Factors associated with survival in patients with meningioma

Factors affecting the survival rate in patients with meningiomas were explored using the National Cancer Database (NCDB), which includes tumors from approximately 1000 hospitals participating in the American College of Surgeons tumor registry program. Analysis included over 9000 cases diagnosed from 1985 to 1988 and 1990 to 1992. Survival estimates were computed and prognostic factors were identified using a proportional hazards model. The overall 5-year survival rate was 69% and it declined with age. This rate was 81% in patients aged 21 to 64 and 56% for patients 65 years of age or older. When patients were grouped by the histological type of their tumors, those with benign tumors had an overall 5-year survival rate of 70%, whereas the overall 5-year survival rates in patients with atypical and malignant meningiomas were 75% and 55%, respectively. Prognostic factors for benign tumors included age at diagnosis, tumor size, whether treated surgically, hospital type, and radiation therapy; for malignant tumors, age at diagnosis, whether treated surgically, and radiation therapy were statistically significant. The 5-year rate for recurrence of symptoms (regardless of the method of treatment) was 18.2% for those with benign tumors and 27.5% for those with malignant tumors. In patients whose benign tumor had been completely removed, the 5-year rate of tumor recurrence was 20.5%. Although not population-based, the NCDB has the potential for providing pertinent information regarding patient characteristics and methods of treatment for benign, as well as malignant, brain tumors.

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Factors associated with survival in patients with meningioma

Journal of Neurosurgery ◽

10.3171/jns.1998.88.5.0831 ◽

1998 ◽

Vol 88 (5) ◽

pp. 831-839 ◽

Cited By ~ 148

Author(s):

Bridget J. McCarthy ◽

Faith G. Davis ◽

Sally Freels ◽

Tanya S. Surawicz ◽

Denise M. Damek ◽

...

Keyword(s):

Radiation Therapy ◽

Prognostic Factors ◽

Survival Rate ◽

Proportional Hazards Model ◽

Malignant Tumors ◽

Age At Diagnosis ◽

Benign Tumors ◽

Content Type ◽

Cancer Data ◽

Fine Print

Object. To explore factors affecting the survival rate in patients with meningiomas, the authors used the National Cancer Data Base (NCDB), which includes tumors from approximately 1000 hospitals participating in the American College of Surgeons tumor registry program. Methods. Analysis included over 9000 cases diagnosed from 1985 to 1988 and 1990 to 1992. Survival estimates were computed and prognostic factors were identified using a proportional hazards model. The overall 5-year survival rate was 69% and it declined with patient age. This rate was 81% in patients aged 21 to 64 years and 56% for patients 65 years of age or older. When patients were grouped by the histological type of their tumors, those with benign tumors had an overall 5-year survival rate of 70%, whereas the overall 5-year survival rates in patients with atypical and malignant meningiomas were 75% and 55%, respectively. Prognostic factors for benign tumors included age at diagnosis, tumor size, whether treated surgically, hospital type, and radiation therapy; for malignant tumors, the prognostic factors included: age at diagnosis, whether treated surgically, and radiation therapy. These factors were statistically significant. The 5-year rate for recurrence of symptoms (regardless of the method of treatment) was 19.2% for those with benign tumors and 32.4% for those with malignant tumors. In patients whose benign tumor had been completely removed, the 5-year rate of tumor recurrence was 20.5%. Conclusions. Although not population-based, the NCDB has the potential for providing pertinent information regarding patient characteristics and methods of treatment for benign, as well as malignant, brain tumors.

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Improved survival in patients with limited stage IIIA Hodgkin's disease treated with combined radiation therapy and chemotherapy.

Journal of Clinical Oncology ◽

10.1200/jco.1994.12.12.2567 ◽

1994 ◽

Vol 12 (12) ◽

pp. 2567-2572 ◽

Cited By ~ 7

Author(s):

K C Marcus ◽

L A Kalish ◽

C N Coleman ◽

L N Shulman ◽

D S Rosenthal ◽

...

Keyword(s):

Radiation Therapy ◽

Prognostic Factors ◽

Survival Rate ◽

Hodgkin's Disease ◽

Hodgkin’S Disease ◽

Survival Rates ◽

Stage Iii ◽

Combined Modality Treatment ◽

Stage Iiia ◽

Long Term Treatment

PURPOSE Patients with laparotomy-staged (PS) III 1A Hodgkin's disease confined to the upper abdomen are believed to have a favorable prognosis and require less aggressive treatment than patients with more-extensive stage III disease. We evaluated prognostic factors and outcome in 93 patients with PS III 1A Hodgkin's disease treated either with radiation therapy (RT) alone or combined RT and chemotherapy (combined modality treatment [CMT]) to determine the extent of treatment needed in this subgroup of stage IIIA patients. MATERIALS AND METHODS We retrospectively reviewed the freedom from relapse (FFR) rate, sites of recurrence, and survival rate of PS III 1A patients selected to receive extended-field irradiation (MPA, n = 27), total-nodal irradiation (TNI, n = 34), and CMT (n = 32) between 1969 and 1987. CMT consisted of six cycles of mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) chemotherapy and MPA. Patients treated with MPA were part of a prospective trial designed to reduce treatment to patients with minimal stage III disease with very favorable characteristics. RESULTS Histologic subclass and treatment were the only prognostic factors for FFR and survival rates. Patients with nodular sclerosis or lymphocyte predominance histology had significantly higher FFR and survival rates compared to patients with mixed-cellularity (MC) histology. The 10-year actuarial FFR of PSIII 1A patients treated with MPA was only 39%, versus 55% for TNI (P = .02) and 94% for CMT (v MPA, P < .0001; v TNI, P = .006). The patterns of recurrence in patients who received MPA and TNI were significantly different, with MPA patients relapsing more often in untreated pelvic or inguinal nodes, and TNI patients relapsing more often in extranodal sites with or without nodal sites. The 10-year actuarial overall survival rate for patients treated with CMT was 89% versus 78% for MPA (v CMT, P = .09) and 70% for TNI (v CMT, P = .05). CONCLUSION Patients with PSIII 1A Hodgkin's disease treated with RT have a significantly higher risk of relapse and potentially a poorer survival compared with patients treated with CMT. These findings suggest that CMT should play a greater role in the treatment of this favorable substage of patients. Management with modified chemotherapy and RT in an attempt to reduce long-term treatment-induced complications may be a preferred approach for future trials.

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Assessment of prognostic factors in extracranial germ cell tumors in children

Problems in oncology ◽

10.37469/0507-3758-2021-67-6-829-836 ◽

2021 ◽

Vol 67 (6) ◽

pp. 829-836

Author(s):

Symbat Salieva ◽

Riza Boranbayeva ◽

Bakhram Zhumadullayev ◽

Ergali Sarsekbayev ◽

Oleg Bydanov

Keyword(s):

Overall Survival ◽

Prognostic Factors ◽

Survival Rate ◽

Germ Cell ◽

Malignant Tumors ◽

Survival Rates ◽

Tumor Resection ◽

Germ Cell Tumors ◽

Morphological Structure ◽

High Sensitivity

Germ cell neoplasms in the group of benign and malignant tumors heterogeneous in morphological structure, clinical features and prognosis. A special characteristic of germ cell tumors is their high sensitivity to platinum-containing chemotherapy, which allows cure of up to 80–90% patients. However 20–25% of patients with a common type have overall survival rate of less than 50%. The aim of the study is to assess the survival rate of children with extracranial germ cell tumors and to identify adverse risk factors. Methods. The study includes 116 children with extracranial germ cell tumors treated from 2013 to September 2009. Treatment consisted of tumor resection and platinum based on platinum chemotherapy. Survival rate was assessed by the Kaplan-Mayer method. Prognostic factors are determined according to IGCCCG, MaGIC, MAKEI, RODO. Results. Overall and event free survival rates were 79±5% and 76±4%, respectively. The worst overall survival had patients with extragonadal tumors, advanced stages of a disease, high initial level of AFP (≥10 000 ng/ml), non-seminoma version of state treasury bills and extra pulmonary metastases. Conclusion. Survival rate in children with extracranial germ cell tumors depends on the prognostic factors. Statistically significant predictors of the poor prognosis were extragonadal localization of a tumor and the AFP level ≥10 000 ng/ml.

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Factors Affecting Survival in Patients with Breast Cancer in Hamedan Province from 2001 to 2018

10.30699/ijbd.12.4.31 ◽

2019 ◽

Vol 12 (4) ◽

pp. 31-38

Author(s):

Rasoul Najafi ◽

Fatemeh Amiri ◽

Ghodrat Roshanaei ◽

Mohammad Abbasi ◽

Mahdi Razi

Keyword(s):

Breast Cancer ◽

Survival Rate ◽

Cancer Progression ◽

Tumor Size ◽

Proportional Hazards ◽

Proportional Hazards Model ◽

Survival Rates ◽

Cox Proportional Hazards ◽

Cox Proportional Hazards Model ◽

Factors Affecting

Introduction: Breast cancer is the most common cancer and one of the leading causes of death in women. Identification of factors affecting the survival rate of these patients is important for the prevention of breast cancer progression and better treatment. Methods: This retrospective cohort study was performed on 493 women with breast cancer referred to Imam Khomeini clinic in Hamadan between 2001 and 2018. The Kaplan-Meier method and the Cox proportional hazard model were used to estimate the survival rate and factors affecting patient survival. All analyses were performed using SPSS 21. Results: The mean (standard deviation) age of the patients was 49.75 (11.34) years, and the 5- and 10-year survival rates were 61% and86%, respectively. The Cox proportional hazards model showed a significant relationship between age(HR (%95 CI)=1.53(1.23-2.78)) and tumor size (HR (%95 CI)=1.49(1.16-2.89)) and mortality risk (P < 0.05). Conclusion: Age and tumor size are associated with survival in patients with breast cancer. Therefore, increasing women’s awareness of the benefits of periodic examinations and early diagnosis can contribute to early detection of the disease and improved survival.

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Factors Predicting Survival for Cancer of the Ethmoid Sinus

American Journal of Rhinology ◽

10.1177/194589240201600512 ◽

2002 ◽

Vol 16 (5) ◽

pp. 281-286 ◽

Cited By ~ 26

Author(s):

Neil Bhattacharyya

Keyword(s):

Radiation Therapy ◽

Prognostic Factors ◽

Survival Data ◽

Proportional Hazards ◽

Proportional Hazards Model ◽

Cox Proportional Hazards ◽

Ethmoid Sinus ◽

Cox Proportional Hazards Model ◽

T Stage ◽

Hazards Model

Objective The aim of this study was to determine survival and prognostic factors for ethmoid sinus cancer. Methods From the Surveillance, Epidemiology, and End Results database for the time period 1988–1998, all cases of ethmoid sinus malignancy were extracted. Demographic, staging, treatment, and survival data were computed. Survival analysis was conducted with the Kaplan-Meier method. Clinical factors influencing survival were determined with the Cox proportional hazards model. Results After excluding patients with metastatic disease on presentation (8.9%) and patients with missing data for T stage, a total of 180 cases were identified. Average age was 60.2 years. Squamous cell carcinoma was the most common tumor (27.8%), followed by adenocarcinoma (12.8%). Overall mean survival was 57 months (median, 38 months) with a 5-year survival of 40.3%. The percentage of patients presenting with T4 lesions was 45.6%, which had a notably lower mean survival of 38 months (median, 18 months). Only 2.3% of patients had positive nodal disease. Increasing age, T stage, and absence of radiation therapy predicted poorer survival in the multivariate model. Adenocarcinoma, adenoid cystic carcinoma, esthesioneuroblastoma, and melanoma showed more favorable survival than other tumor types. Conclusions T stage and tumor histology are the most important prognostic factors in ethmoid sinus carcinoma. Survival for T4 lesions is markedly worse than survival for T1-T3 lesions. Radiation therapy offers a survival benefit in ethmoid sinus malignancy.

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Questioning the sex-specific differences in the association of smoking on the survival rate of hospitalized COVID-19 patients

PLoS ONE ◽

10.1371/journal.pone.0255692 ◽

2021 ◽

Vol 16 (8) ◽

pp. e0255692

Author(s):

Athar Khalil ◽

Radhika Dhingra ◽

Jida Al-Mulki ◽

Mahmoud Hassoun ◽

Neil Alexis

Keyword(s):

Survival Rate ◽

Smoking Prevalence ◽

Proportional Hazards ◽

Proportional Hazards Model ◽

Smoking Status ◽

Survival Rates ◽

Cox Proportional Hazards ◽

Cox Proportional Hazards Model ◽

Current Cigarette Smoking ◽

High Smoking Prevalence

Introduction In the absence of a universally accepted association between smoking and COVID-19 health outcomes, we investigated this relationship in a representative cohort from one of the world’s highest tobacco consuming regions. This is the first report from the Middle East and North Africa that tackles specifically the association of smoking and COVID-19 mortality while demonstrating a novel sex-discrepancy in the survival rates among patients. Methods Clinical data for 743 hospitalized COVID-19 patients was retrospectively collected from the leading centre for COVID-19 testing and treatment in Lebanon. Logistic regression, Kaplan-Meier survival curves and Cox proportional hazards model adjusted for age and stratified by sex were used to assess the association between the current cigarette smoking status of patients and COVID-19 outcomes. Results In addition to the high smoking prevalence among our hospitalized COVID-19 patients (42.3%), enrolled smokers tended to have higher reported ICU admissions (28.3% vs 16.6%, p<0.001), longer length of stay in the hospital (12.0 ± 7.8 vs 10.8 days, p<0.001) and higher death incidences as compared to non-smokers (60.5% vs 39.5%, p<0.001). Smokers had an elevated odds ratio for death (OR = 2.3, p<0.001) and for ICU admission (OR = 2.0, p<0.001) which remained significant in a multivariate regression model. Once adjusted for age and stratified by sex, our data revealed that current smoking status reduces survival rate in male patients ([HR] = 1.9 [95% (CI), 1.029–3.616]; p = 0.041) but it does not affect survival outcomes among hospitalized female patients([HR] = 0.79 [95% CI = 0.374–1.689]; p = 0.551). Conclusion A high smoking prevalence was detected in our hospitalized COVID-19 cohort combined with worse prognosis and higher mortality rate in smoking patients. Our study was the first to highlight potential sex-specific consequences for smoking on COVID-19 outcomes that might further explain the higher vulnerability to death from this disease among men.

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Breast Cancer Survival Defined by Biological Receptor and Menopausal Status in Vietnamese Women

Cancer Control ◽

10.1177/1073274819865279 ◽

2019 ◽

Vol 26 (1) ◽

pp. 107327481986527 ◽

Cited By ~ 1

Author(s):

Thang Vu Hong ◽

Duc Nguyen Ba ◽

Lambert Skoog ◽

Van Ta Thanh ◽

Edneia Tani

Keyword(s):

Breast Cancer ◽

Prognostic Factors ◽

Survival Rate ◽

Progesterone Receptor ◽

Cox Model ◽

Menopausal Status ◽

Survival Rates ◽

Factors Associated ◽

Vietnamese Women ◽

Significant Difference

Little is known about breast cancer in Vietnamese women. Previous studies have reported the frequencies of prognostic factors of breast cancer in this population. The aim of this study was to examine the prognostic factors associated with the survival rates of patients with breast cancer treated at the National Cancer Hospital, Hanoi, Vietnam. We recruited 248 women with operable breast cancer treated with surgery and adjuvant therapy. Tumor tissue samples were stained by many immunohistochemical approaches and analyzed for estrogen receptor, progesterone receptor, and HER2 gene amplification status. A Cox model was used to determine the relationship between survival and the prognostic factors. The disease-free survival rate, overall survival rate, and cancer-specific survival rate were 75.8%, 80.6%, and 86.4%, respectively, at 5 years and 62.3%, 68.1%, and 78.9%, respectively, at 10 years. The lung was the most common metastatic site. Women with factors associated with a poor prognosis (eg, advanced clinical stage, high tumor grade, progesterone receptor [PR] negativity, HER2 amplification) had significantly lower survival rates. Patients with PR-negative breast cancer had significantly worse survival rates compared to those who were PR positive, according to multivariate analysis (hazard ratio = 1.77, 95% confidence interval: 1.01-3.11, P = .045); however, there was only a statistically significant difference in postmenopausal patients. The PR was a prognostic factor in postmenopausal women with breast cancer, but not in premenopausal women.

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Stages I and II diffuse large cell lymphomas: prognostic factors and long-term results with CHOP-bleo and radiotherapy

Blood ◽

10.1182/blood.v77.5.942.942 ◽

1991 ◽

Vol 77 (5) ◽

pp. 942-947 ◽

Cited By ~ 45

Author(s):

WS Velasquez ◽

LM Fuller ◽

S Jagannath ◽

SL Tucker ◽

LB North ◽

...

Keyword(s):

Prognostic Factors ◽

Survival Rate ◽

Survival Rates ◽

Treatment Strategies ◽

Large Cell ◽

Stage I ◽

Stage Ii ◽

Long Term Results ◽

Ann Arbor ◽

Tumor Extent

Abstract One hundred forty-seven patients with Ann Arbor stages I and II diffuse large cell lymphoma (DLCL) were treated with combination chemotherapy consisting of cyclophosphamide, doxyrubicin, prednisone, and low-dose bleomycin (CHOP-Bleo) and involved-field radiation (IF XRT) between 1974 and 1984. A complete remission (CR) was attained by 54 of 57 patients with stage I disease and by 78 of 90 patients with stage II disease. Thirty-five patients had relapsing disease that occurred within 3 years in 31. The overall 10-year survival rate, counting all deaths, for patients with stage I was 72% as compared with 43% for patients with stage II (P less than .01). Determinate survival rates, censoring eight unrelated deaths, were similar to the overall survival rates: 77% and 51%, respectively. A multivariate analysis identified three independent prognostic factors: age, tumor extent, and serum lactic dehydrogenase (LDH) level. When the combined effect of tumor extent and LDH level were taken into consideration in the analysis, three risk groups for survival were identified. The best group, which consists of patients with minimum tumor and normal LDH levels, had a 10- year determinate survival of 79%. Patients with extensive tumors and elevated LDH levels had the poorest survival rate of 44%. An intermediate-risk group with a determinant survival of 62% was composed of patients with either extensive tumors or elevated LDH levels. These differences demonstrate the need to develop different treatment strategies based on risk factors for survival for patients with apparently localized Ann Arbor stages I/II DLCL.

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Comorbidities and Outcome of Alcoholic and Non-Alcoholic Liver Cirrhosis in Taiwan: A Population-Based Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17082825 ◽

2020 ◽

Vol 17 (8) ◽

pp. 2825

Author(s):

Tzu-Wei Yang ◽

Chi-Chih Wang ◽

Ming-Chang Tsai ◽

Yao-Tung Wang ◽

Ming-Hseng Tseng ◽

...

Keyword(s):

Liver Cirrhosis ◽

Proportional Hazards ◽

Proportional Hazards Model ◽

Survival Rates ◽

Study Groups ◽

Population Based ◽

Cox Proportional Hazards ◽

Cox Proportional Hazards Model ◽

Study Cohort ◽

Hazards Model

The prognosis of different etiologies of liver cirrhosis (LC) is not well understood. Previous studies performed on alcoholic LC-dominated cohorts have demonstrated a few conflicting results. We aimed to compare the outcome and the effect of comorbidities on survival between alcoholic and non-alcoholic LC in a viral hepatitis-dominated LC cohort. We identified newly diagnosed alcoholic and non-alcoholic LC patients, aged ≥40 years old, between 2006 and 2011, by using the Longitudinal Health Insurance Database. The hazard ratios (HRs) were calculated using the Cox proportional hazards model and the Kaplan–Meier method. A total of 472 alcoholic LC and 4313 non-alcoholic LC patients were identified in our study cohort. We found that alcoholic LC patients were predominantly male (94.7% of alcoholic LC and 62.6% of non-alcoholic LC patients were male) and younger (78.8% of alcoholic LC and 37.4% of non-alcoholic LC patients were less than 60 years old) compared with non-alcoholic LC patients. Non-alcoholic LC patients had a higher rate of concomitant comorbidities than alcoholic LC patients (79.6% vs. 68.6%, p < 0.001). LC patients with chronic kidney disease demonstrated the highest adjusted HRs of 2.762 in alcoholic LC and 1.751 in non-alcoholic LC (all p < 0.001). In contrast, LC patients with hypertension and hyperlipidemia had a decreased risk of mortality. The six-year survival rates showed no difference between both study groups (p = 0.312). In conclusion, alcoholic LC patients were younger and had lower rates of concomitant comorbidities compared with non-alcoholic LC patients. However, all-cause mortality was not different between alcoholic and non-alcoholic LC patients.

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EPID-09. PROGNOSTIC FACTORS IN ADULT PATIENTS WITH PRIMARY INTRACRANIAL EPENDYMOMAS: A POPULATION-BASED STUDY

Neuro-Oncology ◽

10.1093/neuonc/noz175.309 ◽

2019 ◽

Vol 21 (Supplement_6) ◽

pp. vi76-vi76

Author(s):

Helen Yang ◽

Abdullah Malik ◽

Sunit Das

Keyword(s):

Radiation Therapy ◽

Prognostic Factors ◽

Health Care Professionals ◽

Adult Patients ◽

Age At Diagnosis ◽

Who Grade ◽

Intracranial Ependymoma ◽

One Year ◽

Who Grade Iii ◽

Grade Iii

Abstract BACKGROUND Outcomes for patients with intracranial ependymoma remain poor in the current era of cancer treatment. This study aims to investigate the prognostic value of demographic and clinical variables to predict survival using the largest current database of patients with intracranial ependymoma. METHODS The Surveillance, Epidemiology and End Results (SEER) registry was queried for prognostic factors and survival outcomes of adult (≥18 years) patients diagnosed with intracranial ependymoma from 2004–2016. Survival was estimated using Kaplan Meier curves. Cox proportional hazards modeling was used to identify correlates of survival. RESULTS We identified a cohort of 229 primary intracranial ependymoma patients. The cohort showed a slight male predominance (52%) and had a mean age of 43 ± 17 years. 107 patients (47%) had WHO grade II tumors and 122 patients (53%) had WHO grade III tumors. One year survival was 85% for the entire cohort. Increasing age at diagnosis (HR: 1.05, 95% CI: 1.03–1.07) and WHO grade III tumor (HR: 4.20, 95% CI: 2.02–8.75) were independently associated with mortality after adjusting for age, sex, tumor location, extent of surgery, use of radiation therapy, and use of chemotherapy. Use of radiation therapy was associated with better one-year survival in cases of gross total resection (GTR) and subtotal resection (STR). Use of chemotherapy was not associated with mortality in the adjusted analysis (HR: 2.16, 95% CI: 0.96–4.84). CONCLUSION Our results suggest that age at diagnosis and tumor grade are independent factors associated with mortality in adult patients with intracranial ependymoma. Furthermore, use of chemotherapy was not shown to decrease mortality. These findings help guide future prognostic model making and therapeutic strategies designed by health care professionals.

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