scholarly journals Clinico- Biochemical Profile of Neonatal Seizure

1970 ◽  
Vol 28 (1) ◽  
pp. 7-9 ◽  
Author(s):  
GS Shah ◽  
MK Singh ◽  
S Budhathoki ◽  
BK Kalakheti ◽  
DD Baral
Keyword(s):  
Neonatal Intensive Care ◽  
Birth Asphyxia ◽  
Etiological Factor ◽  
Neonatal Seizure ◽  
Test Results ◽  
Neonatal Seizures ◽  
Chi Square ◽  
Common Cause ◽  
Multiparous Women ◽  
Biochemical Abnormalities

Objectives: The present study was undertaken to study the incidence, etiological factor, and days of onset, clinical types and biochemical abnormalities in babies having neonatal seizures. Materials and Methods: This is a retrospective, observational hospital based study. Ninety neonates, who developed seizures before 28 days of life and admitted to neonatal intensive care unit and nursery with neonatal seizure, were evaluated for incidence, etiological factor, clinical types and biochemical abnormalities found in neonatal seizure. The variables were analysed using Chi- Square and student t- test. Results: The incidence of neonatal seizure was 10.3/ 1000 live births. The seizures were common in male babies. 65 (72.2%) neonates were born to multiparous women while 35 (38%) were born to primigravidas. In birth asphyxia (n= 40), the most common type of seizure observed was subtle seizure 20 (50%), followed by focal clonic 10 (25%) and multifocal clonic 5 (12.5%). Tonic type of seizure was observed in 3 (7.5%) and myoclonic in 2 (5%). Meningitis and septicaemia was the second most common cause of neonatal seizure observed in our study. Among metabolic abnormalities hypoglycaemia was found in 20 (22%) and hypocalcaemia in 10 (11%). Conclusion: The commonest cause of seizure was birth asphyxia presenting within 72 hours of life. Among infection septicaemia and meningitis was the most common cause leading to neonatal seizure. Among biochemical abnormalities the most common cause of seizure observed in our study was hypoglycaemia and hypocalcaemia. Subtle seizures were the commonest type of seizure observed in this study. Key words: Neonatal seizure, biochemical disturbances in seizure.    DOI = 10.3126/jnps.v28i1.1398   J. Nepal Paediatr. Soc. Vol.28(1) p.7-9

scholarly journals ETIOLOGICAL PROFILE OF NEONATAL SEIZURES WITH SPECIAL REFERENCE TO BIOCHEMICAL ABNORMALITIES

2019 ◽  
Vol 8 (6) ◽  
Author(s):  
Gurdeep Singh Dhanjal ◽  
Vikramjot Singh ◽  
Gurnoor Singh
Keyword(s):  
Seizure Activity ◽  
Early Recognition ◽  
Birth Asphyxia ◽  
Neurological Dysfunction ◽  
Neonatal Seizure ◽  
Neonatal Seizures ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Biochemical Abnormalities

Introduction: Neonatal seizure are the most frequent manifestation of neurological dysfunction in a neonate.  Detection of seizure and its etiology is important for guiding therapy. In the presence of biochemical abnormalities, it is difficult to control seizures and there is a risk of further brain damage. Early recognition and treatment of biochemical abnormalities are essential for optimal management and satisfactory long term outcome. The aim was to determine the etiology of neonatal seizures and to study the biochemical abnormalities. Material and Methods: The present study included 70 inborn neonates presenting with seizures admitted to the neonatal unit in MMIMSR, Mullana, Ambala, Haryana, India over a period of one and a half years. A detailed history was taken and clinical examination of the neonate was done. Etiological causes and various biochemical parameters were evaluated. Results:  Neonatal seizures occurred more commonly in males. The most common cause of neonatal seizures was birth asphyxia seen in 26 (37.1%) neonates followed by sepsis in 24 (34.3%) neonates. The Primary Biochemical abnormalities were seen in 12 (17.1%) neonates with seizures. Among these neonates, hypoglycemia was most commonly seen in 4 (33.3%) neonates followed by hypocalcemia seen in 3 (25%) neonates. Conclusion: Biochemical abnormalities are common in neonatal seizures and often go unrecognized. These abnormalities may significantly contribute to seizure activity and hence a biochemical workup is necessary for all cases of neonatal seizures.

scholarly journals Clinico-aetiological profile and outcome patterns of neonatal seizures at a tertiary care centre

2020 ◽  
Vol 7 (2) ◽  
pp. 316
Author(s):  
Vijay Agrawal ◽  
Dhan Raj Bagri ◽  
J. N. Sharma ◽  
Roop Singh
Keyword(s):  
Birth Weight ◽  
Tertiary Care ◽  
Birth Asphyxia ◽  
Common Type ◽  
Full Term ◽  
Neonatal Seizure ◽  
Neonatal Seizures ◽  
Tertiary Care Centre ◽  
Term Outcome ◽  
Common Cause

Background: Neonatal seizures are a major risk factor for neonatal mortality and subsequent neurological disability. The incidence of seizure varies from 1.5-3.7/1000 live birth; while in NICU it can be up to 5/1000 live birth.Methods: This Descriptive type of observational study aimed to study clinical profile, aetiology in neonatal seizures and short term outcome was done in all Neonatal units attached to paediatric Department of SMS Medical College, Jaipur.Results: In the 100 cases Majority of neonates had onset of seizure <3 days (<72 hours) 53% and remaining 47% neonates had onset of seizure >3 days (>72 hours). Most common type of neonatal seizure was subtle(75%), other types were tonic seizure (17.3%), clonic seizure (5.1%) and least common type was myoclonic (2.5%). Most common cause of neonates seizure noted was birth asphyxia (73%) second common cause is pyomeningitis and third common cause is hypoglycaemia. Most common cause of neonatal seizure both in full term (71.17%) and preterm (25%) is birth asphyxia. Second most common cause of neonatal seizure in full term is pyomeningitis (8.70%) and in preterm is pyomeningitis and hypoglycaemia (25%). Most common cause of neonatal seizure both in onset of seizure <3 days (<72 hours) 53% and in onset of seizure >3 days (>72 hours).Conclusions: Out of total 100 cases, neonates with normal birth weight 92% and low birth weight 8%. Majority of neonates had onset of seizure <3 days (<72 hours) 53% and remaining 47% neonates had onset of seizure >3 days (>72 hours). Majority of neonates with seizure delivered by vaginal route (86%) and remaining 14% neonates were delivered by LSCS.

scholarly journals Prevalence of Biochemical Abnormalities in Neonatal Seizures in Term and Preterm Neonates

2020 ◽  
pp. 35-45
Author(s):  
K. M. Vinay ◽  
Goutham Shankargoud Patil ◽  
S. S. Prakash
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Gestational Age ◽  
Neonatal Intensive Care ◽  
Birth Asphyxia ◽  
Categorical Variables ◽  
Preterm Neonates ◽  
Neonatal Seizures ◽  
Biochemical Abnormalities

Background: The most vulnerable period of life to develop seizures is the neonatal period. These events very often signify serious damage or malfunction of the immature developing central nervous system. Neonatal seizures may arise as a result of diverse etiologies and can have varied presentations. Biochemical abnormalities are commonly observed in neonates who are admitted in neonatal intensive care unit with seizures. Early recognition and treatment of biochemical disturbances is essential for optimal management and satisfactory long-term outcome. Objective: To assess clinical types and importance of biochemical abnormalities in neonatal seizures and to evaluate clinical type & time of onset of seizures in term and preterm neonates. Methods: A prospective observational study, where 100 neonates presenting with seizures admitted to neonatal intensive care unit of Jagadguru Jayadeva Murugarajendra Medical College, Davangere, from September 2015 to August 2017 were enrolled in the study. The detailed history along with clinical examination, baseline characteristics of convulsing neonate were recorded at admission. Clinical details of each seizure episode reported by the mother and subsequently observed by the resident doctors on duty were recorded. The relevant biochemical investigations were done immediately after baby had seizures and before instituting any specific treatment. The descriptive statistics such as mean and standard deviation (SD) for continuous variables, frequencies and percentages were calculated for categorical variables. The association between gestational age and other categorical variables were analyzed using chi-square test of independence. The comparison of mean of various quantitative variables was analyzed using ANOVA test. Etiology of neonatal seizures and associated biochemical abnormalities were diagnosed. Results: In the present study, out of 100 neonates studied, 64 were full term of which 49(76.5%) were appropriate for gestational age and 15(23.5%) were small gestational age, whereas 36 cases were preterm. Most neonatal seizures occur in first 3 days of life, i.e. 59%. Most of them occurred on first day of life (34%). Birth asphyxia was the cause of neonatal seizures in 82.35% neonates who developed seizures on day-1 of life. Birth asphyxia and septicemia are common cause of neonatal seizures in our study (38 cases each), followed by pure metabolic disturbances 19%. In pure metabolic seizures, hypoglycemia (47.8%) is most common more in preterm babies (55%) followed by hypocalcemia. In cases of non- metabolic seizures, which showed associated biochemical abnormalities, hypoglycemia was most common abnormality 23 of 52 cases (44.2%). 12 cases (52.1%) are associated with birth asphyxia and 11 cases (47.9%) are associated with septicemia. Subtle seizures were most common type of seizures in our study, followed by focal clonic, multifocal clonic, generalized tonic, subtle with GTC and subtle with clonic. Conclusion: Biochemical abnormalities are common in neonatal seizures and often go unorganized. These abnormalities may significantly contribute to seizure activity correction of these abnormalities work up is necessary for all cases of neonatal seizures.

scholarly journals Incidence and outcome of neonatal seizures at a tertiary care hospital

2017 ◽  
Vol 4 (6) ◽  
pp. 2165
Author(s):  
Abdul Naseer Abdul Bari ◽  
Habib G. Pathan ◽  
Prashant R. Kokiwar
Keyword(s):  
Neonatal Intensive Care ◽  
Tertiary Care Hospital ◽  
Perinatal Care ◽  
Tertiary Care ◽  
Birth Asphyxia ◽  
Care Hospital ◽  
Neonatal Seizures ◽  
Term Neonates ◽  
Common Cause ◽  
Ventricular Hemorrhage

Background: Seizures are associated with poor neuro developmental outcome if not diagnosed early and treated properly. During newborn period, seizures indicate underlying neurological disease. Neonatal seizures lead to increased morbidity and mortality usually found in neonatal intensive care unit. The objective of this study was to evaluate incidence and outcome of neonatal seizures.Methods: Present study was hospital based prospective study conducted among 117 neonates of 0-28 days of age at a tertiary care hospital for a period of one year. The data like history, clinical examination and investigation findings was recorded in the pre-designed, pre-tested, semi structured questionnaire.Results: The incidence of neonatal seizures was higher in male neonates. Subtle types of seizures were the commonest type of seizures. In term neonates, the birth asphyxia was the most common cause of neonatal seizures. The incidence of intra-ventricular hemorrhage (IVH) was significantly higher in preterm than term neonates. Out of biochemical abnormalities, the hypocalcemia was the most common cause of the neonatal seizures. Common causes of neonatal deaths in our center were severe birth asphyxia, intra-ventricular hemorrhage (IVH), septicemia and meningitis. Conclusions: Most of the causes of neonatal seizures are preventable by good perinatal care and early interventions while metabolic seizures need a sharp vigilance and early suspicion. 

scholarly journals Clinical profile, etiology, type and outcome of neonatal seizures: a hospital-based study

2021 ◽  
Vol 9 (1) ◽  
pp. 104
Author(s):  
Mohmad Saleem Chesti ◽  
Naveed Shahzad ◽  
Shilakha Chaman ◽  
Sheenam Gazala
Keyword(s):  
Birth Asphyxia ◽  
Clinical Profile ◽  
Neonatal Seizure ◽  
Neonatal Seizures ◽  
Medical Sciences ◽  
Long Term Outcomes ◽  
Acute Symptomatic Seizure ◽  
Ethical Clearance ◽  
Common Infections

Background: Our study was undertaken to study the etiological factor, clinical profile, types and outcome of newborn with neonatal seizures (NNS).Methods: Our study was hospital based prospective study was done in Sheri Kashmir institute of medical sciences (SKIMS) Bemina from April 2013 to April 2015 in NICU, after obtaining ethical clearance from institutional ethical committee. All neonates fulfilling inclusion criteria were included in our study.Results: In our study, 80 neonates with seizures were included in our study, among them 48 were males and 32 were females. Majority of neonates (57.5%) developed seizures during first 72 hours of life due to birth asphyxia. Commonest types of neonatal seizures observed in our study were subtle observed in 46 cases, followed by tonic (21.2 %), clonic (14.9 %) and mixed (6.2%) seizures. Birth asphyxia was commonest cause (57.5%) of NNS, sepsis with meningitis (18.7%) followed by hypoglycemia (13.7%) and hypocalcemia (5%). Cases of birth asphyxia were associated with higher mortality (58.3%) as compared to cases with metabolic seizures.Conclusions: From our study we conclude that commonest cause of neonatal seizure was birth asphyxia occurring within 72 hours of birth. Sepsis and meningitis were also common infections resulting in neonatal seizure, while as hypoglycaemia and hypocalcemia were common biochemical abnormalities leading to NNS. Early identification and treatment are likely important for long-term outcomes in acute symptomatic seizure.

scholarly journals Metabolic and Electrolyte profile in Birth Asphyxia

2020 ◽  
Vol 7 (7) ◽  
pp. 331-336
Author(s):  
Dr. Abhishek Kumar Singh ◽  
◽  
Dr. Bhoopendra Sharma ◽  
Dr. Anita Mehta ◽  
Dr. Karm Chand Gandhi ◽  
...  
Keyword(s):  
Neonatal Intensive Care ◽  
Birth Asphyxia ◽  
Cross Sectional Study ◽  
Metabolic Abnormalities ◽  
Neonatal Seizures ◽  
Inborn Errors ◽  
Cross Sectional ◽  
Medical College ◽  
Definition Of ◽  
Ischemic Encephalopathy

Introduction: The definition of birth asphyxia is given by the ACOG, AAP includes the existence of 3factors: Metabolic or mixed acidemia (pH<7) which is determined by umbilical cord arterial bloodsamples. The major causes of neonatal seizures are Hypoxic-ischemic encephalopathy (HIE), whichrepresents about 50% of the causes of neonatal seizures. Metabolic abnormalities, infection,intracranial hemorrhage, developmental anomalies, and other like inborn errors of metabolism areother causes of neonatal seizures. Material and Methods: A cross-sectional study. This is ahospital-based prospective study conducted at Nehru Hospital, BRD Medical College, Gorakhpur (UP)in the Neonatal Intensive Care Unit of the pediatric department. This study was conducted from July2018 to July 2019. Result: Prevalence of Hypocalcemia was 7.6%, Prevalence of hypernatremia was1.3%, Out of 315 patients 32 (10.2%) patients expired and 283 (89.8%) was successfullydischarged. Conclusion: No association between Hypocalcemia and Hypomagnesemia Prevalence ofhyponatremia was 6.3% and no association between hyponatremia and Hypomagnesemia. Theprevalence of hypernatremia was 1.3% and there was no association between hypernatremia andHypomagnesemia.

TO STUDY CLINICAL PRESENTATION AND TIME OF ONSET OF SEIZURE IN TERM AND PRETERM NEONATES AND THE BIOCHEMICALABNORMALITY IN SEIZURES IN TERM AND PRETERM NEONATES.

2021 ◽  
pp. 17-19
Author(s):  
Ashwini Kumar Singh ◽  
Gaurav Choudhary ◽  
Akhilesh Patel
Keyword(s):  
Clinical Presentation ◽  
Age At Onset ◽  
Birth Asphyxia ◽  
Detailed Examination ◽  
Preterm Neonates ◽  
Neonatal Seizures ◽  
Metabolic Disturbances ◽  
Female Ratio ◽  
Seizure Episode ◽  
Biochemical Abnormalities

INTRODUCTION: Seizure is dened as paroxysmal involuntary disturbance of brain function. It may manifest as impairment or loss of consciousness, abnormal motor activity, behavioural abnormality, sensory disturbance or autonomic dysfunction. Any abnormal, repetitive and stereotypic behaviour in neonates should be evaluated as possible seizure. Neonatal seizures is a common neurological problem with a frequency range from 0.95 to 3.5/1000 live births. AIMS & OBJECTIVES:To assess the importance of biochemical abnormalities in neonatal seizures and to evaluate clinical presentation & time of onset of seizures in term and preterm neonates. MATERIAL & METHODS: A total of 90 neonates presenting with seizures admitted to NICU of National Institute of Medical Sciences & Research, Jaipur from conducted from 1st January 2019 till 30 th June 2020 were enrolled in the study. Detailed antenatal, natal, postnatal history along with detailed examination was done. Baseline characteristics of convulsing neonate including sex, gestational age, birth weight, head circumference & length were recorded at admission. Clinical details of each seizure episode reported by the mother and subsequently observed by the resident doctors on duty were recorded i.e. age at onset of seizures, duration of seizure, number and type of seizure. Relevant investigations including biochemical parameters were done immediately after baby had seizures and before instituting any specic treatment. Etiology of neonatal seizures and associated biochemical abnormalities were diagnosed. RESULTS: In the present study, out of 90 neonates studied, 64 were full term of which 49(76.5%) were AGAand 15(23.5%) were SGA, whereas 26 cases were preterm. The male: female ratio is 1.3:1. Most neonatal seizures occur in rst 3 days of life, i.e. 60 %. Most of them occurred on rst day of life (34%). Birth asphyxia was the cause of neonatal seizures in 82 % neonates who developed seizures on day-1 of life. Birth asphyxia and septicemia are common cause of neonatal seizures in our study, followed by pure metabolic disturbances 20 %. In pure metabolic seizures, hypoglycemia (47.8%) is most common more in preterm babies (55%) followed by hypocalcemia. In cases of non- metabolic seizures, which showed associated biochemical abnormalities, hypoglycemia was most common abnormality 24 of 52 cases (46.15%). 12 cases (52.1%) are associated with birth asphyxia and 11 cases (47.9%) are associated with septicemia. CONCLUSION: Biochemical abnormalities are common in neonatal seizures and often go unrecognized. These abnormalities may signicantly contribute to seizure activity correction of these abnormalities may play a signicant role in seizure control. Hence, a biochemical work up is necessary for all cases of neonatal seizures.

scholarly journals Biochemical abnormalities in neonatal seizures in term and preterm neonates

2018 ◽  
Vol 6 (1) ◽  
pp. 40
Author(s):  
Manoj D. ◽  
Rajesh Reddy K. ◽  
S. S. Prakash
Keyword(s):  
Early Recognition ◽  
Birth Asphyxia ◽  
Detailed Examination ◽  
Preterm Neonates ◽  
Neonatal Seizures ◽  
Metabolic Disturbances ◽  
Medical College ◽  
Preterm Babies ◽  
Work Up ◽  
Biochemical Abnormalities

Background: Neonatal seizures may arise as a result of diverse etiologies and can have varied presentations. Biochemical abnormalities are commonly observed in neonates which can be either primary or secondary. Early recognition and treatment of biochemical disturbances is essential for optimal management and satisfactory long-term outcome.Methods: A total of 100 neonates presenting with seizures admitted to NICU of JJM Medical College, Davanagere, from November 2015 to April 2017 were enrolled in the study. Detailed antenatal, natal, postnatal history along with detailed examination was done along with baseline characteristics of convulsing were recorded at admission along with relevant biochemical investigations before instituting any specific treatment.Results: In the present study, out of 100 neonates studied, 64 were full term of which 49(76.5%) were AGA and 15(23.5%) were SGA, whereas 36 cases were preterm. Most neonatal seizures occurred in first 3 days of life, i.e. 59% of which majority occurred on first day of life (34%). Birth asphyxia and septicemia are common cause of neonatal seizures in present study (38 cases each), followed by pure metabolic disturbances 19%. In pure metabolic seizures, hypoglycemia (47.8%) is most common more in preterm babies (55%) followed by hypocalcemia.Conclusions: Biochemical abnormalities are common in neonatal seizures and often go unrecognized and may significantly contribute to seizure activity. Hence, a biochemical work up is necessary for all cases of neonatal seizures.

scholarly journals A clinico-etiological evaluation of neonatal seizures in a tertiary care hospital: a prospective cohort study

2020 ◽  
Vol 7 (3) ◽  
pp. 659
Author(s):  
Kuldeep Kumar Sharma ◽  
Shifa Bidhan ◽  
Sandeep D. Paimode
Keyword(s):  
Tertiary Care ◽  
Birth Asphyxia ◽  
Sampling Technique ◽  
Neonatal Seizure ◽  
Care Hospital ◽  
Metabolic Abnormalities ◽  
Neonatal Seizures ◽  
Study Results ◽  
Term Delivery ◽  
Common Etiology

Background: Neonatal seizure is defined as a paroxysmal alteration in neurological function. The diagnosis of neonatal seizures is difficult to establish because of varied etiologies involved. The incidences vary from 1.5-3.7/1000 live births in term babies.Methods: Hospital based observational Study was conducted from December 1, 2016 till March 31, 2018. Universal sampling technique was followed. 93 neonates fulfilling the inclusion criteria were included in the study after consent from parents.Results: Present study results showed that 60.2% were males. Pre-term delivery occurred in 12.9% neonates. Most common etiology of neonatal seizures was birth asphyxia with 47.3% followed by metabolic abnormalities 32.3%.Conclusions: The most common etiology for neonatal seizures was birth asphyxia followed by metabolic abnormalities in which hypoglycaemia was the most common type. A significant association of seizures due to meningitis and metabolic abnormalities was observed with pre-term gestation.

scholarly journals A clinico-etiological evaluation and EEG correlation of neonatal seizures in a tertiary care hospital: a prospective cohort study

2020 ◽  
Vol 7 (4) ◽  
pp. 860
Author(s):  
Kuldeep Kumar Sharma ◽  
Sandeep D. Paimode ◽  
Navjot Kour
Keyword(s):  
Tertiary Care ◽  
Birth Asphyxia ◽  
Sampling Technique ◽  
Neonatal Seizure ◽  
Care Hospital ◽  
Metabolic Abnormalities ◽  
Neonatal Seizures ◽  
Study Results ◽  
Common Etiology ◽  
Eeg Pattern

Background: Neonatal seizure is defined as a paroxysmal alteration in neurological function. The diagnosis of neonatal seizures is difficult to establish because of varied etiologies involved. The incidences vary from 1.5-3.7/1000 live births in term babies.Methods: Hospital based observational study was conducted from December 1, 2016 till March 31, 2018. Universal sampling technique was followed. 93 neonates fulfilling the inclusion criteria were included in the study after consent from parents.Results: This study results showed that 60.2% were males. Pre-term delivery occurred in 12.9% neonates. Most common etiology of neonatal seizures was birth asphyxia with 47.3% followed by metabolic abnormalities 32.3%. Abnormal EEG pattern was seen in 29% cases of neonatal seizures.Conclusions: To conclude, the most common aetiology for neonatal seizures was birth asphyxia followed by metabolic abnormalities in which hypoglycaemia was the most common type. A significant association of seizures due to meningitis and metabolic abnormalities was observed with pre-term gestation while abnormal EEG pattern was observed with birth asphyxia and meningitis. EEG findings were found normal in majority of cases of neonatal seizure.

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