scholarly journals Oral Condition Between Assisted Reproductive Technology Children And Natural Conceived Children

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Norzaiti Mohd Kenali ◽  
Mohd Syazwan Aidid Mohamad Basir ◽  
Mohd Firdaus Lokhman ◽  
Susi Sukmasari ◽  
Roszaman Ramli
Keyword(s):  
Assisted Reproductive Technology ◽  
Primary Teeth ◽  
Tooth Development ◽  
Reproductive Technology ◽  
Caries Experience ◽  
P Value ◽  
Developmental Defect ◽  
Cross Sectional ◽  
Oral Condition

Introduction: Assisted Reproductive Technology (ART) children were shown to have higher neurological and musculoskeletal disorder. However, limited number of studies found concerning oral condition of ART children. This research aimed to determine oral condition between ART children and Natural Conceived (NC) children. Materials and Methods: This cross-sectional study consisted of 34 subjects, 17 ART children and 17 NC children. Intraoral examination and orthopantomogram (OPG) radiograph were done in these subjects. Any abnormalities of tooth development such as number and tooth structure was recorded. Caries experience of both groups were recorded using decayed, missing, filled tooth (dmft) index. Descriptive analysis and Mann-Whitney’s Test were used. Results: Most of the participants were female (58.8%) and majority aged 7 to 8 years old (47.1%). Of the patients, 70.6% of ART group were from intra-uterine insemination (IUI) technique while 29.4% were from in-vitro fertilization (IVF). One hypodontia case were found in each group. Caries experience in primary teeth were significantly lower in the ART group compared the NC group, with p value of 0.003. Conclusion: Children in ART group experience less dental caries in the primary teeth compared with NC children. However, there was a comparable case of tooth developmental defect in both groups.

scholarly journals Attitude and acceptability of assisted reproductive technology among women in a tertiary hospital in Sokoto, northern Nigeria

2021 ◽  
Vol 10 (5) ◽  
pp. 1770
Author(s):  
Amina G. Umar ◽  
Aisha N. Adamu
Keyword(s):  
Assisted Reproductive Technology ◽  
Tertiary Education ◽  
Educational Status ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Reproductive Technology ◽  
University Teaching ◽  
P Value ◽  
Cross Sectional ◽  
Living Children

Background: Infertility couple affects the couple's life, work, health, personality, identity and quality of life. The aim of the study is to determine the attitude and acceptability of assisted reproductive technology among women at the Usmanu Danfodiyo University Teaching Hospital, Sokoto.Methods: This is a cross-sectional study that involved three 350 women attending infertility clinic. They were recruited via convenient sampling method using semi-structured questionnaire. The data obtained was managed using the statistical package for social sciences version 20. A p value of <0.05 was considered statistically significant and the result obtained was presented in charts and tables.Results: Among the 350 women recruited, their ages ranged between 14-58 years with a modal age of 25-35 yeas (58.0%) and a mean of 28.59±6.7. They are mostly (78.6%), of the Hausa/Fulani ethnic group. Almost all (98.9%) of them were married and unto 40.5% of them were in polygamous marriage. Majority, 36.9% had tertiary education, and about same proportion, about half, 51.7%% were gainfully employed. About 60.3% of them were nulliparae with a mean duration of infertility of 5.07±4.8 years. Approximately half, 53.1% had secondary infertility and only about half, 51.4% will accept ART if offered. Unfortunately, among those who declined, majority (40.9%) had no reason for doing so. There was statistically significant association between educational status and acceptance of assisted reproductive technology (ART) at p value 0.02.Conclusions: The acceptance of ART in our environment is influenced by the educational status and number of living children.

Follicular fluid and assisted reproductive technology programs outcomes (literature review)

GYNECOLOGY ◽  
2020 ◽  
Vol 21 (6) ◽  
pp. 36-40
Author(s):  
Anna G. Burduli ◽  
Natalia A. Kitsilovskaya ◽  
Yuliya V. Sukhova ◽  
Irina A. Vedikhina ◽  
Tatiana Y. Ivanets ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Assisted Reproductive Technology ◽  
Follicular Fluid ◽  
Economic Cost ◽  
Reproductive Technology ◽  
Art Programs ◽  
Vitro Fertilization ◽  
Non Invasive ◽  
Established Fact

The review presents data on metabolites in the follicular fluid (FF) from the perspective of reproductive medicine and their use in order to predict outcomes of assisted reproductive technology (ART) programs. It considers various components of this biological medium (hormones, lipids, melatonin, etc.) with an assessment of their predictive value in prognosis of the effectiveness of in vitro fertilization (IVF) programs. The data on experimental directions in this field and the prospects for their use in clinical practice are presented. The article emphasizes that the growing clinical need and the unsolved problem of increasing the effectiveness of ART programs determine the need for further studies of the FF composition. Materials and methods. The review includes data related to this topic from foreign and Russian articles found in PubMed which were published in recent years. Results. Given the established fact of a direct effect of FF composition on growth and maturation of oocytes, and further, on the fertilization process, various FF metabolites are actively investigated as non-invasive markers of quality of oocytes/embryos. The article provides data on the experimental directions in this field and the prospects for their use in clinical practice. However, clinical studies of a relation between various FF metabolites levels and outcomes of IVF programs are contradictory. Conclusion. Owing large economic cost for treatment of infertility with IVF, there is need for expansion and intensification of studies to identify and use reliable predictors in prognosis of ART programs outcomes.

Pregnancy Outcomes Using Assisted Reproductive Technology After Fertility-Preserving Therapy in Patients With Endometrial Adenocarcinoma or Atypical Complex Hyperplasia

2009 ◽  
Vol 19 (1) ◽  
pp. 147-151 ◽  
Author(s):  
Aera R. Han ◽  
Yong-Soon Kwon ◽  
D. Y. Kim ◽  
J. H. Kim ◽  
Y. M. Kim ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Assisted Reproductive Technology ◽  
Intrauterine Insemination ◽  
Medical Center ◽  
Endometrial Adenocarcinoma ◽  
Controlled Ovarian Hyperstimulation ◽  
Reproductive Technology ◽  
Vitro Fertilization ◽  
Asan Medical

Objectives:To evaluate the outcomes of pregnancy in young women (<40 years old) with early endometrial cancer or atypical complex hyperplasia who were treated by conservative management followed by assisted reproductive technology (ART).Materials and Methods:Medical charts of 11 patients treated from January 1997 to October 2007 at Asan Medical Center were retrospectively reviewed. These patients had all been treated with progestin and serial dilatation and curettage as primary fertility-preserving therapies.Results:After pathological remission of disease, 10 patients tried to become pregnant by ART, 4 by in vitro fertilization and embryo transfer, and 6 by controlled ovarian hyperstimulation, with or without intrauterine insemination. Eight women had intrauterine pregnancies, and 6 patients had live births. Patients have been followed up for 9 to 51 months (mean, 21 months) after delivery, with no evidence of tumor recurrence.Conclusions:Fertility-preserving therapy followed by ART can be a good option in well-selected patients with early endometrial cancer who want to become pregnant.

In Vitro Fertilization, Assisted Reproductive Technology

2013 ◽  
pp. 1050-1052
Author(s):  
Marie Boltz ◽  
Holly Rau ◽  
Paula Williams ◽  
Holly Rau ◽  
Paula Williams ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Assisted Reproductive Technology ◽  
Reproductive Technology ◽  
Vitro Fertilization

scholarly journals Significance of disorders of proteomic profile of follicular fluid for predicting the effectiveness of in vitro fertilisation in women with infertility

2018 ◽  
Vol 99 (3) ◽  
pp. 496-503
Author(s):  
O S Zolotykh ◽  
S V Lomteva ◽  
K Yu Sagamonova
Keyword(s):  
Assisted Reproductive Technology ◽  
Follicular Fluid ◽  
Molecular Mechanisms ◽  
Reproductive Technologies ◽  
Reproductive Technology ◽  
In Vitro Fertilisation ◽  
Proteomic Profile ◽  
Technology Programs ◽  
Group 2

Aim. To study the proteomic profile of follicular fluid in patients with infertility in assisted reproductive technology programs. Methods. The study included women with infertility included in assisted reproductive technology programs: 15 women who had in vitro fertilisation which resulted in pregnancy (group 1) and 16 women with a negative result of this program (group 2). Fractionation of the follicular fluid samples was performed using the sets of special magnetic beads. Proteomic profiling was performed by tandem MALDI-mass-spectrometry. The anti-Müllerian hormone level was measured by ELISA. Results. The study revealed differences in the detectability of follicular fluid proteins with different regulatory properties in patients of groups 1 and 2. With the negative outcome of in vitro fertilisation, expression of a number of proteins involved in the processes of folliculogenesis, ovulation, selection of the dominant follicle, as well as proteins necessary for the development of the zygote and blastula was reduced in females' follicular fluid. Increased expression in women from group 2 was registered for proteins enhancing proteolytic reactions, cell apoptosis, including oocytes, which disrupt the positive action of activin and damage structural and functional state of mitochondria. A definite relationship was found between the level of anti-Müllerian hormone and rate of detection of a number of proteins, in particular protocadherin-2α, cystatin C, betaglycan, prostatic acid phosphatase, and dermicidin. Conclusion. The revealed changes in proteomic profile of the follicular fluid obviously play an important role in the molecular mechanisms that determine the effectiveness of assisted reproductive technologies; the identified differentially expressed proteins can serve as objective markers for predicting the outcomes of in vitro fertilisation.

Thyroid Disorders and In Vitro Outcomes of Assisted Reproductive Technology: An Unfortunate Combination?

Thyroid ◽  
2020 ◽  
Vol 30 (8) ◽  
pp. 1177-1185 ◽  
Author(s):  
Kris Poppe ◽  
Candice Autin ◽  
Flora Veltri ◽  
Georgiana Sitoris ◽  
Pierre Kleynen ◽  
...  
Keyword(s):  
Assisted Reproductive Technology ◽  
Reproductive Technology ◽  
Thyroid Disorders

84 MARKERS OF DNA METHYLATION IN OVINE UTERO–PLACENTAL TISSUES DURING EARLY PREGNANCY: EFFECTS OF ASSISTED REPRODUCTIVE TECHNOLOGY

2012 ◽  
Vol 24 (1) ◽  
pp. 154
Author(s):  
A. T. Grazul-Bilska ◽  
M. L. Johnson ◽  
P. P. Borowicz ◽  
D. A. Redmer ◽  
L. P. Reynolds
Keyword(s):  
Dna Methylation ◽  
Assisted Reproductive Technology ◽  
Early Pregnancy ◽  
De Novo ◽  
Reproductive Technology ◽  
The Other ◽  
Gravid Uterus ◽  
Natural Breeding ◽  
De Novo Methylation

Compromised pregnancies can be caused by genetic, epigenetic, environmental and/or other factors. Assisted reproductive technology (ART) may have profound effects on placental and fetal development, leading eventually to compromised pregnancy. DNA methylation, regulated by DNA methyltransferases (Dnmt) and other factors, plays an important role during embryonic, including placental, development. Altered DNA methylation in the trophoblast and, subsequently, the placenta has been reported for compromised pregnancies and may contribute to embryonic/fetal loss. Little is known, however, about DNA methylation processes in placental tissues during early stages of normal or compromised pregnancies in any species. Thus, we hypothesised that ART would affect the expression of 5 methylcytosine (5mC; a marker of global methylation) and mRNA for Dnmt1, 3a and 3b in utero-placental tissues during early pregnancy in sheep. Pregnancies (n = 7 per group) were achieved through natural breeding (NAT, control), or transfer of embryos generated through natural breeding (NAT-ET), in vitro fertilization (IVF) or in vitro activation (IVA; parthenogenetic clones). On Day 22 of pregnancy, caruncle (CAR; maternal placenta) and fetal membranes (FM; fetal placenta) were snap-frozen separately for RNA extraction followed by quantitative real-time PCR. In addition, cross sections of gravid uterus were fixed and then used for immunohistochemical detection and image analysis of 5 mC in FM. In FM, expression of mRNA for Dnmt3a was ∼2-fold greater (P < 0.01) in IVA compared with the other groups and was similar in NAT, NAT-ET and IVF groups. Expression of 5 mC was ∼2- to 3-fold greater (P < 0.02) in IVF and IVA than in NAT. In CAR, mRNA expression for Dnmt1 was ∼1.5-fold greater (P < 0.04) in IVA compared with the other groups, but Dnmt3a expression was less (P < 0.04) in NAT-ET and IVA than NAT. Expression of mRNA for Dnmt1 in FM and 3b in FM and CAR was similar in all groups. In IVA and/or IVF pregnancy, increased expression of Dnmt3a mRNA and/or 5 mC in FM may indicate de novo methylation in the fetal placenta. Furthermore, in pregnancies created through ART, decreased expression of Dnmt3a in CAR may indicate reduced de novo methylation in maternal placenta. Thus, in sheep, ART may have specific effects on growth and function of utero-placental and fetal tissues through regulation of DNA methylation and likely other mechanisms. These data provide a foundation for determining the basis for altered DNA methylation of specific genes in placental and embryonic tissues in compromised pregnancies. In addition, these data will help us to better understand placental regulatory mechanisms in compromised pregnancies and to identify strategies for rescuing such pregnancies. Supported by Hatch Project ND01712; USDA grant 2007-01215 to LPR and ATGB, NIH grant HL64141 to LPR and DAR and NSF-MRI-ARRA grant to ATGB.

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