The Sensitivity of Traditional Chinese Medical Diagnostic Tools for Diabetic Retinopathy Diabetic retinopathy-a Pilot Study

2019 ◽  
Author(s):  
Keyword(s):  
Diabetic Retinopathy ◽  
Pilot Study ◽  
Diagnostic Tools ◽  
Medical Diagnostic ◽  
Traditional Chinese Medical

scholarly journals Feasibility of screening for diabetic retinopathy at an Australian pathology collection service: a pilot study

2013 ◽  
Vol 198 (2) ◽  
pp. 97-99 ◽  
Author(s):  
Melanie F Larizza ◽  
Lauren A Hodgson ◽  
Eva K Fenwick ◽  
Ryo Kawasaki ◽  
Ralph Audehm ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Pilot Study

scholarly journals Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Olga Simó-Servat ◽  
Rafael Simó ◽  
Cristina Hernández
Keyword(s):  
Diabetic Retinopathy ◽  
Therapeutic Strategy ◽  
New Drugs ◽  
Diagnostic Tools ◽  
Diabetic Patients ◽  
Circulating Biomarkers ◽  
Pharmacological Treatments ◽  
Early Stages ◽  
Working Age ◽  
Advanced Stages

Diabetic retinopathy (DR) is the main cause of working-age adult-onset blindness. The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects. In early stages of DR the only therapeutic strategy that physicians can offer is a tight control of the risk factors for DR. Therefore, new pharmacological treatments for these early stages of the disease are required. In order to develop therapeutic strategies for early stages of DR new diagnostic tools are urgently needed. In this regard, circulating biomarkers could be useful to detect early disease, to identify those diabetic patients most prone to progressive worsening who ought to be followed up more often and who could obtain the most benefit from these therapies, and to monitor the effectiveness of new drugs for DR before more advanced DR stages have been reached. Research of biomarkers for DR has been mainly based on the pathogenic mechanism involved in the development of DR (i.e., AGEs, oxidative stress, endothelial dysfunction, inflammation, and proangiogenic factors). This review focuses on circulating biomarkers at both early and advanced stages that could be relevant for the prediction or detection of DR.

scholarly journals Nanostructured SmFeO3 Gas Sensors: Investigation of the Gas Sensing Performance Reproducibility for Colorectal Cancer Screening

Sensors ◽  
2020 ◽  
Vol 20 (20) ◽  
pp. 5910
Author(s):  
Andrea Gaiardo ◽  
Giulia Zonta ◽  
Sandro Gherardi ◽  
Cesare Malagù ◽  
Barbara Fabbri ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gas Sensors ◽  
Process Development ◽  
Gas Sensing ◽  
Diagnostic Tools ◽  
Fecal Samples ◽  
Recovery Times ◽  
Medical Diagnostic ◽  
Response And Recovery ◽  
Sensing Performance

Among the various chemoresistive gas sensing properties studied so far, the sensing response reproducibility, i.e., the capability to reproduce a device with the same sensing performance, has been poorly investigated. However, the reproducibility of the gas sensing performance is of fundamental importance for the employment of these devices in on-field applications, and to demonstrate the reliability of the process development. This sensor property became crucial for the preparation of medical diagnostic tools, in which the use of specific chemoresistive gas sensors along with a dedicated algorithm can be used for screening diseases. In this work, the reproducibility of SmFeO3 perovskite-based gas sensors has been investigated. A set of four SmFeO3 devices, obtained from the same screen-printing deposition, have been tested in laboratory with both controlled concentrations of CO and biological fecal samples. The fecal samples tested were employed in the clinical validation protocol of a prototype for non-invasive colorectal cancer prescreening. Sensors showed a high reproducibility degree, with an error lower than 2% of the response value for the test with CO and lower than 6% for fecal samples. Finally, the reproducibility of the SmFeO3 sensor response and recovery times for fecal samples was also evaluated.

scholarly journals Breath Analysis Using eNose and Ion Mobility Technology to Diagnose Inflammatory Bowel Disease—A Pilot Study

Biosensors ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 55 ◽  
Author(s):  
Tiele ◽  
Wicaksono ◽  
Kansara ◽  
Arasaradnam ◽  
Covington
Keyword(s):  
Inflammatory Bowel Disease ◽  
Pilot Study ◽  
Ion Mobility ◽  
Bowel Disease ◽  
Breath Analysis ◽  
Diagnostic Tools ◽  
Exhaled Breath ◽  
Faecal Calprotectin ◽  
Non Invasive ◽  
Inflammatory Bowel

Early diagnosis of inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), remains a clinical challenge with current tests being invasive and costly. The analysis of volatile organic compounds (VOCs) in exhaled breath and biomarkers in stool (faecal calprotectin (FCP)) show increasing potential as non-invasive diagnostic tools. The aim of this pilot study is to evaluate the efficacy of breath analysis and determine if FCP can be used as an additional non-invasive parameter to supplement breath results, for the diagnosis of IBD. Thirty-nine subjects were recruited (14 CD, 16 UC, 9 controls). Breath samples were analysed using an in-house built electronic nose (Wolf eNose) and commercial gas chromatograph–ion mobility spectrometer (G.A.S. BreathSpec GC-IMS). Both technologies could consistently separate IBD and controls [AUC ± 95%, sensitivity, specificity], eNose: [0.81, 0.67, 0.89]; GC-IMS: [0.93, 0.87, 0.89]. Furthermore, we could separate CD from UC, eNose: [0.88, 0.71, 0.88]; GC-IMS: [0.71, 0.86, 0.62]. Including FCP did not improve distinction between CD vs UC; eNose: [0.74, 1.00, 0.56], but rather, improved separation of CD vs controls and UC vs controls; eNose: [0.77, 0.55, 1.00] and [0.72, 0.89, 0.67] without FCP, [0.81, 0.73, 0.78] and [0.90, 1.00, 0.78] with FCP, respectively. These results confirm the utility of breath analysis to distinguish between IBD-related diagnostic groups. FCP does not add significant diagnostic value to breath analysis within this study.

Lectinomics I. Relevance of exogenous plant lectins in biomedical diagnostics

Biologia ◽  
2009 ◽  
Vol 64 (1) ◽  
pp. 1-19 ◽  
Author(s):  
Danica Mislovičová ◽  
Peter Gemeiner ◽  
Anna Kozarova ◽  
Tibor Kožár
Keyword(s):  
Biological Samples ◽  
Clinical Microbiology ◽  
Screening Tools ◽  
Diagnostic Tools ◽  
Whole Cells ◽  
Plant Lectins ◽  
Innovative Methods ◽  
Medical Diagnostic ◽  
Biomedical Diagnostics ◽  
Efficient Screening

AbstractThis review focuses on utilization of plant lectins as medical diagnostic reagents and tools. The lectin-related diagnostic is aimed at detection of several diseases connected to alteration of the glycosylation profiles of cells and at identification of microbial and viral agents in clinical microbiology. Certain lectins, proposed for or used as diagnostic tools could even recognize those cellular determinants, which are not detected by available antibodies. Broad information is presented on the lectinomics field, illustrating that lectin diagnostics might become practical alternative to antibody-based diagnostic products. In addition, the rising trend of lectin utilization in biomedical diagnostics might initiate a development of innovative methods based on better analytical technologies. Lectin microarray, a rapid and simple methodology, can be viewed as an example for such initiative. This technology could provide simple and efficient screening tools for analysis of glycosylation patterns in biological samples (cellular extracts, tissues and the whole cells), allowing thus personalized detection of changes associated with carbohydrate-related diseases.

scholarly journals Diabetic Retinopathy Screening Using Telemedicine Tools: Pilot Study in Hungary

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Dóra J. Eszes ◽  
Dóra J. Szabó ◽  
Greg Russell ◽  
Phil Kirby ◽  
Edit Paulik ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Pilot Study ◽  
Socioeconomic Factors ◽  
Fundus Camera ◽  
Diabetic Retinopathy Screening ◽  
Patients Satisfaction ◽  
Retinal Screening ◽  
Self Administered Questionnaire ◽  
Southeastern Region ◽  
Retinopathy Screening

Introduction.Diabetic retinopathy (DR) is a sight-threatening complication of diabetes. Telemedicine tools can prevent blindness. We aimed to investigate the patients’ satisfaction when using such tools (fundus camera examination) and the effect of demographic and socioeconomic factors on participation in screening.Methods.Pilot study involving fundus camera screening and self-administered questionnaire on participants’ experience during fundus examination (comfort, reliability, and future interest in participation), as well as demographic and socioeconomic factors was performed on 89 patients with known diabetes in Csongrád County, a southeastern region of Hungary.Results.Thirty percent of the patients had never participated in any ophthalmological screening, while 25.7% had DR of some grade based upon a standard fundus camera examination and UK-based DR grading protocol (Spectra™ software). Large majority of the patients were satisfied with the screening and found it reliable and acceptable to undertake examination under pupil dilation; 67.3% were willing to undergo nonmydriatic fundus camera examination again. There was a statistically significant relationship between economic activity, education and marital status, and future interest in participation.Discussion.Participants found digital retinal screening to be reliable and satisfactory. Telemedicine can be a strong tool, supporting eye care professionals and allowing for faster and more comfortable DR screening.

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