scholarly journals Internal stigma features at relatives of psychotic patients

Author(s):  
N. B. Lutova ◽  
O. V. Makarevich

The aim of the work was to study the severity and structure of self-stigma in relatives ofpsychotic patients. The study recruited 34 people who take care for patients with psychotic disorders (F2 and F3 according to ICD-10). Among them: 26-parents of patients (26-mothers), 4-spouses, 3- siblings and 1 child. The socio-demographic data of patients’ relatives were collected, for self-stigma evaluation was used SSI-F (Self-Stigma Family Inventory), which allows assessing the severity and structure of the family self-stigma. As a result, of the study, it was found that the intensity (by sub-scales and general point) of the caregivers did not threshold the mean score 2,5. The majority of respondents (76,5%) were patients’ parents and in 67,7% — were mothers. The differences in structure and overall intensity in different groups (gender, age, family position, employment and presence of other persons for care (children)) were found. Mild positive correlation between subscale social withdrawal (SSI-F) and age was observed. Discussed: general self-stigma vulnerability in groups of mothers and in persons over 50 years of age were higher, than in other relatives’ groups; sensitivity of internal stigma formation in spouses, working persons and relatives taking care with other family members,including children, had specific features.

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
J. Wancata ◽  
M. Freidl ◽  
F. Friedrich ◽  
T. Matschnig ◽  
A. Unger ◽  
...  

Aims:The purpose of this study was to investigate disability among patients suffering from schizophrenia and to identify predictors of disability.Methods:101 patients from different types of psychiatric services in Vienna and diagnosed with schizophrenia according to ICD-10 were included. They were investigates by means of 36-Item self-administered version of the WHO Disability Assessment Schedule II (WHO-DAS-II) and the PANSS-scale. Patients’ mothers and fathers were asked to fill in the Family Problem Questionnaire.Results:The mean total score of the WHO-DAS-II was 74.1 (SD 21.9). When using weighted sub-scores the highest disability scores were found for social contacts, participation in society and household (means 2.58, 2.57 and 2.51 respectively). Using logistic regression, overall disability was positively associated with patient's age, overall severity of symptoms (PANSS) and number of previous hospital admissions. Overall disability was not associated with duration of illness and or patient's gender. The subjective burden experienced by patients’ fathers and mothers were increased by reduced social contacts and impaired participation in society, while we could not find an association with other domains of patient's disability (understanding, mobility, self-care, household).Conclusions:This study shows that schizophrenia results in disability in several domains. Family caregivers’ burden was predominantly increased by social consequences of schizophrenia.


2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S192-S193
Author(s):  
Cherrie Galletly ◽  
Xiaoli Wu ◽  
Zili Han ◽  
Dennis Liu

Abstract Background People with psychotic disorders, including schizophrenia, suffer premature cardiovascular morbidity and mortality. Obesity is a major factor in cardiometabolic disorders in this population. There has been very little research investigating differences in patterns of obesity in diverse ethnic populations. Guidelines for treatment of complex comorbidities in people with schizophrenia and related psychoses may need to provide specific recomendations for different ethnic groups. Methods The Chinese sample consisted 192 subjects were recruited from the outpatients and inpatients department of the psychiatry department of the third affiliated hospital of Sun Yat-sen. All enrolled subjects were Chinese Han ethnicity, aged 16–45 years, with a diagnosis of schizophrenia according to ICD-10 criteria for schizophrenia, excluding other acute psychiatric disorders. The Australian sample (N=1825) were drawn from the Survey of High Impact Psychosis. BMI and central obesity were measured in all subjects. Results 10.3% of men and 4.7% of women in the China sample were obese (BMI>30). In the Australian sample, 41.6% of men and 50.3% of women were obese. Overall, 7.8% of Chinese sample and 45.1% of the Australian sample were obese. However, amongst the non-obese China sample, 41.7% of men and 53.1% of women had central obesity; the mean for all non-obese Chinese people was 46.7%. 73% of non-obese Australian men and 81.5% of non-obese Australian women had central obesity; the mean for all non-obese Australians was 76%. Discussion Chinese Han people with schizophrenia have much lower rates of obesity than the Australian sample. In both groups, rates of abdominal obesity were higher than rates of obesity as defined by BMI. These ethnic differences may help in understanding the high rates of cardiometabolic disorder in people with psychotic disorders in Western countries. They may also inform interventions to assist Western people with psychoses to maintain better physical health.


2012 ◽  
Vol 6 (4) ◽  
pp. 1-6
Author(s):  
B Yengkokpam ◽  
SK Shah ◽  
GR Bhantana

This study was carried out among the patients working abroad and their family members, having various psychiatric disorders. 80 patients attending psychiatry OPD between the age of 15 to 65 years both male and female in the period of July 2009 to July 2010 were included. The results were tabulated as per the diagnostic criteria of International Classification of Diseases (ICD-10). Out of total 80 patients, 41 were males and 39 were females, whose husbands were working abroad. 30 cases were of depression,out of which 16 were males and 14 were females.18 cases were having anxiety disorders out of which 5 were males and 13 were females. 12 cases were suffering from psychotic disorders out of which 10 were males and 2 were females.7 cases were having dissociative disorders with 1 male and 6 females.4 cases were having somatoform disorders with 2 males and 2 females.1 male and 1 female were suffering from mania.1 male and 1 female were suffering from bipolar affective disorder. 2 males were alcohol dependent and 2 males were having obsessive compulsive disorder. 1 male was having organic psychosis. Journal of College of Medical Sciences-Nepal,2011,Vol-6,No-4, 1-6 DOI: http://dx.doi.org/10.3126/jcmsn.v6i4.6718


Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 2139-2139
Author(s):  
Maria Carolina Pintao ◽  
Sara Roshani ◽  
Marieke C.H. de Visser ◽  
Cris Tieken ◽  
Michael W.T. Tanck ◽  
...  

Abstract Abstract 2139 Poster Board II-116 The natural anticoagulant protein C (PC) circulates in blood at a concentration of about 60 nM. Inter-individual variations in the levels of PC are in part genetically determined, but which loci in the genome are involved is only partially known. In a recent study we identified a locus on chromosome 20 which was associated with high PC levels in a large pedigree from the GENES study (LOD score >5 at 55 cMorgan). Candidate genes related to the PC pathway under the LOD-1 region encoded FOXA2 (previously known as HNF3 beta, a nuclear factor regulating protein C gene transcription), thrombomodulin (THBD,which is key to activation of PC), and the endothelial protein C receptor (PROCR). Here we present data that pinpoint a SNP in PROCRas being responsible for the observed segregation of high PC levels. The pedigree has 218 members and was ascertained through a proband with a family history of venous thrombosis (VT). Classical genetic risk factors for thrombosis (i.e. PC-, PS-, antithrombin deficiency, factor V Leiden and prothrombin G20201A) were not present. Complete medical data, plasma measurements and DNA was available for 161 family members. The mean age was 47±15 (range 15-87) years. The mean PC plasma level was 116±25% (range 72-212). Four family members had experienced VT and 2 had had recurrence. These symptomatic members had normal to high PC levels (66, 82, 114 and 178%).Haplotypes (and genotypes) for PROCR were determined in the family members by TaqMan assay using tag SNPs (single nucleotide polymorphisms) and PROCR H3 was associated with the levels of PC in the family. Furthermore, the promoter, exons, and 3`UTR of the 3 candidate genes were sequenced in 13 individuals, 9 with high and 4 with normal plasma PC levels. Critical SNPs that were encountered during sequencing were genotyped in all family members, namely FOXA2 rs1055080 (3`UTR) and rs2277764 (promoter region). As those 2 SNPs were inherited together in the set of 13 patients and also in the LETS (data not shown), our further analysis used only rs1055080. Plasma soluble endothelial protein C receptor (sEPCR) and soluble thrombomodulin (sTM) levels were measured with an ELISA assay. PC and sEPCR and levels were compared between PROCR H3 and FOXA2 rs1055080 carriers and non carriers by Student's t-test. sTM was analyzed by Mann-Whitney test. Association between PC levels and sEPCR/sTM levels were evaluated using linear regression analysis. Afterwards associations were adjusted for the PROCR H3 and FOXA2 rs1055080 SNP separately to detect their possible confounding effect. DNA sequencing only yielded previously reported SNPs in FOXA2, THBD and PROCR. Only the above mentioned SNPs were associated with PC plasma levels. Linkage analysis for PC levels using the original markers (from Marshifield) and adding the new PROCR and FOXA2 SNPs did not change the LOD score. When the analysis was adjusted for the mentioned markers, the LOD score dropped below 2. sEPCR has a bimodal distribution; mean ± SD was 103±27 ng/ml for the first mode and 262±70 ng/ml for the second mode. Median (range) sTM was 1.2 ng/ml (0.1-4). Linkage analysis for sEPCR levels yielded a high LOD score (above 6) that was accentuated to above 8 when PROCR H3 was included as a marker. For sTM, the LOD score was low with every combination of markers. PC, sEPCR and sTM levels were compared between PROCR H3 carriers and non-carriers and both PC levels and sEPCR levels were influenced by this PROCR haplotype, but not sTM. In conclusion, chromosome 20 harbors a locus which influences PC levels and also the levels of sEPCR, but not the levels of sTM. A detailed analysis with SNPs in PROCR, THBD and FOXA2suggests that the so-called PROCR H3 is directly responsible for the increased PC and sEPCR levels in this family. PROCR H3 is known to represent a g.A6936G substitution leading to a p.Ser219Gly replacement in the transmembrane domain of EPCR. The Gly219 isoform is more sensitive to sheddases (such as the ADAM17 metalloprotease) and is associated with generation of truncated mRNA lacking the transmembrane domain. However, the exact mechanism by which EPCR and sEPCR levels influence the level of PC remains to be determined Disclosures: No relevant conflicts of interest to declare.


2013 ◽  
Vol 43 (11) ◽  
pp. 2369-2375 ◽  
Author(s):  
A. C. Castagnini ◽  
T. M. Laursen ◽  
P. B. Mortensen ◽  
A. Bertelsen

BackgroundAlthough transient psychotic disorders are currently classified as a category separate from schizophrenia (SZ) and affective disorders, their distinctive features remain uncertain. This study examines the family psychiatric morbidity of the ICD-10 category of ‘acute and transient psychotic disorders’ (ATPDs), pointing out differences from SZ and bipolar disorder (BD).MethodFrom a cohort of 2.5 million persons, we identified all patients enrolled in the Danish Psychiatric Register who were ever admitted with ATPDs (n=2537), SZ (n = 10639) and BD disorder (n=5292) between 1996 and 2008. The relative risk (RR) of ATPDs, SZ and BD associated with psychiatric morbidity in first-degree relatives (FDRs) was calculated as the incidence rate ratio using Poisson regression.ResultsThe RR of ATPDs [1.93, 95% confidence interval (CI) 1.76–2.11] was higher if patients with ATPDs had at least one FDR admitted with any mental disorder than patients without family psychiatric antecedents. An additional risk arose if they had FDRs admitted not only with ATPDs (RR 1.60, 95% CI 1.33–1.92) but also with SZ (RR 2.06, 95% CI 1.70–2.50) and/or BD (RR 1.55, 95% CI 1.23–1.96). Despite some overlap, the risk of SZ (RR 2.80, 95% CI 2.58–3.04) and BD (RR 3.68, 95% CI 3.29–4.12) was markedly higher if patients with SZ and BD had FDRs admitted with the same condition.ConclusionsThese findings suggest that family psychiatric predisposition has a relatively modest impact on ATPDs and argue against a sharp differentiation of ATPDs from SZ and BD.


2017 ◽  
Vol 5 (1) ◽  
pp. 82
Author(s):  
Maria Tegelela Iyambo ◽  
Louis Small ◽  
Agnes Van Dyk ◽  
Esther Kamenye

The purpose of this article is to describe the guidelines for the family members on how to cope and support a person with a head injury. A qualitative explorative, descriptive and contextual research design was conducted utilizing individual in-depth face-to-face interview to gather data from family members of a person with a head injury. This study was conducted in three of the northern regions of Namibia, i.e. Oshana, Omusati and Ohangwena. Data was analyzed using Tech’s method for content analysis.The results of this study showed that family members of a person with head a injury had varied and different experiences varying from different feelings, challenges and support to them.Based on these findings, the guidelines were developed to assist the family members of a person with a head injury on how to cope and support the person with a head injury. These guidelines may be implemented by any family who are taking care of a person with a head injury.


2020 ◽  
Author(s):  
Najmeh Moradi ◽  
Abraha Woldemichael ◽  
Parisa Malekian ◽  
Delnia Moradi Rotavandi ◽  
Satar Rezaei

Abstract Background Cost-effectiveness analysis provides a crucial means for evidence-informed decision-making on resource allocation. This study aims to elicit individuals' willingness to pay (WTP) for one additional quality-adjusted life-year (QALY) gained from life-saving treatment and associated factors in Kermanshah city, western Iran. Methods We conducted a cross-sectional study on a total of 847 adults aged 18 years and above to elicit their WTP for one additional QALY gained by oneself and a family member using a hypothetical life-saving treatment. We used a multistage sampling technique to select the samples, and the Iranian version of EQ-5D-3L, and visual analogue scale (VAS) measures was used to obtain the participants’ health utility value. The Tobit regression model was used to identify the factors affecting WTP per QALY values. Results The mean WTP value and standard deviation (SD) was US$ 862 (3224) for the respondents and US$ 1355 (3993) for the family members. The mean utility values using EQ-5D-3L and VAS methods were 0.779 and 0.800, respectively. The WTP for the additional QALY gained by the individual participants using the EQ-5D-3L and VAS methods were respectively US$ 1202 and US$ 1101, while the estimated value of the family members was US$ 1355 (SD= 3993). The Tobit regression models indicated that monthly income, education level, sex, and birthplace were statistically significantly associated (p < 0.05) with both the WTP for the extra QALY values using the EQ-5D-3L and the VAS methods. Besides, education level and monthly income showed statistically significant relationships with the WTP for the additional QALY gained by the family members (p < 0.05). Conclusion Our findings indicated that the participants' WTP value of the additional QALY gained from the hypothetical life-saving treatment was in the rage of 0.20 to 0.24 of Iran’s gross domestic product (GDP) per capita, which is far lower than the World Health Organization (WHO) recommended CE threshold value of one. This wide gap reflects the challenges the health system is facing and requires further research for defining the most appropriate CE threshold at the local level.


2020 ◽  
Author(s):  
Najmeh Moradi ◽  
Abraha Woldemichael ◽  
Parisa Malekian ◽  
Delnia Moradi Rotavandi ◽  
Satar Rezaei

Abstract Background: Cost-effectiveness analysis provides a crucial means for evidence-informed decision-making on resource allocation. This study aims to elicit individuals' willingness to pay (WTP) for one additional quality-adjusted life-year (QALY) gained from life-saving treatment and associated factors in Kermanshah city, western Iran.Methods: We conducted a cross-sectional study on a total of 847 adults aged 18 years and above to elicit their WTP for one additional QALY gained by oneself and a family member using a hypothetical life-saving treatment. We used a multistage sampling technique to select the samples, and the Iranian version of EQ-5D-3L, and visual analogue scale (VAS) measures was used to obtain the participants’ health utility value. The Tobit regression model was used to identify the factors affecting WTP per QALY values.Results: The mean WTP value and standard deviation (SD) was US$ 862 (3224) for the respondents and US$ 1355 (3993) for the family members. The mean utility values using EQ-5D-3L and VAS methods were 0.779 and 0.800, respectively. The WTP for the additional QALY gained by the individual participants using the EQ-5D-3L and VAS methods were respectively US$ 1202 and US$ 1101, while the estimated value of the family members was US$ 1355 (SD= 3993). The Tobit regression models indicated that monthly income, education level, sex, and birthplace were statistically significantly associated (p < 0.05) with both the WTP for the extra QALY values using the EQ-5D-3L and the VAS methods. Besides, education level and monthly income showed statistically significant relationships with the WTP for the additional QALY gained by the family members (p < 0.05). Conclusion: Our findings indicated that the participants' WTP value of the additional QALY gained from the hypothetical life-saving treatment was in the rage of 0.20 to 0.24 of Iran’s gross domestic product (GDP) per capita, which is far lower than the World Health Organization (WHO) recommended CE threshold value of one. This wide gap reflects the challenges the health system is facing and requires further research for defining the most appropriate CE threshold at the local level.


2020 ◽  
Author(s):  
Najmeh Moradi ◽  
Abraha Woldemichael ◽  
Parisa Malekian ◽  
Delnia Moradi Rotavandi ◽  
Satar Rezaei

Abstract Background: Cost-effectiveness analysis provides a crucial means for evidence-informed decision-making on resource allocation. This study aims to elicit individuals' willingness to pay (WTP) for one additional quality-adjusted life-year (QALY) gained from life-saving treatment and associated factors in Kermanshah city, western Iran.Methods: We conducted a cross-sectional study on a total of 847 adults aged 18 years and above to elicit their WTP for one additional QALY gained by oneself and a family member using a hypothetical life-saving treatment. We used a multistage sampling technique to select the samples, and the Iranian version of EQ-5D-3L, and visual analogue scale (VAS) measures was used to obtain the participants’ health utility value. The Tobit regression model was used to identify the factors affecting WTP per QALY values.Results: The mean WTP value and standard deviation (SD) was US$ 862 (3,224) for the respondents and US$ 1,355 (3,993) for the family members. The mean utility values using EQ-5D-3L and VAS methods were 0.779 and 0.800, respectively. Besides, Tthe WTP for the additional QALY gained by the individual participants using the EQ-5D-3L and VAS methods were respectively US$ 1,202 and US$ 1,101, while the estimated value of the family members was US$ 1,355 (SD= 3,993). The Tobit regression models indicated that monthly income, education level, sex, and birthplace were statistically significantly associated (p < 0.05) with both the WTP for the extra QALY values using the EQ-5D-3L and the VAS methods. Besides, eEducational level and monthly income also showed statistically significant relationships with the WTP for the additional QALY gained by the family members (p < 0.05). Conclusion: Our findings indicated that the participants' WTP value of the additional QALY gained from the hypothetical life-saving treatment was in the range of 0.20 to 0.24 of the Iran’s gross domestic product (GDP) per capita of Iran. This value, which is far lower than the World Health Organization (WHO) recommended CE threshold value of one. This wide gap reflects the challenges the health system is facing and requires further research for defining the most appropriate CE threshold at the local level.


2017 ◽  
Vol 1 (1) ◽  
pp. 9
Author(s):  
Lia Meilianingsih ◽  
Ridwan Setiawan

ABSTRAKTujuan penelitian: Penelitian ini bertujuan untuk mengetahui pengaruh pelayanan home careterhadap tingkat kemandirian keluarga dalam merawat anggota keluarga dengan diabetesmelitus (DM) tipe 2 di Wilayah Kerja Puskesmas Pasirkaliki, Bandung. Metode: Desain penelitianmenggunakan quasi experiment dengan pendekatan pre- post-test control group design. Sampelberjumlah 27 orang untuk kelompok perlakuan dan 27 orang untuk kelompok kontrol. Teknikpengambilan sampel secara purposive sampling. Intervensi pelayanan home care dilakukan enamkali kunjungan. Kemandirian keluarga dalam merawat anggota keluarga dengan DM tipe 2 sebelumdan sesudah diberikan pelayanan home care dilakukan dengan uji statistik T test independent dandependent. Instrumen untuk menilai kemandirian keluarga dengan kuesioner tentang kemandiriankeluarga dari Kementrian Kesehatan. Hasil: Terdapat perbedaan yang bermakna pada tingkatkemandirian keluarga dalam merawat anggota keluarga dengan DM tipe 2 sebelum dan setelahdilakukan pelayanan home care pada kelompok perlakuan (p=0,00), selanjutnya terdapat perbedaanyang bermakna juga antara kelompok kontrol dan kelompok perlakuan (p=0,00). Diskusi: Untukmencapai hasil yang maksimal perlu peningkatan pelayanan keperawatan keluarga dalam bentukHome Care secara berkesinambungan sehingga kemandirian keluarga dalam mengenal danmengatasi masalah kesehatan di keluarganya semakin meningkat. Simpulan: pelayanan homecare dapat meningkatkan kemandirian keluarga dalam merawat anggota keluarga dengan DM tipe2.Kata Kunci: diabetes melitus tipe 2, home care, kemandirian keluargaABSTRACTObjectives: This study aimed to identify the effect of home care services on the levels of independenceof family in taking care of family members with type 2 diabetes mellitus (DM) at Pasirkaliki PublicHealth Centre, Bandung. Method: This study was quasi-experimental with pre-post-test approachcontrol group design. Samples were divided into treatment group and control group, each of whichconsisted of 27 people. They were taken using purposive sampling. Home care services interventioninvolved six visits. The independence of the family in taking care of family members with type 2DM before and after home care services was analyzed using independent and dependent t test.Result: There were signifi cant differences in the levels of independence of the family in taking careof family members with type 2 DM before and after the home care services in the treatment group(p=0.00). There were also signifi cant differences between the control group and the treatment group(p 0.00). Discussion: In order to achieve maximum results, it was necessary to improve familynursing services in the form of Home Care on an ongoing basis so that the independence of thefamily in identifying and addressing family health issues would increase. Conclusion: Home careservices could improve the independence of the family in taking care of family members with type 2DM.Keywords: type 2 diabetes mellitus, home care, independence of family.


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