scholarly journals ABO blood group discrepancies: Study of prevalence and related factors

2019 ◽  
Vol 1 (2) ◽  
pp. 88-91
Author(s):  
Bipin Nepal ◽  
Bikash Shrestha ◽  
Sabindra Maharjan ◽  
Sunil Bhasima ◽  
Shrawan Kumar Shrestha

Background: ABO discrepancy is any deviation from the expected pattern of red cell antigen grouping with serum-grouping or when the forward-grouping results do not correlate with reverse-grouping results. This study was done to determine the incidence and causes of ABO discrepancies and to identify the correct blood group for safe blood transfusions. Methods: This is a retrospective descriptive study. It was done on 9970 samples collected between June 2017and May 2018. All ABO typing records kept at the Grande International Hospital (GIH) blood bank laboratory were reviewed. Results: During the study period, 9970 blood grouping tests were performed. ABO discrepancies occurred in 26 of them. Discrepancies were more prevalent in the age of 20-30 and 30-40 years. Majority were seen in patients with history of pregnancy/miscarriage (30%) and with any Carcinoma (23%). The most common blood group involved was B with 34% frequency. 96% were reverse discrepancy type, 84% with extra antibody which was resolved by incubating the sample at 37°C for 30 minutes signifying most probably A and B subgroups and auto/allo antibodies. Conclusion: This study emphasizes the need of considering ABO discrepancies in blood banks for donors and recipients for safe blood transfusion to avoid any fatal complications. This discrepancy ratio of 1/384 is more than in other studied population of other countries and also higher than ABO mismatched transfusion in standard centers in Nepal. Repeat testing and investigating for ABO subgroups and auto/allo antibodies is important.

1970 ◽  
Vol 175 (1039) ◽  
pp. 183-200 ◽  

Karyotyping and blood grouping methods were used to identify sheep twin chimaeras. Evidence that an exchange of blood cell precursors (the origin of chimaerism) had taken place in utero was obtained by examining lymphocytes in culture and finding the chromosomes of both sexes in one individual, or by finding admixture of red cell antigens, haemoglobin or ‘X ’ protein. Where chimaerism of sex chromosomes was found the pairs had identical red cell types, but two separate populations of red cells were not always identifiable. The four females in the pairs studied were freemartins. No correlation was found between the relative proportions of the two red cell populations and those of the two white cell populations. In one pair of chimaeric ewes, breeding tests showed that the major red cell populations in each case were the true genetic type. In the freemartins no correlation was found between the degree of masculinity and the numbers of male lymphocytes. A possible correlation of masculinity with red cell proportions is discussed.


Mediscope ◽  
2015 ◽  
Vol 2 (1) ◽  
pp. 22-26
Author(s):  
RM Hira ◽  
LK Dhali ◽  
ND Dhali ◽  
DK Akash

This is an observational cross-sectional study aiming to identify the distribution patterns of ABO and Rh-D blood group in a rural population of Bagerhat District, Bangladesh in order to promote social awareness and safe blood transfusion among the population. After proper ethical consideration, a total of 164 people of a village in Bagerhat District were included in this study. They were selected irrespective of age and sex by systematic random sampling. ABO and Rh-D blood groups were determined by the antigen antibody agglutination test of slide method. The ABO group distribution, O (34.1%), A (26.2%), B (25.6% and AB (14.0%). Of the respondents, 105 (64.0%) were male and 59 (36.0%). The frequency of group O+ve comprised the highest (32.9%) of the samples followed by group A+ve, B+ve and AB+ve. The majority of the subjects were Rh-D positive (94.5%). It is observed that Rh-D positive group is more common in subjects with O group whereas Rh-D negative group is more common in B group. Most common blood group among this village population was O+ve which can safely be transfused to any other group. The study of blood grouping can generate database and create social awareness about self-blood grouping and safe blood transfusion among the population.Mediscope Vol. 2, No. 1: 2015, Pages 22-26


2017 ◽  
Vol 6 (2) ◽  
pp. 12-14
Author(s):  
Nilufar Begum ◽  
Amdadul Haque ◽  
Fatema Akhter Tumpa

This cross sectional study was done at department of Transfusion Medicine in Community Based Medical College (CBMCB) to know the Prevalence of ABO blood group and Rh group systems among the students selected for admission into CBMCB. Sample size was 555. Male female ratio was 67:33 with mean age was ±19 years. Maintaining aseptic precaution blood samples were collected by venepuncture with disposable syringe without anticoagulant. Antigen-antibody agglutination test was done in slide method for ABO and Rh(D) blood grouping by mixing individual blood sample with Anti A, Anti -B, Anti-D human antisera. Results were taken by visually and under microscope in low power. Blood group differs person to person due to genetically determined antigen. This study showed highest frequency of blood group B (33.5%) followed by O (32.5 %), A (23.37%) and AB (10.63%) in ABO system and In Rhesus system, frequency of Rh-positive was 97.12% and Rh-negative was 2.88%. Results were comparable with different foreign studies. Fair blood grouping assist the safe blood transfusion and reduce the morbidity and mortality considerably. CBMJ 2017 July: Vol. 06 No. 02 P: 12-14


2020 ◽  
Vol 27 (08) ◽  
pp. 1686-1691
Author(s):  
Sidra Ghazanfer ◽  
Mona Aziz ◽  
Hasan Osman Mahmood ◽  
Sarah Rafi

Objectives: To assess the extent of Blood Request Forms (BRFs) usage in routine blood banking, at a major Hospital in Lahore. Study Design: Cross-sectional Descriptive study. Setting: Shaikh Zayed Medical Complex Blood Bank, Lahore. Period: 6 months (Sept 2016 to March 2017). Material & Methods: A total of 1052 BRFs dispatched from in-patient of Shaikh Zayed Medical Complex, Lahore were selected. Patient’s MR number, date, demographic information, diagnosis, ward, history of transfusions, type of blood transfused, phlebotomist’s name etc., were analyzed. They were assessed and the results were produced in tabulated form as well as in graph. Results: Among the 1052 BRFs, “MR number” was filled in 99.4% (n=1046) forms, while 0.6% (n=6) were not filled. The column of “Date” was filled in 97% (n=1020) forms, while it was left blank in 3% (n=32) forms. Similarly, the column of “Age” was filled in 97.7% (n=1028) forms, whereas it was left empty in 2.3% (n=24) forms. Demographic information like “Patient’s Name” and “Gender” were filled in 100% forms. “Ward” was filled in 97.1% (n=1022) forms, while 2.9% (n=30) were unfilled. As far as “H/O previous transfusion(s)” column is concerned, 40.9% (n=430) forms were filled and 59.1% (n=622) were left unfilled. “H/O previous transfusion reaction(s)” column had almost the similar number with 37.6% (n=396) filled and 62.4% (n=656) left empty. The column of “Diagnosis” was filled in 22.4% (n=236) and was found unfilled in 77.6% (n=816). Moreover, the column of “Which type of component transfused” was filled in 96% (n=1010), while 4% (n=42) were unfilled. The column of “Amount of blood needed” was filled in 96.4% (n=1014) forms, while 3.6% (n=38) forms were unfilled. “When is the blood needed” column had only 29.3% (n=308) filled forms, whereas 70.7% (n=744) forms did not mention when the blood was needed. One of the most important columns is “Patient’s blood group”, which was filled in only 53.4% (n=562) forms, while 46.6% (n=490) forms were left empty. The column of “Name of phlebotomist” was filled in only 13.9% (n=146), while 86.1% (n=906) of the forms were found unfilled in this column. In total, our study revealed that among 1052 BRFs, only 6.8% (n=72) werecompletely filled, while 93.2% (n=980) were incompletely filled. Conclusion: Lack of awareness in BRF filling should be properly addressed to enhance efficiency and to reduce pre-analytical errors in healthcare setups. It is of utmost need that the clinicians and nurses should be made aware that BRFs play a pivotal role in smooth and error-free functioning of the healthcare setups.


2014 ◽  
Vol 23 (1) ◽  
pp. 34-36
Author(s):  
Tahmina Banu ◽  
SM Ali

A 35 years old lady was admitted to Square Hospital for termination of pregnancy on a medico-legal background. She was a diagnosed case of carcinoma of pancreas with Whipple’s operation performed six months back and was on chemotherapy. During pre-operative check-up we surprisingly noticed that she has ‘Bombay Blood Group’. It is a very rare type of blood group and on routine blood grouping behaves as “O” unless reverse grouping or serum grouping has been done and can receive transfusion from only peoples having Bombay group. As the patients general condition was poor and had recently received chemotherapy and also had a extremely rare blood group ((I in 250000) we decided to keep ready one unit of blood. We decided to provide autologus blood transfusion, as there was no known person in family or in our blood banks record with Bombay Blood Group. The procedure was uneventful and needed no transfusion. As the patient was anaemic and weak, we decided to transfuse the blood in the post-operative period and the patient was discharged from the hospital next day morning. DOI: http://dx.doi.org/10.3329/jbsa.v23i1.18157 Journal of BSA, 2010; 23(1): 34-36


1980 ◽  
Vol 43 (02) ◽  
pp. 137-140 ◽  
Author(s):  
Jan Erikssen ◽  
Erik Thaulow ◽  
Helge Stormorken ◽  
Ole Brendemoen ◽  
Arvid Hellem

SummaryThe view based on epidemiological and laboratory data that blood group A subjects (=A) have clinically significant higher thrombotic potential than blood group 0 subjects (= O), is supported by the present finding of a significantly higher platelet retention in A than 0.The completely normal ABO distribution found among 71 cases of proven latent CHD, and the disproportionate excess of 0 vs. A in a consecutive series of 191 coronary artery bypass candidates apparently conflict with epidemiological data indicating a higher risk of achieving CHD in A than 0. The conflict may be solved by suggestinga) that the »thrombotic proneness« in A compared with 0 causes a poorer prognosis in CHD among the former, leaving a disproportionate excess of 0 among longterm CHD survivors, and b) that AB0-related factors have had an insignificant, independent impact on the evolution of preclinical coronary artery disease in our 71 men with latent CHD.


2014 ◽  
pp. 140-152
Author(s):  
Manh Hoan Nguyen ◽  
Ngoc Thanh Cao

Background and Objective: HIV infection is also a cause of postpartum depression, however, in Vietnam, there has not yet the prevalence of postpartum depression in HIV infected women. The objective is to determine prevalence and related factors of postpartum depression in HIV infected women. Materials and Methods: From November 30th, 2012 to March 30th, 2014, a prospective cohort study is done at Dong Nai and Binh Duong province. The sample includes135 HIV infected women and 405 non infected women (ratio 1/3) who accepted to participate to the research. We used “Edinburgh Postnatal Depression Scale (EPDS) as a screening test when women hospitalized for delivery and 1 week, 6weeks postpartum. Mother who score EPDS ≥ 13 are likely to be suffering from depression. We exclude women who have EPDS ≥ 13 since just hospitalize. Data are collected by a structural questionaire. Results: At 6 weeks postpartum, prevalence of depression in HIV infected women is 61%, in the HIV non infected women is 8.7% (p < 0.001). There are statistical significant differences (p<0.05) between two groups for some factors: education, profession, income, past history of depression, child’s health, breast feeding. Logistical regression analysis determine these factors are related with depression: late diagnosis of HIV infection, child infected of HIV, feeling guilty of HIV infected and feeling guilty with their family. Multivariate regression analysis showed 4 factors are related with depression: HIV infection, living in the province, child’s health, past history of depression. Conclusion: Prevalence of postpartum depression in HIV infected women is 61.2%; risk of depression of postnatal HIV infected women is 6.4 times the risk of postnatal HIV non infected women, RR=6.4 (95% CI:4.3 – 9.4). Domestic women have lower risk than immigrant women from other province, RR=0.72 (95% CI:0.5 – 0.9). Past history of depression is a risk factor with RR=1.7 (95% CI:1.02 – 0.9. Women whose child is weak or die, RR=1.7(95% CI:0.9 – 3.1). Keywords: Postpartum depression, HIV-positive postpartum women


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