scholarly journals Uric Acid: Friend or Foe?

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wan Muhammad Azfar Bin Wan Shuaib ◽  
Nor Azlin Mohamed Ismail ◽  
Mohd Rizal Abdul Manaf ◽  
Hanita Othman
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Predictive Value ◽  
Gestational Hypertension ◽  
Serum Uric Acid Level ◽  
Reference Value ◽  
Roc Curves ◽  
Third Trimester ◽  
The Third ◽  
Adverse Pregnancy

Introduction. Adverse Pregnancy outcomes (APO) continue to trouble physicians worldwide, and uric acid has become a marker of interest in its prediction. Despite this, the correlation of uric acid in the third trimester is rarely studied, and the reference value for normal uric acid levels in pregnancy has yet to be established. This study was done to evaluate the association of uric acid levels in the third trimester of pregnancy and the development of APO, specifically gestational hypertension (GH), pre-eclampsia (PE), gestational diabetes mellitus (GDM), small for gestational age (SGA) and to determine a cut-off value of serum uric acid levels for screening of the APO. Materials and methods. A retrospective observational study was conducted among 374 women who delivered at Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM) and developed the APO of interest and had serum uric acid levels taken during the third trimester of pregnancy. A cut off value of 309 µmol/L was used to assess the sensitivity and specificity in predicting the APO. Results.  Associations are observed between 309 µmol/L and the development of GH (p<0.0005), PE (p<0.0005), GDM (p<0.0005), SGA (p=0.0264). Plotted ROC curves with cutoff point of 309 µmol/L demonstrated moderate predictive value of serum uric acid and the development of GH (AUC 0.639), PE (AUC 0.713), SGA (AUC 0.649) and low predictive value for GDM (AUC 0.4). Conclusion. Serum uric acid level of 309 µmol/L in the third trimester of pregnancy is a moderate predictor of GH, PE, SGA and a poor predictor of GDM. KEYWORDS: Uric acid; pregnancy trimester, third; pregnancy outcome

scholarly journals Assessing the Role of Uric Acid as a Predictor of Preeclampsia

2022 ◽  
Vol 12 ◽  
Author(s):  
Ana I. Corominas ◽  
Yollyseth Medina ◽  
Silvia Balconi ◽  
Roberto Casale ◽  
Mariana Farina ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Predictive Value ◽  
Gestational Hypertension ◽  
Low Cost ◽  
High Sensitivity ◽  
Use Of Resources ◽  
Before And After ◽  
High Negative Predictive Value ◽  
Group A

We assessed the diagnostic utility of uric acid for the prediction of preeclampsia. An observational prospective approach was carried out during 2014. Preeclamptic women were classified into 4 groups accordingly to the onset of preeclampsia and the presence of intrauterine growth restriction (IUGR). Serum uric acid levels, urea, and creatinine were measured. Receiver operating curves (ROC) of the uric acid levels ratio (UAr) between a dosage before and after the 20th week of gestation were performed. One thousand two hundred and ninety-third pregnant women were enrolled in this study. Eight hundred ten had non-complicated pregnancies, 40 preeclampsia, 33 gestational hypertension, and 20 IUGR without preeclampsia. Uric acid significantly raised after 20 weeks of gestation in women who develop preeclampsia before 34 weeks (Group A) or in those who develop preeclampsia after 37 weeks associated with IUGR (Group C). In women who develop preeclampsia after 34 weeks without IUGR (Groups B and D), uric acid increased after the 30th week of gestation. In all groups, UAr was greater than 1.5. In gestational hypertension, UAr was superior to 1.5 toward the end of gestation, while in IUGR without preeclampsia, the behavior of serum uric acid was similar to non-complicated pregnancies. In all cases, urea and creatinine showed normal values, confirming that patients had no renal compromise. ROC area was 0.918 [95% confidence interval (CI): 0.858–0.979) for the preeclampsia group and 0.955 (95% CI: 0.908–1.000) for Group A. UAr at a cut-off point ≥1.5 had a very low positive predictive value, but a high negative predictive value of 99.5% for preeclampsia and it reached 100% for Group A. Thus, a UAr less than 1.5 may be a helpful parameter with a strong exclusion value and high sensitivity for those women who are not expected to develop preeclampsia. Additionally, this low-cost test would allow for better use of resources in developing countries.

A PROSPECTIVE STUDY TO EVALUATE THE ROLE OF URIC ACID FOR PROGRESSION TO PREECLAMPSIA IN GESTATIONAL HYPERTENSIVE PREGNANCIES IN THE DEPARTMENT OF OBSTRETICS AND GYNECOLOGY, SMS MEDICAL COLLEGE

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Hetal More ◽  
Archana Singh ◽  
B.S. Meena
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Gestational Hypertension ◽  
Serum Uric Acid Level ◽  
Characteristic Curve ◽  
Initial Presentation ◽  
Medical College

Background: The purpose of this study was to study the role of serum uric acid level in progression to preeclampsia in gestational hypertensive pregnancies. Methods: Hospital based comparative study was conducted at Department of Obstetrics and Gynaecology, SMS medical college, Jaipur. Results: Uric acid level was significantly higher in with PIH (6.68±0.36 mg/dl) as compared to without PIH (4.92±0.57 mg/dl). Receiver-operator characteristic curve showed relatively poor sensitivity and specificity performance (area under the curve= 1.00) of serum uric acid level at the initial presentation of gestational hypertension for predicting the progression to preeclampsia The best cut-off revealed from the curve was 6.18 mg/dl. Conclusion: In conclusion, higher serum uric acid levels at the initial presentation of gestational hypertension may indicate heightened risk of progression to preeclampsia and development of adverse maternal/ infant conditions. Keywords: Eclampsia, Uric acid, Hypertension

scholarly journals Level of Serum Uric Acid in Pre-eclamptic and Normal Pregnant Women

2020 ◽  
Vol 4 (1) ◽  
pp. 20-22
Author(s):  
Hudda Abbas ◽  
Samina Badar ◽  
Zunera Javed ◽  
Mohammad Ahmed Abdelmoneam Ramdan
Keyword(s):  
Uric Acid ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Outpatient Department ◽  
Obstetrics And Gynecology ◽  
P Value ◽  
Third Trimester

Objective: The objective of study was to find out serum uric acid level in normal andpreeclamptic pregnant women of third trimester visiting outpatient department of obstetrics and gynecology of Bahawal Victoria Hospital, Bahawalpur. Methodology: It was a cross sectional descriptive study conducted form July 2018 to June 2019. All primigravida women of age 18-35 years in third trimester of singleton pregnancy attending in Obstetrics and Gynecology Outpatient Department of Bahawal Victoria Hospital in study duration were included in the study. Statistical analysis was performed by using SPSS version 14. Chi-square test was performed to find the statistical difference regarding uric acid distribution between groups and ‘p’ value <0.05 was considered as a lowest level of significance. Results: Out of total 1212 women 84.6% were normal and 15.4% had preeclampsia. In our study out of 187 preeclamptic women, 63.6% had raised serum uric acid level and out of 268 normal pregnant women uric acid level was raised in only 39.5%. Results were found statistically significant. Conclusion: Results of our study suggest that serum uric acid level in pregnant women can be used as a useful and inexpensive marker in prediction of preeclampsia and preventive measures can be taken accordingly.

scholarly journals Alterations in serum uric acid values in a sample of Nigerian pregnant women.

2019 ◽  
Vol 6 (4) ◽  
pp. 111-114
Author(s):  
Chisom Clara Wagbara ◽  
Chizindu Akudubike Alikor
Keyword(s):  
Uric Acid ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Elevated Serum ◽  
First Trimester ◽  
Progressive Increase ◽  
Third Trimester ◽  
Mean Values ◽  
Renal Tubular

Introduction: Serum uric acid level is an important prognostic variable in pregnancy as subjects with preeclampsia have elevated serum uric acid levels. Methods: The concentrations of serum uric acid were investigated in 100 women of which 75 were pregnant women and categorized into 3 groups of 25 each, based on their trimesters of pregnancy and 25 non-pregnant women, which served as control. Results: In the first trimester, the mean values of uric acid were 122 μmol/L with a decrease in the levels of uric acid when compared with the control levels of 308 μmol/L (p<0.05). In the second trimester, the values of uric acid were 199umol/l with a significant (p<0.05) decrease in the levels of uric acid when compared with the controls. In the third trimester of pregnancy, the values of uric acid were 360 μmol/L. There was a significant (p<0.05) increase in the level of uric acid when compared with the controls. Conclusion: The progressive increase in the levels of uric acid through the trimesters of pregnancy suggests an impairment in uric acid excretion, may be with concomitant increase in renal tubular re-absorption of uric acid, thereby leading to hyperuricaemia.

Glycated Albumin in Pregnancy: Reference Intervals Establishment and Its Predictive Value in Adverse Pregnant Outcomes

2019 ◽  
Author(s):  
Ying Dong ◽  
Yanhong Zhai ◽  
Jing Wang ◽  
Xin Xie ◽  
Chunhong Zhang ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Predictive Value ◽  
Glycated Albumin ◽  
Late Pregnancy ◽  
Reference Intervals ◽  
Diabetic Patients ◽  
Third Trimester ◽  
The Third ◽  
Adverse Pregnancy ◽  
In Pregnancy

Abstract Background As one of the most common pregnant complications, the gestational diabetes mellitus (GDM) is associated with significant adverse pregnant outcomes and it is crucial to accurately monitor the glycemic states of GDM patients. The HbA1c which is a traditional long-term glycemic marker used in diabetic patients, is not recommended in GDM patients during pregnancy. Recently, many efforts have been focused on the alternative marker glycated albumin (GA) and its application in pregnancy during which profound physiological changes take place. Our objective was to determine the reference intervals (RIs) of GA in healthy Chinese pregnant women and to assess the predictive value of serum GA in adverse pregnant outcomes. Methods Totally 479 healthy subjects including 153 in the first trimester, 174 in the second trimester, and 152 in the third trimester were enrolled from March to July 2019, for the purpose of establishing the trimester-specific RIs of GA. The diagnostic value of GA for GDM patients was evaluated and compared with that of fasting plasma glucose (FPG) at 24-28 weeks of gestation. The association between GA in the late pregnancy and the adverse pregnant outcomes was analyzed retrospectively with the data collected from January to June 2018 at our hospital. Results The estimated RIs of GA in present study were 10.87-15.09 %, 10.04-13.50 %, and 9.78-13.03 % in the first, second, and third trimesters respectively. The areas under receiver operating characteristic (ROC) curves were 0.503 for GA and 0.705 for FPG. More importantly, the GA levels of the third trimester did not show significant changes in women with large-for-date birth weight, preterm delivery, postpartum hemorrhage or hypertension when compared in women with normal pregnancy outcomes. The exception was that the GDM patients who developed preeclampsia did have a lower GA level in their late pregnancy. Conclusions Our results show that the GA was continuously decreased as the gestational age went up. It has limited value in diagnosing GDM and predicting adverse pregnancy outcomes.

scholarly journals Serum uric acid levels as a risk stratification tool in hypertensive pregnancy

2018 ◽  
Vol 7 (12) ◽  
pp. 4804
Author(s):  
Cimona Lyn Saldanha ◽  
Sabha Malik ◽  
Azhar Un-Nisa Quraishi
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Gestational Hypertension ◽  
Serum Uric Acid Level ◽  
Blood Platelet ◽  
Medical Complication ◽  
Maternal Complications ◽  
Risk Of Progression ◽  
Risk Stratification Tool ◽  
Control Study

Background: Hypertensive disorders represent the most common medical complication of pregnancy affecting between 7-15% of all gestations and accounts for approximately a quarter of antenatal admissions.Methods: A case-control study was conducted over a period of 1 year. A total of 200 subjects were enrolled in the study and were divided into two groups; 100 cases and 100 controls. Serum uric acid levels were measured in cases and controls. The serum uric acid levels were correlated with the severity of PIH and maternal and fetal complications.Results: It was observed that the mean serum uric acid level in cases (5.0±1.74 mg/dl) was significantly higher compared to 2.66±0.39 mg/dl in controls. Serum uric acid levels also tended to increase with increasing severity of PIH, increasing from 3.69±0.95 mg/dl in gestational hypertension to 6.36±1.38mg/dl in severe PE. Maternal complications during antepartum and postpartum period were higher once SUA≥5mg/dl was taken as a cut-off. Protienuria(p=0.00), coagulopathy(p=0.007), need for blood/platelet transfusion(p=0.01) and eclampsia (p= 0.007) were significantly more. Similarly, complications were found to be higher, in babies born to mothers having serum uric acid more than 5 mg/dl compared to others in case group.Conclusions: Higher serum uric acid levels may indicate higher risk of progression to preeclampsia and development of adverse maternal/infant conditions.

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