Topical issues of midwifery services under coronavirus pandemic in the area with low population density

The purpose was to describe the algorithms of midwifery services in the area with low population density under the coronavirus pandemic and to evaluate SARS-Cov-2 as a threatening factor for pregnancy and childbirth. Material and methods. 205 pregnant women aged from 16 to 42 y. o., with virusologically conformed presence of SARS-Cov-2, in the gestation period from 5 to 40 weeks were explored. Of them, 126 pregnant patients were hospitalized and monitored up to the recovery from COVID-19 or delivery. The features of pregnancy and childbirth, perinatal outcomes were studied. The obtained data were compared with the published data to identify the true and false threats of COVID-19 to a mother and a baby in case of the «third wave» of the pandemic. Results. Observation showed that pregnant women tend to have a lighter course of SARS-Cov-2 compared to the population and the frequency of critical condition is no more that 0.8%. The frequency of preterm birth is 1.5 % of all births of COVID-19 infected pregnant women, and the frequency of miscarriage is 0.58 % of all COVID-19 infected pregnant women. This does not confirm the published data of high proportion of preterm birth and misbirth (18-19%). Conclusion. Our investigation does not confirm that COVID-19 adds the complexity of the course of pregnancy and makes its outcomes worse.

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PERINATAL ASPECTS OF PREGNANCY AND CHILDBIRTH ON THE BACKGROUND OF VITAMIN D LACK IN PREGNANT WOMEN

Wiadomości Lekarskie ◽

10.36740/wlek202110210 ◽

2021 ◽

Vol 74 (10) ◽

pp. 2585-2587

Author(s):

Vitaliy V. Maliar

Keyword(s):

Vitamin D ◽

Blood Serum ◽

Pregnant Women ◽

Perinatal Outcomes ◽

Fetal Distress ◽

Test System ◽

Perinatal Complications ◽

Pregnancy And Childbirth ◽

Wide Range ◽

Pregnancy And Delivery

The aim: To study the features of the course of gestation and perinatal outcomes of delivery in women with vitamin D lack. Materials and methods: The article presents the results of studies of the characteristics of the course of pregnancy and delivery outcomes in 50 patients with vitamin D lack compared with a group of 50 somatically healthy pregnant women with normal level of 25 (OH) D. In order to establish a lack of vitamin D in pregnant women in the 10-12, 20-22, 30-32 weeks of gestation electrochemiluminiscence method by using a test system EURIMMUN (Germany) in the blood serum level of 25-hydroxycalciferol (25 (OH) D) in pregnant women. Results: When analyzing the structure of complications in women with vitamin D lack during pregnancy and childbirth we found out that risk of premature birth and premature births dominated among all the complications, respectively (58.0% and 36.0%) against (12.0% and 16.0%), p <0.05. Vitamin D lack in pregnant women is often associated with a wide range of obstetric and perinatal complications, namely: preeclampsia, gestational diabetes, bacterial vaginosis , premature rupture of membranes, placental abruption, abnormal labor activity, fetal distress that required delivery by Caesarean section. Conclusions: An analysis of the course of pregnancy and childbirth in women of thematic groups proved the expediency of an individual approach to the therapy of obstetric pathology among women with vitamin D lack. Despite the level of 25 (OH) D in the blood serum of a pregnant woman of 30 ng / ml and below, it is advisable to prescribe vitamin D for prophylaxes and treatment of Vitamin D deficiency in mother and fetus.

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Tingkat Kecemasan Ibu Hamil Trimester III dalam Menghadapi Persalinan

Jurnal Bidan Cerdas (JBC) ◽

10.33860/jbc.v3i1.131 ◽

2021 ◽

Vol 3 (1) ◽

pp. 18-24

Author(s):

Nilda Yulita Siregar ◽

Cici Fitrayanti Kias ◽

Nurfatimah Nurfatimah ◽

Fransisca Noya ◽

Lisda Widianti Longgupa ◽

...

Keyword(s):

Pregnant Women ◽

Preterm Labor ◽

Community Health Center ◽

Sampling Technique ◽

Descriptive Study ◽

Age Group ◽

Third Trimester ◽

Pregnancy And Childbirth ◽

The Third ◽

Fear And Anxiety

Introduction: Fear and anxiety during pregnancy and childbirth can cause problems such as preterm labor and low birth weight. Purpose: The purpose of this study was to determine the level of anxiety of third-trimester pregnant women in dealing with labor. Methods: This type of research is a descriptive study and analyzed with frequency distribution. The population was all pregnant women in the third trimester who were in the working area of the Mapane Community Health Center with a total of 37 people. The sampling technique used total sampling. The results showed that only 8.1% of pregnant women experienced mild anxiety, while 91.9% did not experience anxiety. pregnant women who experience mild anxiety are 20% in the risk age group, 20% with diploma education, 11.5% in mothers who do not work, 60% in primigravidas, and 15.8% in mothers who do not get support from their husbands. Anxiety occurs mostly in primigravida because it is the first experience of pregnancy. It suggested for village midwives providing information about pregnancy and childbirth, especially for primigravida mothers, and involving their husbands in posyandu activities for pregnant women.

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3162 Colonization of Pregnant Women with Group B streptococcus in Latin America and Infant Outcomes

Journal of Clinical and Translational Science ◽

10.1017/cts.2019.92 ◽

2019 ◽

Vol 3 (s1) ◽

pp. 37-38

Author(s):

Elena HogenEsch ◽

Lisa Haddad ◽

Inci Yildirim ◽

Saad B Omer

Keyword(s):

Risk Factors ◽

Latin America ◽

Preterm Birth ◽

Cesarean Section ◽

Pregnant Women ◽

Perinatal Outcomes ◽

Clinical Risk Factor ◽

Prevalence Rates ◽

Data Set ◽

Study Population

OBJECTIVES/SPECIFIC AIMS: The primary objective of this study is to determine the prevalence of maternal GBS colonization and demographic risk factors associated with maternal GBS colonization in Latin America. Secondary objectives include: To determine if there is an association between maternal colonization with GBS and stillbirth or preterm birth in Latin America. To determine the effect of cesarean section (CS) on the incidence of neonatal sepsis with GBS in mothers colonized with GBS. METHODS/STUDY POPULATION: Study Population: Pregnant women who received prenatal care at sites that utilize the Perinatal Information System (SIP) from 1989 through 2015, and were screened for GBS between 35 and 37 weeks of gestation. Maternal exclusion criteria included spontaneous abortion, stillbirth before 35 weeks, and lack of screening for GBS. Methods: Estimated prevalence (and 95% confidence interval) of maternal GBS colonization for the entire data set, by region, and by country. The prevalence data for each country further stratified by maternal age, ethnicity, education, civil status and habitation. Descriptive statistics calculated for each clinical prenatal and clinical perinatal health indicator as well as for each clinical history variable for GBS colonized and non-GBS colonized women. Odds ratios will be calculated for each demographic and clinical risk factor. Fisher’s exact tests will be used to test hypotheses about the relationship between maternal GBS colonization and specific perinatal outcomes such as stillbirth or preterm birth. We will use multiple logistic regression models to test the hypotheses about the relationships between demographic variables, maternal GBS colonization and perinatal outcomes. RESULTS/ANTICIPATED RESULTS: Preliminary results: 712,061 records included in database. 98,852 records with data for GBS screening. o90.6% White, 7.4% Mixed, 0.6% Black, 0.3% Native Indian, 0.1% Other. GBS prevalence among screened women, 17.5% There was a significant association between maternal GBS colonization and ethnicity (X2 (4, N=97006)=569.901, p<0.01) o Prevalence rates by ethnicity: 20.5% Black, 18.4% White, 15.2% Native Indian, 8.8% Mixed, 3.3% Other. There was a significant association between maternal GBS colonization and age (X2 (4, N=98655)=119.901, p<0.01) o Prevalence rates by age group:. Age ≤ 20 - 15.2%. Age 21-34 – 17.8%. Age ≥ 35 – 19.6% Anticipated results:. GBS positive mothers will have an increased burden of stillbirth and preterm birth compared to GBS negative mothers. Neonates born to GBS colonized mothers who deliver via cesarean section will have a decreased incidence of sepsis compared to neonates born to GBS colonized mothers who deliver vaginally DISCUSSION/SIGNIFICANCE OF IMPACT: There have been no comprehensive studies to date that use the CLAP data to characterize the epidemiology of maternal GBS colonization and GBS disease and the burden of neonatal GBS disease in Latin America. Taking advantage of this unique database, this is the first region-wide study using systematically collected data. Our preliminary analysis indicates that GBS colonization status among pregnant women in Latin America is 17.5%, which is greater than previously reported. While there is evidence that maternal carriage of GBS is associated with stillbirth, this will be the first study to quantify the burden of GBS-associated stillbirth in Latin America. Additionally, previous work has been inconclusive in regards to maternal colonization with GBS and its association with preterm birth. This will be the largest study to evaluate the association of maternal GBS carriage with preterm birth. Findings from this study have the potential to inform public health policy and interventions by identifying the prevalence and risk factors.

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Perinatal Outcomes in HIV Positive Pregnant Women with Concomitant Sexually Transmitted Infections

Infectious Diseases in Obstetrics and Gynecology ◽

10.1155/2015/508482 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Erin Burnett ◽

Tammy L. Loucks ◽

Michael Lindsay

Keyword(s):

Preterm Birth ◽

Prenatal Care ◽

Pregnant Women ◽

Perinatal Outcomes ◽

Neonatal Outcomes ◽

Hiv Positive ◽

City Hospital ◽

Transmitted Infection ◽

Sexually Transmitted ◽

Increased Risk

Objective. To evaluate whether HIV infected pregnant women with concomitant sexually transmitted infection (STIs) are at increased risk of adverse perinatal and neonatal outcomes.Methods. We conducted a cohort study of HIV positive women who delivered at an inner-city hospital in Atlanta, Georgia, from 2003 to 2013. Demographics, presence of concomitant STIs, prenatal care information, and maternal and neonatal outcomes were collected. The outcomes examined were the association of the presence of concomitant STIs on the risk of preterm birth (PTB), postpartum hemorrhage, chorioamnionitis, preeclampsia, intrauterine growth restriction, small for gestational age, low Apgar scores, and neonatal intensive care admission. Multiple logistic regression was performed to adjust for potential confounders.Results. HIV positive pregnant women with concomitant STIs had an increased risk of spontaneous PTB (odds ratio (OR) 2.11, 95% confidence interval [CI] 1.12–3.97). After adjusting for a history of preterm birth, maternal age, and low CD4+ count at prenatal care entry the association between concomitant STIs and spontaneous PTB persisted (adjusted OR 1.96, 95% CI 1.01–3.78).Conclusions. HIV infected pregnant women with concomitant STIs relative to HIV positive pregnant women without a concomitant STI are at increased risk of spontaneous PTB.

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The adverse maternal and perinatal outcomes of adolescent pregnancy: a cross sectional study in Hebei, China

10.21203/rs.2.17282/v2 ◽

2020 ◽

Author(s):

Ting Zhang ◽

Huien Wang ◽

Xinling Wang ◽

Yue Yang ◽

Yingkui Zhang ◽

...

Keyword(s):

Preterm Birth ◽

Pregnant Women ◽

Adolescent Pregnancy ◽

Pregnancy Outcomes ◽

Neonatal Death ◽

Perinatal Outcomes ◽

Hebei Province ◽

Adolescent Group ◽

Adolescent Women ◽

Adverse Pregnancy

Abstract Background The adverse pregnancy outcomes caused by teenage pregnancy are major public health problems with significant social impact, especially in developing countries. While China is the most populous country in the world, and 8.5% of the women aged 10-50 years are adolescent women, we aimed to analyze the adverse maternal and perinatal outcomes of the adolescent pregnant women in Hebei Province, China.Methods There were 238,598 singleton pregnant women aged 10-34 years from January 1, 2013 to December 31, 2017 in the database of Hebei Province Maternal Near Miss Surveillance System (HBMNMSS). The 238,598 pregnant women were divided into two groups: adolescent group (aged 10-19 years) and adult group (aged 20-34 years), the adolescent group was divided into two subgroups (aged 10-17 years, aged 18-19 years). The information that was collected included sociodemographic characteristics, obstetric history, place and mode of delivery, pregnancy outcome, complications during pregnancy. We compared the risk of adverse pregnancy outcomes between the two groups and two subgroups using univariate and multivariate Logistic regression. Results Compared with women aged 20-34 years, women aged 10-19 years had lower risk of cesarean delivery [adjusted risk ratio (aRR): 0.75, 95% confidence interval (CI): 0.70-0.80], gestational diabetes mellitus (GDM) (aRR: 0.55, 95% CI: 0.41-0.73). The women aged 10-19 years had higher risk of preterm birth (aRR: 1.76, 95% CI: 1.54-2.01), small for gestational age (SGA) (aRR: 1.19, 95% CI: 1.08-1.30), stillbirth (aRR: 2.58, 95% CI: 1.83-3.62), neonatal death (aRR: 2.63, 95% CI: 1.60-4.32). The adolescent women aged 10-17 years had significantly higher risk of stillbirth (aRR: 4.83, 95% CI: 2.86-8.14) and neonatal death (aRR: 6.35, 95% CI: 3.16-12.77) compared with the women aged 20-34 years, but there was no association with the risk of incidence of GDM (aRR: 1.03, 95% CI: 0.63-1.68) and SGA (aRR: 1.11, 95% CI: 0.89-1.39). Conclusions The adolescent pregnancy was related to adverse perinatal (fetal and neonatal) outcomes, such as preterm birth, stillbirth and neonatal death, especially in younger adolescent pregnancies (aged 10-17 years).

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Fetomaternal outcome in COVID-19 infected pregnant women: a preliminary clinical study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20203843 ◽

2020 ◽

Vol 9 (9) ◽

pp. 3704

Author(s):

Parul T. Shah ◽

Sapana R. Shah ◽

Sushma R. Shah ◽

Pushpa A. Yadava ◽

Babulal S. Patel ◽

...

Keyword(s):

Preterm Birth ◽

Clinical Study ◽

Pregnant Women ◽

Clinical Characteristics ◽

Severe Pneumonia ◽

Third Trimester ◽

Missed Abortion ◽

Viral Nucleic Acid ◽

Live Births ◽

The Third

Background: WHO has declared COVID-19 infection a health emergency of international concern on 11th March, 2020. It is not clear whether clinical characteristics of pregnant women with COVID-19 differ from those of nonpregnant women and whether it aggravates COVID-19 symptoms and whether antiviral therapy is necessary for COVID-19 infected pregnant women.Methods: This is prospective study of 125 cases based on the compiled clinical data for pregnant women with COVID-19 between 15th April 2020 and 10th June 2020. A laboratory confirmed positive case of COVID-19 infection in pregnant women were included.Results: The most common symptoms at presentation were cough in 61.6% (77/125) and fever in 46.4% (58/125). Other reported symptoms were sore throat in 13.6% (17/125), myalgia in 10.4% (13/125) while 38.4% (48/125) were asymptomatic. There were total 97 deliveries (including 2 twins’ deliveries) among which 3 cases had IUD. Present study reported 96 live births. The incidence of missed abortion was 2.4% (3/125). The incidence of preterm birth before 37 weeks was 8.2% (8/97). Ninety-six (96.9%) of neonates were tested for SARS-CoV-2 viral nucleic acid on nasopharyngeal and pharyngeal samples and 16.67% (16/96) were resulted positive.Conclusions: At present, there is no evidence regarding the greater risk of pregnant women to succumb to COVID-19 infection and experience severe pneumonia. The risks of spontaneous abortion and preterm birth are not increased as reported in this study but shows possibility of vertical transmission when it manifests during the third trimester of pregnancy.

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Management of born too soon preterm birth complicated by preterm premature rupture of membranes

HEALTH OF WOMAN ◽

10.15574/hw.2016.111.58 ◽

2016 ◽

pp. 58-64

Author(s):

O.B. Malanchuk ◽

◽

V.P. Lakatosh ◽

O.U. Kostenko ◽

M.I. Antonuk ◽

...

Keyword(s):

Preterm Birth ◽

Statistical Analysis ◽

Pregnant Women ◽

Neonatal Mortality ◽

Perinatal Complications ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Mortality And Morbidity ◽

Pregnancy And Childbirth ◽

Preterm Premature Rupture

In Ukraine, each year born about 1,000 children ELBW, representing 0.3% of all newborns. The survival of infants with ELBW in our country has a slow upward trend and does not exceed 50%. Infants with ELBW have the highest risk of death and are the group most at risk for the development of chronic diseases of the respiratory and nervous systems and sensory apparatus and associated disability. Considering the growth of the number of children at private ELBW on the background PPROM, high perinatal morbidity and infant mortality, reduced health and reproductive capacity of women becoming urgency tactics of pregnancy and labor with premature rupture of membranes. The objective: perynatalniyh reduce complications in terms of 22-28 weeks of pregnancy complicated by premature rupture of membranes based on developing the tactics of pregnancy and childbirth. Patients and methods. To reduce perinatal complications analyzed the effect of different methods of pregnancy and childbirth on the state of newborns in gestational age 22-28 weeks against the backdrop of premature discharge of amniotic fluid. The control group consisted of 56 women who had less than a day anhydrous term. In the study group applied expectant tactics of anhydrous long term. Depending on the length of the term of anhydrous main group was divided into 2 subgroups. Sub-IA amounted to 86 pregnant women with anhydrous period of 5 days, and IP subgroup totaled 64 pregnant women with anhydrous period of 25 days. Statistical analysis of the results was performed using Microsoft Excel. Probability difference calculated by Student’s t-criterion. Results. Аnalyzing the structure and frequency of obstetric and perinatal complications in women in the period 22-28 weeks of pregnancy with different duration waterless terms, different terms of delivery proved the effectiveness of the tactics of delivery, which is used in perinatal centers m. Kyiv. This correlates with clinical data - statistical analysis of indicators of neonatal mortality and morbidity. Conclusion. Оf the research found that the rates of neonatal mortality and morbidity affecting: duration of anhydrous interval, gestational period, methods of delivery. Long expectant tactics leads to a real reduction of RDS, but an increase in the incidence of chorioamnionitis and neonatal infection. Therefore, wait-recommended tactics for 5 days, followed by delivery of women. At 22-27 weeks of pregnancy delivery path has no impact on rates of neonatal morbidity. The advantage in the delivery of women in the period 27-28 weeks, especially in the immature cervix and pelvic peredlezhenni fetal provided cesarean section. Key words: born too soon preterm birth, preterm premature rupture of membranes, pregnancy, method of delivery, birth with extremely low body weight.

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Frequency and weight of complications of pregnancy and childbirth at women with tuberculosis of various localization in Krasnoyarskiy kraY

Journal of obstetrics and women s diseases ◽

10.17816/jowd63358-65 ◽

2014 ◽

Vol 63 (3) ◽

pp. 58-65

Author(s):

Svetlana Anatolyevna Vetushenko ◽

Tatyana Grigoryevna Zakharova

Keyword(s):

Pregnant Women ◽

Premature Birth ◽

Clinical Manifestations ◽

Perinatal Outcomes ◽

Maternity Hospital ◽

Obstetric Complications ◽

Medical Monitoring ◽

Pregnancy And Childbirth ◽

Prevention And Treatment

The purpose of researches - to reveal clinical manifestations of obstetric complications at pregnant women with tuberculosis of various localization on the basis of results of medical monitoring, and also to establish the complications of fetoplatsentarny insufficiency taking place in the studied period, at pregnant women with tuberculosis according to localizations of tubercular process. During medical monitoring stories of families of 210 women with tuberculosis of various localization and a condition of their newborns during 2006-2013 on the basis of interdistrict maternity hospital N 4 of Krasnoyarsk, profiled on this pathology are analysed. As a result of the analysis of structure of obstetric complications at women with tuberculosis in the territory of Krasnoyarsk Kray it is established: from 210 pregnant women at 76 there were no complications; at 133 pregnant women with FPN clinical manifestations are noted it are 43 cases of a hypoxia of a fruit, 31 cases of SZRP, 14 cases of SZRP with a hypoxia, thus clinical manifestations were accompanied by lack of water and abundance of water at the level of 22 and 4 cases respectively; in the same group the increase in number of complications of pregnancy by a preeklampsiya, anomalies of patrimonial activity, premature birth at the level of 51, 16 and 28 cases respectively is looked through. From only 133 pregnant women with placentary insufficiency 11 cases of childbirth without clinical manifestations of FPN are noted. The revealed number of clinical manifestations of placentary insufficiency and other complications of pregnancy says that at pregnant women with a disease of tuberculosis these indicators many times is more, than at pregnant women without disease of tuberculosis. The established structure of obstetric complications at pregnant women with tuberculosis of various localization highlighted prevalence of FPN proceeding with heavy clinical manifestations, such as SZRP, the fruit hypoxia, and also revealed most often meeting complications of pregnancy, such as a preeklampsiya, abnormal patrimonial activity, premature birth. It is the indication for development of effective measures of prevention and treatment of these complications, their forecasting from early terms of pregnancy for improvement of perinatal outcomes.

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1096. Effect of Diarrheal Illness During Pregnancy on Adverse Birth Outcomes in Nepal

Open Forum Infectious Diseases ◽

10.1093/ofid/ofy210.931 ◽

2018 ◽

Vol 5 (suppl_1) ◽

pp. S328-S329

Author(s):

Kira Newman ◽

Katie Gustafson ◽

Janet Englund ◽

Joanne Katz ◽

Amalia Magaret ◽

...

Keyword(s):

Preterm Birth ◽

Medical Care ◽

Pregnant Women ◽

Birth Outcomes ◽

Low Birthweight ◽

Published Data ◽

Adverse Birth Outcomes ◽

South Asian Population ◽

Adjusted Risk ◽

Diarrheal Illness

Abstract Background Adverse birth outcomes, including low birthweight (LBW), small-for-gestational-age (SGA) and preterm birth, contribute to 60–80% of infant mortality worldwide. Little published data exist on the association between diarrhea during pregnancy and adverse birth outcomes. We sought to identify whether diarrhea during pregnancy was associated with adverse birth outcomes. Methods We used data from a community-based, prospective randomized trial of maternal influenza immunization of pregnant women and their infants conducted in rural Nepal from 2011 to 2014. Illness episodes were defined as at least three watery bowel movements per day for one or more days with 7 diarrhea-free days between episodes. Diarrheal illnesses were identified through longitudinal household-based weekly symptom surveillance. The c2 test, two-sample t-test, and log-binomial regression were performed to evaluate baseline characteristics and the association between diarrhea during pregnancy and adverse birth outcomes. Results Of 3,682 women in the study, 527 (14.3%) experienced one or more episodes of diarrhea during pregnancy. Diarrhea incidence was not seasonal. Women with diarrhea had a median of one episode of diarrhea (interquartile range (IQR) 1–2 episodes) and two cumulative days of diarrhea (IQR 1–3 days). Of women with diarrhea, 16.1% (85) sought medical care. Mean maternal age, parity, biomass cook stove use, home latrine, water source, caste, and smoking did not differ in pregnant women with and without diarrhea. In crude and adjusted analyses, women with diarrhea during pregnancy were significantly more likely to have SGA infants (42.6% vs. 36.8%; adjusted risk ratio=1.20, 95% CI 1.06–1.36, P = 0.005). LBW and preterm birth incidence did not significantly differ between women with diarrhea during pregnancy and those without. There was no significant association between seeking medical care for diarrhea and birth outcomes. Conclusion Diarrheal illness during pregnancy was associated with a significantly higher risk of SGA infants in this rural South Asian population. Interventions to reduce the burden of diarrheal illness during pregnancy may have an impact on SGA births in resource-limited settings. Disclosures All authors: No reported disclosures.

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КОМПЛЕКС ПРОФІЛАКТИЧНИХ ЗАХОДІВ ДЛЯ ВАГІТНИХ ПІСЛЯ ДРТ З ВИСОКИМ РИЗИКОМ ПРЕЕКЛАМПСІЇ

World Science ◽

10.31435/rsglobal_ws/30122020/7279 ◽

2020 ◽

pp. 1-6

Author(s):

Камінський В’ячеслав Володимирович ◽

Коломійченко Тетяна Василівна ◽

Жданович Олексій Ігоревич ◽

Рогава Ірина Володимирівна

Keyword(s):

Pregnant Women ◽

Perinatal Outcomes ◽

Fetal Distress ◽

Pregnancy And Childbirth ◽

System Reduction ◽

Vascular Regulation ◽

Prophylactic Measures ◽

Neonatal Adaptation ◽

Gynecological Care

The purpose of the study: to evaluate the effectiveness of the proposed set of preventive measures for pregnant women after ART with a high risk of preeclampsia. Material and methods. To test the effectiveness of the proposed set of prophylactic measures, 60 pregnant women after ART were selected, which were randomly divided into 2 groups: 30 women who received the recommended complex (main group) and 30 women (comparison group), whose preeclampsia was prevented by order of the Ministry of Health. № 417 "Guidelines for the provision of outpatient obstetric and gynecological care." Results. The use of the recommended measures improves lipid metabolism (significant reduction of triglycerides and low density cholesterol), eliminates vitamin D deficiency, balances the cytokine profile (reduction of proinflammatory focus), reduces the prothrombotic potential of the hemostasis system (reduction of D-dimer and background marker damage). Improving the general condition and the use of psychotherapy can reduce the manifestations of vegetative-vascular dystonia, anxiety and improve quality of life. Such changes provide a more favorable background for the development of gestation. The incidence of preeclampsia decreased by 43.8% (from 26.7 to 15.0%), and mainly due to early preeclampsia, the incidence of which decreased by 78%, no cases of severe preeclampsia were reported. The frequency of placental insufficiency, fetal distress and growth retardation is reduced. The frequency of birth of children in a state of asphyxia is reduced by 2 times (up to 20.0 vs. 46.7%), severe asphyxia is not observed. Significantly lower and the frequency of violations of the period of neonatal adaptation (30.0 vs. 53.3%). Conclusions. The use of treatment and prophylactic complex to prevent preeclampsia in pregnant women after ART can improve a woman's homeostasis, balance vegetative-vascular regulation, reduce the incidence of preeclampsia by 43.8% (from 26.7 to 15.0%) and other complications of pregnancy and childbirth, improve perinatal outcomes. Proven medical, social and economic efficiency of the developed complex allows to recommend it for implementation in medical practice.

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