scholarly journals Comparison of Chest X-Ray Findings Between Primary and Secondary Multidrug Resistant Pulmonary Tuberculosis

2021 ◽  
Vol 5 (4) ◽  
pp. 855-862
Author(s):  
Ricky Septafianty ◽  
Anita Widyoningroem ◽  
M. Yamin S. S ◽  
Rosy Setiawati ◽  
Soedarsono
Keyword(s):  
Pulmonary Tuberculosis ◽  
Multidrug Resistant ◽  
X Rays ◽  
Pulmonary Tb ◽  
X Ray ◽  
Pleural Thickening ◽  
Significant Difference ◽  
Record Data ◽  
Mdr Tb ◽  
Chest X Ray

Introduction: Radiological imaging has a key role in multidrug-resistant (MDR) pulmonary tuberculosis (TB) screening and diagnosis. However, new cases of MDR pulmonary TB are often overlooked; therefore, its transmission might continue before its diagnosis. The most widely used and affordable radiological modality is a chest radiograph. This study aims to describe the characteristics of primary and secondary MDR pulmonary TB chest x-ray findings for differential diagnosis. Methods: This study was an analytic observational study with a retrospective design. Researchers evaluated medical record data of primary and secondary MDR pulmonary TB patients who underwent chest x-ray examinations. The patient's chest x-rays were then evaluated. Evaluated variables were lung, pleural, and mediastinal abnormalities and severity category. Results: The most common chest x-ray finding in primary MDR pulmonary TB was consolidation (96.2%), which was mostly unilateral (52.0%), accompanied by cavities (71.2%), most of which were multiple (83.8%) with a moderate category of severity. The most common chest x-ray finding in secondary MDR pulmonary TB was consolidation (100%), which was mostly bilateral (60.4%), accompanied by cavities (80.2%), most of which were multiple (90.1%) with severe category of severity. Pleural thickening (47.5%) was also found. Conclusion: There was a significant difference between primary and secondary MDR pulmonary TB in terms of mild severity category, and pleural thickening. Mild severity category is mostly found in primary MDR-TB and pleural thickening is mostly found in secondary TB.

scholarly journals Comparison of Chest X-Ray Findings Between Primary and Secondary Multidrug Resistant Pulmonary Tuberculosis

2021 ◽  
Vol 5 (10) ◽  
pp. 903-910
Author(s):  
Ricky Septafianty ◽  
Anita Widyoningroem ◽  
M. Yamin S. S ◽  
Rosy Setiawati ◽  
Soedarsono
Keyword(s):  
Pulmonary Tuberculosis ◽  
Multidrug Resistant ◽  
X Rays ◽  
Pulmonary Tb ◽  
X Ray ◽  
Pleural Thickening ◽  
Significant Difference ◽  
Record Data ◽  
Mdr Tb ◽  
Chest X Ray

Introduction: Radiological imaging has a key role in multidrug-resistant (MDR) pulmonary tuberculosis (TB) screening and diagnosis. However, new cases of MDR pulmonary TB are often overlooked; therefore, its transmission might continue before its diagnosis. The most widely used and affordable radiological modality is a chest radiograph. This study aims to describe the characteristics of primary and secondary MDR pulmonary TB chest x-ray findings for differential diagnosis. Methods: This study was an analytic observational study with a retrospective design. Researchers evaluated medical record data of primary and secondary MDR pulmonary TB patients who underwent chest x-ray examinations. The patient's chest x-rays were then evaluated. Evaluated variables were lung, pleural, and mediastinal abnormalities and severity category. Results: The most common chest x-ray finding in primary MDR pulmonary TB was consolidation (96.2%), which was mostly unilateral (52.0%), accompanied by cavities (71.2%), most of which were multiple (83.8%) with a moderate category of severity. The most common chest x-ray finding in secondary MDR pulmonary TB was consolidation (100%), which was mostly bilateral (60.4%), accompanied by cavities (80.2%), most of which were multiple (90.1%) with severe category of severity. Pleural thickening (47.5%) was also found. Conclusion: There was a significant difference between primary and secondary MDR pulmonary TB in terms of mild severity category, and pleural thickening. Mild severity category is mostly found in primary MDR-TB and pleural thickening is mostly found in secondary TB.

scholarly journals Chest X-ray patterns of pulmonary multidrug-resistant tuberculosis in children in a high HIV-prevalence setting

2016 ◽  
Vol 20 (1) ◽  
Author(s):  
Samuel Manikkam ◽  
Moherndran Archary ◽  
Raziya Bobat
Keyword(s):  
Multidrug Resistant ◽  
Mediastinal Lymphadenopathy ◽  
X Rays ◽  
X Ray ◽  
Tb Treatment ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb ◽  
Chest X Ray ◽  
Ray Patterns

Background: Paediatric multidrug-resistant tuberculosis (MDR-TB) necessitates a prolonged duration of treatment with an intensive treatment regimen. The chest X-ray patterns of pulmonary TB depend on a multiplicity of factors, including immune status, and therefore identifying the influence of HIV on the chest X-ray appearances of MDR-TB may assist with improving the diagnostic criteria. Objectives: To describe the demographic characteristics and chest X-ray patterns of children with pulmonary MDR-TB and to compare the chest X-ray patterns of pulmonary MDR-TB between children who are HIV-infected and HIV-uninfected.Method: Retrospective chart review of hospital notes and chest X-rays of children with pulmonary MDR-TB at King Dinuzulu Hospital, Durban. The chest X-rays were systematically reviewed for the presence of the following variables: hilar/mediastinal lymphadenopathy, bronchopneumonic opacification, segmental/lobar consolidation, cavities, miliary opacification and pleural effusion.Results: Forty-five children (mean age, 6.29 years; median age, 6.00 years) with pulmonary MDR-TB met the inclusion criteria. The most common chest X-ray finding was consolidation (53.5%), followed by lymphadenopathy (35.6%), bronchopneumonic opacification (33.3%) and cavities (31.1%). Cavities were more common (OR 6.1; 95% CI 1.52–24.66) in children who had been initiated on standard anti-TB treatment for the current TB episode. There were no statistically significant differences in any of the chest X-ray patterns in HIV-uninfected (n = 22) compared with HIV-infected (n = 20) children. Conclusion: The most common chest X-ray finding was consolidation, followed by lymphadenopathy, bronchopneumonic opacification and cavities. The finding of a significantly higher frequency of cavities in children who had received prior standard anti-TB treatment for the current TB episode could reflect poor disease containment and increased parenchymal damage, owing to a delay in the recognition of MDR-TB. The development of cavitation in chest X-rays of children with TB could raise concern for the possibility of MDR-TB, and prompt further testing.

scholarly journals Therapeutic effect of cycloserine combined with anti-tuberculosis drugs in the treatment of multidrug-resistant tuberculosis

2022 ◽  
Vol 20 (2) ◽  
pp. 419-424
Author(s):  
Yang Zhao ◽  
Mabin Si ◽  
Zhihui Li ◽  
Xiulei Yu
Keyword(s):  
Ct Scan ◽  
Multidrug Resistant ◽  
Chest Ct ◽  
Case Detection Rate ◽  
X Ray ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Before And After ◽  
Mdr Tb ◽  
Chest X Ray

Purpose: The present study analyzes the comprehensive therapeutic effect of cycloserine, in combination with anti-tuberculosis drugs using chest X-ray and chest CT (computed tomography) scan techniques. Methods: A total of 90 patients, diagnosed with multidrug resistant tuberculosis (MDR TB) were subjected to chest x-ray and CT scan before and after treatment in the two groups. Different views such as sagittal, coronal, lung window and multiplanar imaging of mediastinal window were taken. Some parameters such as case detection rate (CDR) in chest X-ray and CT scan and comprehensive curative effect were observed in two groups. Further, the changes in chest CT signs in addition to absorption of focus, cavity closure and changes in CT extra pulmonary signs were also observed. Results: The clinical profile of the patients and the course of disease were statistically insignificant (p > 0.05). Total effectiveness rate and case detection rate (CDR) values exhibited a significant difference between the groups (p < 0.05). Lung consolidation, nodules and cavities significantly improved in both groups before and after the treatment (p < 0.05). Both groups showed significant improvements in extrapulmonary signs in CT scan (p < 0.05) after the treatment. Conclusion: Based on the study outcomes, the CT scan method has good potentials for diagnosing and treating MDR TB at the early stages. Further, it can clarify the signs and outcomes of the disease at early stages, thus providing the medical fraternity a great opportunity to cure the disease.

scholarly journals Factors Associated with Participation in Pulmonary Tuberculosis Screening Using Chest X-Ray among Diabetes Mellitus Type II Patients in Denpasar, Bali, Indonesia

2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
I Gusti Ngurah Edi Putra ◽  
Putu Ayu Swandewi Astuti ◽  
I Ketut Suarjana ◽  
Ketut Hari Mulyawan ◽  
I Made Kerta Duana ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Health Insurance ◽  
Pulmonary Tuberculosis ◽  
Health Provider ◽  
Type Ii ◽  
Cross Sectional ◽  
Pulmonary Tb ◽  
X Ray ◽  
Factors Associated ◽  
Chest X Ray

Diabetes mellitus (DM) increases the risk of developing pulmonary tuberculosis (TB) disease. Therefore, pulmonary TB screening among DM patients is essential. This study aimed to identify factors associated with participation of DM type II patients in pulmonary TB screening using chest X-ray. This was a cross-sectional analytic study and was part of TB-DM screening study in Denpasar, Bali, Indonesia. The sample consisted of 365 DM type II patients selected by quota sampling among DM type II patients joining the screening program from January until March 2016 in 11 public health centres in Denpasar. Data were collected via structured interviews. The contributing factors were determined by modified Poisson regression test for cross-sectional data. From the findings, less than half (45.48%) of DM type II patients participated in chest X-ray examination for TB. Factors associated with participation in pulmonary TB screening were having a higher educational level [APR = 1.34, 95% CI (1.07–1.67)], having family member who developed pulmonary TB disease [APR = 1.47, 95% CI (1.12–1.93)], the travel time to referral hospital for screening being ≤ 15 minutes [APR = 1.6, 95% CI (1.26–2.03)], having health insurance [APR = 2.69, 95% CI (1.10–6.56)], and receiving good support from health provider [APR = 1.35, 95% CI (1.06–1.70)]. Therefore, training for health provider on providing counselling, involvement of family members in screening process, and improving the health insurance coverage and referral system are worth considering.

scholarly journals Study of Clinical and Biochemical Parameters of Type 2 Diabetic Subjects with Pulmonary Tuberculosis

2014 ◽  
Vol 4 (1) ◽  
pp. 5-8
Author(s):  
F Afsana ◽  
SNAA Jamil ◽  
ZA Latif
Keyword(s):  
Pulmonary Tuberculosis ◽  
Biochemical Parameters ◽  
Complete Blood Count ◽  
Radiological Finding ◽  
X Rays ◽  
Radiographic Findings ◽  
Bacteriological Culture ◽  
X Ray ◽  
Chest X Ray

Aims: Type 2 DM is a global epidemic and recognized as a threat to pulmonary tuberculosis (PTB) control worldwide especially in developing countries. When tuberculosis is diagnosed in diabetic subjects both can be affected in term of clinical presentation and course of disease. The aim of the study was to evaluate the demographic, clinical and biochemical parameters of newly detected PTB patients with type 2 diabetes. Methods: Seventy two diabetic subjects with newly detected PTB attending outpatient department, BIRDEM were studied. Patients with fever, cough, hemoptysis and/or weight loss were interviewed by a structured questionnaire. After thorough clinical examination, blood sugar, complete blood count (CBC), ESR, sputum for bacteriological culture and acid fast bacilli (AFB) (3 samples), X-ray chest were done. The diagnosis of PTB was based on a positive sputum AFB test, a suggestive CBC report or typical radiographic findings with high clinical probability. Diagnosed PTB cases were included in the study. All patients were followed up at least at1st, 3rd and 6th month of antitubercular therapy. Result: Mean age of study subjects was 46(19-75) years. The study subjects do not have past history of tuberculosis. Most of the study subjects (98.6%) were on insulin for treatment of diabetes. Mean body mass index (BMI) was 19.9kg/m². Mean ESR (mm in 1st hour) was 94.5 with 60% subjects having ESR >100. Sputum for bacteriological culture revealed no growth in 77.3% patients. Chest X-ray revealed cavity in 47.2%, opacity in 40.3%, both opacity and cavity in 5.6 %, pleural effusion in 5.6% and 5.5% had no detectable lesion. All patients were sputum AFB positive and among them 73.6% (n=53) had AFB positive in all 3 samples. Most of the patients (n=62, 86.6%) become sputum AFB negative after one month of treatment initiation. Rest 10 subjects (13.4%) become sputum negative in 2 months follow up and all of these patients had cavitary lesions in chest X-rays. A good number of the patients (98%) with positive x-ray finding showed radiological improvement after 2 months of antitubercular treatment. All the patients completed their therapy without any interruption for 6 months. Conclusion: Pulmonary cavity and opacity is the commonest radiological finding among study subjects. Sputum positivity for AFB is a good diagnostic tool for PTB in diabetic subjects. Subjects with cavitary lesion in chest X-ray become sputum negative than others. DOI: http://dx.doi.org/10.3329/birdem.v4i1.18545 Birdem Med J 2014; 4(1): 5-8

scholarly journals The Proportion and Radiological Features of Pneumoconiosis in Workers Exposed to Dust in The Workplace

2019 ◽  
Vol 39 (4) ◽  
pp. 266-271
Author(s):  
Mukhtar Ikhsan
Keyword(s):  
Pulmonary Tuberculosis ◽  
X Rays ◽  
International Labor Organization ◽  
Cross Sectional ◽  
X Ray ◽  
Radiological Features ◽  
International Labor ◽  
Chest X Ray ◽  
Sinus Obliteration ◽  
Parenchymal Abnormalities

Background: One of the most common occupational diseases found in workplace is pneumoconiosis. The most disease is silicosis, which is lung disease caused by inhalation of dust containing free crystalline silica which afflicts tens of millions of workers in hazardous work and kill thousands of people worldwide. This study aimed to determine proportion and radiologic appearance of pneumoconiosis in workers exposed to dust in various industrial and mining processes. Method: This research used cross-sectional desaign, was conducted 2017 until September 2019 for various industrial and mining workers exposed to dust. Chest X-ray with digital radiography was read in International Classification of Pneumoconiosis Radiography from ILO version 2011, by a lung specialist who certified by The International Labor Organization (ILO) and The Asian Intensive Reader of Pneumoconiosis Project (AIR Pneumo). Results: ILO chest X-ray readings were carried out on 810 chest photos. Various radiological features of pneumoconiosis were obtained in 132 chest X-rays (16.2%), mostly abnormalities in parenchyma 87.1%. Parenchymal abnormalities are mostly of small round (p/p) with a profusion of 0/1 (89.6%). The most zones were lower right (58.1%). Pleural disorders (2%) mostly of costophrenic sinus obliteration 64.8%. Other disorders were 61/810 (7.24%), mostly of diaphragm abnormalities 15/61 (27.9%). Relevant appearance with pulmonary tuberculosis (infiltrates) was 8/810 (0.9%). Conclusion: The proportion of pneumoconiosis was 16.2%, mostly of parenchymal abnormalities (87.1%). Parenchymal abnormalities that occured still in the early phase, most zones were lower right (58.1%), pleural disorders 2%, other abnormalities were 7.24% and those that relevant to pulmonary tuberculosis 0.9%. (J Respir Indo. 2019; 39(4): 266-71)

scholarly journals Diagnostic accuracy of computer aided reading of chest x-ray in screening for pulmonary tuberculosis in comparison with Gene-Xpert

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Tahira Nishtar ◽  
Shamsullah Burki ◽  
Fatima Sultan Ahmad ◽  
Tabish Ahmad
Keyword(s):  
Pulmonary Tuberculosis ◽  
Diagnostic Accuracy ◽  
World Health ◽  
Computer Aided Detection ◽  
Pulmonary Tb ◽  
High Burden ◽  
X Ray ◽  
Computer Aided ◽  
Chest X Ray ◽  
Computer Aided Reading

Background & Objectives: Pakistan ranked fifth amongst 22 high-burden Tuberculosis countries, and it is  an epidemic in Pakistan, hence screening is performed nationally, as part of the ambitious ZERO TB drive. Our objective was to assess the diagnostic accuracy of Computer Aided Detection (CAD4TB) software on chest Xray in screening for pulmonary tuberculosis in comparison with gene-Xpert. Methods: The study was conducted by Radiology Department Lady Reading Hospital Peshawar in affiliation with Indus Hospital network over a period of one year. Screening was done by using mobile Xray unit equipped with CAD4TB software with scoring system. All of those having score of more than 70 and few selected cases with strong clinical suspicion but score of less than 70 were referred to dedicated TB clinic for Gene-Xpert analysis. Results: Among 26,997 individuals screened, 2617 (9.7%) individuals were found presumptive for pulmonary TB. Sputum samples for Gene-Xpert were obtained in 2100 (80.24%) individuals, out of which 1825 (86.9%) were presumptive for pulmonary TB on CAD4TB only. Gene-Xpert was positive in 159 (8.7%) patients and negative in 1,666(91.3%). Sensitivity and specificity of CAD4TB and symptomatology with threshold score of ≥70 was 83.2% and 12.7% respectively keeping Gene-Xpert as gold standard. Conclusion: Combination of chest X-ray analysis by CAD4TB and symptomatology is of immense value to screen a large population at risk in a developing high burden country. It is significantly a more effective tool for screening and early diagnosis of TB in individuals, who would otherwise go undiagnosed. Abbreviations: TB = Tuberculosis, WHO = World Health Organization, CAD4TB = Computer aided detection for tuberculosis, CXR = Chest X-Ray, CAR = Computer aided reading. doi: https://doi.org/10.12669/pjms.38.1.4531 How to cite this:Nishtar T, Burki S, Ahmad FS, Ahmad T. Diagnostic accuracy of computer aided reading of chest x-ray in screening for pulmonary tuberculosis in comparison with Gene-Xpert. Pak J Med Sci. 2022;38(1):---------.   doi: https://doi.org/10.12669/pjms.38.1.4531 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Karakteristik Penderita Tuberculosis Multidrug Resistant (TB MDR) di Sulawesi Tenggara Tahun 2014-2017

MEDULA ◽  
2019 ◽  
Vol 6 (2) ◽  
Author(s):  
Zida Maulina Aini ◽  
Nur Martina Rufia
Keyword(s):  
Research Result ◽  
Multidrug Resistant ◽  
Drop Out ◽  
Sputum Smear ◽  
First Line ◽  
X Ray ◽  
Mdr Tb ◽  
Study Population ◽  
Chest X Ray ◽  
Sputum Smear Examination

                                                            ABSTRACTBackground:MDR TB is one type of bacterial tuberculosis resistance to first-line anti-TB drugs, Isoniazid and Rifampicin. Data from the Provincial Health Office of Southeast Sulawesi cases of MDR TB increase every year that is in 2014 there are 7 patients with MDR TB, 2015 there are 8 patients with MDR TB, 2016 there are 23 patients with MDR TB, and in 2017 there are 28 patients with MDR TB. The purpose of this study is to explain the characteristics of patients with MDR TB in Southeast Sulawesi in 2014-2017. Research Purpose: This study is to explain the characteristics of patients with MDR TB in Southeast Sulawesi in 2014-2017.  Research Method: The location of this study was in the Provincial Health Office of Southeast Sulawesi and Bahteramas General Hospital of Southeast Sulawesi Province with study population included all patients diagnosed with MDR TB in Southeast Sulawesi Province 2014-2017. The research data is processed to know the number and percentage of each characteristic of MDR TB patients in Southeast Sulawesi 2014-2017. Research result: The conclusion of the result of the study is characteristic of MDR TB patient in Southeast Sulawesi 2014-2017 dominated by age 15-55 years old, male gender, entrepreneur job, case of drop out treatment, examination of chest X-ray in the form of infiltrate and cavity, sputum smear examination (+1), the type of Rifampicin resistance, and is still temporarily treated.Keyword: MDR TB, age, sex, occupation, medical history, investigation, type of resistance and treatment outcome.

Spoligotyping for Identification of Pulmonary Tuberculosis with Type 2 Diabetes Mellitus Profiles in Warangal, T.S.

2018 ◽  
Vol 16 (2) ◽  
pp. 129-135
Author(s):  
Sireesha Tanniru ◽  
Syed Asha ◽  
Malathi Jojula
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pulmonary Tuberculosis ◽  
Clinical Isolates ◽  
Mediastinal Lymphadenopathy ◽  
X Ray ◽  
Mdr Tb ◽  
Chest X Ray

Background: The prevalence of pulmonary tuberculosis infections had increased among the type 2 Diabetes Mellitus (DM) patients in India, although the biological basis underlying this susceptibility remains poorly characterized. Based on the symptom’s, chest X-rays and their correlation with clinical and diagnostic parameters, we had suspected diabetic-tuberculosis co-infections. As Chest XRay plays a vital role in the identification of pulmonary tuberculosis infections, we emphasized more on it. Chest X-ray features included were; (infiltrate, cavitation, miliary shadows, pleural effusion, mediastinal lymphadenopathy and extent of lesions) such features were analyzed to identify associations with biological/clinical parameters through univariate and multivariate logistic regression. Method: The study was carried out in diabetic type 2 patients suspected with pulmonary tuberculosis infections, Warangal, India. Spoligotyping was used for identification, detection and characterization of M. tuberculosis complex bacteria in clinical samples. This method is based on polymerase chain reaction (PCR) amplification of a highly polymorphic direct repeat locus in the M. tuberculosis genome. It is helpful in detecting causative bacteria and in providing epidemiologic information on genotyping strain identities. Results: Based on the chest X-Ray of 200 diabetic patients suspected with pulmonary infections, we found 26 infiltrates, 30 cavitation, 28 miliary shadows, 35 pleural effusion, 46 mediastinal lymphadenopathy and 35 were confirmed for the extent of lesions, which supported us to further screen for pulmonary tuberculosis of 200 subjects tested, 113 were males, 85 were females and 2 were children. All 200 subjects were tested for pulmonary tuberculosis, 36 were positive by smear microscopy and 20 were culture positive. Phenotypic and genotypic variations were found for all the 20 identified clinical isolates, by conventional and molecular methods of 20 clinical isolates, 4 MDR-TB were identified based on the Drug Susceptibility Test for first-line drugs. Of 20 clinical isolates, we took 10 clinical isolates (4-were MDR-TB and 6- were MTB) and 1- was control sample of H37RV used for spoligotyping and showed different patterns Bejing (1) and Lineages of East Asian, of family EA13(2) and Lineages of Indo-Oceanic, of family LAM1(1) and Lineages of Euro-American and 6 were found to be MTB of family 33(2) and Lineages of Indo-Oceanic, of family CAS(4) and Lineages of Un-known family. CAS (Central Asian) of M.tuberculosis strains showed more prevailing spoligotype pattern in Diabetic Pulmonary Tuberculosis patients. Conclusion: Implementing such a method in clinical settings would be useful in surveillance of tuberculosis transmission and in interventions to prevent further spread of this disease among the Diabetic Pulmonary Tuberculosis co-infections.

scholarly journals 1364. Pretreatment Chest X-ray Stability Duration and Tuberculosis Disease in San Diego County, 2012–2017

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S494-S494
Author(s):  
Casey Barber ◽  
Eyal Oren ◽  
Yi-Ning Cheng ◽  
Madeline Slater ◽  
Susannah Graves
Keyword(s):  
San Diego ◽  
San Diego County ◽  
X Rays ◽  
Appreciable Change ◽  
Pulmonary Tb ◽  
X Ray ◽  
Lung Abnormalities ◽  
Wide Range ◽  
Chest X Ray ◽  
Pulmonary Status

Abstract Background Repeated chest X-rays serve as an essential screening tool to identify and describe new or stable (i.e., unchanged) lung abnormalities suggestive of pulmonary tuberculosis (TB) disease. The time for which a patient’s chest X-ray has not demonstrated appreciable change prior to treatment, or pretreatment chest X-ray stability duration, has been considered clinically useful in distinguishing inactive from active disease at four or 6 months. This relationship, however, has not been previously quantified. Methods This study relied on retrospective medical record review to assess the relationship of documented pretreatment chest X-ray stability duration thresholds relative to four and 6 months with a future clinical or culture-confirmed (Class 3) diagnosis of pulmonary TB disease. Multivariable logistic regression quantified this association among 146 patients who were evaluated and started on treatment for pulmonary TB disease in the San Diego County tuberculosis clinic between May 2012 and March 2017. Results After adjusting for age and Class B1 TB, Pulmonary status, a CXR stability duration of 4 months or more was not significantly associated with a Class 3 pulmonary TB diagnosis (adjusted odds ratio [AOR], 0.830; 95% confidence interval [CI], 0.198–3.48). Results were similar for the 6-month cut-point after adjusting for age and Class B1 Pulmonary status (AOR, 0.970; 95% CI, 0.304–3.10). Compared with less than 4 months, CXR stability durations of four to 6 months (AOR, 0.778; 95% CI, 0.156–3.89) and greater than 6 months (AOR, 0.875; 95% CI, 0.187–4.10) were also not significantly associated with a Class 3 TB diagnosis after adjusting for covariates. Conclusion Repeated chest X-rays remain a valuable tool for clinicians identifying and describing new or unchanged lung abnormalities suggestive of pulmonary TB disease. This study found no statistically significant association between pretreatment chest X-ray stability duration and subsequent TB disease diagnosis, with a wide range of estimates compatible with the data, suggesting the stability duration cut points relative to four and 6 months may not be as informative as previously understood. Disclosures All authors: No reported disclosures.

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