scholarly journals Serum Levels of Selenium, Zinc, Copper, Manganese, and Iron in Prostate Cancer Patients

2020 ◽  
Vol 14 (1) ◽  
pp. 44-49 ◽  
Author(s):  
Saleh A.K. Saleh ◽  
Heba M. Adly ◽  
Altaf A. Abdelkhaliq ◽  
Anmar M. Nassir
Keyword(s):  
Prostate Cancer ◽  
Trace Elements ◽  
Cancer Patients ◽  
Serum Levels ◽  
Cellular Growth ◽  
Control Groups ◽  
Icp Ms ◽  
Copper Manganese ◽  
Trace Element Contents ◽  
Serum Trace Elements

Backgrounds: Variations of trace element contents may be associated with several diseases including metabolic disorders, cellular growth disturbance, mutation and tumorigenesis. Prostate cancer is the second most common male cancer worldwide and stand fifth most common male cancer in Saudi Arabia. Objective: In the present study, Serum levels of selenium, zinc, copper, manganese, and iron were measured in patients with BPH and prostate cancer aiming to explore the association between these elements and prostate cancer. Patients and Methods: The study included 40 newly diagnosed prostate cancer patients, 22 patients with BPH and 30 healthy male subjects. All participant groups had similar socio-economic levels. Fasting blood samples were collected from all subjects and before any intervention for the patients. Serum PSA concentrations were analyzed by ELIZA and trace elements Se, Zn, Cu, Mn and Fe were measured by ICP-MS. Results: Serum Se, Zn, and Mn levels of prostate cancer patients were significantly decreased compared to control groups. The levels of serum Cu and Fe were significantly higher in prostate cancer patients than in control groups. Conclusion: In the present study, an association was noticed between serum trace elements disturbance and prostate cancer. The decreased levels of Se, Zn, and Mn, and increased Cu and Fe levels may play significant roles in the initiation of prostate cancer. However, future prospective studies on the causes of trace elements alteration in prostate cancer patients are needed as well as to illustrate the relation between different prostate cancer stages and trace elements concentrations.

scholarly journals Biochemical changes in some trace elements, antioxidant vitamins and their therapeutic importance in prostate cancer patients

2014 ◽  
Vol 6 (1) ◽  
pp. 95-97 ◽  
Author(s):  
Bridget Obiageli Onyema-iloh ◽  
Samuel C Meludu ◽  
Emmanuel Iloh ◽  
Johnkennedy Nnodim ◽  
Onyema Onyegbule ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Trace Elements ◽  
Vitamin A ◽  
Cancer Patients ◽  
High Performance ◽  
Serum Levels ◽  
Serum Copper ◽  
Antioxidant Vitamins ◽  
Copper Level ◽  
Antioxidant Vitamin

Aim: This study was conducted to evaluate the serum levels of some trace-elements (zinc, copper and selenium) and antioxidant vitamins (vitamin A, C and E) in prostate cancer patients. Method: A total of 50 prostate cancer patients aged 50-70 years with PSA > 4.0 ng/dl were recruited for the study while 50 apparently healthy individual were used as control subjects. Zinc, copper and selenium were determined using atomic absorption spectrophotometer while vitamin A, C and E were determined using high performance liquid chromatography. Result: The result showed that the mean levels of Se (0.77±0.26), Zn(147.75±42.05) were significantly lower (p <0.05) when compared with the control (1.47±0.13) and (168.78±59.80) respectively. The serum copper level (187. 76±66.05) was significantly higher (p<0.05) when compared with control (126.40±31.24).The antioxidant vitamin A (0.42±0.19), vitamin C (3.62±1.81) and vitamin E (0.39±0.13) were Significantly lower p(<0.05) when compared with the control (0.68±0.32)(12.16±4.07) and (1.40±0.16) respectively. Concusion: The decreased trace elements and antioxidant vitamins may be associated with high free radicals generated due to oxidative stress in prostate cancer patient. DOI: http://dx.doi.org/10.3126/ajms.v6i1.10799 Asian Journal of Medical Sciences Vol.6(1) 2015 95-97

scholarly journals A correlative study of copper, iron, zinc and haematological parameters in oral cancer patients

2021 ◽  
Vol 19 (2) ◽  
pp. 22-25
Author(s):  
Joel Sabu ◽  
Keyword(s):  
Trace Elements ◽  
Oral Cancer ◽  
Serum Level ◽  
Cancer Patients ◽  
Serum Levels ◽  
Haematological Parameters ◽  
Oral Carcinogenesis ◽  
Group I ◽  
Iron And Zinc ◽  
Oral Cancer Patients

Background: Alteration in levels of copper, iron and zinc variate the enzymatic actions in our body and thereby play a major role in etiopathogenesis of oral carcinogenesis. Aim of the study: The present study was mainly aimed to estimate, compare and correlate the serum levels of copper, iron and zinc with haematological parameters in oral cancer patients in comparison to normal controls. Methods: The collected serum of cases and controls were analyzed by using standard spectrophotometric methods in spectrophotometer analyzer and the data obtained was analysed and represented as Mean ± SD, mean difference was analyzed by Student’s T-test and Chi- square test for significance and strength of association by Karl Pearson’s correlation using SPSSv23 software. Results: Mean serum level of iron was significantly lower and the levels of zinc and copper in patients with oral cancerous lesions were significantly higher than that of healthy individuals. Pearson’s r data analysis, revealed a significant negative correlation between iron with platelets, and MCHC (Mean Corpuscular Haemoglobin Concentration). A significant positive correlation was seen between iron with haemoglobin and lymphocytes; between copper with leucocytes. Conclusions: The serum levels of zinc and copper in group I were significantly higher when compared to controls. There was a significant lower serum level of iron in Group-I when compared to controls. A significant correlation was seen in between serum trace elements and haematological parameters in oral cancer. This suggests the involvement of trace elements in variations of haematological parameters in the pathogenesis of oral carcinogenesis.

scholarly journals Trace elements geochemistry in high-incidence areas of liver-related diseases, northwestern Ethiopia

2019 ◽  
Vol 42 (5) ◽  
pp. 1235-1254
Author(s):  
Jemal Ahmed
Keyword(s):  
Trace Elements ◽  
Trace Element ◽  
Selenium Deficiency ◽  
Stream Sediments ◽  
Low Grade ◽  
Geochemical Background ◽  
Water Stream ◽  
Icp Ms ◽  
History Of ◽  
Trace Element Contents

Abstract This paper reports the results of trace elements geochemistry from Tigray national state, northwestern Ethiopia. The area is part of the Arabian-Nubian Shield, where the dominant exposure is low-grade metamorphic rocks and has a long history of liver-related diseases. The increase in the number of liver-related disease patients of the area has been an environmental health issue of national concern. The aim of the study is to determine the level of trace element concentrations and distributions in water and stream sediments of the area and identify the possible sources in relation to human health. Water, stream sediment and rocks samples (20 water, 20 stream sediments, and 6 rock samples) were collected in March 2011 and analyzed for major and trace element contents using ICP-MS, ICP-OES, ion Chromatography, and XRF methods. Bromine, aluminum, fluorine, arsenic, and nitrate values exceed the WHO maximum acceptable concentration (MAC) for drinking purpose. Bromine ranges from 0.11 to 1.48 mg/l show higher values in all samples, and fluorine ranges from 0.21 to 16.49 mg/l show higher values in 20% of the samples. Other trace elements are aluminum—30%, arsenic—10%, and nitrate (NO3)—10%, and they are examples of elements which have above MAC for drinking water. Selenium deficiency may be the other problematic element in the area for which its deficiency is associated with liver damage and heart muscle disorder. The concentration of cobalt and chromium exceeded world geochemical background value in average shale at most sample stations indicated that these stations were in potential risk.

Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients

2016 ◽  
Vol 175 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Abdulkerim Kasim Baltaci ◽  
Tugrul Kadir Dundar ◽  
Faruk Aksoy ◽  
Rasim Mogulkoc
Keyword(s):  
Trace Elements ◽  
Thyroid Cancer ◽  
Cancer Patients ◽  
Serum Levels ◽  
Before And After

scholarly journals The Effects of Serum from Prostate Cancer Patients with Elevated Body Mass Index on Prostate Cancer Cells in Vitro

2015 ◽  
Vol 8 ◽  
pp. LPI.S23135
Author(s):  
Benjamin C. Mora ◽  
Neil E. Fleshner ◽  
Laurence H. Klotz ◽  
Vasundara Venkateswaran
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cell Migration ◽  
Cancer Patients ◽  
Migration And Invasion ◽  
Obese Patients ◽  
Control Groups ◽  
Necrosis Factor Alpha ◽  
Pc3 Cells

We examined whether serum from obese, compared to non-obese, PCa (prostate cancer) patients creates a growth-enhancing tumor micro-environment in vitro. Serum from 80 subjects was divided into four groups: normal weight men with and without PCa and overweight/obese men with and without PCa. Cell proliferation, migration, and invasion were measured in LNCaP, and PC3 cells treated with patient serum were obtained from the above groups. The results reveal that proliferation of LNCaP cells was significantly ( P = 0.05) greater with serum from non-obese (mean = 1.26 ± 0.20) compared to that from obese patients (mean = 1.16 ± 0.19). Serum from obese PCa patients compared to non-obese PCa patients induced significantly greater amounts of cell migration ( P < 0.01) in PC3 cells. Serum from obese patients induced significantly ( P < 0.01) lower amounts of cell invasion (mean = 8.2 ± 4.5) compared to non-obese patients (mean = 18.1 ± 5.0) when treated on PC3 cells. Serum TNF-α (tumor necrosis factor alpha) levels correlated with LNCaP cell proliferation in vitro in non-obese PCa ( P < 0.01) and non-obese control groups ( P = 0.05). All statistical calculations controlled for age, since the PCa patient groups were significantly older than the control groups ( P < 0.01). In conclusion, serum from obese PCa patients induced greater PCa cell migration and lower cell proliferation and invasion in vitro.

scholarly journals Serum Trace Elements in Manic Patients

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
Md Abu Baker ◽  
AFM Nazmus Sadat ◽  
Md Lutfor Rahman ◽  
MMA Shalahuddin Qusar ◽  
SM Imamul Huq ◽  
...  
Keyword(s):  
Trace Elements ◽  
Serum Concentration ◽  
Prognostic Significance ◽  
Flame Atomic Absorption Spectroscopy ◽  
Flame Atomic Absorption ◽  
Human Volunteers ◽  
Copper Manganese ◽  
Serum Trace Elements ◽  
Manic Patients ◽  
Exact Correlation

The serum concentration of zinc, copper, manganese and lead in 30 manic patients and 30 human volunteers were determined by flame atomic absorption spectroscopy. It was observed that the concentration of zinc in manic patients increased significantly (P < 0.05), where as the concentrations of copper, manganese and lead were found to be within the limit (P > 0.05). These concentrations of different trace elements may have some prognostic significance for the diagnosis of manic patients, but more work is suggested to find out the exact correlation between trace elements level & the degree of disorder in manic patients. Key words: Mania, trace elements, serum etc. Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

scholarly journals Altered Trace Elements Levels in Hair of Prostate Cancer Patients

2017 ◽  
Vol 09 (02) ◽  
Author(s):  
Saleh A K Saleh ◽  
Heba M Adly ◽  
Anmar M Nassir
Keyword(s):  
Prostate Cancer ◽  
Trace Elements ◽  
Cancer Patients
Sign in / Sign up

Export Citation Format

Share Document