scholarly journals HELLP syndrome against the background of glomerulonephritis: Clinical casereport

2019 ◽  
pp. 27-30
Author(s):  
L. Lebid ◽  
L. Snisar ◽  
L. Liksunova
Keyword(s):  
Hellp Syndrome ◽  
Laboratory Tests ◽  
Clinical Presentation ◽  
Liver Enzymes ◽  
Morbidity And Mortality ◽  
Chronic Glomerulonephritis ◽  
Medical Sciences ◽  
Severe Morbidity ◽  
Elevated Liver Enzymes

 HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) is a severe and rapidly progressing condition that requires distinct diagnostic considerations. The clinical presentation varied within all of the classes, and the only objective means of diagnosis and evaluation of progression of the condition are laboratory tests. HELLP syndrome may result in severe morbidity and mortality to both the mother and fetus. In this case, we reported that a patient with chronic glomerulonephritis was diagnosed with HELLP syndrome.The case was collected in Institute of Nephrology of the National Academy of Medical Sciences, Kyiv, Ukraine.

scholarly journals Babesiosis in Pregnancy: An Imitator of HELLP Syndrome

2019 ◽  
Vol 09 (02) ◽  
pp. e147-e152 ◽  
Author(s):  
Raminder Khangura ◽  
Nayo Williams ◽  
Shontreal Cooper ◽  
Anne- Marie Prabulos
Keyword(s):  
Hellp Syndrome ◽  
Clinical Presentation ◽  
Liver Enzymes ◽  
Neonatal Morbidity ◽  
Pregnancy Complication ◽  
Morbidity And Mortality ◽  
Fetal Outcomes ◽  
Laboratory Findings ◽  
Elevated Liver Enzymes ◽  
In Pregnancy

AbstractHELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) is a serious pregnancy complication that can cause significant maternal and neonatal morbidity and mortality. There are several conditions that may occur in pregnancy that may imitate the laboratory findings and clinical presentation of HELLP syndrome. Babesiosis is a parasitic imitator of HELLP syndrome that can be spread by the tick, transfusions, or congenitally. Recognition and treatment of this condition is important to optimize maternal and fetal outcomes.

scholarly journals Normotensive HELLP syndrome in the midst of Dengue fever

2018 ◽  
Vol 9 (2) ◽  
pp. 40-42
Author(s):  
Robin George Manappallil ◽  
Sithara Surendran ◽  
Anoop Kumar ◽  
Ganga Prasad
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Dengue Fever ◽  
Hellp Syndrome ◽  
Liver Enzymes ◽  
Elevated Blood ◽  
Medical Sciences ◽  
Elevated Liver Enzymes ◽  
Life Threatening ◽  
Life Threatening Complication

HELLP syndrome is a life threatening complication of pregnancy, characterized by haemolysis, elevated liver enzymes and low platelet counts. Preeclampsia is a risk factor for developing HELLP. However, some patients can have HELLP in the absence of elevated blood pressure. Dengue fever is a mosquito-borne viral infection characterized by fever, leucopenia and thrombocytopenia, and bleeding manifestations. This is a case of a young primigravida who presented with dengue fever and was found to have an associated normotensive HELLP syndrome.Asian Journal of Medical Sciences Vol.9(2) 2018 40-42

scholarly journals SÍNDROME HELLP: A CONDUTA OBSTÉTRICA E SUAS CONTROVÉRSIAS

2018 ◽  
Vol 5 (3) ◽  
pp. 75-78
Author(s):  
Flávia da Silva Oliveira ◽  
Fábio Roberto Ruiz de Moraes
Keyword(s):  
Conservative Treatment ◽  
Perinatal Mortality ◽  
Hellp Syndrome ◽  
Liver Enzymes ◽  
Signs And Symptoms ◽  
Clinical Entity ◽  
Morbidity And Mortality ◽  
General Malaise ◽  
Elevated Liver Enzymes ◽  
Mortalidade Materna

RESUMO A síndrome HELLP pode ocorrer na pré-eclâmpsia (PE) ou na eclampsia e se caracteriza pelo conjunto de sinais e sintomas associados à hemólise microangiopática, elevação de enzimas hepáticas e plaquetopenia, podendo afetar 0,6% das gestações e 4-12% das pacientes com PE grave. Responsável por elevados índices de mortalidade materna e perinatal, a paciente pode apresentar-se com mal estar geral, epigastralgia, dor em hipocôndrio direito, náuseas ou vômitos, cefaléia, escotomas, associados a quadro hipertensivo e proteinúria. A conduta obstétrica na Síndrome HELLP ainda apresenta controvérsias na literatura, principalmente quando estamos diante de gestações em estágio inicial. Existem condutas favoráveis ao tratamento conservador no intuito de estabilizar a progressão da doença e reduzir a morbidade e mortalidade da mãe e do feto. Outras que postergam a interrupção da gestação por período de 48 horas nos menores de 34 semanas. E ainda temos condutas obstétricas que adotam a interrupção de emergência, independente da idade gestacional.   Palavras-chave: Síndrome HELLP, Pré-eclâmpsia grave, Eclâmpsia, gestação de alto risco. ABSTRACT HELLP syndrome is a clinical entity that can occur in pre-eclampsia or eclampsia and is characterized by presenting a set of signs and symptoms associated with mircroangiopathic hemolysis, raised elevated liver enzymes and thrombocytopenia, which may affect 0.6% of pregnancies and 4-12% of patients with severe PE. Responsible for high rates of maternal and perinatal mortality, the patient may present with general malaise, epigastralgia, right hypochondrium pain, nausea or vomiting, headache, scotomas, associated with hypertension and proteinuria. The obstetric behavior in HELLP syndrome is still controversial in the literature, especially when we are in the early stages of pregnancy. It was observed that some authors favor conservative treatment in order to stabilize the progression of the disease and reduce morbidity and mortality of the mother and the fetus. However, other authors take the course of postponing gestation of less than 34 weeks per 48-hour period. And we still have obstetric behaviors that adopt the emergency interruption, regardless of gestational.

Severe HELLP syndrome presenting with acute gum bleeding following toothbrushing at 38 weeks' gestation

1993 ◽  
Vol 2 (5) ◽  
pp. 395-396 ◽  
Author(s):  
KA Jones ◽  
JS Abramowicz ◽  
D Anissi ◽  
MA Mirwald ◽  
DM Sherer
Keyword(s):  
Platelet Count ◽  
Hellp Syndrome ◽  
Clinical Presentation ◽  
Liver Enzymes ◽  
Laboratory Studies ◽  
Elevated Liver Enzymes ◽  
Intravenous Hydration ◽  
Low Platelet Count ◽  
Low Threshold

We describe a case of hemolysis, elevated liver enzymes and low platelet count (HELLP syndrome) at 38 weeks' gestation. This condition was diagnosed when the patient presented with acute, persistent gum bleeding after toothbrushing. Her platelet count was 26,000/mm3. Bleeding gums have rarely led to the diagnosis of this syndrome; this case appears to be the most severe description of this clinical presentation following toothbrushing yet presented in the literature. Although the patient had been hospitalized 48 hours earlier with nonspecific viral-like symptoms, she was discharged after being treated with intravenous hydration. Reexamination of laboratory studies obtained at the time of her first presentation revealed thrombocytopenia. The diagnosis of this syndrome could possibly have been made at that time. This case emphasizes the importance of maintaining a low threshold of suspicion for this syndrome.

scholarly journals Haemolysis, elevated liver enzymes and low platelets: Diagnosis and management in critical care

2021 ◽  
pp. 175114372110254
Author(s):  
Evangelia Poimenidi ◽  
Yavor Metodiev ◽  
Natasha Nicole Archer ◽  
Richard Jackson ◽  
Mansoor Nawaz Bangash ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Critical Care ◽  
Liver Failure ◽  
Hellp Syndrome ◽  
Seizure Control ◽  
Liver Enzymes ◽  
Kidney Injury ◽  
Definitive Treatment ◽  
Multisystem Disease ◽  
Elevated Liver Enzymes

A thirty-year-old pregnant woman was admitted to hospital with headache and gastrointestinal discomfort. She developed peripheral oedema and had an emergency caesarean section following an episode of tonic-clonic seizures. Her delivery was further complicated by postpartum haemorrhage and she was admitted to the Intensive Care Unit (ICU) for further resuscitation and seizure control which required infusions of magnesium and multiple anticonvulsants. Despite haemodynamic optimisation she developed an acute kidney injury with evidence of liver damage, thrombocytopenia and haemolysis. Haemolysis, Elevated Liver enzymes and Low Platelets (HELLP) syndrome, a multisystem disease of advanced pregnancy which overlaps with pre-eclampsia, was diagnosed. HELLP syndrome is associated with a range of complications which may require critical care support, including placental abruption and foetal loss, acute kidney injury, microangiopathic haemolytic anaemia, acute liver failure and liver capsule rupture. Definitive treatment of HELLP is delivery of the fetus and in its most severe forms requires admission to the ICU for multiorgan support. Therapeutic strategies in ICU are mainly supportive and include blood pressure control, meticulous fluid balance and possibly escalation to renal replacement therapy, mechanical ventilation, neuroprotection, seizure control, and management of liver failure-related complications. Multidisciplinary input is essential for optimal treatment.

scholarly journals Hemolysis, Elevated Liver Enzymes and Low Platelet (HELLP) Syndrome Associated with Systemic Lupus Erythematosus

2003 ◽  
Vol 42 (10) ◽  
pp. 1052-1053 ◽  
Author(s):  
Masayuki MATSUDA ◽  
Shigeaki MITSUHASHI ◽  
Megumi WATARAI ◽  
Kanji YAMAMOTO ◽  
Takao HASHIMOTO ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Hellp Syndrome ◽  
Liver Enzymes ◽  
Systemic Lupus ◽  
Elevated Liver Enzymes

scholarly journals The psychological experience of women who survived HELLP syndrome in Cape Town, South Africa

2014 ◽  
Vol 19 (1) ◽  
Author(s):  
Rizwana Roomaney ◽  
Michelle G. Andipatin ◽  
Anika Naidoo
Keyword(s):  
Hellp Syndrome ◽  
Liver Enzymes ◽  
Blood Platelets ◽  
African Women ◽  
Theory Approach ◽  
Psychological Experience ◽  
Lack Of Information ◽  
Risk Pregnancy ◽  
Elevated Liver Enzymes ◽  
South African Women

Background: Haemolysis, elevated liver enzymes and low platelet count (HELLP syndrome) is a high-risk pregnancy condition that could be fatal to mother and/or baby. It is characterised, as the acronym indicates, by haemolysis, elevated liver enzymes and low blood platelets. Objective: This study explored women in Cape Town’s psychological experience of HELLP syndrome.Method: Six participants who previously experienced HELLP syndrome were interviewed. Using a grounded theory approach, themes emerged and a model illlustrating the psychological experience of HELLP syndrome was constructed.Results: The major themes that emerged were the perceived lack of information, a need to assign blame and a shift in focus. Themes of not knowing and trance and/or surreal experience underpin the cognitive aspects of the HELLP syndrome experience. Themes that expressed feelings of an inability to control, whirlwind and/or rapid pace and support acted together to bind the experience. Finally, emotions such as anger, ambivalence, disbelief, anxiety, guilt, loneliness and fear were present throughout the experience.Conclusion: This study developed an initial exploratory model representing the psychological experience of HELLP syndrome in a sample of South African women. Underlying this entire experience was a perceived lack of information which had a profound effect on numerous aspects of the experience ranging from where to locate blame to the varied emotions experienced. Agtergrond: Die HELLP sindroom is ‘n hoë-risiko swangerskap toestand wat kan dodelik vir moeder en/of baba wees. Dit word gekenmerk deur hemolise, verhoogde lewerensieme en lae bloedplaatjies.Doelwit: Hierdie studie het Suid-Afrikaanse vroue se sielkundige ervaring van die HELLP sindroom ondersoek.Metode: Ses deelnemers wat voorheen HELLP sindroom ervaar het is ondervra. Met die gebuik van gefundeerde teorie as ‘n teoretiese raamwerk en ontleding het temas na vore gekom en ‘n model wat die sielkundige ervaring van HELLP sindroom illustreer, is gebou.Resultate: Die vernaamste temas wat na vore gekom het was die oënskynlike gebrek aan inligting, ‘n behoefte om skuld toe te skryf en ‘n verskuiwing in fokus. Die tema van nie weet en beswyming en/of surrealistiese ervaring ondersteun die kognitiewe aspekte van die HELLP sindroom. Temas wat gevoelens van geen beheer, warrelwind en/of vinnige tempo en ondersteuning uitgesprek het, het saam opgetree om die ervaring te bind. Ten slotte, emosies soos woede, teenstrydigheid, ongeloof, angs, skuldgevoelens, eensaamheid en vrees was teenwoordig in die hele ervaring.Gevolgtrekking: Hierdie studie het van’n aanvanklike ondersoekende model van die sielkundige ervaring van HELLP sindroom tot ‘n steekproef van die Suid-Afrikaanse vroue ontwikkel. Onderliggend aan hierdie hele ervaring was ‘n oënskynlike gebrek aan inligting wat ‘n diepgaande uitwerking gehad het op talle aspekte van die ervaring wat gewissel het van waar om die blaam te plaas tot die uiteenlopende ervaarde emosies.

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