scholarly journals Forecasting Of Content Ca 125 Endometriosis Using Logistic Regression Model

Author(s):  
Sardjana Atmadja ◽  
Gulam Gumilar

Objective : This study is to prove that there is a significant relationship between the absence of students participating in activities at school / on campus and the symptoms of primary dysmenorrhoea experienced during menstruation. Endometriosis is characterized as pain under the abdomen during menstruation. In addition, this study is also to obtain a profile of students and factors that influence primary dysmenorrhoea. A logistic regression model has been used to assess the main factors of dysmenorrhoea among these students.Methods : The study was conducted at the RSK Permata Hati Malang. A total of 123 students were randomly selected in this study. The factors observed were menarche, menstruation, menstruation period and blood loss volume and CA 125 level. From the logistic regression model, it was found that there were three factors that influence the occurrence of dysmenorrhoea among students, namely menarche, menstruation period and menstrual blood volume.Results: The Hosmer and Lemeshow test showed that the measurement model of CA 125 levels in endometriosis was appropriate (Chi squar test value was 2.847 with p-value = 0.416). Instead of Press. (3) and Eq. (4), it was found that the contributors to dismenortea were menstrual length, menstrual discharge and the beginning of menarche. By looking at the odds ratio it is found that the risk of students experiencing dysmenorrhoea is (i) 2.5 times higher for those with longer menstrual periods (ii) 3.7 times higher for those who have menstrual expenditure which is a little and (iii) three times higher for those who have mined it for more than 13 years.Conclusion: Significant CA 125 levels were obtained for students and students suffering from dysmenorrhoea. The study also found that the risk of getting dysmenorrhoea increased if students and students had menstrual periods longer than 35 days, menstrual expenditure levels were small and menarche was more than 13 years old.International Journal of Human and Health Sciences Vol. 05 No. 01 January’21 Page: 47-49

2020 ◽  
Vol 8 (2) ◽  
pp. e001314
Author(s):  
Chao Liu ◽  
Li Li ◽  
Kehan Song ◽  
Zhi-Ying Zhan ◽  
Yi Yao ◽  
...  

BackgroundIndividualized prediction of mortality risk can inform the treatment strategy for patients with COVID-19 and solid tumors and potentially improve patient outcomes. We aimed to develop a nomogram for predicting in-hospital mortality of patients with COVID-19 with solid tumors.MethodsWe enrolled patients with COVID-19 with solid tumors admitted to 32 hospitals in China between December 17, 2020, and March 18, 2020. A multivariate logistic regression model was constructed via stepwise regression analysis, and a nomogram was subsequently developed based on the fitted multivariate logistic regression model. Discrimination and calibration of the nomogram were evaluated by estimating the area under the receiver operator characteristic curve (AUC) for the model and by bootstrap resampling, a Hosmer-Lemeshow test, and visual inspection of the calibration curve.ResultsThere were 216 patients with COVID-19 with solid tumors included in the present study, of whom 37 (17%) died and the other 179 all recovered from COVID-19 and were discharged. The median age of the enrolled patients was 63.0 years and 113 (52.3%) were men. Multivariate logistic regression revealed that increasing age (OR=1.08, 95% CI 1.00 to 1.16), receipt of antitumor treatment within 3 months before COVID-19 (OR=28.65, 95% CI 3.54 to 231.97), peripheral white blood cell (WBC) count ≥6.93 ×109/L (OR=14.52, 95% CI 2.45 to 86.14), derived neutrophil-to-lymphocyte ratio (dNLR; neutrophil count/(WBC count minus neutrophil count)) ≥4.19 (OR=18.99, 95% CI 3.58 to 100.65), and dyspnea on admission (OR=20.38, 95% CI 3.55 to 117.02) were associated with elevated mortality risk. The performance of the established nomogram was satisfactory, with an AUC of 0.953 (95% CI 0.908 to 0.997) for the model, non-significant findings on the Hosmer-Lemeshow test, and rough agreement between predicted and observed probabilities as suggested in calibration curves. The sensitivity and specificity of the model were 86.4% and 92.5%.ConclusionIncreasing age, receipt of antitumor treatment within 3 months before COVID-19 diagnosis, elevated WBC count and dNLR, and having dyspnea on admission were independent risk factors for mortality among patients with COVID-19 and solid tumors. The nomogram based on these factors accurately predicted mortality risk for individual patients.


2010 ◽  
Vol 5 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Benjamin C. Warf ◽  
John Mugamba ◽  
Abhaya V. Kulkarni

Object In Uganda, childhood hydrocephalus is common and difficult to treat. In some children, endoscopic third ventriculostomy (ETV) can be successful and avoid dependence on a shunt. This can be especially beneficial in Uganda, because of the high risk of infection and long-term failure associated with shunting. Therefore, the authors developed and validated a model to predict the chances of ETV success, taking into account the unique characteristics of a large sub-Saharan African population. Methods All children presenting with hydrocephalus at CURE Children's Hospital of Uganda (CCHU) between 2001 and 2007 were offered ETV as first-line treatment and were prospectively followed up. A multivariable logistic regression model was built using ETV success at 6 months as the outcome. The model was derived on 70% of the sample (training set) and validated on the remaining 30% (validation set). Results Endoscopic third ventriculostomy was attempted in 1406 patients. Of these, 427 were lost to follow-up prior to 6 months. In the remaining 979 patients, the ETV was aborted in 281 due to poor anatomy/visibility and in 310 the ETV failed during the first 6 months. Therefore, a total of 388 of 979 (39.6% and [55.6% of completed ETVs]) procedures were successful at 6 months. The mean age at ETV was 12.6 months, and 57.8% of cases were postinfectious in origin. The authors' logistic regression model contained the following significant variables: patient age at ETV, cause of hydrocephalus, and whether choroid plexus cauterization was performed. In the training set (676 patients) and validation set (303 patients), the model was able to accurately predict the probability of successful ETV (Hosmer-Lemeshow p value > 0.60 and C statistic > 0.70). The authors developed the simplified CCHU ETV Success Score that can be used in the field to predict the probability of ETV success. Conclusions The authors' model will allow clinicians to accurately identify children with a good chance of successful outcome with ETV, taking into account the unique characteristics and circumstances of the Ugandan population.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Amanuel Mengistu Merera

Abstract Introduction In low- and middle-income nations, acute respiratory infection (ARI) is the primary cause of morbidity and mortality. According to some studies, Ethiopia has a higher prevalence of childhood acute respiratory infection, ranging from 16 to 33.5%. The goal of this study was to determine the risk factors for acute respiratory infection in children under the age of five in rural Ethiopia. Methods A cross-sectional study involving 7911 children under the age of five from rural Ethiopia was carried out from January 18 to June 27, 2016. A two stage cluster sampling technique was used recruit study subjects and SPSS version 20 was used to extract and analyze data. A binary logistic regression model was used to identify factors associated with a childhood acute respiratory infection. The multivariable logistic regression analysis includes variables with a p-value less than 0.2 during the bivariate logistic regression analysis. Adjusted odds ratios were used as measures of effect with a 95% confidence interval (CI) and variables with a p-value less than 0.05 were considered as significantly associated with an acute respiratory infection. Results The total ARI prevalence rate among 7911 under-five children from rural Ethiopia was 7.8%, according to the findings of the study. The highest prevalence of ARI was found in Oromia (12.8%), followed by Tigray (12.7%), with the lowest frequency found in Benishangul Gumuz (2.4%). A multivariable logistic regression model revealed that child from Poor household (AOR = 2.170, 95% CI: 1.631–2.887), mother’s no education (AOR = 2.050,95% CI: 1.017–4.133), mother’s Primary education (AOR = 2.387, 95% CI:1.176–4.845), child had not received vitamin A (AOR = 1.926, 95% CI:1.578–2.351), child had no diarrhea (AOR = 0.257, 95% CI: 0.210–0.314), mothers not working (AOR = 0.773, 95% CI:0.630–0.948), not stunted (AOR = 0.663, 95% CI: 0.552–0.796), and not improved water source (AOR = 1.715, 95% CI: 1.395–2.109). Similarly, among under-five children, the age of the child, the month of data collection, anemia status, and the province were all substantially linked to ARI. Conclusions Childhood ARI morbidity is a serious health challenge in rural Ethiopia, according to this study, with demographic, socioeconomic, nutritional, health, and environmental factors all having a role. As a result, regional governments, healthcare staff, and concerned groups should place a priority on reducing ARI, and attempts to solve the issue should take these variables into account.


2021 ◽  
Author(s):  
Amanuel Mengistu Merera

Abstract Introduction: In low- and middle-income nations, acute respiratory infection (ARI) is the primary cause of morbidity and mortality. According to some studies, Ethiopia has a higher prevalence of childhood acute respiratory infection, ranging from 16 % to 33.5 %. The goal of this study was to determine the risk factors for acute respiratory infection in children under the age of five in rural Ethiopia. Methods: A cross-sectional study involving 7,911 children under the age of five from rural Ethiopia was carried out from January 18 to June 27, 2016. A two stage cluster sampling technique was used recruit study subjects and SPSS version 20 was used to extract and analyze data. A binary logistic regression model was used to identify factors associated with a childhood acute respiratory infection. The multivariable logistic regression analysis includes variables with a p-value less than 0.2 during the bivariate logistic regression analysis. Adjusted odds ratios were used as measures of effect with a 95% confidence interval (CI) and variables with a p-value less than 0.05 were considered as significantly associated with an acute respiratory infection. Results: The total ARI prevalence rate among 7,911 under-five children from rural Ethiopia was 7.8%, according to the findings of the study. The highest prevalence of ARI was found in Oromia (12.8 %), followed by Tigray (12.7 %), with the lowest frequency found in Benishangul Gumuz (2.4 %). A multivariable logistic regression model revealed that child from Poor household (AOR=2.170, 95% CI: 1.631-2.887), mother’s no education (AOR=2.050,95% CI: 1.017-4.133), mother’s Primary education (AOR=2.387, 95% CI:1.176-4.845), child had not received vitamin A (AOR=1.926, 95% CI:1.578-2.351), child had no diarrhea (AOR=0.257, 95% CI: 0.210-0.314), mothers not working (AOR=0.773, 95% CI:0.630-0.948), not stunted (AOR=0.663, 95% CI: 0.552-0.796), and not improved water source (AOR=1.715, 95% CI: 1.395-2.109). Similarly, among under-five children, the age of the child, the month of data collection, anemia status, and the province were all substantially linked to ARI. Conclusions: Childhood ARI morbidity is a serious health challenge in rural Ethiopia, according to this study, with demographic, socioeconomic, nutritional, health, and environmental factors all having a role. As a result, regional governments, healthcare staff, and concerned groups should place a priority on reducing ARI, and attempts to solve the issue should take these variables into account.


Author(s):  
Jafar Fili ◽  
Marzieh Nojomi ◽  
Katayoon Razjouyan ◽  
Mojgan Kahdemi ◽  
Rozita Davari- Ashtiani

Objective: The present study aimed to examine the association between ADHD and suicide attempts among adolescents with bipolar disorder. Method: Participants were 168 adolescents who fulfilled DSM-IV-TR criteria for bipolar disorder. They were divided into 2 groups: The first group of patients with bipolar disorder with a history of suicide attempts (n = 84) and the second group without a history of suicide attempts (n = 84). ADHD and other variables were analyzed using a chi-squared test and logistic regression model. Results: No significant difference was observed between the 2 groups in comorbidity of ADHD and other psychiatric disorders (P value > 0/05). In the logistic regression model, and after controlling for other factors, gender (OR = 3.9, CI 95%: 1.5-9.6) and history of sexual abuse (OR = 3.4; CI 95%: 1.06-11.3) were the only 2 factors associated with a history of suicide attempts. Conclusion: No significant association was found between ADHD and suicide attempts in adolescents with bipolar disorder.


MedPharmRes ◽  
2020 ◽  
Vol 4 (4) ◽  
pp. 27-32
Author(s):  
Giao Huynh ◽  
Le An Pham ◽  
Vien Truong Nguyen ◽  
Thuong Thi Hoai Do ◽  
Han Thi Ngoc Nguyen ◽  
...  

Objectives: We assessed the factors relating to the prevention of the Novel Coronavirus Disease (COVID-19) for students at the University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam. Methods: A cross-sectional study was performed in February and March 2020. A 21 item self-administered questionnaire on the knowledge, attitude, and practices regarding COVID-19 was collected from students of the first to the sixth year using the strategy of simple random sampling. The aim was to establish factors that relate to practices using Odds ratio (OR) and 95% confidence interval (95% CI) which were estimated by the logistic regression model, p-value <0.05 shows a significant difference. Results: Of the 551 students, 41.0% recorded responses indicating good practices toward prevention measures, while around half the students reported that they did not wash their hands for 20 full seconds (50.5%). The overall rate of good knowledge and positive attitude was 49.0% and 26.1%, respectively. When adjusted for all variables in the logistic regression model, a positive overall attitude was associated with good overall preventive practice; AOR = 1.72 (95% CI: 1.16 – 2.55). Furthermore, students mainly accessed information via social media and television (95.8% and 85.8%, respectively). Conclusions: There were only 41.0% recorded responses indicating good practices toward prevention measures. Besides, knowledge and attitudes about COVID-19 among students were inadequate. Further health education interventions should be focused to change bad hand-washing habits via mass media messages.


2017 ◽  
Vol 11 (8) ◽  
pp. 38
Author(s):  
Adeeb Ahmed Ali AL Rahamneh ◽  
Omar M. Hawamdeh

This study aims to use the logistic regression model to classify patients as infected and without cataracts. The independent variables were used to represent the gender, the age, the pressure in the right eye, the pressure in the left eye, HbA1C, and the anemia, representative variables for the study of Cataract disease affects the eyes, based on a random sample of (116) patients. The results proved that the used logistic regression model is an efficient and representative for data that shows through (Likelihood Ratio Test) and (Hosmer and Lemeshow test), and the study proved that the value of (R Square Nagelkerke=1) this means that 100% of the change in the occurred changes in the response variable explained through the Logistic regression model.


PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256598
Author(s):  
Samuel Dessu ◽  
Tadesse Tsehay ◽  
Tadele Girum ◽  
Abebe Timerga ◽  
Mamo Solomon ◽  
...  

Introduction Internationally, countries have reacted to the COVID-19 outbreak by introducing key public health non-pharmaceutical interventions to protect vulnerable population groups. In response to COVID-19, the Government of Ethiopia has been taking a series of policy actions beyond public health initiatives alone. Therefore, this study was aimed to assess the applicability of basic preventive measures of the pandemic COVID-19 and associated factors among the residents of Guraghe Zone from 18th to 29th September, 2020. Methods Community based cross sectional study was conducted at Guraghe Zone from 18th to 29th September, 2020. Systematic random sampling method was applied among the predetermined 634 samples. Variables which had p-value less than 0.25 in bivariate analysis were considered as candidate for multivariable logistic regression model. P-value <0.05 was used as a cutoff point to determine statistical significance in multiple logistic regressions for the final model. Result In this study, 17.7% (95% CI: 14.7, 20.5) of the respondents apply the basic preventive measures towards the prevention of the pandemic COVID-19. In addition, being rural resident (AOR: 4.78,; 95%CI: 2.50, 8.90), being studied grade 1–8 (AOR: 3.70; 95%CI: 1.70, 7.90), being a farmer (AOR: 4.10; 95%CI: 1.25, 13.35), currently not married (AOR: 2.20, 95%CI: 1.24, 4.06), having family size 1-3(AOR: 6.50; 95%CI: 3.21, 3.35), have no diagnosed medical illness (AOR: 6.40; 95%CI: 3.85, 10.83) and having poor knowledge (AOR: 3.50; 95%CI: 1.60, 7.40) were factors which are statistically significant in multivariable logistic regression model. Conclusion Despite the application of preventive measures and vaccine delivery, the applicability of the pandemic COVID-19 preventive measures was too low, which indicate that the Zone is at risk for the infection. Rural residents, those who have lower educational level, farmers, non-marrieds, those who have lower family size, those who have diagnosed medical illnesses and those who have poor knowledge were prone to the infection with the pandemic COVID-19 due to the lower practice of applying the basic preventive measures. In addition, awareness creation should be in practice at all levels of the community especially lower educational classes and rural residents.


2018 ◽  
Author(s):  
Χλόη Κωνσταντίνου

Ο τριπλά αρνητικός καρκίνος του μαστού (TNBC) αντιπροσωπεύει το 10-15% των καρκίνωντου μαστού και ορίζεται ανοσοΐστοχημικά από την έλλειψη έκφρασης των ER, PR και HER2.Χαρακτηρίζεται από υψηλότερη θνησιμότητα σε σχέση με τους άλλους υποτύπους λόγω τηςεπιθετικής κλινικής συμπεριφοράς του, της κακής πρόγνωσης του και της έλλειψης στοχευμένων θεραπειών. Σκοπός της παρούσας μελέτης ήταν η αξιολόγηση προγνωστικών δεικτών για τους TNBCs -p53, p63, C-KIT, Ki67, cMet, claudin 7, CK 5/6, CK17, AR, PTEN, EGFR, ALK, PDL-1 και cMYC - σε σχέση με τον υψηλότερο βαθμό κακοήθειας, θετικούς λεμφαδένες, την λεμφαγγειακήδιήθηση (LVI), τοπική υποτροπή, μεταστάσεις, την ελεύθερη νόσου επιβίωση (DFS) καθώς και την συνολική επιβίωση (OS). Υλικό-Μέθοδοι: Διενεργήθηκε απλή ανοσοϊστοχημεία έναντι των 14 αντιγόνων σε 84 ασθενείς με τριπλά αρνητικό διηθητικό καρκίνωμα του μαστού. Επιλέγηκαν κατάλληλοι κύβοι παραφίνης για την δημιουργία ιστικών μικροσυστοιχιών (Tissue MicroArrays-TMA). Η ανοσοϊστοχημική διερεύνηση εφαρμόσθηκε σε τομές πάχους 3 μm, από τους τρεις ΤΜΑ κύβους παραφίνης. Αποτελέσματα: Μονοπαραγοντική ανάλυση με το Fisher’s exact test εδειξε στατιστικάσημαντική σχέση μεταξύ του βαθμού κακοήθειας του όγκου και της CLAUDIN 7 (pvalue=0.004), των θετικών λεμφαδένων και της πρωτεΐνης p53 (p-value=0.015), της λεμφαγγειακής διήθησης και της CLAUDIN 7 (p-value=0.032), καθώς και μεταξύ των μοριακών δεικτών ckit και των ck5/6 (p-value=0.022), ckit και EGFR (p-value=0.055), AR και cΜet (p-value=0.041), CK5/6 και EGFR (p-value=0.004), CK17 και Ki67 (p-value=0.041), Ki67 και cΜet (p-value=0.002). Η σημασία αυτής της συσχέτισης μεταξύ των δεικτών δεν έχει διερευνηθεί. Πολυπαραγοντική ανάλυση με logistic regression model with stepwise backward elimination of variables with a p-value=0.05 για τον βαθμό κακοήθειας έδειξε: Υψηλότερη έκφραση της cl7 ( OR=65.8, 95%CI=4.35-995.19, p-value=0.003), χαμηλότερη έκφραση της ckit (OR=0.14, 95%CI=0.025-0.793, p-value=0.026) αλλά και της πρωτεΐνης p63 (OR=0.18 95%CI=0.035-0.978, p-value=0.047) σχετίζονταν με υψηλότερο βαθμό κακοήθειας του όγκου. Παρατηρήθηκε υψηλότερη έκφραση του AR (OR=13.44, 95%CI=1.28-141.56, pvalue=0.031) και χαμηλότερη έκφραση των CK5/6 OR=0.072, 95%CI=0.007-0.732, (pvalue=0.026) σε ασθενείς με θετική LVI. Σύμφωνα με το Α-rank B, μόνο το Κi67 απεδείχθη στατιστικά σημαντικό για την OS (pvalue=0.0186) και για την DFS (p-alue=0.0378).Συμπέρασμα: Υψηλή έκφραση της claudin-7 και χαμηλή έκφραση της c-kit και της πρωτεΐνης p63 σχετίζονταν με υψηλότερο βαθμό κακοήθειας του όγκου. Υψηλότερη έκφραση του AR, και χαμηλότερη έκφραση των CK5/6 φαίνεται να σχετίζονται με θετικό LVI. Αυτά τα ευρήματα εισηγούνται ότι αυτοί οι μοριακοί δείκτες μπορεί να χρησιμοποιηθούν ως προγνωστικοί δείκτεςγια τους TNBCς.


Author(s):  
E. K. Akinyem ◽  
O. A. Ogunleye ◽  
H.O Olaoye ◽  
J. Brakoru

This paper considers the application of logistic regression model to predict academics performance of students. The choice of this model becomes imperative as a result of dichotomous relationship existing in the model (either pass or fail). 100 students from the four department where engaged in the study. Statistical package for social scientist (SPSS) was used for the analysis. The results show that monthly allowance of students, and study time of the students were significant predictors. While gender and educational level of parent were insignificant predictors. The fitness of the model was assessed using Hosmer and Lemeshow test, split-sample approach and other supplementary indices to validate the model. The fitted model indicated that fitted binary logistic regression model could be used to predict the future performance of students.


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