scholarly journals The Effect of Anti-anxiety Medications on the Clinical Symptoms of Anal Fissure: A Randomized Clinical Trial

2021 ◽  
Keyword(s):  
Anal Fissure ◽  
Clinical Symptoms ◽  
Demographic Data ◽  
Etiologic Factor ◽  
Anal Fissures ◽  
Duration Of Illness ◽  
Patient Consent ◽  
High Prevalence ◽  
Psychiatric Complications

Background: Fissure is a common chronic anorectal disease that causes symptoms such as pain, burning, bleeding, and psychiatric problems. One of the psychiatric complications is anxiety, which might be an etiologic factor or secondary to the disease. Materials and Methods: A total of 160 patients with anal fissure were randomly divided into two groups (80 patients treated with anti-anxiety medications along with standard anal fissure treatment and 80 patients with standard anal fissure treatment alone) after obtaining patient consent and demographic data. Then, the symptoms have recorded after treatment. Results: The results of our study indicated that the administration of anti-anxiety medications in patients with anal fissures relieved pain and anxiety scores among all patients. The anti-anxiety medications were more effective on patients younger than 40 years, men with less than two weeks duration of illness, and baseline anxiety greater than 26. Conclusion: A high prevalence of anal fissures affects the quality of life of patients. Besides the lack of effective treatment that shortens the pain and recovers patients faster, anti-anxiety medications such as benzodiazepines can use along with standard anal fissure treatment to reduce pain and anxiety in patients with acute anal fissure.

scholarly journals A prospective non-comparative study to assess the effectiveness and safety of combination laxative therapy containing milk of magnesia, liquid paraffin and sodium picosulphate (Cremaffin-Plus®) in the management of constipation in patients with anal fissure/hemorrhoids/obstructive defecation syndrome

2017 ◽  
Vol 4 (12) ◽  
pp. 3899 ◽  
Author(s):  
Roy Patankar ◽  
Ajeet Mishra
Keyword(s):  
Quality Of Life ◽  
Anal Fissure ◽  
Liquid Paraffin ◽  
Stool Frequency ◽  
Stool Consistency ◽  
Obstructive Defecation Syndrome ◽  
Anal Fissures ◽  
Sodium Picosulphate ◽  
Obstructive Defecation

Background: Assess the effectiveness and safety of combination laxative therapy containing milk of magnesia, liquid paraffin and sodium picosulphate (Cremaffin-Plus®) in management of constipation, in patients with anal fissure/haemorrhoids/obstructive defecation syndrome (ODS).Methods: Patients visiting study site with complaints of constipation secondary to anal fissures/haemorrhoids/ODS, intended to receive combination laxative therapy (as per physicians’ discretion), were enrolled. Primary objectives were to assess the change in number of bowel movements per day and stool consistency; secondary objectives were to assess change in straining, physician global efficacy assessment, quality of life (PAC-QOL score), Constipation Symptoms (CSS), Fecal Incontinence Score (FIS), Patient Assessment of Constipation Symptoms (PAC-SYM) score, along with the Modified Longo Score (MODS) for ODS from baseline to end of 4 weeks. Safety, tolerability and treatment adherence were also assessed.Results: About 32 patients (anal fissure:19, haemorrhoids:5, ODS:8) met inclusion criteria. Significant improvement in stool frequency was observed in all patients pooled together (p=0.016); group wise, statistical significance was noted in patients of anal fissures. Stool consistency was improved in all patients pooled together (p<0.001); group wise, significant improvement was seen in patients of anal fissure and ODS. There was a significant improvement in straining noted in all patients pooled together (p=0.002). Significant reduction (p<0.001) was noted in all the symptom scores (CSS, FIS, PAC-SYM and PAC-QOL) from baseline to 4 weeks in all patients. About 51.44% reduction in MODS score was noted in patients with ODS.Conclusions: Improvement in stool frequency, consistency and straining was noted in all patients with constipation (with fissure/haemorrhoids/ODS) treated with Cremaffin-plus for 4-weeks, improving the quality of life. All patients showed good therapy adherence with better safety and tolerability profile.

scholarly journals Analgesic Effectiveness and Improvement in Quality of Life after Using Topical Sevoflurane for an Extremely Painful Anal Fissure

2021 ◽  
Author(s):  
Jesús Cifuentes-Tébar ◽  
Juan Luis Rueda-Martínez ◽  
Carmen Selva-Sevilla ◽  
Manuel Gerónimo-Pardo
Keyword(s):  
Quality Of Life ◽  
Anal Fissure ◽  
Chronic Wounds ◽  
Chronic Anal Fissure ◽  
Symptomatic Treatment ◽  
Off Label ◽  
Anal Fissures ◽  
Inhalational Anesthetic ◽  
The Cost

AbstractPainful anal fissures could be distressing conditions that severely impair the patients' quality of life. The analgesic effectiveness of topical drugs, such as calcium-antagonists and nitrates is quite variable. The inhalational anesthetic sevoflurane is being repurposed as a topical analgesic for painful chronic wounds. We report a pioneer experience treating a painful chronic anal fissure with topical sevoflurane. A young adult male was suffering from an extremely painful chronic anal fissure, which severely affected his quality of life. The topical treatment with nitroglycerine and diltiazem gels failed. The patient agreed to the treatement with topical sevoflurane as an off-label medication, and it produced an immediate, intense, and long-lasting analgesic effect. An intense but rapidly transient burning sensation, as well as persistent but well-tolerated flatulence were the only adverse effects. The quality of life was greatly improved, and the cost of the treatment was affordable. Therefore, the off-label use of topical sevoflurane appears to be an effective alternative for the symptomatic treatment of painful anal fissures.

scholarly journals Nėščiųjų ir pagimdžiusiųjų hemorojus ir išangės įplėša: paplitimas, rizikos veiksniai bei įtaka moters gyvenimo kokybei

2014 ◽  
Vol 13 (2) ◽  
pp. 72-87
Author(s):  
Diana Bužinskienė ◽  
Gražina Drąsutienė ◽  
Tomas Poškus
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Cohort Studies ◽  
Anal Fissure ◽  
Prospective Cohort ◽  
Anal Fissures ◽  
Prospective Cohort Studies ◽  
Before And After ◽  
Pregnancy And Delivery

Šio straipsnio tikslas – apžvelgti literatūrą, nagrinėjančią nėščiųjų hemorojaus ir išangės įplėšos paplitimą, priežastis, dažnį, rizikos veiksnius bei šių ligų įtaką moterų gyvenimo kokybei.Išangės ligos (hemorojus ir išangės įplėša) tiek nėštumo metu, tiek laikotarpiu po gimdymo yra dažna patologija, kuriai vis dar stinga tiek koloproktologų, tiek akušerių ginekologų dėmesio. Šiuo metu nėra tyrimų, kuriuose perspektyviuoju būdu nėštumo metu ir po gimdymo būtų vertinamas išangės ligų atsiradimas, nustatomi jų rizikos veiksniai. Labai svarbu ištirti ir įvertinti šių ligų paplitimą Lietuvoje ir rizikos veiksnius, jų ryšį su nėštumo ir gimdymo veiksniais, laiku šias ligas diagnozuoti ir gydyti bei atrasti priemonių, kaip jų išvengti, taip pagerinant moterų gyvenimo kokybę ne tik nėštumo ir gimdymo metu, bet ir laikotarpiu po gimdymo.Reikšminiai žodžiai: hemorojus, išangės įplėša, nėštumas, gimdymas, rizikos veiksniai, gyvenimo kokybė Hemorrhoids and anal fissures during pregnancy and after childbirth: prevalence, risk factors and impact on women’s quality of lifeDiana Bužinskienė, Gražina Drąsutienė, Tomas Poškus The aim of this study was to review the literature regarding the incidence, prevalence, risk factors of hemorrhoids and anal fissures during, before, and after pregnancy and their impact on the quality of life of women.Both hemorrhoids and anal fissures are common during and after pregnancy; however, they are frequently overlooked by both coloproctologists and gynecologists. There are no prospective cohort studies of perianal diseases during and after pregnancy with an emphasis on identifying the possible risk factors. Thus, it is important to identify the incidence and risk factors of perianal diseases in Lithuania and to find the factors of pregnancy and delivery that could be related to the occurrence or prevent the occurrence of these diseases. In this way, the possible areas of correction and intervention could be identified.Key words: hemorrhoids, anal fissure, pregnancy, delivery, risk factors, quality of life  

scholarly journals Nėščiųjų ir pagimdžiusiųjų hemorojus ir išangės įplėša: paplitimas, rizikos veiksniai bei įtaka moters gyvenimo kokybei

2014 ◽  
Vol 13 (2) ◽  
pp. 72-87
Author(s):  
Diana Bužinskienė ◽  
Gražina Drąsutienė ◽  
Tomas Poškus
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Cohort Studies ◽  
Anal Fissure ◽  
Prospective Cohort ◽  
Anal Fissures ◽  
Prospective Cohort Studies ◽  
Before And After ◽  
Pregnancy And Delivery

Šio straipsnio tikslas – apžvelgti literatūrą, nagrinėjančią nėščiųjų hemorojaus ir išangės įplėšos paplitimą, priežastis, dažnį, rizikos veiksnius bei šių ligų įtaką moterų gyvenimo kokybei.Išangės ligos (hemorojus ir išangės įplėša) tiek nėštumo metu, tiek laikotarpiu po gimdymo yra dažna patologija, kuriai vis dar stinga tiek koloproktologų, tiek akušerių ginekologų dėmesio. Šiuo metu nėra tyrimų, kuriuose perspektyviuoju būdu nėštumo metu ir po gimdymo būtų vertinamas išangės ligų atsiradimas, nustatomi jų rizikos veiksniai. Labai svarbu ištirti ir įvertinti šių ligų paplitimą Lietuvoje ir rizikos veiksnius, jų ryšį su nėštumo ir gimdymo veiksniais, laiku šias ligas diagnozuoti ir gydyti bei atrasti priemonių, kaip jų išvengti, taip pagerinant moterų gyvenimo kokybę ne tik nėštumo ir gimdymo metu, bet ir laikotarpiu po gimdymo.Reikšminiai žodžiai: hemorojus, išangės įplėša, nėštumas, gimdymas, rizikos veiksniai, gyvenimo kokybė Hemorrhoids and anal fissures during pregnancy and after childbirth: prevalence, risk factors and impact on women’s quality of lifeDiana Bužinskienė, Gražina Drąsutienė, Tomas Poškus The aim of this study was to review the literature regarding the incidence, prevalence, risk factors of hemorrhoids and anal fissures during, before, and after pregnancy and their impact on the quality of life of women.Both hemorrhoids and anal fissures are common during and after pregnancy; however, they are frequently overlooked by both coloproctologists and gynecologists. There are no prospective cohort studies of perianal diseases during and after pregnancy with an emphasis on identifying the possible risk factors. Thus, it is important to identify the incidence and risk factors of perianal diseases in Lithuania and to find the factors of pregnancy and delivery that could be related to the occurrence or prevent the occurrence of these diseases. In this way, the possible areas of correction and intervention could be identified.Key words: hemorrhoids, anal fissure, pregnancy, delivery, risk factors, quality of life  

scholarly journals Clinical study of the efficacy and safety of jamu for hyperuricemia

2019 ◽  
Vol 4 (1) ◽  
pp. 13
Author(s):  
Agus Triyono ◽  
Fajar Novianto
Keyword(s):  
Herbal Medicine ◽  
Clinical Symptoms ◽  
Term Treatment ◽  
Efficacy And Safety ◽  
Sf 36 ◽  
Long Term Treatment ◽  
High Prevalence ◽  
Post Test

Hyperuricemia is a degenerative disease with a reasonably high prevalence and requires long-term treatment. Clinical research has been conducted to test the efficacy and safety of herbal medicine for hyperuricemia. The research involved 30 subjects who had fulfilled the inclusion and exclusion criteria and conducted with a pre-post test research design. Subjects were treated with herbal medicine for hyperuricemia three times a day for 28 days. From the research, jamu for hyperuricemia was effective in reducing blood uric acid levels from 7.43 mg/dL to 5.72 mg/dL, raising the quality of life score (SF-36) from 78.06 to 81.50, and disappeared of clinical symptoms. Use of herbal medicine for hyperuricemia for 28 days in subjects had no symptoms of severe side effects found and did not interfere with liver, kidney, and blood function.

Musical Anhedonia

2020 ◽  
Vol 31 (2) ◽  
pp. 62-68
Author(s):  
Sara E. Holm ◽  
Alexander Schmidt ◽  
Christoph J. Ploner
Keyword(s):  
Quality Of Life ◽  
Nucleus Accumbens ◽  
Brain Damage ◽  
Parietal Cortex ◽  
Neurological Disorders ◽  
Brain Regions ◽  
Precise Information ◽  
Exact Localization ◽  
High Prevalence

Abstract. Some people, although they are perfectly healthy and happy, cannot enjoy music. These individuals have musical anhedonia, a condition which can be congenital or may occur after focal brain damage. To date, only a few cases of acquired musical anhedonia have been reported in the literature with lesions of the temporo-parietal cortex being particularly important. Even less literature exists on congenital musical anhedonia, in which impaired connectivity of temporal brain regions with the Nucleus accumbens is implicated. Nonetheless, there is no precise information on the prevalence, causes or exact localization of both congenital and acquired musical anhedonia. However, the frequent involvement of temporo-parietal brain regions in neurological disorders such as stroke suggest the possibility of a high prevalence of this disorder, which leads to a considerable reduction in the quality of life.

OPEN HAEMORRHOIDS SURGERY IN SPINAL CORD INJURY PATIENTS

2020 ◽  
Vol 4 (11) ◽  
Author(s):  
Khaled Hassan
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Anal Fissure ◽  
Open Surgery ◽  
Anal Fissures ◽  
Cord Injury ◽  
Long Term Follow Up ◽  
Grade Iii

This Pilot retrospective research conducted on the results of open surgery in patients with Grade III and IV haemorrhoids With SCI. No major complications had arisen at 6 weeks post-operative and all wounds had healed, but 1 patient Anal fissure recurrence. 75% of patients reported a substantial increase in anorectal anorexia during long-term follow-up. With symptoms. Five patients reported recurrences: three haemorrhoids (18 percent) and two anal fissures (25 percent).   Keywords: Haemorrhoids, Pilot retrospective research, Anorectal Anorexia.

The experience of using a diode laser in the herpes labial treatment

2020 ◽  
Vol 25 (1) ◽  
pp. 43-46
Author(s):  
S. L. Blashkova ◽  
E. V. Krikun ◽  
Yu. V. Fazylova ◽  
Yu. V. Blashkova
Keyword(s):  
Oral Cavity ◽  
Diode Laser ◽  
Comparison Group ◽  
Treatment Time ◽  
Local Treatment ◽  
Allergic Reactions ◽  
High Prevalence ◽  
Dental Diseases ◽  
Simplex Virus

Relevance. The relevance of the problem is in the high prevalence of the herpes simplex virus. According to WHO, nearly 90% of the population are carriers. Relapses can occur several times a year, which leads to disability and impairs the quality of life. Currently, there are a large number of drugs for general and local treatment. However, they are toxic and can cause allergic reactions. In recent years, a large number of studies have been devoted to the use of lasers in the treatment of dental diseases. Therefore, the question of the use of a laser in the treatment of herpetic lesions of the oral cavity remains relevant.Purpose. The research purpose was to determine the effectiveness of the use of a diode laser in the treatment of herpetic lesions of the lips.Materials and methods. We conducted a comparative assessment of the effectiveness of the use of a diode laser in monotherapy of herpetic lip lesions in 18 patients. The comparison group consisted of 18 patients, in the local treatment of which antiviral ointments were used.Results. The results of the study showed that the use of a diode laser can reduce treatment time, accelerate the epithelization of foci.Conclusion. The results of our study allow us to recommend the use of a diode laser in the complex treatment of herpetic lesions of the oral cavity.

ASSECSSING MOCA TEST IN SUBACUTE STROKE PATIENTS AND COMPARE MOCA VERSUS MMSE

2016 ◽  
pp. 120-127
Author(s):  
Dinh Toan Nguyen
Keyword(s):  
Human Life ◽  
Statistical Significance ◽  
High Sensitivity ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Female Age ◽  
Subacute Stroke ◽  
Duration Of Illness ◽  
Dsm Iv

Background: Dementia after stroke, particularly subacute period is often overlooked. Today the quality of human life is increasingly high, finding scales that have high value for detection of dementia in patients with stroke is increasingly interested. MoCA test is high sensitivity with mild dementia and identify more abnormalities of awareness caused by vascular, but MoCA have not been studied much in Vietnam. Objective: Assessing MoCA test in subacute stroke patients and compare MoCA versus MMSE in these patients. Subjects: 90 patients with subacute stroke period, these people are being treated at Department of cardiovascular internal medicine at Hue Central Hospital, from 7/2014 - 7/2015. Methods: cross-sectional description and analysis. Results: The mean age is 65.57 ± 13.38, accounting for 54.4% male and 45.6% female. Age, duration of illness has weak correlation with MoCA. The risk factors: hypertension, stroke ischemic transient, alcoholism, smoking, heart disease, diabetes, dyslipidemia related no statistical significance with MoCA. The proportion of dementia in subacute stroke according MoCA is 82.2%. The concordance between MoCA and MMSE was good (kappa = 0.684). Using DSM-IV criteria as the gold standard we found MoCA more valuable in the dementia diagnosis than MMSE (AUC 0.864 versus 0.774, p <0.05). Conclusion: The rate of dementia in stroke subacute period according MoCA is quite high. MoCA is valuable than MMSE in detecting dementia in patients with stroke subacute period, this scale is short, easy to implement so should put into using widely in clinical practice. Key words: MoCA test, subacute stroke, dementia

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