scholarly journals The state of experimental alkalosis and content of free aminoacids in the blood plasma of newborn calves

2016 ◽  
Vol 8 (3-4) ◽  
pp. 76-80
Author(s):  
V. A. Hryshchenko ◽  
Keyword(s):  
Blood Plasma ◽  
The State ◽  
Newborn Calves ◽  
Free Aminoacids

The state of the blood antioxidant system in the patients presenting with acromegaly

2015 ◽  
Vol 61 (2) ◽  
pp. 8-11
Author(s):  
M V Faassen ◽  
M S Pankratova ◽  
N N Molitvoslovova ◽  
A A Baizhumanov ◽  
S S Kovalenko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Blood Plasma ◽  
Antioxidant System ◽  
The State ◽  
Total Antioxidant Activity ◽  
Sod Activity ◽  
Protein Thiols ◽  
Total Antioxidant

The state of the blood antioxidant system in the patients presenting with acromegaly. The objective of the present study was to evaluate the total antioxidant activity (TAA) of blood plasma, the levels of non-protein thiols and 2-thyobarbituric acid-active products (TBA-AP), superoxide dismutase (SOD) and catalase (CAT) activities as well as ceruloplasmin (CP) level in the patients presenting with acromegaly. It was shown that plasma TAA and SOD activity in this patients was on the average 20 and 30% lower respectively than in the control subjects. At the same time, the TBA-AP and CP levels increased by 50 and 40% respectively. These data suggest the development of oxidative stress in the acromegalic patients.

scholarly journals Assessment of the state of the oxidant-antioxidant system and lipid peroxidation in patients with chronic pancreatitis combined with hypothyroidism

2021 ◽  
Vol 25 (3 (99)) ◽  
pp. 97-101
Author(s):  
V. Ratsa ◽  
O. Fedіv
Keyword(s):  
Lipid Peroxidation ◽  
Chronic Pancreatitis ◽  
Blood Plasma ◽  
Antioxidant System ◽  
Underlying Disease ◽  
The State ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
In Blood Plasma

Changes in oxidative-antioxidant homeostasis is one of the pathogenetic links in the onset and progression of many nosologies, including chronic pancreatitis (CP) and hypothyroidism (HТ), however, data on the development of oxidative stress (OS) with a combination of CP and HP are insufficient, therefore, determining the role of these systems with a comorbid course of these pathologies is an urgent issue of our time.The aim of the work is to study the state of the oxidative and antioxidant system in patients with CP and CP combined with HT.Material and methods. 96 people were examined, including 26 patients with chronic pancreatitis (group 1), 24 patients with hypothyroidism (group 2), 26 patients with chronic pancreatitis on the background of hypothyroidism (group 3), 20 almost healthy individuals (group 4). Evaluation of the oxidative-antioxidant system and lipid peroxidation was assessed by determining the content of malonic aldehyde in blood plasma (MA pl.) And erythrocytes (MA er.), The level of reduced glutathione, glutathione peroxidase (GP) and glutathione-S-trans-ion (GT). Enzyme activity was calculated per 1 g of hemoglobin (HB).Research results. The analysis of the obtained results revealed clear patterns of changes in the state of the oxidative-antioxidant system and lipid peroxidation in patients with chronic pancreatitis on the background of hypothyroidism. Namely, violation of lipid peroxidation in patients with comorbid pathology, accompanied by an increase in the content of MA er. by 44.87% and the content of MA in blood plasma by 46.42%; oxidative-antioxidant system: decrease in HF in the blood by 51,61%, combined of a compensatory increase in BP - by 48.03% and HT - by 34.76%.Conclusion. Under the conditions of comorbidity of CP and HT, there is a violation of the oxidative-antioxidant system and the state of lipid peroxidation, which is characterized by a significant increase in MA in erythrocytes and MA in plasma against a decrease in glutathione and which complicates the course of the underlying disease, its diagnosis and treatment.

The state of beryllium in blood plasma

1953 ◽  
Vol 46 (2) ◽  
pp. 443-453 ◽  
Author(s):  
Isaac Feldman ◽  
Jean R. Havill ◽  
W.F. Neuman
Keyword(s):  
Blood Plasma ◽  
The State ◽  
In Blood Plasma

Peculiarities of Fibrinolytic and Proteolytic Activity of Blood Plasma in Patients with Chronic Pancreatitis Combined with Hypothyroidism

2021 ◽  
Vol 6 (5) ◽  
pp. 233-238
Author(s):  
V. V. Ratsa ◽  
◽  
O. I. Fediv
Keyword(s):  
Molecular Weight ◽  
Chronic Pancreatitis ◽  
Blood Plasma ◽  
Fibrinolytic Activity ◽  
The State ◽  
Low Molecular Weight ◽  
Healthy Individuals ◽  
Group 2 ◽  
Low Molecular Weight Proteins ◽  
Group 1

The purpose of the study is to analyze the state of proteolytic and fibrinolytic activities of blood plasma in patients with chronic pancreatitis combined with hypothyroidism. Materials and methods. 105 people participated in our study, of which group 1 consisted of patients with chronic pancreatitis (n = 27), group 2 – patients with hypothyroidism (n = 30), group 3 – patients with chronic pancreatitis combined with hypothyroidism (n = 28), group 4 – almost healthy individuals (n = 20). The state of fibrinolytic activity of blood plasma was studied by lysis of azofibrin, followed by determination of total fibrinolytic activity, non-enzymatic fibrinolytic activity and enzymatic fibrinolytic activity. Assessment of the state of the proteolysis system was studied by lysis of azoalbumin (breakdown of low molecular weight proteins), azocasein (breakdown of high molecular weight proteins) and azocol (breakdown of collagen). Results. When analyzing the results of the study, we observe a probable increase in lysis of azoalbumin by 1.89, 1.96 and 2.16 times (p <0.05) in groups 1, 2, 3 compared with the group of almost healthy individuals. In patients with chronic pancreatitis and hypothyroidism, the most pronounced degradation of low molecular weight proteins was observed, which was 13.86% and 9.75% (p <0.05) higher than in the first and second groups. Indicators of azocasein lysis by 52.48%, 56.35% and 95.03% (p <0.05) were found in groups 1, 2, 3 compared with almost healthy individuals. Azocasein lysis was higher by 27.89% and 24.73% (p <0.05) in patients with chronic pancreatitis combined with hypothyroidism than in patients in groups 1 and 2. Azocol lysis was significantly higher by 10.85%, 12.05%, 16.87% (p <0.05) in groups 1, 2, 3 compared with almost healthy individuals. In addition, in patients with comorbid pathology there was an increase in lysis of azocol by 5.3% and 4.3% (p <0.05) compared with the first and second groups. The total fibrinolytic activity of blood plasma was 8.3%, 6.7%, 16.26% (p <0.05) lower in patients of groups 1, 2, 3 compared with almost healthy individuals. Non-enzymatic fibrinolytic activity of blood plasma was 44.89%, 49.64%, 66.27% higher in groups 1, 2 and 3 than in almost healthy individuals. Enzymatic fibrinolytic activity of blood plasma was 44.28%, 42.25%, 90.57% (p <0.05) lower in group 1, 2, 3 compared with the group of almost healthy individuals (p <0,05). There was a decrease in the level of enzymatic fibrinolytic activity of blood plasma by 32.07% and 33.96% (p <0.05) in patients with chronic pancreatitis associated with hypothyroidism compared with participants in groups 1 and 2 without comorbid pathology. Conclusion. The most pronounced changes in proteolytic (increased lysis of azoalbumin, azocasein, azocol) and fibrinolytic (decrease in total, non-enzymatic and enzymatic) activities of blood plasma in patients with chronic pancreatitis associated with hypothyroidism were determined

ASSESSMENT OFTHE SEVERITY OF ACUTE OBSTRUCTIVE BRONCHITIS AND BRONCHIOLITIS IN EARLY CHILDREN DEPENDING ON THE LEVEL OF OXIPROLIN IN THE BLOOD

2021 ◽  
Vol Special issue (1) ◽  
pp. 5-10
Author(s):  
Makhzuna Mukhsinova ◽  
◽  
Rano Yunusova ◽  
Khilola Ilkhamova
Keyword(s):  
Blood Plasma ◽  
Clinical Significance ◽  
The State ◽  
Collagen Metabolism ◽  
Early Age ◽  
Basic Treatment ◽  
In Blood Plasma

The article presents data on the state of collagen metabolism in terms of oxyproline in the blood, its clinical significance for assessing the severity and outcome of the disease, the criterion for the effectiveness of therapy in children of early age withacute obstructive bronchitis and bronchiolitis. The author recommends to determine the level of free and protein-bound oxyproline in blood plasma, an increase in which reflects the degree of destruction in the bronchopulmonary apparatus. The inclusion of immunomodulin into the basic treatment contributes to an increase in the effectiveness of therapy, a reduction of treatment duration.Keywords: oxyproline, bronchitis and bronchiolitis, immunomodulin, treatment, children

MOLECULAR COMPOSITION OF BLOOD PLASMA AND CONDITION OF HUMAN ORGANISM AT THE NORMAL AND PATHOLOGICAL STATE

2019 ◽  
pp. 37-42
Keyword(s):  
Blood Plasma ◽  
The State ◽  
The Body ◽  
Micro Rna ◽  
Extracellular Dna ◽  
Human Organism ◽  
Pathological State ◽  
Dynamic Changes ◽  
Control Chemical ◽  
Individual Profiles

Blood (blood plasma) is a special all-pervading medium that functionally matches all organs, tissues and cells of the body, to some extent similar to the Ether of the ancients. In addition to performing utilitarian and economic functions, blood is a medium for the transfer of huge amounts of information, which is continuously exchanged between all the compartments and structures of the macroorganism and its microbiome. This information is transmitted in the form of control chemical signals (peptides, micro-RNA, extracellular DNA, microbiome products, antibodies, etc.). molecules), the totality of which controls a variety of biological processes. It is noted that the blood is not only a control, but also a reflective (reflecting) environment: dynamic changes in the composition of this environment carry information about the smallest changes in the state of individual populations of cells, tissues, organs and the body as a whole. The prospects of practical use of information about the state of the organism and its changes, transmitted by blood and quantitatively reflected in individual profiles of immunoreactivity are analyzed.

Spin probe investigation of the state of blood plasma

1980 ◽  
Vol 89 (6) ◽  
pp. 776-779
Author(s):  
A. N. Kuznetsov ◽  
S. I. Ogurtsov ◽  
B. Ebert ◽  
T. I. Tokhovskaya
Keyword(s):  
Blood Plasma ◽  
Spin Probe ◽  
The State ◽  
Probe Investigation

scholarly journals INFLUENCE OF HEPARINOID FROM PAEONIA LACTIFLORA ON HEMOSTATIC SYSTEM WITHIN CONDITIONS OF PRETHROMBOSIS

2019 ◽  
Vol 7 (4) ◽  
pp. 208-214
Author(s):  
M. G. Lyapina ◽  
M. S. Uspenkaya ◽  
E. S. Maistrenko ◽  
M. D. Kalugina
Keyword(s):  
Oral Administration ◽  
Blood Plasma ◽  
Fibrinolytic Activity ◽  
The State ◽  
The Body ◽  
Thrombin Time ◽  
Paeonia Lactiflora ◽  
Fibrin Polymerization ◽  
Reference Drug ◽  
Hemostatic System

The search and development of direct and rapid anticoagulants used per os, is an urgent problem in physiological and medical science. A number of plants contain heparin-like components with a positive effect on the hemostatic system, both within normal and in some pathological conditions of the body.The aim of the work was to study the complex effect of fibrin, a heparin-like substance (heparinoid) from the roots of Paeonia lactiflora, on fibrinolytic, anticoagulant systems of the body and polymerization processes, when it is administered per os in animals within normal conditions and when modeling the state of prethrombosis.Materials and methods. To carry out the research, the roots of Paeonia lactiflora growing in the Botanical Garden of Moscow State University, and laboratory animals – male Wistar rats – were used. To study the antithrombotic effects of the extract from roots containing heparinoid, the state of prethrombosis was modeled in rats. The determined parameters of hemostasis were: anticoagulant activity according to the tests of activated partial thromboplastin time and thrombin time, fibrinolytic activity according to the test of total fibrinolytic activity, fibrin polymerization according to the test of fibrindepolymerization activity of blood plasma.Results. With repeated (every 24 hours within 3 days) oral administration of the extract containing heparinoid, in animals within normal conditions and with prethrombosis, the following anticoagulant effects were established in the blood: an increase in anticoagulant, fibrindepolymerization and fibrinolytic plasma activity. Possible mechanisms of the activating effect of heparinoid on fibrinolysis and anticoagulant properties of plasma due to the excretion of tissue plasminogen activator into the bloodstream from the endothelium, thrombin inhibition, and fibrin polymerization are described. Moreover, the anticoagulant effect of the use of the extract from the peony roots was equivalent to that of the reference drug of low molecular weight heparin from Celsus (USA). For the first time, it was revealed that when modeling experimental prethrombosis, the administration of heparinoid in rats at the dose of 37.5 IU/kg МЕ/кг body weight restored impaired hemostasis, which requires a further study.Conclusion. The ability of heparinoid from peony roots to normalize the functional state of the anticoagulant system during the development of prethrombosis in animals has been established. The restriction of fibrin polymerization during oral administration of heparinoid from peony in animals by increasing the enzymatic fibrinolytic and fibrindepolymerization activity of blood plasma was revealed. In the future, heparinoid can be used as an antithrombotic agent.

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