Biochemical indicators of renal functional state under the conditions of bisphenol A administration and low-level laser irradiation

2020 ◽  
Vol 12 (2) ◽  
pp. 180-186
Author(s):  
Vira Borschovetska ◽  
Valeriia Mamiienko
Keyword(s):  
Bisphenol A ◽  
Laser Irradiation ◽  
Diode Laser ◽  
Functional State ◽  
Negative Impact ◽  
Hepatic Function ◽  
Secondary Products ◽  
Corrective Effect ◽  
Level Laser ◽  
The Impact

Nowadays, due to the mass production of plastic products, the question of the negative impact of bisphenol A on the functioning of organs and systems is acute. However, the question of the effect of this xenobiotic on the functional state of the kidneys remains open. Currently, laser irradiation of various powers is intensively used to correct pathologies. However, its biochemical feathers of the impact on biological objects require detailed research. The work is aimed at the study of nephrotoxic effects of bisphenol A under the conditions of irradiation of animals with a diode laser. ВРА was administered per os daily for 3 days at a dose of 50 mg/kg body weight, which corresponded with LOAEL dose. Irradiation was performed for 2 min with a low-diode laser λ = 650 nm (50 mW, 1.5 J/cm2 and 12.5 mW/cm2). The functional state of the kidneys was performed based on the determination of urea and creatinine content in urine and serum. The content of primary and secondary products of the LP was determined in the kidneys. It is shown, that the administration of bisphenol A is accompanied by a decrease in urea in serum and urine, an increase in serum creatinine and a decrease in this metabolite in urine, which may indicate impaired renal and hepatic function due to the damage of this organ by contaminants due to induction lipid oxidation. This is expressed by an increase in the content of conjugated diene and TBA-active compounds in the kidneys. At the same time, under the irradiation of animals, the concentration of urea and creatinine in the serum decreases compared with the BPA group, and in the urine, these indicators increase. Such results may indicate the normalization of kidney function due to the corrective action of the laser. Thus, the introduction of BPA is accompanied by the induction of LPS processes, which leads to renal dysfunction, and irradiation of animals has a corrective effect of nephrotoxic effects of BPA.

Urbanization of fauna on the example of marsh frog (Pelophylax ridibundus)

2015 ◽  
Vol 26 (3-4) ◽  
pp. 116-123
Author(s):  
A. P. Korzh ◽  
T. V. Zahovalko
Keyword(s):  
Urban Areas ◽  
Cognitive Modeling ◽  
Negative Impact ◽  
Natural Populations ◽  
Cellular Level ◽  
Anthropogenic Factors ◽  
Migration Routes ◽  
Corrective Effect ◽  
The Impact ◽  
The City

Recently, the number of published works devoted to the processes of synanthropization of fauna, is growing like an avalanche, which indicates the extreme urgency of this theme. In our view, the process of forming devices to coexist with human and the results of his life reflects the general tandency of the modern nature evolution. Urbanization is characteristic for such a specific group of animals like amphibians, the evidence of which are numerous literature data. Many researchers use this group to assess the bioindicative quality of the environment. For this aim a variety of indicators are used: from the cellular level of life of organization up to the species composition of the group in different territories. At the same time, the interpretation of the results is not always comparable for different areas and often have significantly different interpretations by experts. Urban environment, primarily due to the contamination is extremely aggressive to amphibians. As a consequence, the urban populations of amphibians may be a change in the demographic structure, affecting the reproductive ability of the population, the disappearance of the most sensitive species or individuals, resizing animals, the appearance of abnormalities in the development, etc. At the same time play an important amphibians in the ecosystems of cities, and some species in these conditions even feel relatively comfortable. Therefore, it is interesting to understand the mechanisms of self-sustaining populations of amphibians in urban environments. To assess the impact of natural and anthropogenic factors on the development of amphibian populations were used cognitive modeling using the program Vensim PLE. Cognitive map of the model for urban and suburban habitat conditions were the same. The differences concerned the strength of connections between individual factors (migration, fertility, pollution) and their orientation. In general, factors like pollution, parasites, predators had negative impact on the population, reducing its number. The birth rate, food and migration contributed to raising number of individuals. Some of the factors affected on the strength to of each other as well: the majority of the factors affected the structure of the population, had an influence on the fertility. Thanks to it the model reflects the additive effect of complex of factors on the subsequent status of the population. Proposed and analyzed four scenarios differing strength and duration of exposure. In the first scenario, a one-time contamination occurs and not subsequently repeated. The second and third scenario assumes half board contamination, 1 year (2 scenario) and two years (scenario 3). In the fourth scenario, the pollution affected the population of amphibians constantly. In accordance with the results of simulation, much weaker than the natural populations respond to pollution - have them as an intensive population growth and its disappearance at constant pollution is slow. Changes to other parameters of the model showed that this pollution is the decisive factor -only the constant action leads to a lethal outcome for the populations. All other components of the model have a corrective effect on the population dynamics, without changing its underlying trand. In urban areas due to the heavy impact of pollution maintaining the population is only possible thanks to the migration process – the constant replenishment of diminishing micropopulations of natural reserves. This confirms the assumption that the form of existence metapopulations lake frog in the city. In order to maintain the number of amphibians in urban areas at a high level it is necessary to maintain existing migration routes and the creation of new ones. Insular nature of the placement of suitable habitats in urban areas causes the metapopulation structure of the types of urbanists. Therefore, the process of urbanization is much easier for those species whicht are capable of migration in conditions of city. In the initial stages of settling the city micropopulationis formed by selective mortality of the most susceptible individuals to adverse effects. In future, maintaining the categories of individuals is provided mainly due to migration processes metapopulisation form of the species of existence is supported). It should be noted that the changes in the previous levels are always saved in future. In the case of reorganizations of individuals we of morphology can assume the existence of extremely adverse environmental conditions that threaten the extinction of the micropopulations. 

Prison stress in women and its negative impact in the process of correcting

2019 ◽  
pp. 69-76
Author(s):  
Марина Владиславовна Минстер
Keyword(s):  
Negative Impact ◽  
Emotional Experiences ◽  
The Public ◽  
Corrective Effect ◽  
Subjective Reaction ◽  
Resistance To Stress ◽  
Prison Environment ◽  
High Level ◽  
The Impact ◽  
Gender Aspect

В статье рассматриваются причины и факторы, способствующие возникновению пенитенциарного стресса у осужденных к лишению свободы женщин. Стресс как субъективная реакция психики на изоляцию от общества больше связан с воздействием пенитенциарной среды и способствует развитию деструктивных проявлений у женщин, что негативно влияет на исправительное воздействие и часто проявляется на стадии адаптации и перед освобождением. В гендерном аспекте результаты исследования показали, что осужденные к лишению свободы мужчины проявляют устойчивость к стрессорным воздействиям при высоком уровне стресса, депрессивные состояния среди них в несколько раз меньше, чем у женщин. Пенитенциарный стресс у женщин является более контрастным, так как уровень психоэмоциональных переживаний выше и требуется значительно больше времени для восстановления, чем мужчинам. Исследуется практика применения индивидуальных и групповых психокоррекционных методик, осуществляемых в процессе исполнения наказания, которые создают условия для самоисправления женщины. Оптимизация исправительного воздействия возможна при условии включения осужденных женщин в воспитательно-ресоциализационные и социально-реабилитационные программы с учетом психофизиологических особенностей и анализа психодинамики их активности, с использованием дополнительного положительного влияния близких родственников и общественности на разных этапах отбывания наказания. The article discusses the causes and factors contributing to stress in prison of persons sentenced to deprivation of liberty of women. Stress as a subjective reaction of the psyche to isolation from society is more related to the impact of the prison environment and contributes to the development of destructive manifestations in women, which negatively affects the corrective effect and often manifests itself at the stage of adaptation and before release. In the gender aspect, the results of the study showed that men sentenced to imprisonment show resistance to stress at a high level of stress, depression among them several times less, unlike women. Penitentiary stress in women is more contrast, because the level of psycho-emotional experiences is higher and it takes much more time to recover than men. The author of the article studies the practice of applying individual and group psychocorrection techniques carried out in the process of execution of punishment, which create conditions for self-correction of women. Optimization of treatment possible, subject to the inclusion of women offenders in a correctional reintegration and social rehabilitation programme taking into account psycho-physiological characteristics and analysis of the psychodynamics of activity, using the influence of relatives and the public at various stages of punishment.

scholarly journals EFFECTS OF LOW LEVEL LASER IRRADIATION (LLLI) WITH 904nm PULSED DIODE LASER ON OSTEOBLASTS: A CONTROLLED TRIAL WITH THE RAT OSTEOBLAST MODEL

LASER THERAPY ◽  
1996 ◽  
Vol 8 (4) ◽  
pp. 223-231 ◽  
Author(s):  
Ki-Suk Kim ◽  
Jung-Ken Kim ◽  
Se-Won Kim ◽  
Jun-Hee Lee ◽  
Yun-Ki Kim ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Diode Laser ◽  
Controlled Trial ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Rat Osteoblast ◽  
Low Level Laser Irradiation

scholarly journals Evaluation of Low-Level Laser Therapy with Diode Laser for the Enhancement of the Orthodontic Tooth Movement: a Split-Mouth Study

2018 ◽  
Author(s):  
Giovanni Matarese ◽  
Marco Matarese ◽  
Giacomo Picciolo ◽  
Luca Fiorillo ◽  
Gaetano Isola
Keyword(s):  
Laser Irradiation ◽  
Laser Therapy ◽  
Diode Laser ◽  
Continuous Wave ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Pain Level ◽  
Canine Retraction ◽  
Level Laser ◽  
Laser Group

This study evaluated the effect of low-level laser irradiation induces by diode laser on the speed of orthodontic tooth movement of canines submitted to initial retraction. Twenty-four mandibular canines were retracted by using NiTi spring (force of 150 g/side). Thirteen of those were irradiated with a diode laser 980-nm diode laser (Wiser Laser Doctor Smile, Lambda) operating at an 810-nm wavelength (1 W of output power, continuous wave of 66.7 J/cm2) that was equipped with a 0.6-mm optical fiber in continuous-wave mode. The canine retraction was accomplished by using prefabricated coil springs. The right of the mandible was chosen to be irradiated with the laser, whereas the left side was considered the control without laser irradiation. The laser was applied with 0-, 3-, 7-, and 14-day intervals. The amount of canine retraction was measured with a digital electronic caliper while the pain level was prompted by a patient questionnaire. The speed of tooth movement was significantly greater in the laser group than in the control group. The pain intensity was also at a lower level in the laser group. Our findings suggest that diode laser therapy can highly accelerate tooth movement during orthodontic treatment and can also effectively reduce pain level.

scholarly journals THE FEATURES OF LIPID METABOLISM IN RATS UNDER THE CONDITIONS OF BISPHENOL A ADMINISTRATION AND LOW-LEVEL LASER IRRADIATION

2020 ◽  
Vol 25 (2(47)) ◽  
pp. 11-22
Author(s):  
В. Л. Борщовецька ◽  
Я. Р. Михальчук ◽  
М. М. Марченко
Keyword(s):  
Lipid Metabolism ◽  
Bisphenol A ◽  
Laser Irradiation ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Low Level Laser Irradiation

scholarly journals Photobiomodulation by a 635nm Diode Laser on Peri-Implant Bone: Primary and Secondary Stability and Bone Density Analysis—A Randomized Clinical Trial

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Jacek Matys ◽  
Katarzyna Świder ◽  
Kinga Grzech-Leśniak ◽  
Marzena Dominiak ◽  
Umberto Romeo
Keyword(s):  
Bone Density ◽  
Total Energy ◽  
Laser Irradiation ◽  
Diode Laser ◽  
Healing Process ◽  
Average Power ◽  
Titanium Implants ◽  
Implant Stability ◽  
The Impact ◽  
Secondary Stability

Introduction. Various procedures in dental implantology are performed to enhance the bone healing process and implant stability. One of these methods can be a low-level laser therapy (LLLT).Objectives. The aim of our study was to evaluate the stabilization (primary and secondary) and bone density in peri-implant zone after LLLT protocol using a 635 nm diode laser.Material and Methods. The research included 40 implants placed in the posterior region of a mandible in 24 patients (8 women and 16 man; age: 46.7 ± 8.7 years). The patients were randomly divided into 2 groups G1 (n=12, 18 implants) and G2 (n=12, 22 implants) according to the treatment procedure; G1 (test): 635 nm laser, with handpiece diameter: 8mm, output power: 100mW, spot area: 0.5024cm2, average power density: 199.04mW/cm2, continuous mode, dose: 4J per point (8J/cm2), time: 40 sec per point, 2 points (irradiation on a buccal and a lingual side of the alveolus/implant), and total energy per session 8J; G2 (control): no laser irradiation. The G1 (test) group’s implants were irradiated according to the following protocol: 1 day before surgery, immediately after the surgery and 2, 4, 7, and 14 days after. The total energy after all therapeutic sessions was 48J. The implants stability was measured employing a Periotest device (Periotest Test Value: PTV) (measured immediately after the surgery, 7 days, 2 weeks, 4 weeks, and 2 and 3 months after the surgery) and the bone density using cone-beam computed tomography (grayscale value) (measured immediately after the surgery, 4 weeks and 12 weeks after the treatment).Results. The average implant stability at different time points showed lower PTV value (higher stability) at2ndand4thweek after 635 nm laser irradiation (G1) compared with a control (G2) group (p<0.01). The secondary stability of the implants after 12 weeks observation was not significantly higher for the laser group in contrast to none-irradiated implants (p>0.05). The mean grayscale value at the apical, middle, and cervical level of the titanium implants showed the reduction of pixel grayscale value after 2 weeks and was lower for the G1 group in contrast to the G2 group (p<0.01). The value of grayscale after 12 weeks was significantly higher at the middle and apical level of the implants in the G1group in contrast to the G2 group (p<0.01).Conclusion. The application of the 635 nm diode laser enhanced secondary implant stability and bone density. However, to assess the impact of the LLLT on peri-implant bone with different bone densities, further well-controlled long-term trials on larger study groups are needed.

Effect of low-level laser irradiation on the bisphenol a-induced free radical processes

2020 ◽  
Vol 12 (2) ◽  
pp. 125-134
Author(s):  
Vira Borschovetska ◽  
Mariia Rubanets
Keyword(s):  
Free Radical ◽  
Liver Injury ◽  
Bisphenol A ◽  
Laser Irradiation ◽  
Anatomical Site ◽  
Therapeutic Effects ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Low Level Laser Irradiation

One of these novel application areas is LLLT for drug-induced liver injury. LLLI employs visible (generally red) or near-infrared light generated from a laser or light-emitting diode (LED) system. The light is typical of narrow spectral width between 600-1000 nm. Despite significant research efforts around the effects and molecular mechanisms of LLLT in various cells or tissues, the appropriate doses of radiation, energy densities, time, and irradiation conditions as well as the appropriate individual settings in the various laser devices, which will predictably lead to optimal therapeutic effects, have not been clarified yet. In the present study, the effect of low-level laser irradiation on oxidative stress parameters in rats under the conditions of BPA administration was investigated. Toxic liver injury induced by bisphenol A (BPA) administration at 50 mg/kg body wt by gavage for 3 days once a day. Low-level laser irradiation was performed after each administration of xenobiotic. A laser diode (50 mW) with 650 nm continuous wavelength was applied to the skin surface at the anatomical site of the liver. The administration of BPA leads to the evaluated of free radical generation and decrease in SOD, CAT and GPx activities in the liver of bisphenol A-exposed animals. The enhanced processes of the generation of superoxide radicals and nitric oxide and exhausting level of antioxidant enzymes under the conditions of BPA administration leads to the increased oxidative damage of lipid and protein in subcellular fraction. The low-level laser irradiation of BPA-treated animals leads to the increase of enzymatic activity of antioxidant defences system, a decrease of free-radical production and oxidative protein and lipid damage in microsome and cytosol.

scholarly journals EFFECTS OF LOW LEVEL LASER IRRADIATION (LLLI) WITH 904 nm PULSED DIODE LASER ON STAPHYLOCOCCUS AUREUS

LASER THERAPY ◽  
1997 ◽  
Vol 9 (3) ◽  
pp. 121-129 ◽  
Author(s):  
Ki-suk Kim ◽  
Phil-Yeon Lee ◽  
Jun-Hee Lee ◽  
Yun-Ki Kim
Keyword(s):  
Staphylococcus Aureus ◽  
Laser Irradiation ◽  
Diode Laser ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Low Level Laser Irradiation
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