Therapeutic effects of synbiotic on neonates with gestational age over 34 weeks admitted for jaundice

2021 ◽  
pp. 1-7
Author(s):  
S.A.H. Nouri ◽  
M.H. Mohammadi ◽  
Y.N. Moghaddam ◽  
A.H. Rad ◽  
M. Zarkesh
Keyword(s):  
Gestational Age ◽  
Mode Of Delivery ◽  
Intervention Group ◽  
Therapeutic Effects ◽  
Double Blind ◽  
Double Blind Clinical Trial ◽  
Hospitalization Period ◽  
Duration Of Hospitalization ◽  
Discharged Patients ◽  
The Mean

BACKGROUND: Hyperbilirubinemia is a common problem in neonates. The aim of this study was to evaluate the effect of synbiotic in addition to routine phototherapy on the treatment of neonatal jaundice. METHOD: This double-blind clinical trial, was performed on 194, 3–14 days old neonates. Neonates were divided into intervention and placebo groups. The intervention group received 5 drops of oral synbiotic daily along with phototherapy and the placebo group underwent phototherapy plus a placebo. Gestational age, age, weight, sex, initial and daily bilirubin level, frequency of defecation, mode of delivery, and length of hospitalization were assessed. RESULTS: The rate of bilirubin reduction on the first day of admission was significantly higher in the intervention group (2.9±1.81 vs. 2.06±1.93, p = 0.002). The mean level of bilirubin on the second (9.8±1.92 vs. 10.88±2.26) and third days (8.06±1.54 vs. 9.86±1.7) was lower in the intervention group (p = 0.001). The proportion of discharged patients in the third and fourth days was higher in the intervention group compared to the control (65% vs. 41%, 99% vs. 86.5%, respectively, p = 0.001). However, the duration of hospitalization was shorter in the intervention group compared to the control (2.36±0.5 vs. 2.74±0.74, p = 0.001). CONCLUSION: Based on our results, daily treatment with 5 drops of synbiotic along with phototherapy can be a safe and effective modality in faster bilirubin reduction, decreasing the hospitalization period and phototherapy. Therefore, it seems that it can be used as an adjunct therapy for neonates with jaundice.

scholarly journals Using Local Nigella Sativa Oil to Relief Premenstrual Syndrome Symptoms

2021 ◽  
Author(s):  
Ezat Samadipour ◽  
Roya Akbarzadeh ◽  
Akram Kooshki
Keyword(s):  
Premenstrual Syndrome ◽  
Nigella Sativa ◽  
Intervention Group ◽  
Analysis Of Covariance ◽  
Double Blind ◽  
Analgesic Effects ◽  
Nigella Sativa Oil ◽  
Double Blind Clinical Trial ◽  
Analgesic Supplement ◽  
The Mean

Background: Premenstrual Syndrome (PMS) is a common problem in women. Nigella sativa has been suggested for its anti-inflammation and analgesic effects. This study was conducted to evaluate the effect of Nigella sativa oil on PMS. Methods: This double-blind clinical trial was conducted on 124 female students within the age range of 18-25 years living in the dormitories of Sabzevar University of Medical Sciences. Participants were randomly divided into two groups. The intervention group (IG) rubbed 1-2 drops of Nigella sativa oil on their fontanels at night for sev­en days before their three menstrual cycles. The placebo group (PG) rubbed placebo in the same way. After three cycles, pain severity was measured by the visual analog scale. Data analysis was carried out using the Mann-Whitney U test and analysis of covariance. Results: The mean age of participants, the mean age of menarche, and the mean age of PMS onset were 20.55 ± 0.2, 13.52 ± 0.15, and 15.35 ± 0.3 years old, respectively. The results showed that Nigella sativa oil reduced the severity of all PMS symptoms except in terms of depression and abdominal bloating in IG compare to the PG. Conclusion: Nigella sativa oil in women with premenstrual syndrome can be a promising, safe, and easily available analgesic supplement.

scholarly journals Therapeutic Effects of Ursodeoxycholic Acid in Neonatal Indirect Hyperbilirubinemia; a Randomized Double-Blind Clinical Trial

2019 ◽  
Author(s):  
Iraj Shahramian ◽  
Kaveh Tabrizian ◽  
Pouya Ostadrahimi ◽  
Mahdi Afshari ◽  
Mahdieh Soleymanifar ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Ursodeoxycholic Acid ◽  
Total Bilirubin ◽  
Intervention Group ◽  
Total Bilirubin Level ◽  
Direct Bilirubin ◽  
Therapeutic Effects ◽  
Double Blind ◽  
Double Blind Clinical Trial ◽  
Double Blinded

Background: Ursodeoxycholic acid (UDCA) is a safe drug used in the treatment of cholestatic liver disorders in children. The aim of this study was to investigate the synergistic effect of UDCA in combination with phototherapy in treating indirect neonatal hyperbilirubinemia. Methods: Present double-blinded, randomized clinical trial was conducted among neonates with jaundice who were under treatment with phototherapy in the neonatal ward affiliated with the Zabol University of Medical Sciences in 2017. The patients (200 neonates) were randomly divided into intervention (phototherapy+ UDCA) and control (phototherapy alone) groups. The intervention group received 15 mg/kg UDCA daily. Results: Total bilirubin levels at birth, 24, 48, and 72 hours after therapy were 16.89± 2.49, 14.28± 2.05, 11.62± 2.46, and 10.26± 1.92 mg/dl in controls and 15.79± 2.18, 12.77± 1.86, 10.08± 1.66, and 8.94± 1.38 mg/dl in intervention group respectively (P< 0.001). The ratio of neonates with total bilirubin< 10 mg/dl were 28% and 55% after 48 hours, and 64% and 90% after 72 hours of therapy initiation in phototherapy alone and phototherapy+ UDCA groups respectively (P< 0.001). The mean reduction of direct bilirubin was not significantly different between the groups. Conclusion: UDCA was effective in accelerating reduction of total bilirubin level in neonates with unconjugated hyperbilirubinemia under phototherapy but had no effect on direct bilirubin levels.

Therapeutic Effects of Hab Shabyar on Open-Angle Glaucoma: A Double-Blinded, Randomized, Placebo-Controlled Trial

2019 ◽  
Vol 8 ◽  
pp. 1218
Author(s):  
Ebrahim Khalil BaniHabib ◽  
Ali Mostafai ◽  
Seyyed Mohammad Bagher Fazljou ◽  
Ghadir Mohammdi
Keyword(s):  
Placebo Group ◽  
Intraocular Pressure ◽  
Open Angle Glaucoma ◽  
Controlled Trial ◽  
Intervention Group ◽  
Therapeutic Effects ◽  
Open Angle ◽  
The Mean ◽  
The Right ◽  
Double Blinded

Background: Open-angle glaucoma (OAG) is one of the leading causes of blindness worldwide. This study evaluates the therapeutic effects of hab shabyar in patients with open-angle glaucoma. Materials and Methods: In this clinical randomized controlled trial, 50 patients with OAG were randomized into two groups. The intervention group was received a drop of timolol plus 500 mg of hab shabyar every 12 hours. The placebo group was received a drop of timolol every 12 hours plus 500 mg of wheat germ as a placebo. The intraocular pressure in patients with OAG was measured in each group and compared at before the intervention (t1), one month (t2), and two months (t3) after the intervention. Results: The mean decrease in intraocular pressure for the right eye at three times in the intervention group was statistically significant, but the mean decrease in the placebo group was not significant. Similar results were obtained for the left eye at t1 when compared to t3. The patients in the intervention group expressed more satisfaction than the patients in the placebo group (P≤0.001). Conclusion: Our study demonstrated that consumption of timolol plus hab shabyar instead of consuming of timolol alone was probably more effective for reducing intraocular pressure in patients with OAG.[GMJ.2019;In press:e1218]

The effect of ear acupressure medicine at the “Shen Men” point on the nausea and vomiting during pregnancy

2021 ◽  
Vol 15 (5) ◽  
pp. 1774-1779
Author(s):  
Sanaz Nehbandani ◽  
Hajar Salehi ◽  
Khadije Rezaie Keikhaie ◽  
Hossein Rashki Ghalenow ◽  
Fatemeh Mirzaie ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Intervention Group ◽  
Nausea And Vomiting ◽  
Control Group ◽  
Health Clinics ◽  
Significant Difference ◽  
Quasi Experimental ◽  
The Mean ◽  
The Difference

Introduction & Objective: Nausea and vomiting during pregnancy is one of the most common gastrointestinal disorders that more than 85% of pregnant women experience. However, controlling and treating this complication is still one of the most important issues in antenatal care. Therefore, the aim of this study was to investigate the effect of ear acupressure at Shen Men point on relieving nausea, vomiting and retching during pregnancy. Materials and Methods: In this quasi-experimental study, 100 pregnant women with a gestational age of less than 16 weeks attending the health clinics of Zabol city during 2019-2020 were studied in two control and intervention groups (n = 50 in each group). The samples in the intervention group were trained to apply pressure on their ears’ Shen Men point with the thumb for three minutes three times a day (morning, noon, and night), for a duration of one month. At the end of second and fourth weeks, the data were collected using the Rhodes index form and then, were analyzed by SPSS software version 22. Results: According to the results, there was no significant difference between the two groups in terms of age, gestational age, occupation and education. The difference in the mean scores of nausea, vomiting and retching was not statistically significant between the control and intervention groups before the study. But four weeks after the study, a significant difference was observed in the mean scores of vomiting, nausea and retching between the two groups, so that the mean scores of vomiting, nausea and retching were significantly lower in the intervention group than in the control group. Conclusion: The ear acupressure medicine at the Shen men point can be used as a non-invasive, safe and inexpensive method to relieve nausea, vomiting and retching during pregnancy. Keywords: Acupressure medicine, Shen Men, Vomiting, Pregnancy, Nausea, Retching, Rhodosis

scholarly journals Effect of probiotics supplementation on acute diarrhea in infants: a randomized double blind clinical trial

2007 ◽  
Vol 47 (4) ◽  
pp. 172
Author(s):  
I Gusti Ngurah Sanjaya Putra ◽  
Sudaryat Suraatmaja ◽  
I Ketut Nomor Aryasa
Keyword(s):  
Treatment Group ◽  
Immune Responses ◽  
Acute Diarrhea ◽  
Relative Risk Reduction ◽  
Cox Regression ◽  
Clinical Effects ◽  
Double Blind ◽  
Standard Management ◽  
Double Blind Clinical Trial ◽  
The Mean

Background Probiotics has advantages as a supplement formanagement of infants with acute diarrhea. It influences theduration of diarrhea by enhancing immune responses, elaboratesantimicrobial substances and occupies intestinal mucosal sites,inhibits the attachment and the growth of pathogenic organismsby achieving competitive exclusion and microbial balance.Objective To assess the clinical effects of probiotics supplementationon acute diarrhea in infants.Methods This was a double blind, randomized clinical controlledtrial performed on infants aged 1-12 months old with acutediarrhea, hospitalized in Sanglah Hospital, Denpasar. Subjectswere divided into two groups; the treatment group had standardmanagement with adjuvant probiotics, while the control groupreceived standard management with placebo.Results From 70 infants enrolled in this study, the mean durationof diarrhea in treatment group was significantly shorter than thatin the placebo group, 49.03 hours (SE 3.09) (95%CI 42.98;55.08)vs 73.03 hours (SE 3.28) (95%CI 66.61;79.45); P=0.001.Regarding failure of the treatment, probiotics supplementationhad relative risk reduction (RRR) of 67% and absolute riskreduction (ARR) of 57%. In multivariate cox regression analysisit was found that only probiotics supplementation influenced theduration of acute diarrhea in infants.Conclusion Probiotics can shorten the duration of acute diarrhea,and is safe as an adjuvant to standard management for infantswith acute diarrhea.

scholarly journals The Effect of Oral Administration of Amantadine on Neurological Outcome of Patients With Diffuse Axonal Injury in ICU

2019 ◽  
Vol 13 ◽  
pp. 117906951882485 ◽  
Author(s):  
Rahman Abbasivash ◽  
Mohammad Amin Valizade Hasanloei ◽  
Aidin Kazempour ◽  
Ata Mahdkhah ◽  
Mir Mehdi Shaaf Ghoreishi ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Oral Administration ◽  
Axonal Injury ◽  
Diffuse Axonal Injury ◽  
Double Blind ◽  
Neurological Outcomes ◽  
Double Blind Clinical Trial ◽  
Significant Difference ◽  
The Mean ◽  
Time Of Admission

Traumatic brain injury is a major cause of death and disability in adults. This study investigated the effect of oral administration of amantadine on the neurological outcomes of patients with diffuse axonal injury (DAI) in the intensive care unit (ICU). This double-blind clinical trial was conducted in the ICU of Imam Hospital in Urmia. Patients with DAI were intubated and received mechanical ventilation in the ICU. They were divided into 2 groups: patients receiving amantadine (A) and placebo (P). The acquired data were analyzed using SPSS, P < .05 significant level. Findings showed no significant difference between the 2 groups in age and sex. There was no significant difference between the mean Glasgow Coma Scale (GCS) at the time of admission and discharge, and the mean Glasgow Outcome Scale (GOS) of the patients in 2 groups. No significant difference was observed in the duration of mechanical ventilation, hospitalization, and mortality in both groups ( P > .05) in ICU. However, there was a significant difference between the mean GCS at the time of admission and discharge and death. Also, significant differences existed between the mean GOS in discharged and deceased patients ( P = .001). This study showed no significant difference between the mean GCS at the time of admission and discharge and the mean GOS of the discharged patients and the mortality rate in the 2 groups. However, there were clear statistical differences between these variables in discharged and deceased patients. It is recommended that further studies are conducted with a larger sample size.

The Efficacy of N-acetilcysteine for the Treatment of the Metamfetamin-addicted Patients Under Methadon Therapy: A Double-blind Clinical Trial

2020 ◽  
Vol 22 (7) ◽  
Author(s):  
Farzaneh Karami ◽  
Fateme Assarian ◽  
Fatemeh Sadat Ghoreishi ◽  
Mojtaba Sehat
Keyword(s):  
Methadone Treatment ◽  
Severity Index ◽  
Addiction Severity Index ◽  
Double Blind ◽  
Addiction Severity ◽  
Methamphetamine Dependence ◽  
Double Blind Clinical Trial ◽  
The Mean ◽  
To Receive ◽  
The Brain

Background: Methamphetamine dependence is a growing global problem. Currently, there are no approved pharmacotherapy options for the management of methamphetamine dependence. One of the alternatives to manage this addiction is the use of N acetylcysteine (NAC) due to its capacity to restore homeostasis in the brain glutamate systems disrupted in addiction and its ability to reduce craving and the risk of relapse. Methods: Methamphetamine‐dependent volunteers under methadone treatment (n = 38) were randomized to receive daily doses of 1200 mg of NAC, or placebo. The participants were followed for 12 weeks (two visits weekly). Craving and Beck Inventory Depression (BDI) was determined at the beginning of the study and also after one month, two months, and three months. Addiction severity index (ASI) was recorded at the beginning of the study and after three months. The data were analyzed via SPSS version 16.0 (SPSS Inc. Chicago, Illinios, USA) Results: The mean score of craving and BDI reduced after two months with NAC treatment. ASI (e.g., substance, familial, and psychiatric categories) was significantly reduced at the end of the study in the NAC group compared to placebo (P < 0.001). The success of the treatment in groups of NAC and placebo were 84% and 73%, respectively (P = 0.001). 63.2% of the NAC group patients avoided substance use for more than a month, but this was 10.5% in the placebo group (P = 0.001). Conclusions: The NAC showed good efficacy in suppressing methamphetamine craving, addiction severity index, and depression. It may be a useful pharmacological treatment for methamphetamine dependency.

scholarly journals The Effect of Probiotics on Childhood Constipation: A Randomized Controlled Double Blind Clinical Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
M. Sadeghzadeh ◽  
A. Rabieefar ◽  
P. Khoshnevisasl ◽  
N. Mousavinasab ◽  
K. Eftekhari
Keyword(s):  
Abdominal Pain ◽  
Weight Gain ◽  
Fecal Incontinence ◽  
Controlled Trial ◽  
Intervention Group ◽  
Double Blind ◽  
Positive Role ◽  
Randomized Controlled ◽  
Double Blind Clinical Trial

Background. Inconsistent data exist about the role of probiotics in the treatment of constipated children. The aim of this study was to investigate the effectiveness of probiotics in childhood constipation.Materials and Methods. In this placebo controlled trial, fifty-six children aged 4–12 years with constipation received randomly lactulose plus Protexin or lactulose plus placebo daily for four weeks. Stool frequency and consistency, abdominal pain, fecal incontinence, and weight gain were studied at the beginning, after the first week, and at the end of the 4th week in both groups.Results. Forty-eight patients completed the study. At the end of the fourth week, the frequency and consistency of defecation improved significantly (P=0.042andP=0.049, resp.). At the end of the first week, fecal incontinence and abdominal pain improved significantly in intervention group (P=0.030andP=0.017, resp.) but, at the end of the fourth week, this difference was not significant (P=0.125andP=0.161, resp.). A significant weight gain was observed at the end of the 1st week in the treatment group.Conclusion. This study showed that probiotics had a positive role in increasing the frequency and improving the consistency at the end of 4th week.

scholarly journals Maternal and perinatal outcome in severe preeclampsia and eclampsia at the Rivers State university teaching hospital, Nigeria

2020 ◽  
Vol 9 (11) ◽  
pp. 4389
Author(s):  
Peter A. Awoyesuku ◽  
Dickson H. John ◽  
Dickson H. John ◽  
Lewis B. Lebara ◽  
Lewis B. Lebara
Keyword(s):  
Birth Weight ◽  
Teaching Hospital ◽  
Gestational Age ◽  
Mode Of Delivery ◽  
Case Fatality ◽  
Severe Preeclampsia ◽  
University Teaching ◽  
State University ◽  
The Mean ◽  
Rivers State

Background: Severe preeclampsia and eclampsia remain a challenge in tropical obstetric practice. It is a major contributor to feto-maternal morbidity and mortality in developing countries. This study seeks to determine the prevalence, associated risk factors and the feto-maternal outcome of severe preeclampsia and eclampsia at the rivers state university teaching hospital (RSUTH).Method: A retrospective study of all women who had severe preeclampsia and eclampsia and were delivered at the RSUTH in a two-year period, 1ST January 2018 to 31ST December 2019, was carried out. Data on patients’ age, parity, education, booking status, gestational age at delivery, diagnosis, complications, mode of delivery and fetal sex, birth weight and Apgar scores were retrieved using structured pro-forma. Data were analyzed using SPSS version 20.Results: There were 4496 deliveries of which 128 had severe preeclampsia and eclampsia, giving a prevalence of 2.85%. Of these, 94 (73.4%) had severe preeclampsia and 34 (26.6%) had eclampsia. The mean age of the women ± SD was 29.84±5.44 years, median parity was para 1, and mean gestational age ± SD was 35.38±3.84 weeks. There were 10 maternal deaths giving case fatality of 7.8%. The mean birth weight ± SD was 2.61±0.91 kg and stillborn rate was 14.4%. There was significant association with maternal age, education, booking status, method of delivery and Apgar score of the baby.Conclusion: The prevalence in this study is high with associated high maternal mortality and stillborn rates. Timely and appropriate intervention including primary management and judicious termination of pregnancy will reduce mortality of mother and fetus.

scholarly journals Effect of Aromatherapy with Lavender 10% Essential Oil on Motor Function, Speech and Delirium in Patients with Acute Thrombotic Cerebral Ischemia

2019 ◽  
Vol 5 (2) ◽  
pp. 49-55
Author(s):  
Shiva Seyed Salehi ◽  
◽  
Zahra Lorigooini ◽  
Nahid Jivad ◽  
Keyvan Ghadimi ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Essential Oil ◽  
Motor Function ◽  
Intervention Group ◽  
Herbal Medicines ◽  
T Test ◽  
Double Blind ◽  
Significance Level ◽  
Significant Difference ◽  
The Mean

Background: Stroke is one of the most disabling diseases worldwide. Herbal medicines, especially lavender, have been used to treat ischemic diseases today. Objectives: The aim of our study was to investigate the effect of aromatherapy with lavender 10% essential oil on motor function, speech and delirium in acute thrombotic cerebral ischemia patients. Materials & Methods: In this double blind clinical trial, 70 patients with acute thrombotic cerebral ischemia were enrolled. Patients were randomly assigned into two equal groups; the first group received lavender essential oil (10%) as aromatherapy, and the second group received placebo. Motor function, speech and delirium scores were calculated using standard questionnaire before and one week after treatment. The level of antioxidants and melancholically was also measured in post-treatment patients .Data were analyzed in SPSS V. 18 using descriptive statistics and paired t-test and independent t-test with a significance level of P<0.05 Results: There was no significant difference between the two groups in terms of demographic information, motor function, speech and delirium scores (P>0.05). After treatment, the mean scores of motor function, speech and delirium were changed significantly in both groups, and the mean of these scores in the intervention group was significantly less than placebo, and in the intervention group the level of antioxidants was significantly higher and level of malondialdehyde was significantly less than placebo group (P<0.05). Conclusion: Using lavender 10% essential oil in our study improved the symptoms of patients such as motor function, speech and delirium after ischemic thrombolytic stroke. This is associated with decrease in malondialdehyde level and an increase in the level of antioxidants.

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