scholarly journals МОРФОЛОГІЧНА ХАРАКТЕРИСТИКА СТРУКТУРНИХ КОМПОНЕНТІВ ХРЯЩОВОГО ПОКРИТТЯ КОЛІННОГО СУГЛОБА НА УЛЬТРАСТРУКТУРНОМУ РІВНІ В НОРМІ

World Science ◽  
2019 ◽  
Vol 2 (1(41)) ◽  
pp. 7-10
Author(s):  
Войценко К. І. ◽  
Пальтов Є. В. ◽  
Кривко Ю. Я.
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Comparative Study ◽  
Structural Organization ◽  
Morphological Changes ◽  
Structural Components ◽  
Cellular Components

The work, presented below, aimed at studying the peculiarities of structural organization of the articular cartilage coating of the knee joint in the norm. The objective was achieved by microscopic visualization of cellular components of the articular cartilage. To obtain the microstructural materials we applied generally accepted, conventional methods.The results of the study will allow to form an ultrastructural base that can be further used for a comparative study of the structural components of the articular cartilage in norm as opposed to morphological changes of some elements in different stages of acute, subchronic and chronic experimental opioid exposure.

scholarly journals ДИНАМІКА МОРФОЛОГІЧНИХ ЗМІН СТРУКТУРНИХ КОМПОНЕНТІВ ХРЯЩОВОГО ПОКРИТТЯ КОЛІННОГО СУГЛОБА НА УЛЬТРАСТРУКТУРНОМУ РІВНІ НАПРИКІНЦІ ПЕРШОГО, ДРУГОГО ТА ТРЕТЬОГО ТИЖНІВ ОПІОЇДНОГО ВПЛИВУ

2019 ◽  
pp. 3-10
Author(s):  
Войценко К. І. ◽  
Пальтов Є. В. ◽  
Кривко Ю. Я. ◽  
Голейко М. В.
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Opioid Analgesics ◽  
Structural Components ◽  
Visualization Technique ◽  
Experimental Exposure ◽  
Comparative Characterization ◽  
Cellular Components ◽  
Late Stages

The work presented below, aimed at studying the onset, development and manifestations of pathomorphic chondropathy in acute and subchronic experimental exposure of opioid analgesics. The objective was achieved by using microscopic visualization technique of cellular components of the articular cartilage. To obtain the microstructural materials we applied generally accepted, conventional methods.The results of the study in the future will allow to form a pathomorphological basis, which can be used for a comparative characterization of the structural components of the articular cartilage of the knee joint in the early and late stages (acute and subchronic) of experimental opioid exposure.

scholarly journals Morphological characteristics of the auxiliary elements of the knee joint in normal and deforming arthrosis

2018 ◽  
Vol 20 (3) ◽  
pp. 175-179
Author(s):  
I V Gaivoronskiy ◽  
V V Hominets ◽  
A A Semenov ◽  
I A Goryacheva
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Medial Meniscus ◽  
Morphological Changes ◽  
Cruciate Ligament ◽  
Posterior Part ◽  
Morphological Characteristics ◽  
Relative Length ◽  
The Body ◽  
Morphological Studies

The results of morphological studies of auxiliary elements (patella, meniscus, cruciate ligament, synovial bags) of 60 knee joints of adult corpses, 30 of which were intact (without signs of deforming arthrosis) and 30 with signs of deforming arthrosis of stages III-IV are presented. It is established that the auxiliary apparatus undergoes significant changes in the progression of deforming arthrosis. In a greater degree degenerative changes prone articular cartilage of the patella and medial condyles of the knee joint. The affected areas were characterized by thinning of the articular cartilage or its complete absence, as well as the presence of osteophytes along the edges of the articular surfaces. The measurements of the relative length, width, and thickness of the meniscus also confirmed the fact of their substantial deformation and degeneration, mainly of the medial meniscus. The posterior part of the body and the horn of the medial meniscus were most susceptible to the destruction of the cartilaginous tissue and were accompanied by the erasure and disintegration of the inner margin. Synovial membranes with deforming arthrosis were thickened, compacted and locally hyperemic, had papillary growths, which indicates the presence of synovitis and fluid accumulation not only in the joint cavity but also in synovial bags, the sizes of which were significantly increased. Intra-articular ligaments are hyperemic, and fragments are noted. Pterygoid folds are enlarged, locally hyperemic, with a vascular pattern, elongated processes are visualized along the edges. Identified morphological changes in the progression of deforming arthrosis lead to trophic and metabolic disturbances of all structures of the knee joint. The results of the study of the auxiliary elements of the knee joint can be used as a control in the diagnosis of deforming arthrosis.

scholarly journals Features of morphological changes in articular tissues in vascular diseases of the lower extremities

Morphologia ◽  
2021 ◽  
Vol 15 (3) ◽  
pp. 84-88
Author(s):  
V.V. Zherebkin ◽  
D.N. Shiyan ◽  
I.V. Borzenkova ◽  
P.V. Tkachenko
Keyword(s):  
Articular Cartilage ◽  
Cardiovascular Diseases ◽  
Knee Joint ◽  
Blood Supply ◽  
Subchondral Bone ◽  
Morphological Changes ◽  
Vascular Diseases ◽  
Lower Extremities ◽  
Joint Surface ◽  
Functional Load

Background. Big epidemiological studies have revealed a link between osteoarthritis and some cardiovascular diseases such as coronary heart disease, heart failure, cerebral circulation disorders, vascular diseases and diabetes mellitus. Objective. Determination of the features of morphological changes in the synovial membrane of the joint, articular cartilage and subchondral bone in patients with cardiovascular diseases. Methods. Histological studies of articular tissues of 30 amputated lower extremities in persons with vascular diseases of the lower extremities were performed. Results. In all samples of the capsule of the knee joint, gross violations of the microcirculatory canal and histological changes of osteoarthritis and subchondral osteoporosis were revealed. At the same time, the revealed changes in the articular cartilage and subchondral bone were more pronounced in the patellar, which in the knee joint carries a negligible functional load, but receives blood supply only from the vessels of the articular capsule than in the joint surface of tibia, carrying the lion's share of the functional load on the knee joint, but receiving blood supply from the posterior tibial artery. Conclusion. The revealed features of morphological changes in articular tissues in vascular diseases of the lower extremities indicate that these diseases play an important role in the development of osteoarthritis and are more significant than the functional load on the joint. Further studies of the features of morphological changes in articular tissues in the samples of various contingents of persons are needed.

scholarly journals The dynamics of morphological changes of structural components of the intervertebral disc at the end of the thirty-fifth and forty-second days while applying the experimental opioid impact

Morphologia ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 42-48
Author(s):  
M. V. Pankiv
Keyword(s):  
Intervertebral Disc ◽  
Musculoskeletal System ◽  
Structural Changes ◽  
Morphological Changes ◽  
Male Rats ◽  
Structural Elements ◽  
Structural Components ◽  
Cellular Components ◽  
The Impact ◽  
Sexually Mature

Background. According to the WHO, the diseases of the musculoskeletal system, which cause disability and mortality, rank fourth in the world following cardiovascular disease, cancer and diabetes. Due to the statistics, every fifth person suffers from back pain. Chronic diseases of musculoskeletal system are also one of the most urgent problems in Ukraine, and about 3.5 million people encountered the problem of musculoskeletal system. Objective. The aim of the study was to investigate the impact of opioids on changes of structural components of the intervertebral disc at the end of the fifth and sixth weeks of the experiment. Methods. The materials of the study were 32 sexually mature, outbred male rats, weighing from 125 to 135 g, aged 4.5 months. Animals were injected with nalbuphine intramuscularly daily in the same intervals (at 10-11 am) for 42 days. This aim was achieved by using microscopic techniques of visualization of cellular components of the rat’s intervertebral disc. Histological specimens were prepared according to the common methods using the dye hematoxylin, eosin, azan according to Heidenhain method, PAS reaction according to McManus and Alcian blue according to Steedman. Results. As a result of experimental opioid exposure for 35 and 42 days, we discovered that in 35 days the gelatinous nucleus was reduced and deformed. Notochondral cells were rare. Mostly cell-free zones with a somewhat compacted matrix were localized in the gelatinous nucleus. In 42 days, there were significant structural changes in the gelatinous nucleus, as well as in the structural elements of the fibrous ring and cartilaginous locking plates. The amount of notochondral cells was reduced. The cytoplasm of some notochondral cells was compacted. Conclusion. Pathomorphological changes in the structural components of the intervertebral disc while applying the experimental opioid effect at the end of the 35th and 42nd days will serve as a basis for further study and comparison of the manifestations of opioid chondropathy in the longer periods applying experimental opioid impact.

scholarly journals OSOBENNOSTI STRUKTURNOY ORGANIZATsIISUSTAVNOGO KhRYaShchA v zavisimosti ot stadii gonartroza

2008 ◽  
Vol 11 (1) ◽  
pp. 6-8 ◽  
Author(s):  
Yu. I. BORODIN ◽  
M. S. LYuBARSKIY ◽  
N. R. MUSTAFAEV ◽  
N. P. BGATOVA
Keyword(s):  
Knee Joint ◽  
Electron Density ◽  
Structural Organization ◽  
Structural Changes ◽  
Morphological Changes ◽  
Control Group ◽  
Intercellular Matrix ◽  
Local Destruction ◽  
Medical Diagnostic ◽  
Lipids Accumulation

The purpose - revealing of features of the structural organization of the articulate cartilage of a knee joint at patients with various stages of arthrosis. Materials and methods. Morphological researches of an articulate cartilage are visited at 52 patients with various stages of gonarthrosis. The control group was made by 5 men and 5 women in the age of from 18 till 25 years with traumatic damages of components of a knee joint. The basic group was made by 42 persons. On a stage of gonarthrosis patients have been divided into 2 subgroups: 23 patients with 1-2 stage and 19 patients with 2-3 stage of gonarthrosis. The histological material for research has been received at performance medical-diagnostic arthroscopies a knee joint. Results. It is noted, that morphological changes in an articulate cartilage at gonarthrosis are connected with change of density intercellular matrix and, depending on a stage of process, of chondrocyte dystrophy, necrosis and apoptosis are took place. In cytoplasm of chondrocyte there is a decrease in concentration of cytoplasmic organelles, lipids accumulation and electron density inclusions. Conclusion. The most expressed structural changes in the articulate cartilage, connected with local destruction of chondrocytes, lipids and electron density inclusions accumulation are noted at patients with 2-3 stage of gonarthrosis.

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