CIRCADIAN-RELATED ECTOPIC RHYTHMS IN YOUNG PATIENTS: ETHIOPATHOLOGICAL FEATURES AND PRINCIPLES OF THERAPY
The autonomic nervous system plays a key role in the processes of adaptation, regulating the functioning of the whole organism. And a disturbance of the heart rhythm is typically one of the first manifestations of autonomic circadian maladaptation. The aim of this study was to assess the relationship between circadian rhythm disorders and autonomic misbalance with the occurrence of arrhythmic events in young patients with the further development of treatment strategy. Materials and methods: the study was performed at the Medical Centre «MEDION». 34 patients aged 18-35 years were enrolled to the study, divided into the test and control groups. Results: despite a significantly higher frequency of supraventricular arrhythmias in the test group compared to the control group, the supraventricular extrasystoles occurred in the control group predominantly at night time (with peak from 3 to 6 a.m.). In the test group, atrial ectopic beats were observed predominantly from 5 to 12 a. m. In the group of patients with the number of ventricular ectopic complexes over 500 / day, no time interval was found, during which the number of ventricular extrasystoles was statistically significantly predominant. The most important factors of ventricular ectopic events occurrence included: sleeping less than 6 hours, job lasting over 10 hours a day, and too little time spent outdoors. All individuals were recommended to modify their lifestyle and take when necessary autonomic normalization agents and antiarrhythmics. Conclusion: the modern lifestyle of the young generation leads to the disturbance of circadian biorhythms as a result of the unbalanced autonomic regulation and the subsequent occurrence of ectopic arrhythmic events. The most unfavourable factors in this case are sleeping less than 6 hours, a working day lasting over 10 hours, and outdoor-spent time lasting less than 2 hours a day.