scholarly journals Polymorphic variants of xenobiotic metabolism genes and body mass index in schizophrenia patients receiving antipsychotic therapy

2019 ◽  
pp. 115-117
Author(s):  
I. V. Pozhidaev ◽  
A. S. Boiko ◽  
E. G. Kornetova
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Side Effect ◽  
Metabolic Disorders ◽  
Antipsychotic Drugs ◽  
Common Side Effect ◽  
Siberian Region ◽  
Antipsychotic Therapy ◽  
Schizophrenic Patients ◽  
Polymorphic Variants

The use of atypical antipsychotic drugs has made metabolic disorders one of the most common side effect of pharmacotherapy for schizophrenic patients. The aim of this study was to assess the contribution of polymorphic variants of genes of the P450 cytochrome system to changes in body mass index in patients with schizophrenia. As a result of the study, we did not identify significant associations of genotypes and alleles of the studied polymorphic variants of the CYP2D6, CYP1A2, CYP2C19 genes with weight gain in patients with schizophrenia of Russian nationality of the Siberian region receiving antipsychotic therapy and can revealed neither protective nor predisposing effects. Metabolic syndrome and, increase in body weight especially, are complex side effect, and further studies is needed to increase successful exploration and identification of the genetic component and assess contribution.

scholarly journals Body mass index and obesity-related metabolic disorders in Taiwanese and US whites and blacks: implications for definitions of overweight and obesity for Asians

2004 ◽  
Vol 79 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Wen-Harn Pan ◽  
Katherine M Flegal ◽  
Hsing-Yi Chang ◽  
Wen-Ting Yeh ◽  
Chih-Jung Yeh ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Metabolic Disorders ◽  
Overweight And Obesity

scholarly journals Testosterone: Relationships with Metabolic Disorders in Men—An Observational Study from SPECT-China

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Jing Cheng ◽  
Bing Han ◽  
Qin Li ◽  
Fangzhen Xia ◽  
Hualing Zhai ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Weight Status ◽  
Metabolic Disorders ◽  
Metabolic Parameters ◽  
Total Testosterone ◽  
Logistic Regressions ◽  
Obesity Indices

Background. The strength of associations between total testosterone (TT) and metabolic parameters may vary in different nature of population structure; however, no study has ever given this information in Chinese population, especially those without metabolic syndrome (MS). We aimed to analyze the association magnitudes between TT and multiple metabolic parameters in general Chinese men. Methods. 4309 men were recruited from SPECT-China study in 2014-2015, which was performed in 22 sites in East China. TT, weight status, and various metabolic parameters were measured. Linear and logistic regressions were used to analyze the associations. Results. Men in lower TT quartiles had worse metabolic parameters including body mass index, triglycerides, HbA1c, and HOMA-IR (all P for trend < 0.001). Body mass index (B −0.32, 95%CI −0.35 to −0.29) and obesity (OR 0.40, 95%CI 0.35–0.45) had the largest association magnitude per one SD increment in TT, while blood pressure and hypertension (OR 0.90, 95%CI 0.84–0.98) had the smallest. These associations also persisted in individuals without metabolic syndrome. Conclusions. Obesity indices had closer relationships with TT than most other metabolic measures with blood pressure the least close. These associations remained robust after adjustment for adiposity and in subjects without metabolic syndrome.

Androgen excess and metabolic disorders in women with PCOS: beyond the body mass index

2017 ◽  
Vol 41 (4) ◽  
pp. 383-388 ◽  
Author(s):  
R. A. Condorelli ◽  
A. E. Calogero ◽  
M. Di Mauro ◽  
L. M. Mongioi’ ◽  
R. Cannarella ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Metabolic Disorders ◽  
The Body ◽  
Androgen Excess

scholarly journals Changes in body mass index in different periods of infants born to diabetic and non-diabetic mothers

KYAMC Journal ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. 13-17
Author(s):  
AKM Yunus Halim ◽  
Syed Nazmul Huda ◽  
Luthfor Ahmed ◽  
Shireen Begum ◽  
Laila Arjumand Banu
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Metabolic Disorders ◽  
Z Score ◽  
Paired Samples ◽  
Z Scores ◽  
Diabetic Mothers ◽  
Apparently Healthy

Background: The growth of infants born to diabetic mothers is at greater risks because of their pregnancy related complications.Objectives: This study concerns comparison of BMI changes in different periods of infants born to pre-diabetic mothers (DM) and gestational diabetic mothers (GDM) with control infants born to apparently healthy non-diabetic mothers (NDM).Materials & Methods: This study comprising 251 newbornmother pairs (n: DM=86; GDM=86 and NDM=79) recruited from the Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka.Results: BMI at birth was significantly higher for DM (BMI: 13.3±0.2 vs.12.6±0.2; p=0.003) and GDM (BMI: 13.7±0.2 vs.12.6±0.2; p<0.001) groups compared to the NDM group. On paired t tests, BMI increased significantly during 0-3 month period and 3-6 months periods in all groups (DM, GDM and NDM). At 0 month, compared to babies in the NDM group, mean BMI z-scores were significantly higher for the DM (-0.095±1.2 vs. -0.73±1.4; p=0.003) and GDM (0.16±1.4 vs.-0.73±1.4; p<0.001) groups. On paired-samples t tests, BMI Z-scores decreased from birth to 3 month of age in DM and GDM groups, but this decrease was significant for the GDM group only. In subsequent periods, BMI z-scores increased in all groups but the increment was more evident in GDM and NDM groups.Conclusion: At 0 month (birth), compared to babies in the NDM group, mean BMIs were significantly higher for the DM and GDM groups which became normalised by 3rd month when they got rid of maternal metabolic influences. The changes in BMI Z-score during 9-12 months period were significantly positive for NDM group compared to others.KYAMC Journal Vol. 8, No.-2, Jan 2018, Page 13-17

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