scholarly journals Perinatal Effects of Metformin use in Gestational Diabetes

2021 ◽  
Vol 4 (7) ◽  
pp. 01-05
Author(s):  
Karen Mireya Topa Pila ◽  
Carlos Acosta Reyes ◽  
Miguel Arturo Llanos Guzmán ◽  
Helvey Ramón Zetién Arteaga ◽  
Lizeth Yurany Gómez Flórez ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Glucose Intolerance ◽  
Pharmacological Therapy ◽  
Narrative Review ◽  
Present Review ◽  
Essential Medicines ◽  
Alternative Management ◽  
Search And Selection ◽  
Selection Of

Background: GD is a condition in which a woman develops glucose intolerance at any time during pregnancy and may or may not resolve at the end of pregnancy. Metformin, from the group of biguanides, is considered an alternative management of gestational diabetes, included in the list of essential medicines by the OMS. Methodology: A narrative review was carried out through various databases from March 2018 to September 2021; the search and selection of articles was carried out in journals indexed in English and Spanish. The following keywords were used: metformin, macrosomia, gestational diabetes. Results: The present review offers pathophysiological measures, complications, pharmacological therapy, for a better approach in perinatals in patients with gestational diabetes. Conclusion: With the results observed, it should be noted that metformin is viable for the management of patients with gestational diabetes.

scholarly journals Gestational Diabetes Mellitus and the Long-Term Risk for Glucose Intolerance and Overweight in the Offspring: A Narrative Review

2020 ◽  
Vol 9 (2) ◽  
pp. 599 ◽  
Author(s):  
Hannah Nijs ◽  
Katrien Benhalima
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Glucose Intolerance ◽  
Narrative Review ◽  
Extensive Literature ◽  
Metabolic Complications ◽  
Increased Risk ◽  
Maternal Overweight

Gestational diabetes mellitus (GDM) is a common condition with increasing prevalence worldwide. GDM is associated with an increased risk for maternal and neonatal complications. In this review we provide an overview of the most recent evidence on the long-term metabolic risk associated with GDM in the offspring. We conducted an extensive literature search on PubMed and Embase between February 2019 and December 2019. We performed a narrative review including 20 cohort studies, one cross-sectional study, and two randomized controlled trials. Our review shows that the prevalence of overweight/obesity and glucose intolerance is higher in children exposed to GDM compared to unexposed children. Maternal overweight is an important confounding factor, but recent studies show that in general the association remains significant after correction for maternal overweight. There is limited evidence suggesting that the association between GDM and adverse metabolic profile in the offspring becomes more significant with increasing offspring age and is also more pronounced in female offspring than in male offspring. More research is needed to evaluate whether treatment of GDM can prevent the long-term metabolic complications in the offspring.

scholarly journals Valorization Options of Strawberry Extrudate Agro-Waste. A Review

2020 ◽  
Author(s):  
Juan Cubero-Cardoso ◽  
Antonio Serrano ◽  
Ángeles Trujillo-Reyes ◽  
Denys K. Villa-Gómez ◽  
Rafael Borja ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Animal Feed ◽  
Extraction Process ◽  
Present Review ◽  
Management Approach ◽  
Management Option ◽  
Alternative Management ◽  
Extraction And Purification ◽  
Different Types ◽  
Selection Of

This review summarizes and critically analyzes the different types of potential valorization options for strawberry extrudate in order to have a broader overview of the potential management of this waste. Animal feed is commonly used as a management option for the strawberry extrudate; however, most of the strawberry extrudate is disposed in landfills. Strawberry extrudate contains different bioactive compounds that encourage the use of an alternative management approach than landfilled. The present review offers a complete comparative, including the advantages and drawbacks of each reviewed technique, to facilitate the selection of the most suitable technology for the different valorization scenarios. This review has been structured in three sections: 1. Composition of the strawberry extrudate and strawberry especially focused on their content in bioactive compounds. 2. The different techniques of extraction and purification of bioactive compounds. 3. The handling and management of the resulting biomass after the extraction process of bioactive compounds.

AVALIAÇÃO DO POTENCIAL TRIPANOCIDA DE DERIVADOS TIOSSEMICARBAZONAS: UMA REVISÃO

2021 ◽  
Vol 2 (9) ◽  
pp. e29658
Author(s):  
Daniel Lopes Araújo ◽  
José Eufrazino Júnior ◽  
Vinicius Santos Silva ◽  
Carla Franco Mendonça de Araújo ◽  
Thaynara Hevellin Evangelista ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Biological Properties ◽  
Pharmacological Therapy ◽  
Neglected Diseases ◽  
Parasitic Diseases ◽  
Tropical Regions ◽  
Trypanocidal Activity ◽  
Search And Selection ◽  
Selection Of

Neglected diseases are a group of communicable diseases that mainly affect tropical regions in developing countries. Among this group of diseases is Chagas disease, which has been classified among the six most important parasitic diseases in the world, and it is estimated that more than one billion people are at risk in countries that are considered endemic. The aim of this study is to conduct a literature review on the trypanocidal activity of thiosemicarbazone derivatives. The study is a review research that used 31 articles to highlight the scientific findings on the trypanocidal activity of the derivatives in question. Articles were included in the time estimate between 2010 - 2021 (last 12 years). The search and selection of the reference studies was performed in Scielo, Science Direct, PubMed and Google Academic databases. The literature highlights that thiosemicarbazones are considered privileged compounds with a wide scientific interest due to their diverse chemical and biological properties, such as: antitumor, antibacterial, antiviral, antiprotozoal, and anti-chagasic. The studies presented here, which demonstrate the investigations of compounds of this class and their derivatives, are an important step towards the conception of therapeutic methods against Trypanosoma cruzi. New studies are necessary to elucidate in an even more specific way the effects of these derivatives in vivo, in order to obtain an alternative pharmacological therapy for Chagas disease.

Highlights From Gastro Update Europe2019 - Budapest - June 14-16, 2019 145

2019 ◽  
pp. 145-160
Author(s):  
Guido N. J. Tytgat
Keyword(s):  
Expert Opinion ◽  
Narrative Review ◽  
Educational Value ◽  
Vital Importance ◽  
Selection Of

This narrative review summarizes a selection of recent, clinically-important novel gastrointestinal developments, presented and discussed at the European Gastro Update In Budapest. The selected topics reflect what the distinguished faculty considered of vital importance to be communicated to the astute busy gastro-hep clinician, who is eager to stay well informed of important novel developments in his discipline. Whenever appropriate a personal comment or addition was added to further raise the educational value of this review. Given its narrative character, statements and conclusions are largely expert opinion-based and referencing is limited to the selected images.

scholarly journals Preparation and Applications of Fluorinated Graphenes

2021 ◽  
Vol 7 (1) ◽  
pp. 20 ◽  
Author(s):  
Yasser Ahmad ◽  
Nicolas Batisse ◽  
Xianjue Chen ◽  
Marc Dubois
Keyword(s):  
Energy Storage ◽  
Chemical Bonding ◽  
Gas Sensing ◽  
Present Review ◽  
Graphite Fluoride ◽  
Fluorinated Graphene ◽  
Selection Of

The present review focuses on the numerous routes for the preparation of fluorinated graphene (FG) according to the starting materials. Two strategies are considered: (i) addition of fluorine atoms on graphenes of various nature and quality and (ii) exfoliation of graphite fluoride. Chemical bonding in fluorinated graphene, related properties and a selection of applications for lubrication, energy storage, and gas sensing will then be discussed.

scholarly journals Screening of Amazonian bacillus strains for lipase production using glycerol as substrate

ScientiaTec ◽  
2020 ◽  
Vol 7 (03) ◽  
Author(s):  
Giandra Volpato ◽  
Victória Furtado Migliavacca ◽  
Bruna Coelho de Andrade ◽  
Júlio Xandro Heck ◽  
Marco Antônio Záchia Ayub
Keyword(s):  
Organic Synthesis ◽  
Culture Medium ◽  
Lipolytic Activity ◽  
Gum Arabic ◽  
Lipase Production ◽  
Culture Conditions ◽  
Search And Selection ◽  
Triton X ◽  
Potential Use ◽  
Selection Of

The industrial application of lipolytic enzymes has been studied mainly due to the ability of these enzymes in catalyze reactions of synthesis and their stability in various organic solvents. One possibility is the use of lipase the organic synthesis, taking advantage as the generation of waste and difficult recovery of sub bioproducts. In this work, we carried out a selection of eighty-four isolates of Bacillus amazonian for lipase production, of which 30 strains showed lipolytic activity. The study of the culture conditions was performed through a Plackett-Burman experimental design using the strain that presented the highest lipolytic activity in a culture medium using glycerol as substrate.  The studied conditions were: concentration of soybean oil, olive oil, triton X-100, gum arabic, glycerol, and (NH4)2SO4, pH, temperature and concentration of inoculums. The best result obtained were 27 U/L in 48 h of cultivation by Bacillus circulans BL53. This work shows that the search and selection of microorganism with lipolytic activities can facilitate the discovery of new lipases, with potential use as by-product surplus.

Chemoattractants: Their essentiality and efficacy in shrimp aquaculture

2021 ◽  
Vol 68 (1) ◽  
Author(s):  
R. Jannathulla ◽  
O. Sravanthi ◽  
H. Imran Khan ◽  
H. Syed Moomeen ◽  
A. Gomathi ◽  
...  
Keyword(s):  
Chemical Compounds ◽  
Nutritional Composition ◽  
Present Review ◽  
Shrimp Aquaculture ◽  
Aquatic Species ◽  
Beneficial Effects ◽  
Shrimp Feed ◽  
High Concentrations ◽  
Plant Sources ◽  
Selection Of

Aquaculture serves as a sustainable source of good quality wholesome food and major input is feed. In recent years, considerable quantities of plant sources have been attempted for inclusion in shrimp feed, due to high demand and high cost of fishmeal. Plant-based ingredients are in general poor in attractability and palatability to aquatic species compared to marine sources. It is desirable to develop an economical and nutritious feed that is attractive and palatable for ensuring reduction of feed wastage. Chemoattractants nowadays are unavoidable in commercial shrimp feeds and are included either individually or in combination. The present review revealed that the various marine sources, in particular krill meal would be more effective for aquatic species, compared to those derived from vegetable origin and chemical compounds. In addition to acting as a feed attractant, marine sources serve as a potential fishmeal substitute due to their rich nutritional composition. However, certain biogenic amines present in these marine-based ingredients need to be examined before their use, since these amines when present in high concentrations reduces feed intake by producing undesirable odour. Use of a combination of chemoattractants would give a better effect, rather than using them individually and compounds from plant origin have limited beneficial effects. The present review concludes that incorporation of chemoattractants would be beneficial in formulation of enriched and economical feeds with better attractability and palatability. The selection of suitable attractant and their supplementation at correct proportion is significantly more important to avoid undesirable effects in cultured shrimp. Further field-based research is needed to predict the actual effects of chemoattractants on farmed shrimp and to provide a sustainable base for the expansion of shrimp aquaculture sector, by reducing feed wastage.

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