scholarly journals Retinal vasculitis

1970 ◽  
Vol 1 (1) ◽  
pp. 66-71 ◽  
Author(s):  
JK Shrestha ◽  
D Khadka ◽  
G Lamichhane ◽  
S Khanal
Keyword(s):  
Young Adults ◽  
Key Words ◽  
Retinal Vasculitis ◽  
Venous Occlusion ◽  
Peripheral Retina ◽  
Unknown Etiology ◽  
Clinical Presentations ◽  
Eales Disease ◽  
Primary Vasculitis

Retinal vasculitis is an idiopathic inflammatory venous occlusion primarily affecting the peripheral retina of otherwise healthy young adults. Eales' disease is recognized as primary vasculitis of unknown etiology occurring in young adults. This article aims at the overall review of the etiopathogenesis, clinical presentations, pathology, management and prognosis of retinal vasculitis. Key words: Retinal vasculitis; Eales' disease DOI: 10.3126/nepjoph.v1i1.3675 Nep J Oph 2009;1(1):66-71

scholarly journals Uveitis Among Children Living with HIV / AIDS in Kinshasa, RD Congo: A Case Series

2020 ◽  
pp. 1-4
Author(s):  
Nadine Nsiangani Lusambo ◽  
Nadine Nsiangani Lusambo ◽  
Dieudonné Kaimbo Wa Kaimbo
Keyword(s):  
Immune Deficiency ◽  
Immune Status ◽  
Retinal Vasculitis ◽  
Case Series ◽  
Peripheral Retina ◽  
Unknown Etiology ◽  
Ophthalmological Examination ◽  
Slit Lamp ◽  
Living With Hiv ◽  
Hiv Aids

Purpose: To report the clinical features of a series of children living with HIV / AIDS (CLWHA) with uveitis. Methods: This was a case series of CLWHA and who had a diagnosis of uveitis examined from November 2010 to April 2011 in five sanitary structures in Kinshasa. For each child, anamnestic elements were collected. Each child underwent an ophthalmological examination including visual acuity measurement, slit lamp examination and fundus examination after dilation. Results: 15 CLWAH presented with uveitis out of a series of 100 CLWHA examined. Fourteen of the children with uveitis were already on treatment and had normal immune status, the only child who had not yet started treatment had a severe immune deficiency. Retinal vasculitis was the most common disorder in 8 children. It was asymptomatic and mainly concerned the veins on the peripheral retina. Four children presented with chorioretinal scars of unknown etiology. HIV-related microangiopathy was found in 2 children. Unilateral anterior uveitis was the only symptomatic involvement, found in the child who were not on treatment. Conclusion: Uveitis is common in African CLWHA. Retinal vasculitis of unknown etiology appears to be the most common clinical manifestation in this population. Antiretroviral therapy seems to decrease the frequency of sight-threatening conditions.

scholarly journals Cerebral Artery Stenosis in a Young Stroke Patient with Eales’ Disease

2021 ◽  
Vol 39 (4) ◽  
pp. 327-330
Author(s):  
Hyun-Ho Kim ◽  
Kyung Mi Lee ◽  
Sung Hyuk Heo
Keyword(s):  
Cerebral Infarction ◽  
Middle Cerebral Artery ◽  
Contrast Enhancement ◽  
Young Patient ◽  
Cerebral Artery ◽  
Retinal Vasculitis ◽  
Artery Stenosis ◽  
Peripheral Retina ◽  
Eales Disease ◽  
History Of

Eales’ disease is an idiopathic disorder induced by ischemic retinal vasculitis, usually affecting the peripheral retina. We encountered a young patient diagnosed as cerebral infarction with a history of Eales’ disease. The patient’s middle cerebral artery showed multifocal stenosis with contrast enhancement, suggesting vasculitis. These findings might give clues to a rare cause of cerebral artery stenosis.

scholarly journals Eales disease’ : etiopatogenesis dan tatalaksana

2019 ◽  
Vol 19 (3) ◽  
Author(s):  
Lia Meuthia Zaini
Keyword(s):  
United Kingdom ◽  
Key Words ◽  
20Th Century ◽  
19Th Century ◽  
Laser Photocoagulation ◽  
Vitreous Hemorrhage ◽  
Peripheral Retina ◽  
Retinal Surgery ◽  
Anti Vegf ◽  
Eales Disease

Abstrak. Eales disease merupakan kelainan vaskulopati obliteratif idiopatik primer, yang ditandai dengan adanya inflamasi pembuluh darah, oklusi, dan neovaskularisai pada retina, terutama mengenai pembuluh vena retina perifer. Kelainan ini pertama kali dideskripsikan oleh Henry Eales pada tahun 1882. Eales disease ditemukan di negara Inggris, Amerika, dan Kanada pada pertengahan abad ke-19 dan awal abad ke-20. Namun saat ini lebih sering ditemukan di negara India, dengan insidensi 1 dari 200-250 pasien dengan kelainan mata. Pada awal penyakit, beberapa pasien tidak menunjukkan gejala, namun yang lainnya menunjukkan gejala berupa adanya bintik-bintik yang melayang (floaters), serta pandangan kabur atau berkabut yang mungkin diakibatkan dari perdarahan vitreous.Terapi dengan kortikosteroid saat ini masih menjadi terapi utama dalam menangani vaskulitis yang terjadi pada retina. Beberapa tindakan lain yang juga dapat dilakukan adalah pemberian anti-VEGF, laser fotokoagulasi, penggunaan obat anti-tuberculosa, serta bedah vitreo-retina untuk mengatasi perdarahan vitreous yang terjadi. Kata kunci : Eales’disease, vaskulitis retina, tuberculosisAbstract. Eales disease is a primary idiopathic occlusive vasculopathy, characterized by venous inflammation (vasculitis), occlusion, and retinal neovascularization that usually involves the peripheral retina. This disease was first describe by Henry Eales in 1882. Eales disease was initially reported in United Kingdom, U.S.A, and Canada in the mid 19th century and the beginning of the 20th century. Now seen more commonly in the Indian, with the incidence was 1 in 200-250 ophthalmic patients. In the initial stages, some patients are often asymptomatic, but some may develop symptoms such as floaters and blurring vision due to vitreous hemorrhage. Corticosteroids remain the mainstay therapy to treat vasculitis in the retina. Others management are anti VEGF, laser photocoagulation, anti tuberculosis drugs, and vitreo-retinal surgery to manage unresolved vitreous hemorrhage. Key words: Eales’disease, retinal  vaskulitis, tuberculosis

scholarly journals Risk factors and mechanisms of stroke in young adults: The FUTURE study

2017 ◽  
Vol 38 (9) ◽  
pp. 1631-1641 ◽  
Author(s):  
Mayte E van Alebeek ◽  
Renate M Arntz ◽  
Merel S Ekker ◽  
Nathalie E Synhaeve ◽  
Noortje AMM Maaijwee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Future Study ◽  
The Elderly ◽  
Classification Systems ◽  
Unknown Etiology ◽  
Stroke Patients ◽  
Young Stroke ◽  
Starting Point ◽  
The Future

Incidence of ischemic stroke and transient ischemic attack in young adults is rising. However, etiology remains unknown in 30–40% of these patients when current classification systems designed for the elderly are used. Our aim was to identify risk factors according to a pediatric approach, which might lead to both better identification of risk factors and provide a stepping stone for the understanding of disease mechanism, particularly in patients currently classified as “unknown etiology”. Risk factors of 656 young stroke patients (aged 18–50) of the FUTURE study were categorized according to the “International Pediatric Stroke Study” (IPSS), with stratification on gender, age and stroke of “unknown etiology”. Categorization of risk factors into ≥1 IPSS category was possible in 94% of young stroke patients. Chronic systemic conditions were more present in patients aged <35 compared to patients ≥35 (32.6% vs. 15.6%, p < 0.05). Among 226 patients classified as “stroke of unknown etiology” using TOAST, we found risk factors in 199 patients (88%) with the IPSS approach. We identified multiple risk factors linked to other mechanisms of stroke in the young than in the elderly . This can be a valuable starting point to develop an etiologic classification system specifically designed for young stroke patients.

scholarly journals Comparison of fundus fluorescein angiography, optical coherence tomography and optical coherence tomography angiography features of macular changes in Eales disease: a case series

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ketaki Rajurkar ◽  
Meenakshi Thakar ◽  
Priyadarshi Gupta ◽  
Anju Rastogi
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Optical Coherence Tomography Angiography ◽  
Disease Process ◽  
Cystoid Macular Oedema ◽  
Peripheral Retina ◽  
Optical Coherence ◽  
Fundus Fluorescein Angiography ◽  
Indirect Ophthalmoscopy ◽  
Eales Disease

Abstract Purpose To study the macular features in Eales disease patients observed with fundus fluorescein angiography (FA), optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Methods A cross-sectional study was done on treatment naïve 31 eyes (23 patients) with Eales disease. Baseline parameters such as Best-corrected visual acuity (BCVA), slit-lamp bio microscopy (SLB), indirect ophthalmoscopy, FA, spectral-domain OCT {quantitative (central macular thickness [CMT]) and qualitative analysis on SD-OCT} and OCTA were performed. Any media opacity precluding the above investigations was excluded. Results Macular findings comprised of- epiretinal membrane, macular exudation, full thickness macular hole, sub internal limiting membrane bleed, cystoid macular oedema, neurosensory detachment and retinal thickening. Sixteen (51.6%) of our patients had macular changes as seen on all modalities together. SLB and indirect ophthalmoscopy missed macular findings in 50% patients and FA in 18.8% patients. OCT and OCTA diagnosed all macular findings. On comparison of mean BCVA in patients with macular involvement on FA, OCT and OCTA, compared to those without macular involvement, patients with macular involvement had lower BCVA (p 0.000, 0.01 and 0.001 respectively). Thus, FA missed many patients who had significant macular involvement and hence less vision. Conclusion Eales disease though described in literature as classically being peripheral retina disease process, also has macular involvement. OCT and OCTA are useful guides to evaluation of macular involvement in these patients. The latter seems to be superior to FA in detecting macular abnormalities in this ailment. OCTA is non-invasive and shows deep capillary plexus changes which are not shown by any other modality.

scholarly journals Optical Coherence Tomography Angiography Features of Macular Epiretinal Neovascularization In Eales’ Disease: A Case Rreport

2021 ◽  
Author(s):  
Nora Alyousif ◽  
Abrar K. Alsalamah ◽  
Hassan Aldhibi
Keyword(s):  
Optical Coherence Tomography ◽  
Blood Vessels ◽  
Optic Disc ◽  
Optical Coherence Tomography Angiography ◽  
Internal Limiting Membrane ◽  
Peripheral Retina ◽  
Optical Coherence ◽  
Retinal Capillary ◽  
Eales Disease ◽  
The Right

Abstract Background: Eales disease primarily affects the peripheral retina. However, posterior involvement can be seen. Macular epiretinal neovascularization is not commonly seen in Eales disease. This report highlights the morphology and origin of macular epiretinal neovascularization (ERN) using multimodal retinal imaging, including optical coherence tomography angiography (OCTA). Results: A 35-year-old man with no history of systemic disorders presented with gradual decrease of vision in his left eye. Fundus examination of his right eye showed peripheral sclerosed blood vessels, neovascularization of the optic disc and elsewhere, and macular ERN. The view of the left fundus was limited by vitreous haemorrhage. Fluorescein angiography (FA), of the right eye showed widespread peripheral capillary nonperfusion and leakage of dye from the retinal neovascularization and macular ERN. Macular Spectral domain optical coherence tomography (SD-OCT) of the right eye showed an epiretinal membrane and the presence of epiretinal neovascular lesions extending above the internal limiting membrane towards the vitreous. Optical coherence tomography angiography (OCTA) showed multiple tiny blood vessels at the macula that arose from the superficial retinal capillary plexuses and extended toward the vitreous. The corresponding B-scan showed flow signal through these vessels and the signal extend above the internal limiting membrane. Systemic work-up was negative except for strongly positive tuberculin skin testing giving the classic diagnosis of Eales disease. Patient was started on empirical anti-tubercular therapy and oral corticosteroids. Scatter laser photocoagulation was applied to nonperfused retinal zones. Despite adequate scatter laser ablation, the ERN failed to regress fully. Conclusions: Macular ERN can be seen in cases of classic Eales disease. The origin of macular ERN in our case was shown to be from the superficial retinal capillary plexuses. We also noted the slower regression rate of macular ERN as compared to the major neovascularizations of the optic disc and peripheral retina. Further research is needed to establish the pathogenesis of ERN and its optimal management.

scholarly journals Immunopathogenesis of Ocular Behçet’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Un Chul Park ◽  
Tae Wan Kim ◽  
Hyeong Gon Yu
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Retinal Vasculitis ◽  
Skin Lesions ◽  
Unknown Etiology ◽  
Ocular Involvement ◽  
Inflammatory Disorder ◽  
General Hypothesis ◽  
Behcet's Disease

Behçet’s disease (BD) is a chronic recurrent systemic inflammatory disorder of unknown etiology characterized by oral and genital ulcerations, skin lesions, and uveitis. The ocular involvement of BD, or Behçet’s uveitis (BU), is characterized by panuveitis or posterior uveitis with occlusive retinal vasculitis and tends to be more recurrent and sight threatening than other endogenous autoimmune uveitides, despite aggressive immunosuppression. Although pathogenesis of BD is unclear, researches have revealed that immunological aberrations may be the cornerstone of BD development. General hypothesis of BD pathogenesis is that inflammatory response is initiated by infectious agents or autoantigens in patients with predisposing genetic factors and perpetuated by both innate and acquired immunity. In addition, a network of immune mediators plays a substantial role in the inflammatory cascade. Recently, we found that the immunopathogenesis of BU is distinct from other autoimmune uveitides regarding intraocular effector cell profiles, maturation markers of dendritic cells, and the cytokine/chemokine environment. In addition, accumulating evidence indicates the involvement of Th17 cells in BD and BU. Recent studies on genetics and biologics therapies in refractory BU also support the immunological association with the pathogenesis of BU. In this review, we provide an overview of novel findings regarding the immunopathogenesis of BU.

Variance in clinical presentation of Ectopic pregnancy

2021 ◽  
Vol 15 (10) ◽  
pp. 2845-2847
Author(s):  
Areeba Aftab ◽  
Memoona Faiyaz ◽  
Uzma Fahim ◽  
Humaira Tabassum ◽  
Saima Rafique ◽  
...  
Keyword(s):  
Ectopic Pregnancy ◽  
Key Words ◽  
Acute Abdomen ◽  
Vaginal Bleeding ◽  
Clinical Presentation ◽  
Uterine Cavity ◽  
Cross Sectional ◽  
Clinical Presentations ◽  
Gestational Sac ◽  
Labour Ward

Objective: To adjudge the prevalence of distinct presentations in ectopic pregnancy. Research Design: Descriptive cross-sectional. Place and Duration of Study: Emergency Labour Ward Department of Obstetrics & Gynecology, Nishtar Hospital Multan from 1.07.2017 to 31.12.2017. Methodology: Ninety five patients having positive pregnancy tests and uterine cavity with no intrauterine gestational sac on ultrasound were included. Clinical presentation like amenorrhea, vaginal bleeding, acute abdomen, shock or asymptomatic were assessed. Results: Amenorrhea observed in 73(76.8%) women, vaginal bleeding was seen in 32 (33.7%) women, 88 (92.6%) patients presented with acute abdomen and vitals instability was seen in 8 (8.4%) patients and 6(6.3%) patients were without symptoms. Conclusion: The two most common clinical presentations in patients included in study were amenorrhea and acute abdomen. Thorough evaluation of the patients with sub-acute or chronic presentation should be adopted to diagnose the cases of ectopic pregnancy. Key words: Ectopic pregnancy; Clinical presentation; Variations

Clinical Findings, Diagnosis, and Classification of Behçet's Disease

2018 ◽  
pp. 329-333
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Retinal Vasculitis ◽  
Clinical Findings ◽  
Unknown Etiology ◽  
Ocular Involvement ◽  
Behcet's Disease ◽  
Diagnosis And Classification

Behçet’s Disease (BD) is a chronic multisystem vasculitis with unknown etiology, which is characterized by the triad of recurrent oral ulcers, genital ulcers, and iritis. The eye is one of the most commonly affected organs and typical ocular involvement is panuveitis with hypopyon and retinal vasculitis. The diagnosis is based on clinical evaluation including biomicroscopic and funduscopic examination. This article aims to review the clinical findings, diagnosis, and classification of BD.

Sign in / Sign up

Export Citation Format

Share Document