scholarly journals Palladium(II) Complex of the 5-Hydroxypyridine-2-carbaldehyde N(4)-ethylthiosemicarbazone: Synthesis and Characterization

2013 ◽  
Vol 28 ◽  
pp. 34-41 ◽  
Author(s):  
Paras Nath Yadav ◽  
Laxman Bhattrai ◽  
Pramod K. Mehta
Keyword(s):  
Chloride Ion ◽  
Chemical Society ◽  
Planar Geometry ◽  
The Novel ◽  
Pyridyl Nitrogen ◽  
Imine Nitrogen ◽  
Thiosemicarbazone Ligand ◽  
Square Planar ◽  
Uv Visible ◽  
Fourth Coordination

The novel complex of 5-hydroxypyridine-2-carbaldehyde N(4)-ethylthiosemicarbazone (HPyEt) with plalladium(II) have been prepared and characterized by elemental analysis, IR, 1H-NMR, UV-visible spectroscopy and mass spectrometry (FAB). Coordination of the anionic thiosemicarbazone ligand is via the pyridyl nitrogen, imine nitrogen and thiolato sulfur atoms and the fourth coordination site being occupied by chloride ion in square planar geometry. DOI: http://dx.doi.org/10.3126/jncs.v28i0.8040 Journal of Nepal Chemical Society Vol.28, 2011 Page 34-41 Uploaded date: March 6, 2013

scholarly journals Structural study of Pt(II) and Pd(II) complexes with quinoline-2-carboxaldehyde thiosemicarbazone

2020 ◽  
pp. 79-79
Author(s):  
Predrag Ristic ◽  
Marko Rodic ◽  
Nenad Filipovic ◽  
Dragana Mitic ◽  
Katarina Andjelkovic ◽  
...  
Keyword(s):  
Chloride Ion ◽  
X Ray Diffraction ◽  
X Ray ◽  
Hirshfeld Surfaces ◽  
Ir And Nmr Spectroscopy ◽  
Thiosemicarbazone Ligand ◽  
Square Planar ◽  
Different Types ◽  
Square Planar Complexes ◽  
Fourth Coordination

Two square-planar complexes, [PtLCl] (1) and [PdLCl] (2), were synthesized with quinoline-2-carboxaldehyde thiosemicarbazone ligand (HL), and characterized by IR and NMR spectroscopy and single crystal X-ray diffraction analysis. In both complexes L? is coordinated tridentately via the same donor atom set, while the fourth coordination site is occupied by chloride ion. However, the complexes are not isostructural due to different types of non-covalent intermolecular interactions. These interactions were analyzed using Hirshfeld surfaces and two-dimensional fingerprint plots.

Synthesis, Characterization and Molecular Structure of 2-Pyridyl-formamide N(4)-Dimethylthiosemicarbazone and Some Five-Coordinated Zinc(II) and Cadmium(II) Complexes

2001 ◽  
Vol 56 (12) ◽  
pp. 1297-1305 ◽  
Author(s):  
Elena Bermejo ◽  
Alfonso Castiñeiras ◽  
Larissa M. Fostiak ◽  
Isabel García ◽  
Antonio L. Llamas-Saiz ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Hydrogen Bonding ◽  
Sulfur Atom ◽  
Hydrogen Bonding Interaction ◽  
Pyridyl Nitrogen ◽  
Zwitterionic Form ◽  
Anionic Ligand ◽  
Imine Nitrogen ◽  
Thiosemicarbazone Ligand ◽  
Bonding Interaction

AbstractSodium in dry methanol reduces 2-cyanopyridine in the presence of N(4)-dimethylthiosemicarbazide to produce 2-pyridyl-formamide N(4)-dimethylthiosemicarbazone, HAm4DM. Com­plexes with zinc(II) and cadmium(II) of formulae [M(Am4DM)(OAc)]2 and [M(HAm4DM)X2] (M = Zn or Cd, X = Cl, Br or I) have been prepared and characterized by spectro­scopic techniques. In addition, the crystal structures of HAm4DM, [Zn(HAm4DM)Br2], and [Cd(HAm4DM)l2] DMSO have been solved. HAm4DM is in the zwitterionic form with a hydrogen bonding interaction between the iminium hydrogen and the thiolato sulfur atom. Co­ ordination of the neutral thiosemicarbazone ligand is via the pyridyl nitrogen, imine nitrogen and thione sulfur atoms, while the anionic ligand in [M(Am4DM)(OAc)]2 coordinates with the same two nitrogen atoms and a thiolato sulfur atom. The [M(HAm4DM)X2] complexes are 5-coordinate with the tridentate thiosemicarbazone and two halogen ligands approaching a square pyramidal stereochemistry.

scholarly journals Preparation Characterization and Antibacterial Studies of Chelates of Schiff Base Derived from4-Aminoantipyrine, Furfural ando-phenylenediamine

2011 ◽  
Vol 8 (3) ◽  
pp. 1408-1416 ◽  
Author(s):  
M. S. Suresh ◽  
V. Prakash
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Free Ligand ◽  
Structural Features ◽  
Screening Tests ◽  
Planar Geometry ◽  
Square Planar ◽  
Elemental Analyses ◽  
Uv Visible ◽  
The Comparative Study

A new series of transition metal complexes of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) were synthesized from the Schiff base ligand derived from 4-aminoantipyrine, furfural ando-phenylenediamine. The structural features were derived from their elemental analyses, infrared, UV-visible spectroscopy, NMR spectroscopy, thermal gravimetric analyses, ESR spectral analyses and conductivity measurements. The data of the complexes suggested square planar geometry for the metals with primary valency two. Antimicrobial screening tests were performed against bacteria. The comparative study of the MIC values of the Schiff base and its metal complexes indicate that the metal complexes exhibit greater antibacterial activity than the free ligand.

scholarly journals Structural and Spectroscopic Characteristics of NiII and CuII Complexes with Poly (Vinyl Alcohol-Nicotinic Acid) Copolymers for Photocatalytic Degradation of Indigo Carmine Dye

Crystals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1244
Author(s):  
Ibraheem O. Ali ◽  
Hisham S. Nassar ◽  
Ahmed M. Naglah ◽  
Laila M. Al-Harbi ◽  
Ahmed A. Elhenawy
Keyword(s):  
Nicotinic Acid ◽  
Vinyl Alcohol ◽  
Indigo Carmine ◽  
Reaction System ◽  
Poly Vinyl Alcohol ◽  
Planar Geometry ◽  
Square Planar ◽  
Spectroscopic Characteristics ◽  
Ft Ir ◽  
Uv Visible

Poly-vinyl-alcohol (PVA) has been cross-linked chemically with nicotinic-acid (NA) in an aqueous medium. The copolymers were complexed with NiII and CuII ions. The complexes and copolymers were analyzed using FT-IR and UV–Visible spectroscopy, XRD and TGA, but copolymers were extra analyzed with nuclear magnetic resonance (1H NMR). FT-IR spectra of copolymer revealed the presence of C=O & C-N groups due to the esterification of PVA-NA. The Cu/NA-PVA formed via bidentate interaction of the pyridinyl and carboxyl of NA. EPR/UV-vis data shows the square-planar geometry for NiII and CuII complexes. The adsorption of IC dye onto CuII/NA-PVA complex was noticeably greater (90%) in 35 min than NiII/NA-PVA. The DFT\B3LYP with 6- 311G* quantum chemical calculations were carried out for tested compounds. The DFT was conducted to examine an interaction mode of the target compounds with the reaction system. The QSPR was calculated as: optimization geometries, (FMOs), chemical-reactivities and NLO for the copolymers. The (MEPs) were figured to predict the interaction behavior of the ligand and its complexes.

scholarly journals Antimicrobial, Anticancer, Antioxidant Potential of Pyridine based Coordination Compounds: In-silico ADMET Prediction and Molecular Docking Simulations

2019 ◽  
Vol 8 (4S2) ◽  
pp. 505-511
Keyword(s):  
Spectral Analysis ◽  
Coordination Compounds ◽  
Planar Geometry ◽  
The Novel ◽  
Antioxidant Ability ◽  
Metal Chlorides ◽  
Docking Simulations ◽  
Square Planar ◽  
In Silico Admet ◽  
Schiff Base Metal Complexes

The novel Schiff base metal complexes were derived from the reaction of 9-anthraldehyde and 2-amino-3-hydroxypyridine and metal chlorides All the compounds were investigated by various spectral analysis. From the analysis, it is clear that compounds have square planar geometry with crystalline look. The DNA synergic studies suggest that the compounds were better DNA binder. The synthesized compounds were screened against several microbes which specified that the compounds have greater screening ability than ligand due to chelation. The anticancer activity of the synthesized compounds was also studied which revealed that the Cu(II) has greater potential rather than other compounds. The antioxidant ability display that the synthesized compounds have excellent ability to destroy the free radical than ligand. The ADMET evaluation shows that the prepared compounds hold good drug-likeness skill.

scholarly journals Antimicrobial, Anticancer, Antioxidant Potential of Pyridine based Coordination Compounds: In-silico ADMET Prediction and Molecular Docking Simulations

2020 ◽  
Vol 8 (4S4) ◽  
pp. 149-155
Keyword(s):  
Spectral Analysis ◽  
Coordination Compounds ◽  
Planar Geometry ◽  
The Novel ◽  
Antioxidant Ability ◽  
Metal Chlorides ◽  
Docking Simulations ◽  
Square Planar ◽  
In Silico Admet ◽  
Schiff Base Metal Complexes

The novel Schiff base metal complexes were derived from the reaction of 9-anthraldehyde and 2-amino-3-hydroxypyridine and metal chlorides All the compounds were investigated by various spectral analysis. From the analysis, it is clear that compounds have square planar geometry with crystalline look. The DNA synergic studies suggest that the compounds were better DNA binder. The synthesized compounds were screened against several microbes which specified that the compounds have greater screening ability than ligand due to chelation. The anticancer activity of the synthesized compounds was also studied which revealed that the Cu(II) has greater potential rather than other compounds. The antioxidant ability display that the synthesized compounds have excellent ability to destroy the free radical than ligand. The ADMET evaluation shows that the prepared compounds hold good drug-likeness skill.

scholarly journals The Preparation and Structure of [(2,4-Dimethyl-8-ethyl-5,8-diazadec-4-ene-2-amine)chlorocopper(II)] Perchlorate

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Neil F. Curtis ◽  
Jan Wikaira
Keyword(s):  
Nitrogen Atom ◽  
Chloride Ion ◽  
Imine Nitrogen ◽  
Square Planar ◽  
Imine Nitrogen Atom

Copper(II) chloride and perchlorate, N,N-diethylethane-1,2-diamine, react in (m)ethanol with acetone and ammonia to form [(2,4-dimethyl-8-ethyl-5,8-diazadec-4-ene-2-amine)chlorocopper(II)] perchlorate, C12H27Cl2CuN3O4, , monoclinic, C2/c, (Hall-C2/c); a, 26.418(1), b, 9.7385(4); c, 14.0993(5) Å; β, 91.134(3)°. This has copper(II) in tetrahedrally distorted square-planar coordination by one primary, one tertiary, and one imine nitrogen atom and the chloride ion.

scholarly journals Enhancement of Anticancer Activity of N(4)1-(2-Pyridyl)piperazinyl 5-Nitroisatin Thiosemicarbazone on Chelation with Copper(II)

2021 ◽  
Vol 33 (3) ◽  
pp. 557-564
Author(s):  
Narendra Kumar Singh ◽  
Smriti Shrestha ◽  
Nerina Shahi ◽  
Ravinder Kumar Choudhary ◽  
Anupa A. Kumbhar ◽  
...  
Keyword(s):  
Cell Lines ◽  
Anticancer Agent ◽  
Free Ligand ◽  
Chloride Ion ◽  
Breast Cancer Cell Lines ◽  
Planar Geometry ◽  
Micromolar Concentration ◽  
Square Planar ◽  
Complex Copper ◽  
Mcf 7

5-Nitroisatin-4-(1-(2-pyridyl)piperazinyl)-3-thiosemicarbazone (Nitistpyrdlpz) and its Cu(II) complex were synthesized and characterized by CHN and thermal analysis and spectroscopic measurements viz. UV-vis, FTIR, 1H NMR, 13C NMR, ESI-HRMS, PXRD and EPR. In the complex, copper(II) ion is coordinated by terdentate thiosemicarbazone anion and one chloride ion in a distorted square planar geometry. The synthesized compounds against breast cancer cell lines; MCF-7 and MDA-MB-231 and epidermoid carcinoma; A431 showed that the complex contributed to reduce the percentage of cell viability toward all the tested cell lines but remarkable contribution toward MDA-MB-231 cell line. The IC50 of the complex and free ligand was found in the range of IC50 0.85-1.24 μM and IC50 3.28-3.53 μM, respectively. Among those cell lines, the complex may be the better anticancer agent toward MDA-MB-231 because of its action at micromolar concentration (IC50 0.85 μM).

New Platinum (II) Ternary Complexes of Formamidine and Pyrophosphate: Synthesis, Characterization and DFT Calculations and In vitro Cytotoxicity

2020 ◽  
Vol 23 (7) ◽  
pp. 611-623
Author(s):  
Ahmed A. Soliman ◽  
Fawzy A. Attaby ◽  
Othman I. Alajrawy ◽  
Azza A.A. Abou-hussein ◽  
Wolfgang Linert
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Theoretical Calculations ◽  
Thermal Analyses ◽  
Cancer Cell Line ◽  
Cellular Growth ◽  
Planar Geometry ◽  
Square Planar ◽  
Vis Spectroscopy

Aim and Objective: Platinum (II) and platinum (IV) of pyrophosphate complexes have been prepared and characterized to discover their potential as antitumor drugs. This study was conducted to prepare and characterize new ternary platinum (II) complexes with formamidine and pyrophosphate as an antitumor candidate. Materials and Methods: The complexes have been characterized by mass, infrared, UV-Vis. spectroscopy, elemental analysis, magnetic susceptibility, thermal analyses, and theoretical calculations. They have been tested for their cytotoxicity, which was carried out using the fastcolorimetric assay for cellular growth and survival against MCF-7 (breast cancer cell line), HCT- 116 (colon carcinoma cell line), and HepG-2 (hepatocellular cancer cell line). Results: All complexes are diamagnetic, and the electronic spectral data displayed the bands due to square planar Pt(II) complexes. The optimized complexes structures (1-4) indicated a distorted square planar geometry where O-Pt-O and N-Pt-N bond angles were 82.04°-96.44°, respectively. Conclusion: The complexes showed noticeable cytotoxicity and are considered as promising antitumor candidates for further applications.

Structure of the complexes of ethylenediphosphinetetraacetic acid in solution

1985 ◽  
Vol 50 (2) ◽  
pp. 445-453 ◽  
Author(s):  
Jana Podlahová ◽  
Josef Šilha ◽  
Jaroslav Podlaha
Keyword(s):  
Metal Ion ◽  
Carboxyl Groups ◽  
Complex Solution ◽  
Square Planar ◽  
Weak Complexes ◽  
Carboxylic Groups ◽  
Uv Visible ◽  
The Stability ◽  
Tetrahedral Complexes ◽  
Free Carboxyl

Ethylenediphosphinetetraacetic acid is bonded to metal ions in aqueous solutions in four ways, depending on the type of metal ion: 1) through an ionic bond of the carboxylic groups to form weak complexes with a metal:ligand ratio of 1 : 1 (Ca(II), Mn(II), Zn(II), Pb(II), La(III)); 2) through type 1) bond with contributions from weak interaction with the phosphorus (Cd(II)); 3) through coordination of the ligand as a monodentate P-donor with the free carboxyl groups with formation of 2 : 1 and 1 : 1 complexes (Cu(I), Ag(I)); 4) through formation of square planar or, for Hg(II), tetrahedral complexes with a ratio of 1 : 2 with the ligand as a bidentate PP-donor with the free carboxyl groups (Fe(II), Co(II), Ni(II), Pd(II), Pt(II)). On acidification of the complex solution, the first two protons are bonded to the carboxyl groups. The behaviour during further protonation depends on the type of complex: in complexes of types 1) and 2) phosphorus is protonated and the complex dissociates; in complexes of types 3) and 4) the free carboxyl groups are protonated and the phosphorus-metal bond remains intact. The results are based on correlation of the stability constants, UV-visible, infrared, 1H and 31P NMR spectra and magnetic susceptibilities of the complexes in aqueous solution.

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