In the course of an investigation on the uptake of labelled ions by the rabbit embryo and its environment (Lutwak-Mann, Boursnell, & Bennett, 1960), experiments were done on pre-implantation blastocysts obtained from rabbits which had been treated parenterally with certain purine analogues. Histological examination of such blastocysts by the method of Moog & Lutwak-Mann (1958) showed that, as a result of treatment of the pregnant animals, the embryos had incurred severe damage chiefly localized in the embryonic disc. This observation prompted a wider study, reported below, of the action of various agents upon the early rabbit embryo, following their administration to the mother. Our investigation was chiefly concerned with the pre-implantation 6½-day-old blastocyst, but 5- and 7-day embryos were also examined. At the same time we have studied the influence of some of these agents upon ovulation, fertilization, and cleavage, as well as on implantation and later stages of pregnancy.