Pleomorphic xanthoastrocytoma presenting with life-threatening hemorrhage in a child

2009 ◽  
Vol 3 (2) ◽  
pp. 157-159 ◽  
Author(s):  
Joshua J. Wind ◽  
P. Benjamin Kerr ◽  
Jennifer A. Sweet ◽  
Vivek R. Deshmukh
Keyword(s):  
Intracerebral Hemorrhage ◽  
Clinical Presentation ◽  
Clinical Course ◽  
Case Reports ◽  
Young Patients ◽  
Pleomorphic Xanthoastrocytoma ◽  
First Case ◽  
Life Threatening

Pleomorphic xanthoastrocytomas are glial-based tumors that arise most frequently in young patients and usually follow a more benign and indolent clinical course than their other glial-based tumor counterparts. These tumors most frequently present with seizures, and only 3 previous case reports exist of hemorrhagic tumor as the clinical presentation. The authors present the first case of life-threatening intracerebral hemorrhage from pleomorphic xanthoastrocytoma in a child.

Epidemiology and clinics of mushroom poisoning in Northern Italy: A 21-year retrospective analysis

2017 ◽  
Vol 37 (7) ◽  
pp. 697-703 ◽  
Author(s):  
G Cervellin ◽  
I Comelli ◽  
G Rastelli ◽  
F Sanchis-Gomar ◽  
F Negri ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Early Identification ◽  
Clinical Presentation ◽  
Clinical Course ◽  
Clinical Information ◽  
Northern Italy ◽  
Gastrointestinal Toxicity ◽  
Mushroom Poisoning ◽  
Limited Information ◽  
Life Threatening

Background: Limited information exists about epidemiology and management of mushroom poisoning. We analyzed and described epidemiology, clinical presentation, and clinical course of mushroom-poisoned patients admitted to emergency departments (EDs) of the Province of Parma, Italy. Methods: Data from the database of mycological service were matched with clinical information retrieved from hospitals’ database, from January 1, 1996 to December 31, 2016. Results: Mycologist consultation was obtained in 379/443 identified mushroom poisonings. A remarkable seasonality was found, with significant peak in autumn. Thanks to the collaboration, the implicated species could be identified in 397 cases (89.6%); 108 cases (24.4%) were due to edible mushrooms, Boletus edulis being the most represented (63 cases). Overall, 408 (92%) cases presented with gastrointestinal toxicity. Twenty cases of amatoxin poisoning were recorded (11 Amanita phalloides and 9 Lepiota brunneoincarnata). One liver transplantation was needed. We observed 13 cases of cholinergic toxicity and 2 cases of hallucinogenic toxicity. Finally, 46 cases were due to “mixed” toxicities, and a total of 69 needed hospitalization. Conclusions: Early identification and management of potentially life-threatening cases is challenging in the ED, so that a mycologist service on call is highly advisable, especially during periods characterized by the highest incidence of poisoning.

The management of bleeding in palliative care

2015 ◽  
Author(s):  
Jose Pereira ◽  
Jennifer Brodeur
Keyword(s):  
Palliative Care ◽  
Care Setting ◽  
Clinical Presentation ◽  
Advanced Disease ◽  
Case Reports ◽  
Treatment Modalities ◽  
Low Grade ◽  
Palliative Care Setting ◽  
Life Threatening ◽  
Number Of Treatment

Bleeding is one of the more distressing symptoms experienced by patients with advanced life-threatening illnesses. The prevalence and incidence of bleeding in these patients vary depending on the disease and the illness trajectory. The causes of bleeding in patients with advanced disease are varied and sometimes several aetiologies or aggravating factors occur simultaneously in any given patient. The clinical presentation may be visible, as in haemoptysis or hematemesis, or invisible, as in cerebral haemorrhaging, and volumes may vary, from low-grade oozing to massive and catastrophic haemorrhaging. Catastrophic, terminal haemorrhaging warrants special attention because of its dramatic clinical presentation and the profound distress it causes to patients, families, and caregivers. A number of treatment modalities are available and these can be divided into (a) general measures, (b) local measures, and (c) systemic measures. Unfortunately studies in the palliative care setting comparing various modalities and approaches are generally lacking and guidelines are largely based on case reports and expert opinion.

Abacavir Hypersensitivity Reaction: The First Case Report in Thailand and Literature Review

2021 ◽  
Vol 104 (1) ◽  
pp. 159-163
Keyword(s):  
Developing Countries ◽  
Case Report ◽  
Hypersensitivity Reaction ◽  
Screening Test ◽  
Blood Test ◽  
Clinical Presentation ◽  
Health Security ◽  
First Case ◽  
Threatening Condition ◽  
Life Threatening

Abacavir-related hypersensitivity reaction (ABC-HSR) is a life-threatening condition. The incidence is low since it could have been prevented by screening with blood test for HLA-B*5701, which is strongly associated with this reaction. However, the affordability for the HLA-B*5701 screening test is still a challenging issue in many developing countries. Thai National Health Security Office (NHSO) recommends either using HLA-B*5701 as a screening test or monitoring clinical presentation for ABC-HSR after using it. Therefore, the clinical presentation of ABC-HSR should be acknowledged for the diagnosis of this condition and death prevention. This was the first reported case and literature reviewed of ABC-HSR associated with the presence of the HLA-B*5701 allele in Thailand. Keywords: Abacavir, Hypersensitivity reaction, HLA-B*5701, Clinical presentation, Thailand

Suicidal thoughts in patients with Parkinson’s disease treated by deep brain stimulation of the subthalamic nuclei: two case reports and review of the literature

2007 ◽  
Vol 19 (3) ◽  
pp. 208-210 ◽  
Author(s):  
Yacov Balash ◽  
Doron Merims ◽  
Nir Giladi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Case Reports ◽  
First Case ◽  
Life Threatening ◽  
Case Presentations ◽  
Depressive Episodes ◽  
Deep Brain

Background:Deep brain stimulation (DBS) of the subthalamic nuclei (STN) can result in depression despite the obvious motor improvement.Case presentations:Two patients with serious life-threatening depressive episodes are described. In the first case, the trigger for depression was a slight adjustment of the left stimulating electrode’s contact. In the second case, reducing both the dopaminergic therapy and the voltage of DBS resulted in the manifestation of depressive symptoms.Conclusions:DBS-induced depression possibly has pathogenetic differences from ordinary Parkinson’s disease depression. The STN region seems to be a sensitive zone that influences emotions.

scholarly journals Haemophagocytic lymphohistiocytosis in an adult with postacute COVID-19 syndrome

2021 ◽  
Vol 14 (9) ◽  
pp. e245031
Author(s):  
Daniel Wiseman ◽  
John Lin ◽  
Jean-Pierre Routy ◽  
Gordan Samoukovic
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspirate ◽  
Clinical Presentation ◽  
Healthy Adult ◽  
Multiorgan Failure ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Initial Infection ◽  
First Case ◽  
Life Threatening

Haemophagocytic lymphohistiocytosis (HLH) causing multiorgan failure has been reported as an acute clinical presentation of COVID-19. However, the literature surrounding HLH in the context of a postacute COVID-19 syndrome is limited. This report presents a case of a life-threatening HLH occurring 6 weeks after a pauci-symptomatic COVID-19 infection in a previously healthy adult. A bone marrow aspirate confirmed the HLH and the patient was successfully treated with dexamethasone and etoposide. To our knowledge, this is the first case of HLH occurring as a postacute COVID-19 syndrome following a pauci-symptomatic initial infection.

scholarly journals Different Manifestations of Rare Cases of Unruptured Sinus of Valsalva Aneurysm—Case Series and Literature Review

2018 ◽  
Vol 28 (03) ◽  
pp. 202-206 ◽  
Author(s):  
Bhagya Narayan Pandit ◽  
Siva Subramaniyan ◽  
Tarun Kumar ◽  
Richa Agrawal ◽  
Deepankar Vatsa
Keyword(s):  
Case Reports ◽  
Case Series ◽  
Individual Case ◽  
Sinus Of Valsalva ◽  
Aortic Sinus ◽  
Sinus Of Valsalva Aneurysm ◽  
Severe Aortic Regurgitation ◽  
First Case ◽  
Threatening Condition ◽  
Life Threatening

AbstractSinus of Valsalva aneurysm (SVA) is rare, and aneurysm of the left sinus of Valsalva is extremely rare cardiovascular disease. Clinical presentation can vary from mostly asymptomatic to catastrophic life-threatening emergency. We report four extremely rare cases of SVA with different manifestations of which one case involved left aortic sinus with large unruptured aneurysm causing severe mitral regurgitation (MR) and severe aortic regurgitation (AR). The second case aneurysm was from right sinus presented with trifascicular block with intermittent complete heart block (CHB). Third was a diagnosed case of unruptured right SVA and while awaiting for surgery he had sudden cardiac death (SCD) at home. Therefore, SVA can present from asymptomatic to life-threatening condition, such as SCD. To the best of our knowledge, there are individual case reports in literature, and this is the first case series of unruptured SVA in literature highlighting the rarity of this disease.

Guillain–Barre syndrome: a rare complication of leptospirosis and scrub typhus co-infection

2019 ◽  
Vol 49 (3) ◽  
pp. 248-249 ◽  
Author(s):  
Nishant Dev ◽  
Rahul Kumar ◽  
Dilip Kumar
Keyword(s):  
Scrub Typhus ◽  
Case Reports ◽  
Rare Complication ◽  
Nerve Conduction Studies ◽  
Guillain Barre Syndrome ◽  
First Case ◽  
Immune Mediated ◽  
Guillain Barré Syndrome ◽  
Life Threatening ◽  
Guillain Barré

Guillain–Barré syndrome (GBS) is a potentially life-threatening immune-mediated acute inflammatory polyneuropathy associated with several antecedent infections. We report a 20-year-old man with GBS associated with concurrent leptospirosis and scrub typhus infection. GBS was confirmed with clinical examination and nerve conduction studies. There have been case reports of GBS in association with Leptospira and Orienta tsusugamushi separately. However, this may be the first case report of GBS associated with concurrent diseases.

scholarly journals Sickle cell disease in Sri Lanka: Clinical and molecular basis and the unanswered questions about disease severeity.

2020 ◽  
Author(s):  
Thamal Darshana ◽  
Dayananda Bandara ◽  
Upul Nawarathne ◽  
Udaya de Silva ◽  
Yasinta Costa ◽  
...  
Keyword(s):  
Sri Lanka ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Clinical Presentation ◽  
Clinical Course ◽  
Case Reports ◽  
Case Series ◽  
Cell Disease ◽  
Phenotypic Analysis ◽  
Rare Group

Abstract Background Though case reports and limited case series of Sickle cell disease in Sri Lanka have been reported previously, no attempt has been made hitherto to undertake a comprehensive genotypic-phenotypic analysis of this “rare” group of patients. Results All accessible Sickle cell disease patients, totaling 60, including, 51 Sickle β-thalassaemia and 9 homozygous sickle patients were enrolled from seven thalassaemia treatment centres between December 2016 - March 2019. The majority of patients were of Sinhalese ethnicity (n=52, 86.67%). Geographically, two prominent clusters were identified and the distribution of Sickle haemoglobin in the island contrasted markedly with the other haemoglobinopathies. 3/ 9 homozygous sickle patients and 3/ 51 Sickle β-thalassaemia patients were receiving regular transfusion. Joint pain was the commonest clinical presentation among all sickle cell disease patients (n=39, 65.0%). Dactylitis was significantly more common in homozygous sickle patients compared with the Sickle β-thalassaemia groups (p 0.027). Two genetic backgrounds sickle mutation were identified namely, Arab Indian and Benin. Among the regulators of Foetal hemoglobin in Sickle patients of the present study rs1427407 G>T seemed to be the most prominent modifier, with a significant association with Foetal haemoglobin levels (p 0.04). Conclusions Overall, the clinical course of the Asian version of Sickle cell disease in Sri Lanka appears to be milder than that described in India.

scholarly journals Andersen-Tawil Syndrome Presenting with Complete Heart Block

2021 ◽  
Vol 8 (1) ◽  
pp. 151-154
Author(s):  
Karen Suetterlin ◽  
Roope Männikkö ◽  
Enrico Flossmann ◽  
Richa Sud ◽  
Doreen Fialho ◽  
...  
Keyword(s):  
Cardiac Involvement ◽  
Autosomal Dominant ◽  
Clinical Presentation ◽  
Neuromuscular Disorder ◽  
Periodic Paralysis ◽  
Cardiac Conduction ◽  
Diagnostic Challenge ◽  
Dysmorphic Features ◽  
First Case ◽  
Life Threatening

Andersen-Tawil syndrome (ATS) is a rare autosomal dominant neuromuscular disorder due to mutations in the KCNJ2 gene. The classical phenotype of ATS consists of a triad of periodic paralysis, cardiac conduction abnormalities and dysmorphic features. Episodes of either muscle weakness or cardiac arrhythmia may predominate however, and dysmorphic features may be subtle, masking the true breadth of the clinical presentation, and posing a diagnostic challenge. The severity of cardiac involvement varies but includes reports of life-threatening events or sudden cardiac death, usually attributed to ventricular tachyarrhythmias. We report the first case of advanced atrioventricular (AV) block in ATS and highlight clinical factors that may delay diagnosis.

scholarly journals Case Reports on Metaplastic Squamous Cell Carcinoma of the Breast and Treatment Dilemma

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Anita Pandey ◽  
Kishor Joshi ◽  
Harry Moussouris ◽  
Gardith Joseph
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Reports ◽  
Young Patients ◽  
Treatment Strategies ◽  
Carcinoma Of The Breast ◽  
First Case ◽  
Heterogeneous Behavior ◽  
Premenopausal Female

Metaplastic squamous cell carcinoma of the breast is a very rare form of breast cancer that consists of both glandular and nonglandular components mixed with epithelial and mesenchymal tissues. Worldwide, the incidence of this tumor is between 0.1 and 2%. Because of the rarity of this tumor and heterogeneous behavior of the tumor cells, it is difficult to establish the standard therapeutic approach. We report 2 cases of metaplastic squamous cell carcinoma of the breast in young patients with different responses to treatment strategies. The first case is a premenopausal female with metaplastic squamous cell carcinoma treated with surgery, chemotherapy, and radiotherapy, and the second case is perimenopausal metaplastic squamous cell carcinoma with sarcomatoid subtype and osteoid matrix production which progressed on chemotherapy and was treated with surgery and radiation.

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