scholarly journals Serum uric acid levels as a risk stratification tool in hypertensive pregnancy

2018 ◽  
Vol 7 (12) ◽  
pp. 4804
Author(s):  
Cimona Lyn Saldanha ◽  
Sabha Malik ◽  
Azhar Un-Nisa Quraishi
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Gestational Hypertension ◽  
Serum Uric Acid Level ◽  
Blood Platelet ◽  
Medical Complication ◽  
Maternal Complications ◽  
Risk Of Progression ◽  
Risk Stratification Tool ◽  
Control Study

Background: Hypertensive disorders represent the most common medical complication of pregnancy affecting between 7-15% of all gestations and accounts for approximately a quarter of antenatal admissions.Methods: A case-control study was conducted over a period of 1 year. A total of 200 subjects were enrolled in the study and were divided into two groups; 100 cases and 100 controls. Serum uric acid levels were measured in cases and controls. The serum uric acid levels were correlated with the severity of PIH and maternal and fetal complications.Results: It was observed that the mean serum uric acid level in cases (5.0±1.74 mg/dl) was significantly higher compared to 2.66±0.39 mg/dl in controls. Serum uric acid levels also tended to increase with increasing severity of PIH, increasing from 3.69±0.95 mg/dl in gestational hypertension to 6.36±1.38mg/dl in severe PE. Maternal complications during antepartum and postpartum period were higher once SUA≥5mg/dl was taken as a cut-off. Protienuria(p=0.00), coagulopathy(p=0.007), need for blood/platelet transfusion(p=0.01) and eclampsia (p= 0.007) were significantly more. Similarly, complications were found to be higher, in babies born to mothers having serum uric acid more than 5 mg/dl compared to others in case group.Conclusions: Higher serum uric acid levels may indicate higher risk of progression to preeclampsia and development of adverse maternal/infant conditions.

A PROSPECTIVE STUDY TO EVALUATE THE ROLE OF URIC ACID FOR PROGRESSION TO PREECLAMPSIA IN GESTATIONAL HYPERTENSIVE PREGNANCIES IN THE DEPARTMENT OF OBSTRETICS AND GYNECOLOGY, SMS MEDICAL COLLEGE

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Hetal More ◽  
Archana Singh ◽  
B.S. Meena
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Gestational Hypertension ◽  
Serum Uric Acid Level ◽  
Characteristic Curve ◽  
Initial Presentation ◽  
Medical College

Background: The purpose of this study was to study the role of serum uric acid level in progression to preeclampsia in gestational hypertensive pregnancies. Methods: Hospital based comparative study was conducted at Department of Obstetrics and Gynaecology, SMS medical college, Jaipur. Results: Uric acid level was significantly higher in with PIH (6.68±0.36 mg/dl) as compared to without PIH (4.92±0.57 mg/dl). Receiver-operator characteristic curve showed relatively poor sensitivity and specificity performance (area under the curve= 1.00) of serum uric acid level at the initial presentation of gestational hypertension for predicting the progression to preeclampsia The best cut-off revealed from the curve was 6.18 mg/dl. Conclusion: In conclusion, higher serum uric acid levels at the initial presentation of gestational hypertension may indicate heightened risk of progression to preeclampsia and development of adverse maternal/ infant conditions. Keywords: Eclampsia, Uric acid, Hypertension

scholarly journals Association Between Serum Uric Acid Level and Psoriasis: A Case Control Study

2021 ◽  
Vol 19 (1) ◽  
pp. 50-54
Author(s):  
Aruna Sayami ◽  
Aatmaram Gupta ◽  
Narayan Gautam
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Case Control Study ◽  
Serum Uric Acid Level ◽  
Acid Value ◽  
High Serum ◽  
Control Group ◽  
Control Study

Introduction: Psoriasis is a common, chronic, inflammatory and proliferative condition of the skin, associated with various disorders including metabolic syndrome. High serum uric acid levels are also associated with metabolic syndrome. Hyperuricemia is associated with psoriasis and psoriatic arthritis. Objectives: To find out the association of serum uric acid with psoriasis. Materials and Method:  It was a case-control study including 104 patients, among them 52 were psoriatic patients (case) and 52 had disease other than psoriasis (control) after matching for age and sex. The study was conducted at Department of Dermatology, Universal College of Medical Science, from January- December 2017. Clinical examination and proforma documentation including patient details, laboratory values of serum uric acid level, Psoriasis Area and Severity Index score were studied. Results:  Mean SUA in psoriasis patients was 4.70±1.37 mg/dl in female, 5.57±1.18 mg/dl in male whereas 4.85±0.74 mg/dl in female and 4.34 ± 0.98 mg/dl in male respectively in control group (p=0.002). Six (18.88%) male and three (15.78%) female patients with psoriasis had higher serum uric acid value whereas only four (3.84%) patient  had  higherserum uric acid  value in control group (p=0.012). There was association between serum uric acid and psoriasis. Conclusion: Our study concludes that serum uric acid level is increased in psoriasis patients when compared with controls. Monitoring of psoriatic patients for high serum uric acid levels during treatment and follow up should be done to prevent the its deleterious effect on psoriasis.

scholarly journals Serum Uric Acid in Pre-eclampsia

2019 ◽  
Vol 4 (04) ◽  
Author(s):  
Dr. Yanglem Ajitkumar ◽  
Dr. Sangeeta Naorem ◽  
Dr. Victoria Kshetrimayum ◽  
Dr. Yengkhom Upen Singh ◽  
Dr. Sneha Saha ◽  
...  
Keyword(s):  
Uric Acid ◽  
Pregnant Women ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Clinical Manifestations ◽  
Common Finding ◽  
Perinatal Morbidity ◽  
Medical Sciences ◽  
Normal Controls ◽  
Control Study

Background: Hypertension in pregnancy is a major cause of maternal death and also a major source of maternal and perinatal morbidity and perinatal morbidity. Hyperuricemia is a common finding in preeclamptic pregnancies. The elevation of uric acid in preeclamtic women often precedes hypertension and proteinuria, the clinical manifestations used to diagnose the disorder. The aim of this study is estimation of serum uric acid in preeclamptic patients. A case-control study was done in the Department of Biochemistry in collaboration with Deptt of Obstetrics & Gynaecology, Regional Institute Of Medical Sciences (RIMS), Impha(Manipur), India. Methods: Data collected from 50 pre-eclamptic pregnant women and 25 normotensive pregnant women admitted in antenatal ward, Deptt of Obstretics and Gynaecology, RIMS hospital. The blood samples were collected from these patients and analysed for serum uric acid level. Results: The serum uric levels were found to be significantly higher in preeclamptic cases than in normal controls. Mean±SD of uric acid was 8.82±1.68 mg% in cases compared to 4.06±0.96 mg% in the controls. Conclusion: Hyperuricemia can be used as biomarker for identifying women at risk of preeclampsia and its complications with adverse effects

scholarly journals Role of Serum Uric Acid as a Protective Biomarker in Patients with Different Histopathological Grades of Oral Squamous Cell Carcinoma: a Case-Control Study

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Soheila Manifar ◽  
Arezoo Rahimzamani ◽  
Mohammad Shirkhoda ◽  
Mohammad Nikkhah Ghamsari ◽  
Mahin Bakhshi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Acid Level ◽  
Case Control Study ◽  
Serum Uric Acid Level ◽  
Case Control ◽  
Healthy Controls ◽  
Control Study

The antioxidant properties of uric acid may have a protective effect against the formation of oxygen radicals and subsequently against carcinogenicity. The present study aimed at evaluating the serum level of uric acid in patients with oral squamous cell carcinoma (OSCC) with different histopathological grades. In this descriptive-analytical, case-control study, patients with OSCC and healthy controls were selected and matched regarding age and gender. The serum samples were collected from patients (before radiotherapy and chemotherapy) and controls, and their serum uric acid levels were measured enzymatically. Data were analyzed using independent t-test and ANOVA at 0.05 level of significance. The mean serum uric acid level in OSCC patients (4.2±1.5 mg/dL) and healthy controls (4.38±1.22 mg/dL) was not significantly different (P=0.377). No significant association was noted between the histopathological grade of OSCC and mean serum uric acid (P=0.781). The serum uric acid level had a direct significant correlation with age in OSCC patients (P<0.001). The results of this study did not support the role of uric acid as a protective biomarker in OSCC. Further prospective studies are recommended to better elucidate the role of uric acid in the etiology of OSCC.

Serum uric acid level as a determinant of the metabolic syndrome: A case control study

2017 ◽  
Vol 11 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Satyendra Khichar ◽  
Shyama Choudhary ◽  
Veer Bahadur Singh ◽  
Priyanka Tater ◽  
R.V. Arvinda ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Case Control Study ◽  
Serum Uric Acid Level ◽  
Case Control ◽  
The Metabolic Syndrome ◽  
Control Study

scholarly journals Uric Acid: Friend or Foe?

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wan Muhammad Azfar Bin Wan Shuaib ◽  
Nor Azlin Mohamed Ismail ◽  
Mohd Rizal Abdul Manaf ◽  
Hanita Othman
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Predictive Value ◽  
Gestational Hypertension ◽  
Serum Uric Acid Level ◽  
Reference Value ◽  
Roc Curves ◽  
Third Trimester ◽  
The Third ◽  
Adverse Pregnancy

Introduction. Adverse Pregnancy outcomes (APO) continue to trouble physicians worldwide, and uric acid has become a marker of interest in its prediction. Despite this, the correlation of uric acid in the third trimester is rarely studied, and the reference value for normal uric acid levels in pregnancy has yet to be established. This study was done to evaluate the association of uric acid levels in the third trimester of pregnancy and the development of APO, specifically gestational hypertension (GH), pre-eclampsia (PE), gestational diabetes mellitus (GDM), small for gestational age (SGA) and to determine a cut-off value of serum uric acid levels for screening of the APO. Materials and methods. A retrospective observational study was conducted among 374 women who delivered at Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM) and developed the APO of interest and had serum uric acid levels taken during the third trimester of pregnancy. A cut off value of 309 µmol/L was used to assess the sensitivity and specificity in predicting the APO. Results.  Associations are observed between 309 µmol/L and the development of GH (p<0.0005), PE (p<0.0005), GDM (p<0.0005), SGA (p=0.0264). Plotted ROC curves with cutoff point of 309 µmol/L demonstrated moderate predictive value of serum uric acid and the development of GH (AUC 0.639), PE (AUC 0.713), SGA (AUC 0.649) and low predictive value for GDM (AUC 0.4). Conclusion. Serum uric acid level of 309 µmol/L in the third trimester of pregnancy is a moderate predictor of GH, PE, SGA and a poor predictor of GDM. KEYWORDS: Uric acid; pregnancy trimester, third; pregnancy outcome

scholarly journals Serum Uric Acid as a Prognostic Marker of Pregnancy induced Hypertension

2012 ◽  
Vol 4 (3) ◽  
pp. 130-133 ◽  
Author(s):  
Disha Sahijwani ◽  
Ajesh Desai ◽  
Hina Oza ◽  
Vijay Kansara ◽  
Pallavi Ninama ◽  
...  
Keyword(s):  
Uric Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Serum Uric Acid ◽  
Prognostic Marker ◽  
Gestational Hypertension ◽  
Pregnancy Induced Hypertension ◽  
Maternal Complications ◽  
Induced Hypertension ◽  
Laboratory Changes

ABSTRACT Objectives The purpose of the study is to determine the level of serum uric acid (s. uric acid) above which all complications occur, to analyze the maternal and fetal clinical and laboratory changes associated with elevated s. uric acid, and to determine whether s. uric acid can be used to predict maternal and fetal complications. Design A retrospective study of hospital records was done on 80 women of pregnancy induced hypertension including both gestational hypertension and preeclampsia from January 2011 to March 2012 at Civil Hospital, Ahmedabad. The women were divided in two groups: with s. uric acid > 6 mg/dl/ s. uric acid < 6 mg/dl. Results S. uric acid > 6 mg/dl was associated with maternal complications while s. uric acid > 5.5 mg/dl was associated with low birth weight babies. The mean creatinine and platelet count in two groups were significantly different at 5% level. Statistically significant elevation of s. uric acid was found in women of eclampsia. Conclusion S. uric acid > 6 mg/dl is associated with increased maternal complications specially eclampsia and higher incidence of low birth weight. Thus, women with pregnancy induced hypertension with s. uric acid > 6 mg/dl should be offered termination of pregnancy. How to cite this article Sahijwani D, Desai A, Oza H, Kansara V, Ninama P, Maheshwari K, Soni C, Padhiyar B. Serum Uric Acid as a Prognostic Marker of Pregnancy induced Hypertension. J South Asian Feder Obst Gynae 2012;4(3):130-133.

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