Mean serum level of iron was significantly lower and the levels of zinc and copper in patients with oral cancerous lesions were significantly higher than that of healthy individuals. Pearson’s r data analysis, revealed a significant negative correlation between iron with platelets, and MCHC (Mean Corpuscular Haemoglobin Concentration). A significant positive correlation was seen between iron with haemoglobin and lymphocytes; between copper with leucocytes. Conclusions: The serum levels of zinc and copper in group I were significantly higher when compared to controls. There was a significant lower serum level of iron in Group-I when compared to controls. A significant correlation was seen in between serum trace elements and haematological parameters in oral cancer. This suggests the involvement of trace elements in variations of haematological parameters in the pathogenesis of oral carcinogenesis.

scholarly journals Effect of immunonutritional status, healthcare factors, and lifestyle on acute respiratory infections among under-5 children in Bangladesh

2020 ◽  
Vol 8 ◽  
pp. 205031212094053
Author(s):  
Md. Mustafa Kamal ◽  
Farina Aziz ◽  
Md. Rabiul Islam ◽  
Monira Ahsan ◽  
Sheikh Nazrul Islam
Keyword(s):  
Vitamin E ◽  
Vitamin A ◽  
Vitamin C ◽  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Serum Vitamin ◽  
Antioxidant Vitamins ◽  
Antioxidant Vitamin ◽  
Z Score ◽  
The Impact

Introduction: Acute respiratory infection is a major cause of death for under-5 children in Bangladesh. We aimed to analyze the effect of immunonutritional status, healthcare factors, and lifestyle on the incidence of acute respiratory infection among under-5 children taking individual-level and contextual-level risk factors into consideration. Methods: This study recruited 200 children suffering from acute respiratory infection and 100 healthy controls matched by age, sex, and sociodemographic profile. Serum antioxidant vitamin A (retinol), vitamin C (ascorbic acid), and vitamin E (α-tocopherol) were assessed along with the impact of vaccination, socioeconomic factors, and Z-score on the incidence of acute respiratory infection. Results: Serum antioxidant vitamins were significantly lower in the acute respiratory infection children compared to the non–acute respiratory infection group. Vitamin A was found to be significantly high in acute respiratory infection children who were breastfed for more than 1 year. Vitamin E levels were found to be significantly higher in the acute respiratory infection children who were immunized. Compared to the children living in tin-shed house or huts, serum vitamin E level increased in those acute respiratory infection children who resided in apartments. Vitamin A level was significantly high in those acute respiratory infection children whose height-for-age was −2 SD and above ( Z-score), and vitamin C levels were also significantly high in those acute respiratory infection children whose weight-for-height was −2 SD and below ( Z-score). Conclusion: Deficiencies of antioxidant vitamins along with healthcare and lifestyle factors have a significant influence on the incidence of acute respiratory infection among under-5 children in Bangladesh.

scholarly journals Serum trace metals in Pre-Eclamptic Nigerians

2016 ◽  
Vol 7 (3) ◽  
pp. 78-83 ◽  
Author(s):  
Ikechukwu Chidiebere Ikaraoha ◽  
Nkeiruka Chigaekwu Mbadiwe ◽  
John Ibhagbemien Anetor ◽  
Isreal Agware Ojareva
Keyword(s):  
Trace Metals ◽  
Pregnant Women ◽  
Serum Levels ◽  
Zinc Level ◽  
Serum Copper ◽  
Copper Level ◽  
Medical Sciences ◽  
Lower Serum ◽  
Significant Difference

Background: The role of trace metals in Pathogenesis of Pre-eclampsia has received insufficient attention in Nigeria.Materials and Methods: We examined the effect of serum levels of some trace metals; selenium (Se), zinc (Zn), copper (Cu), cobalt (Co), and manganese (Mn) in the development of pre-eclampsia in Nigeria. Blood samples were collected from 59 pre-eclamptic, 150 normal pregnant and 122 non pregnant women. Serum Se, Zn, Cu, Co and Mn were determined by AAS.Results: Result shows significantly lower serum Se, Zn, Cu, Cu: Zn ratio, Co and Mn in pre-eclamptics compared to normal pregnant women (p<0.001). Comparison of normal pregnant women and controls showed non significant difference in the zinc level (P>0.05), significantly lower levels of serum Se, Co, Mn (p<0.00011, p=0.0022, p<0.0001 respectively) and significantly raised copper level (p<0.001) in normal pregnant women compared to controls.  Serum Se, Zn, Co and Mn were significantly lower (p<0.001) while serum copper and Cu: Zn ratio were significantly higher (p<0.001) in pregnant women compared to controls. ANOVA shows significant progressive decreases in serum Se, Zn Co and Mn, from controls to normal pregnant women and pre-eclamptics (p<0.0001).Conclusion: Decreases in serum level of Se, Zn, Cu, Cu: Zn ratio, Co and Mn may play important role in the pathogenesis of pre-eclampsia.Asian Journal of Medical Sciences Vol. 7(3) 2016 78-83

Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients

2016 ◽  
Vol 175 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Abdulkerim Kasim Baltaci ◽  
Tugrul Kadir Dundar ◽  
Faruk Aksoy ◽  
Rasim Mogulkoc
Keyword(s):  
Trace Elements ◽  
Thyroid Cancer ◽  
Cancer Patients ◽  
Serum Levels ◽  
Before And After

scholarly journals TRACE METALS IN CANCER PATIENTS AND THEIR CORRELATION WITH RENAL FUNCTION

2003 ◽  
Vol 42 (146) ◽  
pp. 71-73
Author(s):  
Shankhar Majhi ◽  
B D Toora ◽  
S K Sen ◽  
K Anantha ◽  
N Anantha
Keyword(s):  
Trace Elements ◽  
Trace Metals ◽  
Cancer Patients ◽  
Serum Zinc ◽  
Serum Copper ◽  
The Body ◽  
Significant Elevation ◽  
Super Oxide Dismutase ◽  
Carcinoma Stomach ◽  
Cu And Zn

ABSTRACTTwo trace elements, copper (Cu) and zinc (Zn) in serum are elevated in cancer patients since both areconstituents of super oxide dismutase (SOD) as metalloenzyme, the enzyme that scavenge free radicals andactivated oxygen species in the body. The study of 52 cancer patients comprising of 31 carcinoma stomachand 21 breast cancer showed the elevation of both of these trace elements in serum when compared to 32healthy controls and effected the kidney functions as a consequences. Serum Cu and Zn were estimated byAtomic Absorption Spectrometer (AAS), analyzed statistically by student "t" test and marked elevationwas observed in cancer patient compared to healthy controls. Serum Cu and Zn values were 98.13 ± 17.49μg/dl 99..57 ± 13.91 μg /dl respectively in 38 healthy subjects and these trace metals were 156.23 ± 31.02 μg/dl and 171.86 ± 35.15 μg/dl in 52 cancer patients showing significant elevation (P <0.001). These elevatedelements were routed through kidneys and damaged nephrons since both of them are cationic heavy metals.Nephrotoxicity of these trace metals was reflected as elevated level of blood urea and creatinine and werefound to be 27.44 ± 7.72 mg /dl and 0.83 ± 0.30 mg/dl in control groups and 64.49 ± 49 mg /dl and 1.60 ± 0.72mg/dl in cancer patients respectively, a significant elevation (P<0.001) in study group. The elevation ofthese parameters may indicate renal origin.Key Words: Serum copper, serum zinc, super oxide dismutase, carcinoma stomach, carcinoma breastand nephrotoxicity.

Sign in / Sign up

Export Citation Format

Share Document