Efficacy of latanoprost in management of chronic angle closure glaucoma

Background: Chronic angle closure glaucoma is often managed surgically. Aim: To study the effect of Latanoprost 0.005% on intraocular pressure in subjects diagnosed as having chronic angle closure glaucoma. Materials and methods: Forty patients participated in the study. Baseline examination included visual acuity, refraction, slit-lamp examination, intraocular pressure, anterior and posterior segment examination, gonioscopy and perimetry. Patients were treated with Latanoprost 0.005% once daily at bedtime. IOP was recorded at baseline, 2weeks, 4 weeks, 8 weeks and 12 weeks after starting the treatment. Results: The mean age of the study sample was 56.45 years (40-70 years). There were 18 males and 22 females in the study. Mean IOP at baseline was 24.55±3.63. Mean IOP decreased to 17.27±3.19 at 2 weeks, 15.27±3.07 at 4 weeks, 14.60±3.06 at 8 weeks and 14.47±2.66 at 12 weeks. There was a statistically significant reduction in mean IOP (41.03%) at 12 weeks as compared to those of the baseline IOP (p=0.000). There was no significant difference in IOP reduction in eyes with different degrees of angle closure by peripheral anterior synechiae. Conclusion: Latanoprost, a prostaglandin analogue, is effective in reducing IOP in chronic angle closure glaucoma patients and its efficacy is not affected by the degree of angle closure by peripheral anterior synechiae. Key words: latanoprost; chronic angle closure glaucoma; intraocular pressure; peripheral anterior synechiae DOI: 10.3126/nepjoph.v1i1.3671 Nep J Oph 2009;1(1):32-36

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Single-pass four-throw pupilloplasty for secondary angle-closure glaucoma associated with silicon oil tamponade

European Journal of Ophthalmology ◽

10.1177/1120672118780809 ◽

2018 ◽

Vol 29 (5) ◽

pp. 561-565 ◽

Cited By ~ 1

Author(s):

Priya Narang ◽

Ashar Agarwal ◽

Amar Agarwal

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Intraocular Pressure ◽

Anterior Chamber ◽

Anterior Segment ◽

Angle Closure Glaucoma ◽

Angle Closure ◽

Single Pass ◽

Silicon Oil ◽

The Mean

Purpose: To describe the feasibility and efficacy of performing single-pass four-throw pupilloplasty for secondary angle-closure glaucoma post silicon oil tamponade. Methods: The procedure was performed in five eyes of five patients. All the cases underwent silicon oil removal with single-pass four-throw pupilloplasty. Single-pass four-throw procedure involves a single pass of needle through the iris tissue that is to be apposed followed by taking four throws by passing the suture end through the loop that is withdrawn from the anterior chamber as in a modified Siepser’s slip-knot technique. Both the suture ends are pulled and this leads to sliding of the loop into the anterior chamber. Surgical pupilloplasty stretches the peripheral iris tissue and helps in breaking the peripheral anterior synechia. Intraoperative gonioscopy and anterior segment optical coherence tomography were performed in all the cases. Results: Intraoperative gonioscopy and anterior segment optical coherence tomography demonstrated opening of the anterior chamber angles with breakage of peripheral anterior synechia. The mean preoperative and postoperative best-corrected visual acuity in logarithm of minimum angle of resolution was 1.24 ± 0.23 and 0.56 ± 0.18, respectively (p < 0.001). The mean preoperative and postoperative intraocular pressure was 38.2 ± 4.97 and 13.0 ± 2.35 mm Hg, respectively. There was a significant decrease in intraocular pressure and marked improvement in visual acuity in all the cases. Conclusion: Surgical pupilloplasty helps to relieve the post-silicon oil-induced secondary angle-closure glaucoma by breaking peripheral anterior synechia and significantly opening the anterior chamber angles.

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Cataract surgery reduces intraocular pressure but not posture-induced intraocular pressure changes in patients with angle-closure glaucoma

Scientific Reports ◽

10.1038/s41598-019-50598-y ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 1

Author(s):

Pei-Yao Chang ◽

Jia-Kang Wang ◽

Hsin-Yu Weng ◽

Shu-Wen Chang

Keyword(s):

Intraocular Pressure ◽

Cataract Surgery ◽

Anterior Chamber Depth ◽

Angle Closure Glaucoma ◽

Angle Closure ◽

Glaucomatous Optic Neuropathy ◽

Lateral Decubitus ◽

The Mean ◽

Pressure Changes ◽

Icare Rebound Tonometer

Abstract Cataract surgery leads to a sustained decrease in sitting intraocular pressure (IOP) in patients with angle-closure glaucoma (ACG). The purpose of this study is to evaluate whether cataract surgery can also reduce postural IOP changes. We prospectively examined 106 eyes from 53 patients with narrow angles scheduled for phacoemulsification. IOP was measured in the sitting, supine, and lateral decubitus positions using an ICare rebound tonometer before and 1 week, 1 month, and 3 months postoperatively. The mean baseline IOP in the sitting and lateral decubitus positions was 17.9 ± 4.8 mmHg and 21.43 ± 6.44 mmHg, which significantly reduced to 13.52 ± 3.8 and 17.46 ± 3.62, respectively, 3 month postoperatively (p < 0.001). However, postural IOP change (lateral decubitus minus sitting) at 3 months postoperatively was not significantly different from that at the baseline (3.17 ± 2.63 vs. 3.53 ± 3.38 mmHg, p = 0.85). Postural IOP change was not associated with preoperative sitting IOP, anterior chamber depth, axial length, fixed pupil, or presence of glaucomatous optic neuropathy. Patients with higher preoperative IOP exhibited greater IOP reduction after cataract surgery in every posture (p < 0.0001). In conclusion, cataract surgery reduces IOP in all postures among patients with ACG; however, it does not reduce the magnitude of postural IOP change.

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Intraocular asymmetry of visual field defects in primary angle-closure glaucoma, high-tension glaucoma, and normal-tension glaucoma in a Chinese population

Scientific Reports ◽

10.1038/s41598-021-91173-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Junhong Jiang ◽

Cong Ye ◽

Cong Zhang ◽

Wenqing Ye ◽

Xiaoyan Wang ◽

...

Keyword(s):

Visual Field ◽

Normal Tension Glaucoma ◽

Angle Closure Glaucoma ◽

Angle Closure ◽

Primary Angle Closure ◽

Primary Angle Closure Glaucoma ◽

High Tension ◽

Significant Difference ◽

The Mean ◽

Severity Levels

AbstractDirect comparison data on spatial patterns of visual field (VF) defects among primary angle-closure glaucoma (PACG), high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) are not available. We aimed to compare the intraocular asymmetry of VF loss among patients with PACG, NTG and HTG across different severity levels. A total of 162 eyes of 114 patients with PACG, 111 eyes of 74 patients with HTG and 148 eyes of 102 patients with NTG were included. VF defects were categorized into 3 stages (early, moderate, and advanced), and each hemifield was divided into 5 regions according to the Glaucoma hemifield test (GHT). The mean total deviation (TD) of each GHT region was calculated. In the early stage, the paracentral, peripheral arcuate 1 and peripheral arcuate 2 regions in the superior hemifield in the NTG group had significantly worse mean TDs than their corresponding regions in the inferior hemifield. In the advanced stage, the central region in the superior hemifield in the PACG group had a significantly worse mean TD than that in the inferior hemifield. There was no significant difference in the mean TD for any of the five regions between hemifields across all severity levels in the in the HTG group. The superior hemifield was affected more severely than the inferior hemifield in all three subtypes of primary glaucoma. This asymmetric tendency was more pronounced in NTG than in PACG and HTG.

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Outcomes of Small Size Ahmed Glaucoma Valve Implantation in Asian Chronic Angle-Closure Glaucoma

Journal of Clinical Medicine ◽

10.3390/jcm10040813 ◽

2021 ◽

Vol 10 (4) ◽

pp. 813

Author(s):

Ke-Hao Huang ◽

Ching-Long Chen ◽

Da-Wen Lu ◽

Jiann-Torng Chen ◽

Yi-Hao Chen

Keyword(s):

Visual Acuity ◽

Intraocular Pressure ◽

Anterior Chamber ◽

Angle Closure Glaucoma ◽

Adult Patients ◽

Angle Closure ◽

Posterior Chamber ◽

Ahmed Glaucoma Valve ◽

Probability Of Success ◽

The Mean

For chronic angle-closure glaucoma (ACG), Ahmed glaucoma valve (AGV) is a useful drainage device for intraocular pressure (IOP) control but there are few reports discussing the outcomes of small size AGV in adult patients. This retrospective study involved 43 Asian adult patients (43 eyes) with chronic ACG. All patients had undergone small size AGV insertion and were divided into anterior chamber (AC) group and posterior chamber (PC) group. In the AC group, tube was inserted through sclerectomy gap into the anterior chamber. In the PC group, tube was inserted into posterior chamber through a needling tract. Outcome measures were intraocular pressure (IOP), visual acuity, number of antiglaucoma medications, survival curve and incidence of complications. In total, 43 eyes of 43 patients, 24 in the AC group and 19 in the PC group, were reviewed. The mean follow-up period was 28.5 months (95% confidence interval: 25.5–31.4). Mean IOP had significantly decreased following AGV insertion. The Kaplan–Meier survival analysis demonstrated a probability of success at 24 months of 67.4% for qualified success and 39.5% for complete success. There were no significant differences between the AC and PC groups in terms of the mean IOP, cumulative probability of success, visual acuity change or antiglaucoma medication change, except IOP at 1-day and 1-month mean IOP. The most common complications noted was hyphema in the PC group. For adult chronic ACG patients, small size AGV insertion could be effective at lowering IOP. Besides, tube insertion into AC with sclerectomy may prevent the hypertensive phase in the early postoperative period.

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Effects of daily curve and age on intraocular pressure in Criollo horses

Semina Ciências Agrárias ◽

10.5433/1679-0359.2021v42n3supl1p2049 ◽

2021 ◽

pp. 2049-2056

Author(s):

Ângela Beatriz de Oliveira Bacchin ◽

◽

Géssica Maria Ribeiro da Silva ◽

Maiara Poersch Seibel ◽

Alessandra Fernandez da Silva ◽

...

Keyword(s):

Intraocular Pressure ◽

Age Group ◽

Slit Lamp ◽

Group Iii ◽

Indirect Ophthalmoscopy ◽

Group I ◽

Schirmer Tear Test ◽

Significant Difference ◽

The Mean ◽

Made In

The objective of this study was to evaluate the intraocular pressure (IOP) of healthy Criollo horses using a rebound tonometer throughout the day. In addition, assessments were made in horses of different ages. Twenty-seven horses, male and female, were divided into three groups by age: Group I (3-5 years old), Group II (6-8 years old), and Group III: (9-16 years old). Ophthalmic examinations were performed using the Schirmer tear test, slit-lamp biomicroscopy, fluorescein test and indirect ophthalmoscopy. Seven measurements of IOP were assessed on the same day (at 6:00 am, 9:00 am, 12:00 am, 3:00 pm, 6:00 pm, 9:00 pm and 00:00 pm). A t-test was used when there were two groups of comparisons and ANOVA was used to detect differences in IOP between measurement times and between age categories. The average IOP was 28.4 ± 3.7 mmHg for all eyes. The mean IOP for Groups I, II and III were 29.2 ± 3.5, 28.4 ± 4.3 and 27.7 ± 3.2 mmHg, respectively. There was no statistically difference between right and left eyes. There was a significant difference between Group I and Group III (P = 0.008). There were no statistically significant differences between measurements recorded at different times of the day (P = 0.560). The IOP was not influenced by the circadian rhythm, but older horses showed reduced IOP.

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Effect of postural changes on intraocular pressure in patients with acute angle-closure glaucoma in Indian population

Latin American Journal of Ophthalmology ◽

10.25259/lajo_18_2019 ◽

2020 ◽

Vol 3 ◽

pp. 2

Author(s):

Sanjay Mishra ◽

Ashok Kumar

Keyword(s):

Intraocular Pressure ◽

Acute Angle ◽

Angle Closure Glaucoma ◽

Angle Closure ◽

Sitting Position ◽

Rebound Tonometer ◽

Antiglaucoma Medication ◽

Primary Angle Closure Glaucoma ◽

Postural Changes ◽

Healthy Control

Objective: The objective of the study was to compare the posture-induced intraocular pressure (IOP) changes in primary angle-closure glaucoma (PACG) with or without glaucoma medications, and healthy control eyes with normal IOPs in Indian subjects. Materials and Methods: The IOP was measured in the sitting position and the supine position after 10, 20, and 30 min with a rebound tonometer. Results: Twenty-five patients with PACG and 30 controls with normal IOPs were studied. The IOP in the sitting position measured with the rebound tonometer was 13.8 + 3.2 mm Hg in eyes with PAC, and 12.9 + 2.9 mm Hg in eyes with normal IOPs. The IOP increased to 14.4 mm Hg, 16.8 mm Hg, and 18.9 mm Hg at 10 min, 20 min, and 30 min in PACG subjects. In normal age-matched controls, the IOP increased to 13.4 mm Hg, 14.9 mm Hg, and 17.8 mm Hg at 10 min, 20 min, and 30 min, respectively, but none of these differences were significant (P = 0.09; P = 0.08, P = 0.08). The mean postural IOP change from baseline was also not significant between the two groups. Only three patients were on single antiglaucoma medication with well-controlled IOP in the PACG group. Conclusions: Postural IOP changes are comparable among eyes with PACG with and without glaucoma medications, and control eyes.

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Early results of micropulse transscleral cyclophotocoagulation for the treatment of glaucoma

European Journal of Ophthalmology ◽

10.1177/1120672119839303 ◽

2019 ◽

Vol 30 (4) ◽

pp. 700-705 ◽

Cited By ~ 6

Author(s):

Alexander T Nguyen ◽

Jessica Maslin ◽

Robert J Noecker

Keyword(s):

Intraocular Pressure ◽

Continuous Wave ◽

Open Angle Glaucoma ◽

Case Series ◽

Angle Closure ◽

Secondary Outcome ◽

Early Results ◽

Pressure Lowering ◽

Transscleral Cyclophotocoagulation ◽

The Mean

Purpose: To describe our clinical experience with the efficacy and safety of micropulse transscleral cyclophotocoagulation as a treatment for glaucoma. Methods: In this retrospective case series, we reviewed the charts of 95 consecutive patients with various glaucoma subtypes who underwent micropulse transscleral cyclophotocoagulation. Patients were offered micropulse transscleral cyclophotocoagulation if they had perimetric glaucoma refractory to intraocular pressure–lowering topical medications and who were poor candidates for traditional filtering surgery. Eligible patients were treated with the Micropulse P3 device (IQ 810 Laser Systems; Iridex, Mountain View, CA, USA) at 2.0–2.5 W for a duration of 90 s per hemisphere at a 31.3% duty cycle. If a retreatment was needed, the power was increased to up to 3.0 W with other parameters remaining the same. Patients were considered successfully treated if their intraocular pressure was lowered by at least 20% compared to their baseline. The main outcome measure was post-operative intraocular pressure; secondary outcome measures included the number of adverse events and complications that occurred with treatment. Results: The glaucoma subtypes treated included primary open-angle glaucoma (n = 51), exfoliation glaucoma (n = 24), chronic angle-closure glaucoma (n = 15), and congenital/juvenile glaucoma (n = 5). The mean pre-operative intraocular pressure was 25.1 ± 5.3 mm Hg and the mean post-operative intraocular pressure at 12 months was 17.5 ± 5.1 mm Hg (p = 0.004). The mean number of intraocular pressure–lowering medications used preoperatively was 3.0 ± 1.1; the mean number of medications used at the 12-month post-operative visit was 1.4 ± 1.0 (p = 0.03). Success with one treatment was achieved in 73 (76.8%) of patients. With multiple treatments, all patients had significant intraocular pressure–lowering compared to baseline. The maximum number of treatments received by any single patient was 5. There were no instances of prolonged intraocular inflammation or long-term hypotony. Conclusion: Micropulse transscleral cyclophotocoagulation appears to be a safe and efficacious treatment for glaucoma. Given its improved safety profile compared to continuous-wave transscleral cyclophotocoagulation, it deserves consideration as a primary procedure.

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