scholarly journals Pediatric brain abscess clinical profile, management and outcome at tertiary care centre in Nepal

2018 ◽  
Vol 14 (2) ◽  
pp. 102-106
Author(s):  
Prakash Kafle ◽  
Mohan Raj Sharma ◽  
Sushil Krishna Shilpakar ◽  
Gopal Sedain ◽  
Amit Pradhanang ◽  
...  
Keyword(s):  
Brain Abscess ◽  
Pediatric Population ◽  
Tertiary Care ◽  
Clinical Profile ◽  
University Teaching ◽  
Institute Of Medicine ◽  
Tertiary Care Centre ◽  
Female Ratio ◽  
Profile Management ◽  
Pediatric Brain

ABSTRACTBackground: Brain abscess in pediatric population is serious life threatening problem. Many risk factors are associated with this entity like congenital heart disease, ear infection and immunocompromised state. Early diagnosis and treatment with minimal invasive procedure has good outcome. Materials and Methods: This is a hospital based cross-sectional study conducted at institute of Medicine (IOM), Tribhuvan University Teaching Hospital Kathmandu, Nepal over the period of 3 years between September 2014 to August 2017. Clinical profile, management and outcome were analyzed. Results: A total of 27 cases were taken for the surgical management in the present study. There were 18 male and 9 female with the male to female ratio of 2:1. Mean age of the study population was 7.08 years. Otogenic Abscess was the most common 37.03% (n=10) and the temporal lobe was the most common site (37.5%). Headache was the most common clinical presentation seen in 74.07 %. All the cases were initially managed with the burrhole and aspiration. Only 14.8 %( n=4) of cases subsequently required surgical excision of the abscess wall. Only18.5 %( n=5) of the cases required multiple session aspiration. Positive culture was seen in 25.9% (n=7). Pseudomonas aeruginosa and E.coli were the commonest organisms grown. Mortality rate was 3.7%.Conclusion: Modern advances in radio imaging and multidisciplinary team involvement has decreased the morbidity and mortality.Keywords: otogenic brain abscess; pediatric brain abscess; tubercular abscess.

scholarly journals Descriptive study of clinical profile and outcome in patients of acute on chronic liver failure, at a tertiary care center in Northern India

2020 ◽  
Vol 7 (11) ◽  
pp. 1687
Author(s):  
Rakesh Kumar ◽  
Vandana Rana ◽  
Varghese Koshy ◽  
Vandana Gangadharan ◽  
George Koshy
Keyword(s):  
Liver Failure ◽  
Care Center ◽  
Tertiary Care ◽  
Descriptive Study ◽  
Chronic Liver ◽  
Clinical Profile ◽  
Chronic Liver Failure ◽  
Tertiary Care Centre ◽  
Female Ratio ◽  
Common Cause

Background: Acute-on-chronic liver failure (ACLF) is a recently described syndrome that is characterized by abrupt deterioration in patients with chronic liver disease (CLD) and has high short-term mortality. The aim of this study was to describe the clinical profile, causes and outcomes of ACLF at a tertiary care centre in Northern India.Methods: In this descriptive study of 50 consecutive patients, were included, between August 2015 to January 2018, who were admitted and diagnosed as ACLF as defined by APASL. Causes of acute precipitating event and CLD and outcomes were assessed.Occurrence and severity of organ failure was also assessed.Results: 48 (96 %) were males and 2 (4%) were females with male to female ratio was 24:1. The mean age of male and female subjects was similar, 40.7±9.9 years and 39.2±9.4 years respectively. The most common cause of CLD was alcohol in 50% cases and next most common cause was hepato-tropic viruses HBV infection in 20%, HCV in 6% cases and there was unknown cause in 12 % cases. The most common precipitating factor of acute decompensation was alcohol in 50% cases, hepatotropic viruses in 30% cases. Excluded sepsis and GI bleed as precipitating events. The combined mortality at the end of 1-month and 3-months, in our study was 60%. CLIF-SOFA score was found to be the most reliable scoring system to discriminate between survivors and non survivors. Conclusions: Alcohol was the commonest precipitating cause of ACLF. Organ failures (OFs) are independently predictive of mortality.

scholarly journals Postinfective Glomerulonephritis (PIGN) in Children Attending a Tertiary Care Centre in Nepal

2015 ◽  
Vol 34 (3) ◽  
pp. 221-224
Author(s):  
DR Poudel ◽  
S Basnet ◽  
FC Gami
Keyword(s):  
Clinical Features ◽  
Past History ◽  
Tertiary Care ◽  
Skin Lesions ◽  
University Teaching ◽  
Tertiary Care Centre ◽  
Female Ratio ◽  
Pedal Oedema ◽  
The Common ◽  
Pedal Edema

Introduction: Post infectious glomerulonephritis (PIGN) is one of the common paediatric kidney disease in developing countries. This study was undertaken to describe the common clinical features, biochemical findings and complications in children with PIGN. Materials and Methods: This was a retrospective descriptive study in which 30 patients admitted with a diagnosis of PIGN at Tribhuvan University Teaching Hospital (TUTH) in a six month period (July 2014 to Dec 2014) were included. Hospital medical records were reviewed for the data collection. Results: Out of 30 patients, 24 (80%) were between 5 to 15 years of age (mean age of 11.5±3.3) with male to female ratio of 2.3:1. Pedal oedema and hypertension were the clinical features seen in 29 (97%) and 28 (93%) patients respectively. Hypocomplementemia was found in 29 (97%) patients. Recent past history of sore throat seen in 10 (33%) patients and skin lesions in 12 (40%). The complications noted were congestive cardiac failure in 5 (17%) patients, rapidly proliferative glomerulonephritis in 3 (10%) and encephalopathy in 1(3%). Conclusion: The most important clinical and biochemical profile observed in nepalese children with PIGN are the hypertension, pedal edema and hypocomplementemia. J Nepal Paediatr Soc 2014;34(3):221-224 DOI: http://dx.doi.org/10.3126/jnps.v34i3.10707  

scholarly journals A study of clinical profile of patients with chronic pulmonary obstructive disease at a tertiary care centre in North Karnataka, India

2019 ◽  
Vol 6 (2) ◽  
pp. 455
Author(s):  
Ashok Kumar Gudagunti ◽  
Ishwar Hasabi ◽  
Arathy S.
Keyword(s):  
Tertiary Care ◽  
Cross Sectional Study ◽  
Clinical Profile ◽  
Common Symptom ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Female Ratio ◽  
Chronic Pulmonary Obstructive Disease ◽  
Obstructive Disease ◽  
Co Morbidity

Background: Chronic pulmonary obstructive disease (COPD) has been responsible for the decreased quality of life as well as increased morbidity and mortality. Globally it has been estimated that nearly three million die yearly due to COPD and more likely to occupy the third place of mortality by 2030. The objective of the present endeavour was to study clinical profile of patients with chronic pulmonary obstructive disease at a tertiary care centre.Methods: A hospital based cross sectional study was carried out among 200 cases of COPD. Their detailed history, thorough clinical examination and parameters like hemoglobin, serum creatinine, protein etc were investigated. The presence of co-morbidities was noted.Results: As the age increased the prevalence of the COPD increased and highest was found out to be in the age group of above 60 years of age. Males were more affected with COPD as compared with females. The male to female ratio was found out to be 2.4:1. The smokers were more compared to the non smokers. The prevalence of smoking among COPD was noted to be 66% compared to 34% as non smokers. Least proportion of patients of the COPD had fever i.e. in 22% of the cases. Cough was found in 83% of the cases. Breathlessness was found out to be in 98% of the cases. 15% of the cases of the COPD had diabetes only as the co-morbidity along with COPD and no other co-morbidity.Conclusions: Breathlessness was the most common symptom at presentation and diabetes and hypertension were the most common co-morbidities found.

scholarly journals Clinical Profile of Cutaneous Adverse Drug Reactions in a Tertiary Care Centre

2016 ◽  
Vol 3 (3) ◽  
Author(s):  
Priya Prathap ◽  
Elsy M.I ◽  
Ajitha K. N ◽  
Ajith Kumar ◽  
Sandhya George
Keyword(s):  
Adverse Drug Reactions ◽  
Tertiary Care ◽  
Maculopapular Rash ◽  
Clinical Profile ◽  
Drug Reactions ◽  
Fixed Drug Eruption ◽  
Tertiary Care Centre ◽  
Dermatology Department ◽  
Female Ratio ◽  
The Common

<div><p><strong><em>Context</em></strong><em>: C</em><em>utaneous adverse drug reactions  (cADR) constitute 2-3% of all hospitalized patients. However there is paucity of data regarding occurrence of cADR among out patients. Hence we decided to do a study on clinical profile of cADR and to find out the common drugs resulting in cADR  . </em></p><p><strong><em>Objective: </em></strong><em>To observe the clinical spectrum and the causative drugs of cADR  among patients attending  Dermatology Department in our hospital. </em></p><p><strong><em>Methods: </em></strong><em>Patients with cADR who attended Dermatology Out Patient Department (OPD) in our institution  were studied for a period of one year.</em></p><p><strong><em>Results:</em></strong><em>71 patients were diagnosed to have cADR. Male to female ratio was 1.15 :1. Maculopapular rash (22/71 ; 31%) was the commonest presentation followed by generalised pruritus (16/71; 22.5%) , fixed drug eruption( FDE) ( 8/71 ;11.3%) and urticaria (5/71 ;7%). Antimicrobials (40.8%), NSAIDS (22.5%) and  Antiepileptics (22.5 %) were the common drugs responsible for these eruptions.</em>  </p></div>

scholarly journals Clinical profile and outcome of children with acute bacterial meningitis in a tertiary care centre in eastern Nepal

2021 ◽  
Vol 10 (2) ◽  
pp. 64-73
Author(s):  
Mukesh Bhatta ◽  
Shyam Prasad Kafle ◽  
Basant Rai ◽  
Rejeena Subedi
Keyword(s):  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Response To Treatment ◽  
Acute Bacterial Meningitis ◽  
Tertiary Care Centre ◽  
Laboratory Findings ◽  
Female Ratio ◽  
Mortality And Morbidity

Background: Bacterial meningitis is a severe infection of the central nervous system with varied clinical presentations. It is associated with substantial mortality and morbidity. Objectives: The objective of this study was to assess the clinical profile, including the clinical features, laboratory and radiological parameters, clinical course, treatment, response to treatment, complications, and outcome of children at discharge. Methods: A prospective observational study was conducted among 52 inpatient children of acute bacterial meningitis aged one month to 14 years over a period of six months. The patients were enrolled during admission and followed up daily till discharge. Socio-demographic, clinical, and diagnostic details and outcomes were recorded and analysed using statistical package for social sciences version 20. Results: The median age of the patients was two years with male to female ratio of 2:1. Fever (45, 87%), vomiting (37, 71%), seizure (33, 64%) and headache (22, 46%) were the most common symptoms. The cerebrospinal fluid culture was positive in three (6%) cases. Complications were seen in 20 (39%) patients including four (7.7%) deaths. Patients with prolonged fever, malnutrition, loss of consciousness, ear discharge, presence of meningeal signs, abnormal pupil, high cerebrospinal fluid protein, positive cerebrospinal fluid, and blood culture, low blood pH, and hyperlactataemia were significantly associated with complications (p <0.05). Conclusion: Factors like malnutrition, longer duration of fever, and abnormal neurological and laboratory findings were associated with higher rates of complications.

ANALYSIS OF THE CLINICAL PROFILE OF PATIENTS WITH CHRONIC URTICARIA IN TERTIARY TREATMENT CENTRE

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Sanjeev Kumar
Keyword(s):  
Chronic Urticaria ◽  
Social Life ◽  
Tertiary Care ◽  
Chronic Idiopathic Urticaria ◽  
Clinical Profile ◽  
Tertiary Care Centre ◽  
Female Ratio ◽  
Treatment Centre ◽  
The Mean ◽  
Delayed Pressure Urticaria

Introduction: Owing to its persistent relapsing path and inadequate reaction to treatment, persistent urticaria has a detrimental impact on both patients' work and social life. The aetiology and the explanation for the varying severity and frequency of clinical presentation are still a problem, despite advances in science. Aim: To research a tertiary care centre 's clinical profile of chronic urticaria. Methods: The study included patients of both sexes between the ages of 14 and 55 years with a clinical diagnosis of chronic urticaria for whom a cause could not be identified under a standard protocol assessment. Results: One hundred patients with chronic urticaria were studied and the mean age was 30.22 years and the male: female ratio was 1:2.85 predominated among females. The mean period of urticaria was 27.42 months, and urticaria lesions were resolved in less than 30 minutes in 48 percent of cases. In 38 percent, there was associated angioedema and 46 percent delayed pressure urticaria. Limitations: The study's drawback was the limited sample size. Conclusions: In our research, the clinical profile for chronic idiopathic urticaria is similar to that of other studies. Keywords: Chronic urticaria, chronic idiopathic urticaria, chronic spontaneous urticaria

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