scholarly journals The essence of physical therapy of children 7-10 years with chronic gastritis in the hospital period: problems and prospects

2020 ◽  
pp. 152-155
Author(s):  
S. Yu. Putrov ◽  
R. V. Litvinenko
Keyword(s):  
Physical Therapy ◽  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Diet Therapy ◽  
Gastric Epithelium ◽  
Therapeutic Massage ◽  
Entire Thickness ◽  
Inflammatory Processes ◽  
Superficial Epithelium ◽  
Dystrophic Disease

The article substantiates the essence of physical therapy of children 7-10 years old with chronic gastritis in the hospital period: problems and prospects. Chronic gastritis is a chronic polyetiological inflammatory-dystrophic disease of the gastric mucosa with impaired cell regeneration and progressive atrophy of the gastric epithelium. The consequences of the disease are damage to the surface layer of the epithelium and glandular apparatus of the gastric mucosa and the development of inflammatory processes in them. Depending on the etiological factor, the inflammatory process may be limited to the superficial epithelium of the mucous membrane or spread to the entire thickness of the glandular apparatus and even the muscular layer. The main symptoms of gastritis are pain and dyspeptic disorders. Patients complain of heartburn, belching sour, feeling of pressure, burning, distension in the epigastric region, constipation, rarely - vomiting. Usually dyspeptic disorders appear during the exacerbation of the disease. Appetite usually does not change, however at the expressed frustration of function of a stomach and a duodenum can amplify or decrease - up to full (short-term) loss. The analysis of modern approaches to physical therapy of patients with chronic gastritis indicates a lack of attention to this issue. The program of physical therapy for children 7-10 years old with chronic gastritis during the hospital period includes: therapeutic physical training, therapeutic massage, physiotherapy and diet therapy.

scholarly journals Eradication of Helicobacter pylori Infection Restores ki67, p53, and Cyclin D1 Immunoreactivity in the Human Gastric Epithelium

2016 ◽  
Vol 9 ◽  
pp. CGast.S38330 ◽  
Author(s):  
Konstantinos Triantafyllou ◽  
Vasilios Papadopoulos ◽  
Theodoras Emanouil ◽  
Paraskevas Gkolfakis ◽  
Vasileia Damaskou ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Cyclin D1 ◽  
Chronic Gastritis ◽  
Helicobacter Pylori Infection ◽  
Gastric Epithelium ◽  
Ki67 Expression ◽  
P53 Immunoreactivity ◽  
Infection Eradication

Introduction We evaluated the effect of Helicobacter pylori (HP) eradication on p53, cyclin D1 expression, and cell proliferation in gastric mucosa. Materials and Methods We assessed p53, cyclin D1, and ki67 immunoexpression in gastric mucosa from 31 HP chronic gastritis patients and 12 controls. Reassessment was performed 6 months after successful HP eradication. Results Successful eradication resulted in significant decrease of p53 (1.53 ± 0.16 vs 0.83 ± 0.19, P = 0.01) and ki67 (9.84 ± 0.96 vs 4.77 ± 0.27, P < 0.001) staining in the antrum. Similarly, p53 immunoreactivity significantly decreased in the corpus (1.27 ± 0.20 vs 0.46 ± 0.15, P = 0.02), while there was a trend for decreased corpus cyclin D1 and ki67 expression (0.17 ± 0.07 vs 0.0, P = 0.08 and 8.71 ± 1.24 vs 5.85 ± 0.54, P = 0.09, respectively). Importantly, after successful HP eradication, the immunoreactivity of the studied parameters was similar to that of controls. Conclusion Successful HP infection eradication restores p53, cyclin D1, and ki67 immunoreactivity in the gastric mucosa to the level of controls.

scholarly journals State of lipid peroxidation and antioxidant defense in chronic gastritis associated with Helicobacter pylori-infection in middle-aged males

2020 ◽  
Vol 10 (4) ◽  
pp. 741-746
Author(s):  
O. V. Smirnova ◽  
A. A. Sinyakov ◽  
N. M. Titova
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Antioxidant Defense ◽  
Host Cells ◽  
Gastric Epithelium ◽  
Metabolism Enzymes ◽  
H Pylori

Helicobacter pylori is the most widespread human pathogen, with prevalence reaching up to 20—40% and 80— 90% of adult infection in developed and developing countries, respectively. Many authors consider this infection as a major factor in the development of gastric cancer. In case of H. pylori infection, free homogeneous oxidation is augmented, that elevates the blood amount of POL products. Hyperproduction of reactive oxygen species stimulates free radical POL, accompanied by membrane destruction, damage to proteins, lipids, and DNA. Thus, the destruction of the intracellular and cell outer membranes occurs resulting in cell death. In diseases associated with H. pylori infection, there is a dysregulation of the lipid peroxidation system — antioxidant defense contributing to inconsistency in the regeneration phases triggering disease progression. The aim of our work was to study indicators of POL (diene conjugates, malonic dialdehyde) and antioxidant protection (AOP) (superoxide dismutase enzymes, catalase) in chronic gastritis and chronic atrophic gastritis associated with H. pylori infection. In patients with CG associated with H. pylori as well as CAG and CAG associated with H. pylori they were featured with increased amount of primary (↑DC) and end TBA-active products of lipid peroxidation (↑MDA), whereas activity of superoxide dismutase was decreased, additionally highlighted with reduced catalase activity (↑CAT) in CAG and CAG associated with H. pylori. H. pylori just triggers the mechanisms of ROS generation in host cells. The energy of redox reactions is used by the microorganism to carry out its physiological functions and serves as a factor in its own pathogenicity, the ROS generated in such reactions can have a damaging effect on the structure of gastric mucosa. In addition, examining H. pylori genome has shown that it bears the genes encoding oxidative metabolism enzymes, such as SOD, catalase, nitroreductase, flavodoxin oxidoreductase. Long-term persistence of H. pylori in the gastric mucosa paralleled with its increased biomass accounts for it being the main source of ROS production able to augment lipid peroxidation and cause damage to the membrane structures and DNA of gastric epithelium cells.

scholarly journals Changes in Serum Levels of Growth Factors in Chronic Gastritis

2019 ◽  
Vol 23 (3) ◽  
pp. 250-256
Author(s):  
L. V. Matveeva ◽  
L. M. Mosina ◽  
M. A. Stenina
Keyword(s):  
Helicobacter Pylori ◽  
Growth Factors ◽  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Venous Blood ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Gastric Epithelium ◽  
Macrophage Colony ◽  
Endothelial Growth Factor

Chronic inflammation, contributing to atrophy of the gastric epithelium, can develop in the induction of Helicobacter pylori and other microorganisms secretion of cytokines by cells of the gastric mucosa, including growth factors. Violation of the processes of repair of the gastric mucosa in terms of immune and microbiotic imbalance is the basis of ulcer and carcinogenesis. The aim of the study was to determine the serum level and diagnostic value of growth factors in exacerbation of chronic gastritis. Materials and methods . With informed consent in 122 patients with exacerbation of chronic gastritis and 40 healthy volunteers, sampling of gastrobioptates with esophagogastroduodenoscopy (for histological and microbiological examination), 5 ml of venous blood with serum separation (for enzyme immunoassay of serum levels of growth factors) was performed. Results . The amount of granulocyte-macrophage colony stimulating factor, erythropoietin, vascular endothelial growth factor (VEGF) in the serum of patients with atrophic gastritis exceeded the values of healthy individuals, were directly related to the degree and stage of gastritis, Helicobacter pylori infection, and among themselves. The greatest diagnostic value in atrophy gastric epithelial was determined in VEGF (sensitivity - 95,9%, specificity - 48,98%, criterion more 225 pg/ml, AUC 0,654, p = 0,0072). Conclusion. Determination of serum growth factors, especially VEGF, with exacerbation of chronic gastritis is diagnostically valuable, should be used for early diagnosis of atrophy of the gastric epithelium.

scholarly journals QIGOON SYSTEM AND YOGA THERAPY AS A MEANS OF PHYSICAL REHABILITATION OF PATIENTS WITH HYPERTENSION

2020 ◽  
Vol 119 (4) ◽  
pp. 30-36
Author(s):  
Yuliya Kopochynska ◽  
Natalia Kovalenko
Keyword(s):  
Physical Therapy ◽  
Holistic Approach ◽  
Diet Therapy ◽  
Physical Rehabilitation ◽  
Health Programs ◽  
Yoga Therapy ◽  
Therapeutic Massage ◽  
Alternative Approaches ◽  
Physical Therapy Programs ◽  
Positive Effect

The article considers the features of the etiopathogenesis of hypertension and the use of methods and means of physical therapy, which combine diet therapy, exercise therapy, swimming, therapeutic massage, physiotherapy, cardio, etc. However, existing physical therapy programs do not have a holistic approach to restoring the health of people with hypertension, so the article explores alternative approaches to the use of health programs for the rehabilitation of patients with hypertension, in particular, the Qigong system and yogatherapy. The developed program of physical rehabilitation for hypertension allows to reduce the index of the area of ​​hypertension, which increases the effectiveness of rehabilitation treatment, has a positive effect on the psycho-emotional and physical condition of the patient, helps to normalize blood pressure, accelerates recovery and recovery.

scholarly journals The Role of the Pathoanatomical Diagnosis «Chronic Gastritis» in the System of Personified Cancer Prevention

2018 ◽  
Vol 28 (4) ◽  
pp. 91-101
Author(s):  
A. V. Kononov
Keyword(s):  
Gastric Cancer ◽  
Gastric Mucosa ◽  
Cancer Prevention ◽  
Chronic Gastritis ◽  
Structural Changes ◽  
Intraepithelial Neoplasia ◽  
Molecular Classification ◽  
Gastric Epithelium ◽  
Cellular Targets ◽  
Biopsy Diagnosis

Aim.The aim of the review is to systematize the principles of interpretation of morphological and molecular-cellular signs underlying the biopsy diagnosis of chronic gastritis from the standpoint of personified prevention of gastric cancer.Background. The chronicle of cancer prevention is presented as an evolution of views on the possibility of clinical interpretation of structural changes in the gastric mucosa such as early (inflammation, metaplasia, atrophy) and pronounced (intraepithelial neoplasia/dysplasia) precancerous changes. The protocols of taking gastric bioptates and their violations, the principles of formulating the pathoanatomical conclusion (Updated Sydney system, OLGA system) and a personalized forecast of the risk of gastric cancer are discussed. Molecular classification of gastric cancer is considered from the standpoint of carcinogenesis cascade and WHO 2010 histological classification. New molecular and cellular targets for the preparation of bismuth tripotassium dicitrate and practical steps of its use in the prevention of gastric cancer in chronic inflammation of the mucosa of various etiologies are conceptually described.Conclusion.  Biopsy diagnosis of chronic gastritis combined with the evaluation of gene structure (genetic polymorphism) and epigenomic mechanisms (microRNA) allows the risk of gastric cancer to be ranked in a particular patient even with early precancerous changes in the gastric mucosa. The activity of gastritis (infiltration of the mucosa with neutrophilic leukocytes) of any etiology is the theoretical justification for the use of bismuth tripotassium dicitrate pharmacological preparation to protect the genome of stem cells of the gastric epithelium as a secondary prevention of gastric cancer. 

scholarly journals Relation of Helicobacter pylori to the human gastric mucosa in chronic gastritis of the antrum.

Gut ◽  
1990 ◽  
Vol 31 (11) ◽  
pp. 1230-1236 ◽  
Author(s):  
L L Thomsen ◽  
J B Gavin ◽  
C Tasman-Jones
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Human Gastric Mucosa

Effect of dimethyl sulfoxide applications on gastric secretory function

1982 ◽  
Vol 63 (3) ◽  
pp. 24-25
Author(s):  
S. G. Vaynshteyn ◽  
Yu. V. Afanasyeva ◽  
D. H. Maksudova ◽  
M. I. Pivikova
Keyword(s):  
Gastric Mucosa ◽  
Acid Secretion ◽  
Dimethyl Sulfoxide ◽  
Chronic Gastritis ◽  
Secretory Function ◽  
Normal Acid

The use of applications of dimethyl sulfoxide in patients with ulcerative disease and chronic gastritis leads to suppression of increased acid secretion, ambivalence with normal acid secretion and has no effect in patients with atrophy of the gastric mucosa. The normalizing effect of dimethyl sulfoxide (DMSO) applications in persons with acidic, decompensated ^ and subcompensated states of the stomach by stimulating the neutralizing function of the antral glands was established. The use of dimethyl sulfoxide as a transporter of various drugs in physiotherapy can be indicated in patients with HC1 hypersecretion in the interdigestive phase of ventricular secretion.

scholarly journals Statistical analysis of the сhronic gastritis in students

2020 ◽  
Vol 73 (2) ◽  
pp. 360-364
Author(s):  
Aleksandr V. Kharchenko ◽  
Nataliya V. Kharchenko ◽  
Petro M. Makarenko ◽  
Lyudmyla M. Sakharova ◽  
Pavlo V. Khomenko ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Statistical Analysis ◽  
Gastric Mucosa ◽  
Atrophic Gastritis ◽  
Mucous Membrane ◽  
Chronic Gastritis ◽  
Bacterial Contamination ◽  
The Body ◽  
Leukocyte Infiltration ◽  
Lesser Curvature

The aim: The aim of the study is a statistical analysis of the mucosa of the stomach affected by Helicobacter pylori in young people studying at the university. Materials and methods: The work contains the results of the study of chronic gastritis of type B in university volunteer students. The study was attended by students of 1-4 courses, aged 17 to 25 years, a total of 50 people. Among them were 28 men and 22 women. Results: Various forms of chronic gastritis were found in the mucosa of the topographic-anatomical sections of the stomach, 90% of which were associated with Helicobacter pylori (HP). In all departments there is a different amount of common forms of chronic gastritis. In the pyloric section only atrophic gastritis was detected – 31.0 ± 8.5. Atrophic gastritis was also dominant on the lesser curvature – 32.3 ± 7.8, but its forms were significantly (p <0.5) less pronounced than in the pyloric section. In the area of the body, the above variants of chronic gastritis were found in 34.3 ± 8.7 cases, and the majority were flat erosive gastritis 51.0 ± 9.3. There is a tendency to reduce the degree of bacterial contamination of the gastric mucosa from its pyloric section and the lesser curvature to the walls of the body. With a decrease in the degree of bacterial contamination of the gastric mucosa, the degree of leukocyte infiltration also decreases. Between the degree of contamination of the mucous membrane of Helicobacter pylori and the degree of leukocyte infiltration of the mucous membrane, the Pearson correlation coefficient is rxy – 0,935, the correlation is very strong, the coefficient of determination is D=rxy^2 – 0,874, the statistically significant dependence on the probability is 0.99. Conclusions: Atrophic or hyperplastic gastritis associated with HP is found in the gastric mucosa, respectively, 90% of cases. The degree of bacterial contamination correlates with the degree of leukocyte infiltration of the gastric mucosa. Atrophic or hyperplastic gastritis Helicobacter pylori-associated is a common disease of people in young and working age.

scholarly journals Unusual case of adult familial Menetrier disease in siblings

2019 ◽  
Vol 12 (10) ◽  
pp. e231175
Author(s):  
Emily Brownson ◽  
Adrian J Stanley ◽  
Prakash Konanahalli ◽  
John P Seenan
Keyword(s):  
Family History ◽  
Iron Deficiency ◽  
Gastric Mucosa ◽  
Iron Deficiency Anaemia ◽  
Unusual Case ◽  
Gastric Epithelium ◽  
Deficiency Anaemia ◽  
History Of ◽  
Mucosal Folds ◽  
Gastric Malignancy

Menetrier disease is a rare disease characterised by hyperplasia of the gastric epithelium and large gastric folds. We present a case of a 58-year-old woman who was referred with iron deficiency anaemia, with a family history of a sibling who had undergone gastrectomy for presumed gastric malignancy. Endoscopy showed prominent gastric mucosal folds and biopsies showed hyperplastic gastric mucosa, with prominent foveolar hyperplasia suggestive of Menetrier disease. Further information about her brother’s diagnosis was sought, and it was found that his pathology after gastrectomy showed diffuse glandular hyperplasia also in keeping with Menetrier disease. Adult familial Menetrier disease has so far been a rarity in the literature—review elicits five previous cases of this presentation in siblings.

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