Breast fibroadenomas are less frequent in women with uterine fibroids

2021 ◽  
pp. 1-4
Author(s):  
Ashraf Moini ◽  
Bita Eslami ◽  
Sadaf Alipour
Keyword(s):  
Sex Hormones ◽  
Uterine Fibroids ◽  
Breast Ultrasound ◽  
Breast Mass ◽  
Pelvic Ultrasound ◽  
Histologic Diagnosis ◽  
Gynecological Disorders ◽  
The Mean ◽  
Criteria For Diagnosis ◽  
Selective Effects

BACKGROUND: The etiology and incidence of Fibroadenoma (FA) as the most frequent benign breast mass and uterine fibroma (UF) as the most benign gynecological disorders are unknown. OBJECTIVE: Considering the dependency of FA and UF to sex hormones, our objective was to investigate the association of these two neoplasms. METHODS: Among women attending the hospital Gynecology Clinic, those with typical uterine fibroids in their pelvic ultrasound constituted cases and those with no pathology the controls. All participants underwent breast ultrasound for FA. Criteria for diagnosis of FA were a typical image for lumps <2 cm in women aged <40 and <1 cm in ages ≥ 40, and a histologic diagnosis for all other participants or larger lumps. RESULTS: The mean age of cases and controls was 42.4 and 41.7 years, respectively. FA were detected in 140 (23%) of all participants; 19.7% of the cases, and 26.2% of the controls (p = 0.07). FA and UF had a borderline reverse association (OR = 0.69, 95% CI = 0.46–1.02, p = 0.07). CONCLUSION: The incidence of FA is lower in patients with UF. Further studies are needed to find the selective effects of estrogen and progesterone on hormonal receptors of these two tumors.

scholarly journals Effect of a Selective Progesterone Receptor Modulator on Induction of Apoptosis in Uterine Fibroids In Vivo

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Petr Horak ◽  
Michal Mara ◽  
Pavel Dundr ◽  
Kristyna Kubinova ◽  
David Kuzel ◽  
...  
Keyword(s):  
Uterine Fibroids ◽  
Premenopausal Women ◽  
Hormonal Treatment ◽  
Control Groups ◽  
Ulipristal Acetate ◽  
Receptor Modulator ◽  
Positive Clinical Effect ◽  
The Mean ◽  
And Control

Aim. To determine if hormonal treatment induces apoptosis in uterine fibroids.Methods. Immunohistochemical examination of fibroid tissue, using avidin-biotin complex and cleaved caspase-3 antibody for detecting apoptosis, was performed in premenopausal women who underwent 12-week treatment with oral SPRM (6 patients with 5 mg and 5 patients with 10 mg of ulipristal acetate per day) or gonadoliberin agonist (GnRHa, 17 patients) and subsequent myomectomy or hysterectomy for symptomatic uterine fibroids. Ten patients with no presurgical hormonal treatment were used as controls.Results. Apoptosis was present in a significantly higher proportion of patients treated with ulipristal acetate compared to GnRHa (P=0.01) and to patients with no hormonal treatment (P=0.01). In contrast to an AI of 158.9 in SPRM patients, the mean AI was 27.5 and 2.0 in GnRHa and control groups, respectively. No statistical difference in the AI was observed between the two groups of patients treated with ulipristal acetate (5 mg or 10 mg).Conclusion. Treatment with ulipristal acetate induces apoptosis in uterine fibroid cells. This effect of SPRM may contribute to their positive clinical effect on uterine fibroids.

scholarly journals CLINICAL PROFILE AND MANAGEMENT OPTION OF FIBROID UTERUS PATIENTS OF OBSTETRICS AND GYNAECOLOGY DEPARTMENT OF DMCH, LAHERIASARAI, BIHAR

2020 ◽  
pp. 1-2
Author(s):  
Sangeeta Singh ◽  
Renu Jha ◽  
Seema Seema ◽  
Debarshi Jana
Keyword(s):  
Uterine Fibroids ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Management Options ◽  
Fibroid Uterus ◽  
Number Of Patients ◽  
Study Results ◽  
The Mean ◽  
Benign Tumours ◽  
Symptomatic Uterine Fibroid

Background: Fibroids are the most common benign tumours of smooth muscle cells of uterus in females and typically found during the middle and later reproductive years. As fibroid is an estrogen and progesterone dependent tumour, it gradually decreases in size during starting of menopause. The objective of this presented study was to determine management options among fibroid uterus patients. Methods: 50 number of patients were included in this study those who’s age of 20-55, with symptomatic uterine fibroid and undergone hysterectomy or myomectomy. Postmenopausal, Pregnancy and Asymptomatic fibroid were excluded from this study. Results: The study showed that 52 percent of patient having fibroid uterus were belonged to 31-40 years of age. The mean age was 41.2±6.07. The majority 74% of patients in this study presented with menstrual abnormalities, 40% presented with abdominal lump. Dysmenorrhoea was 26%, 6% patient had primary subfertility and 14% secondary subfertility. Total Abdominal Hysterectomy (TAH) with unilateral salpingo- oophorectomy done in 10% cases, TAH with bilateral salpino-oophorectomy in 22% cases, non descent vaginal hysterectomy in 6% cases, myomectomy done in 20% cases and polypectomy was done in 2% cases. Conclusion: Uterine fibroids are very common in women and frequently in late reproductive and perimenopausal years. It is also a common gynecological problem in our country, which frequently disturbs the lives of woman. Women now have choice of therapies for the treatment of fibroids.

scholarly journals TO THE QUESTION ON UTERINE FIBROIDS DURING PREGNANCY

2021 ◽  
pp. 54-59
Author(s):  
T. F. TATARCHUK ◽  
N. V. KOSEY ◽  
S. I. REGEDA ◽  
O. V. ZANKO ◽  
K. D. PLAKSIIEVA
Keyword(s):  
Statistical Analysis ◽  
Cesarean Section ◽  
Live Birth ◽  
Uterine Fibroid ◽  
Postpartum Period ◽  
Uterine Fibroids ◽  
Premature Delivery ◽  
Pelvic Ultrasound ◽  
Natural Childbirth ◽  
Increased Risk

Uterine fibroids is an extremely common tumor of the female reproductive system, among whose manifestations are infertility, spontaneous abortions, incorrect fetal position, placenta previa, premature delivery, bleeding during and after delivery, and an increased risk of cesarean section. According to the literature, myomas are changing in size during pregnancy and in the postpartum period. Aim of the study. To assess the dynamics of uterine fibroid size change during pregnancy and the effect of an existing uterine fibroid on the course of pregnancy and labor. Materials and methods. Outpatient records of patients aged 24 to 45 years (mean age 33.36 ± 4.63 years) who were diagnosed with Pregnancy and uterine fibroids from 2016 to 2021 at Verum Medical Center were evaluated (n = 57). The size of the fibroids (volume and diameter) before, during (I or II prenatal screening) and after pregnancy (first pelvic ultrasound after delivery) was used for statistical analysis. Forty-one of the 57 patients had pelvic ultrasound before, during, and after pregnancy and were included in the statistical analysis of changes in uterine myoma size. Results. Among the patients included in the statistical analysis, uterine fibroids increased in volume by 194.38% ± 86.9 (40.98% ± 18.4 in diameter) during pregnancy, and decreased by 53.98% ± 14.93 in diameter and by 54.28% ± 29.62 of baseline in the postpartum period. A significant number of fibroids (39.47%) did undergo involutionary changes and were not visualized in the first postpartum ultrasound. The live birth rate was high at 90% (64% of deliveries were through natural childbirth and 26% through cesarean section). Conclusions. There was no effect of intramural, intramural-subserosal, and subserosal uterine fibroids with an average diameter of £20 mm on pregnancy and live birth in women. A great amount of uterine fibroids nearly triple in size during pregnancy, but after delivery they return to their original size and even halve in size. This can be regarded as a confirmation of the absence of a negative effect of pregnancy, or, possibly, a positive effect on uterine fibroid size, which requires further investigation.

scholarly journals Evaluation of uterine fibroids as a cause of AUB by pelvic ultrasound

2016 ◽  
Vol 7 (3) ◽  
pp. 107 ◽  
Author(s):  
Kriti Handa ◽  
Atul Tayade ◽  
Sushilkumar Kale ◽  
Akshay Phadke
Keyword(s):  
Uterine Fibroids ◽  
Pelvic Ultrasound

scholarly journals A Literature Review of Women’s Sex Hormone Changes by Acupuncture Treatment: Analysis of Human and Animal Studies

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Jade Heejae Ko ◽  
Seung-Nam Kim
Keyword(s):  
Literature Review ◽  
Sex Hormones ◽  
Methodological Quality ◽  
Animal Studies ◽  
Acupuncture Treatment ◽  
Sex Hormone ◽  
Meaningful Change ◽  
Ovarian Dysfunction ◽  
Gynecological Disorders ◽  
Treatment Analysis

Background. It has been known that acupuncture treatment relieves gynecological disorders such as menopause, ovarian dysfunction, and dysmenorrhea. Sex hormones, including estrogen, progesterone, and gonadotropins, are related to the women disease. However, regulative effect of acupuncture on sex hormones has not been fully identified. Methods. Acupuncture articles including analysis of sex hormones were searched in electronic databases from inception to June 2018. The methodological quality was assessed using modified CAMRADES tool. A total of 23 articles were selected and analyzed. Results. In the results, overall studies showed that acupuncture increases estrogen, especially estradiol, progesterone, prolactin, and other hormones. Estradiol level was increased in most of studies except 3 studies which resulted in decreased level or not meaningful change. Two studies showed increase of FSH and LH whereas it was decreased in other studies. Other hormones were mostly increased by acupuncture. Conclusion. This study possibly indicates that acupuncture changes sex hormone in various gynecological conditions in women.

scholarly journals Caesarean myomectomy - a safe procedure: A retrospective case controlled study

1970 ◽  
Vol 2 (2) ◽  
pp. 59-62 ◽  
Author(s):  
Alexander T Owolabi ◽  
Oluwafemi Kuti ◽  
Olabisi M Loto ◽  
Oluwafemiwa N Makinde ◽  
Adebanjo B Adeyemi
Keyword(s):  
Caesarean Section ◽  
Blood Loss ◽  
Post Partum ◽  
Uterine Fibroids ◽  
Controlled Study ◽  
Control Group ◽  
High Dose ◽  
Safe Procedure ◽  
The Mean ◽  
Duration Of Operation

Objective(s): The aim of the study is to determine whether myomectomy at the time of caesarean section leads to increase incidence of intrapartum and postpartum complications. Methods: Fourteen women, with uterine fibroids in pregnancy who were treated by caesarean myomectomy between January 2001 and June 2007, were compared retrospectively with fourteen women, without uterine fibroids who had routine caesarean section during the same period. Myomectomy for all types of myoma was performed at caesarean section after the delivery of the baby. Haemorrhage was controlled with the use of Foleys catheter tourniquet and high dose oxytocin infusion. The cases and control were analysed for age of the patient, parity, pre and post-operative haematocrit levels, duration of operation, blood loss, blood transfusions, and incidence of postpartum fever. Results: Caesarean myomectomy resulted in the mean blood loss of 589 ml (range 300-1300 ml) compared with 518 ml (range 350-850 ml) in the control group (p=0.376). The mean duration of operation was longer in the cases of caesarean myomectomy (66.8 mins) than those of the controls (56.4 mins). There were no significant differences between the two groups in the incidence of intraoperative haemorrhage, the need for blood transfusion, post partum fever, and length of hospital stay. Conclusions: This study shows that myomectomy during caesarean section is a safe procedure in experienced hands and is not as dangerous as generations of obstetricians have been trained to believe. Further research is necessary to establish the cost effectiveness of the procedure. Key words: myomectomy, cesarean section, hemorrhage      doi:10.3126/njog.v2i2.1457 N. J. Obstet. Gynaecol 2007 Nov-Dec; 2 (2): 59 - 62

scholarly journals The Importance of Multimodality Pelvic Ultrasound Simulation in Teaching of Obstetrics and Gynecology Residents

2014 ◽  
Vol 8 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Vaneesha Vallabh-Patel ◽  
Melissa Mendez
Keyword(s):  
Transvaginal Ultrasound ◽  
Obstetrics And Gynecology ◽  
Pelvic Ultrasound ◽  
Ultrasound Simulation ◽  
Post Evaluation ◽  
Evaluation Scores ◽  
Clinical Presentations ◽  
The Subject ◽  
The Mean ◽  
Level Of Understanding

ABSTRACT Objective The use of transabdominal and transvaginal ultrasound is the test of choice in many Obstetrics and Gynecology practices. The objective of our study is to demonstrate how simulated ultrasound teaching could improve residents’ knowledge between PGY1 and PGY2 years in the area of (1) the ability to perform an accurate transabdominal and transvaginal ultrasound in a sensitive manner, (2) to identify and describe normal and abnormal female pelvic sonographic findings for interpretation and (3) to demonstrate clinical sonographic correlation of the most common clinical presentations on pelvic ultrasound. Materials and methods A total of 24 residents participated in this course during their usual scheduled training period from July 2011 to July 2013. Twelve of the 24 residents had previously taken the course 1 year prior and were used to compare changes in their level of understanding of the subject matter. An introductory lecture with a precourse knowledge assessment was initially provided to the residents prior to simulation training. The residents were then randomized into four groups of 2 to 3 residents and provided 45 minutes of training at each simulation station. Results Overall, the mean score for all three stations was noted to be 81.1 and 88.9%, respectively, between PGY1 and PGY2 residents during the 3 years. Conclusion The results of both high fidelity and low fidelity simulations have improved when comparing the increase in scores between the PGY1 and the same learners as PGY2s in the following year. We have shown that of the 12 residents who were able to repeat the course during concurrent years, there was an increase in the post evaluation scores each year. How to cite this article Vallabh-Patel V, Mendez M, Kupesic Plavsic S. The Importance of Multimodality Pelvic Ultrasound Simulation in Teaching of Obstetrics and Gynecology Residents. Donald School J Ultrasound Obstet Gynecol 2014;8(1):1-5.

Ultrasound-Guided Renal Biopsy with Biopsy Gun Technique — Efficacy and Complications

1995 ◽  
Vol 36 (3) ◽  
pp. 276-279 ◽  
Author(s):  
J. Christensen ◽  
S. Lindequist ◽  
D. Ulrik Knudsen ◽  
R. Smith Pedersen
Keyword(s):  
Renal Biopsy ◽  
Severe Hypertension ◽  
Ultrasound Guided ◽  
Histologic Diagnosis ◽  
Biopsy Technique ◽  
Major Complications ◽  
Renal Biopsies ◽  
The Mean ◽  
Adequate Tissue

One hundred and thirty-one ultrasound-guided renal biopsies performed in 127 patients with automated spring-loaded biopsy technique were evaluated. Adequate tissue for histologic diagnosis was obtained in 92% of the procedures (94% of the patients). The mean glomerular yield was 16.8 glomeruli. Complications were seen in 21% of the patients, 18% having minor and 3% having major complications. Patients with severe hypertension had significantly more complications than the rest of the patients. The rate of complications in patients who had 3 or 4 biopsy passes was not increased compared to patients who had one or 2 biopsy passes. Thus, this study indicates that the risk of complications and the safety of the procedure is not influenced by increasing the number of biopsy passes in order to obtain representative specimens.

scholarly journals Prevalence and Management of Dysmenorrhea Among Secondary School Adolescents in Enugu State, Nigeria

2020 ◽  
Author(s):  
Amaka Onu ◽  
Deborah Aluh ◽  
Michael Ikehi
Keyword(s):  
Management Practices ◽  
Common Symptom ◽  
Management Options ◽  
Cross Sectional ◽  
Gynecological Disorders ◽  
Menstrual Symptoms ◽  
Significant Difference ◽  
The Mean ◽  
Enugu State ◽  
Descriptive Survey

Abstract Background: Dysmenorrhea is reported to be among the most common gynecological disorders worldwide. The current study aimed to determine the prevalence and management practices for dysmenorrhea among adolescent school girls in Nigeria. The study also aimed to determine the predictors for choosing a management option for dysmenorrhea.Methods: The study was a cross-sectional descriptive survey conducted in five conveniently selected secondary schools (high schools) in Enugu State. A 12-item questionnaire including a Visual Analog Scale was used to collect data. All data were analyzed using SPSS with significance set at p<0.05.Results: A total of 1,486 survey questionnaires were completed (88.45% response rate). The mean age of the study respondents was 15.26±1.517. The prevalence of dysmenorrhea was 51.1%. There was a significant difference (t =-6.299, p < 0.001) between the ages of the dysmenorrheic girls (15.50±1.466) and the ages of girls who were not dysmenorrheic (15.01±1.529). The mean age of Menarche was 12.64±1.450. Pain in the waist was the most common symptom reported among the respondents (57.4%, n = 853). More than one-third of the respondents reported that they take OTC medications for menstrual symptoms (31.8%, n = 472). Age and severity of dysmenorrhea significantly predicted the likelihood of taking a pharmacological agent for dysmenorrhea.Conclusion: Younger females were more likely to do nothing about menstrual pain. There is a need for adolescents to be educated on the safety and efficacy of different management options for dysmenorrhea early.

REPRODUCTIVE ASPECTS IN BRAZILIAN CELIAC WOMEN

2020 ◽  
Vol 57 (1) ◽  
pp. 107-109
Author(s):  
Lorete Maria da Silva KOTZE ◽  
Andyara MALLMANN ◽  
Rebeca C MIECZNIKOWSKI ◽  
Kadija Rahal CHRISOSTOMO ◽  
Luiz Roberto KOTZE ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Retrospective Study ◽  
Control Group ◽  
Spontaneous Abortions ◽  
Healthy Group ◽  
Gynecological Disorders ◽  
Significant Difference ◽  
The Mean ◽  
Age Of Menarche ◽  
Menarche Age

ABSTRACT BACKGROUND: Celiac disease (CD) is a chronic enteropathy in response to ingestion of gluten. CD was associated with gynecological disorders. OBJECTIVE: In this retrospective study, we aimed to investigate the age of menarche, age of menopause, number of pregnancies and abortions in Brazilian celiac patients. METHODS: We studied 214 women diagnosed with CD and as control group 286 women were investigated. RESULTS: Regarding the mean age of menarche, a significant difference was found (12.6±1.40 in CD and 12.8±1.22 years in healthy group; P=0.04). Regarding abortions, in CD women 38/214 (17.8%) and 28/286 (9.8%) in the control group reported abortion (P=0.0092, OR:1.98; CI95%=1.1- 3.3). There was no significant difference in the mean age of menopause nor number of pregnancies per woman. CONCLUSION: In this study, we found that celiac women had a higher mean age of menarche and higher risk of spontaneous abortions.

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