scholarly journals Relationship Between Triglycerides And Glucose Index (TyG) And Lipid Profile In Patients With Dyslipidemia Treated With Bay Leaf Extract [Syzygium Polyanthum (Wight) Walp]

2020 ◽  
Vol 2 (4) ◽  
pp. 177-182
Author(s):  
Catur Prianwari ◽  
Santi Syafril
Keyword(s):  
Lipid Profile ◽  
Leaf Extract ◽  
Total Cholesterol Level ◽  
Hdl Cholesterol ◽  
Lipid Lowering ◽  
Biochemical Tests ◽  
Cholesterol Levels ◽  
Standard Procedures ◽  
Relationship Of ◽  
The Relationship

Background: Insulin Resistance (IR) causes a metabolic disorder including hyperglycemia, high blood pressure, and dyslipidemia. The purpose of the study was to assess the relationship of Triglycerides and Glucose Index (Tyg) decline relationship with lipid profile after bay leaf extract treatment in dyslipidemia patients. Method: Fifteen dyslipidemia patients were administered 2x200 mg salam leaf extract capsules for 30 days. Criteria dyslipidemia is defined as one of the following: total cholesterol level ≥ 240 mg/dL, triglyceride levels ≥150 mg/dL, LDL cholesterol levels ≥140 mg/dL, HDL cholesterol levels <40 mg/dL, or the use of lipid-lowering drugs. Blood samples lipid profile for biochemical tests were drawn in the morning after fasting 12 h. Anthropometric BMI and waist circumference measures were taken using standard procedures. The TG/HDL-C ratio was calculated by dividing the serum concentration of TG by HDL-C measured in mg/dL. TyG index was calculated based on formula: Ln [TG (mg/dL) x FG (mg/dL). Result: After 30 days of salam leaf extract treatment, there was a significant correlation of TyG reduction with parameters TC, LDL-C, TG, TG/HD ratio (p: 0.025*, p: 0.001*, p: 0.013*, sequentially) Conclusion: There is a significant correlation between Tyg reduction with TC, TG, and TG/HDL, which leads to a decrease in cardiovascular risk in dyslipidemia patients.

scholarly journals Hubungan Umur, Jenis Kelamin dan Kegemukan dengan Kadar Kolesterol Total Guru SMAN 1 Sei Raya

2019 ◽  
Vol 2 (2) ◽  
pp. 72
Author(s):  
Fadhil Kurniawan ◽  
Slamet Slamet ◽  
Laila Kamilla
Keyword(s):  
Total Cholesterol ◽  
Sampling Method ◽  
Total Cholesterol Level ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Level Data ◽  
Total Data ◽  
Relationship Of ◽  
The Relationship ◽  
Test Result

Abstract: Cholesterol is often seen as something that is very scary and associate high levels of cholesterol in the blood with the risk of heart disease. Increasing cholesterol levels are something to avoid because it can endanger health. The purpose of this study was to examine the relationship age, sex, and obesity with total cholesterol levels on teachers SMAN 1 Sei. Raya. The design in this study using Cross-Sectional. The population of this study is all teachers SMAN 1 Sei. Raya took with total sampling method and obtained as many as 46 respondents. From each respondent obtained data onto age, sex, obesity level and measurement of total cholesterol level. Data were analyzed by univariate and bivariate with correlation test for Kendall tau with value ɑ = 0.05. The test result using Kendall tau to analyze the relationship of age, sex, and obesity with total cholesterol showed that there is no relationship between age (p = 0.648), sex (p = 0.418), and obesity (p = 0.542) with total cholesterol levels in teachers SMAN 1 Sei. Raya.Abstrak: Kolesterol sering dilihat sebagai sesuatu yang sangat menakutkan dan tingginya kadar kolesterol dalam darah dikaitan dengan risiko penyakit jantung. Peningkatan kadar kolesterol merupakan hal yang harus dihindari, karena dapat membahayakan kesehatan. Tujuan penelitian ini adalah untuk mengkaji hubungan antara umur, jenis kelamin dan kegemukan dengan kadar kolesterol total pada guru SMAN 1 Sei. Raya. Desain dalam penelitian ini menggunakan Cross Sectional. Populasi dalam penelitian ini yaitu seluruh guru SMAN 1 Sei. Raya yang diambil dengan metode total sampling dan diperoleh sebanyak 46 orang responden. Dari setiap responden diperoleh data umur, jenis kelamin, tingkat kegemukan dan pengukuran kadar kolesterol total. Data dianalisis secara univariat dan bivariat dengan uji korelasi Kendall tau dengan nilai ɑ = 0.05. Hasil uji menggunakan kendall tau untuk menganalisis hubungan umur, jenis kelamin, dan kegemukan dengan kadar kolestrol total menunjukan bahwa tidak ada hubungan antara umur (p = 0.648), jenis kelamin (p = 0.418) dan kegemukan (p = 0.542) dengan kadar kolesterol total pada guru SMAN 1 Sei. Raya.

scholarly journals APOA5 gene polymorphism assessment and association with hypertriglyceridemia in the military force of the State of Goiás

2021 ◽  
Vol 10 (7) ◽  
pp. e8410716229
Author(s):  
Raphael dos Reis Frazao Silva ◽  
Tiago Lemos de Nascimento ◽  
Antonio Marcio Teodoro Cordeiro Silva ◽  
Sergio Henrique Nascente Costa ◽  
Frank Sousa Castro ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Lipid Profile ◽  
Real Time ◽  
Hdl Cholesterol ◽  
The State ◽  
Control Group ◽  
Military Force ◽  
Cholesterol Levels ◽  
The Military ◽  
The Relationship

According to the World Health Organization (WHO), dyslipidemias are determinant for the onset of cardiovascular diseases and represent more than 30% of global deaths. Changes in serum lipid levels are a direct consequence of dyslipidemia.   This study aimed to verify the relationship between genetic polymorphism APOA5  and dyslipidemia. This is a case-control study with 199 officers of the military force of the state of Goiás in which the relationship between lipid profile and genetic polymorphism rs964184 was evaluated. Real-time Polymerase Chain Reaction (real-time PCR) was used to identify genetic polymorphism rs964184. Of the participants analyzed, 93% were male and 7% female, the lipid profile showed that 115 participants had dyslipidemia (group of cases) and 84 were within the reference range (control group). The genetic polymorphism rs964184 of the case group showed that 64.3% (74/115) of the participants had genotype CC, 33.0% (38/115) had cg genotype and 2.6% (3/115) had GG genotype. In the control group, 69.0% (58/84) had genotype CC, 27.4% (23/84) had cg genotype, 3.6% (3/84) had GG genotype. In conclusion, the G alllea is related to high levels of triglycerides (≥ 150 mg/dL) and the C allea is related to normal HDL cholesterol levels (≥ 40 mg/dL). Therefore, homozygous (GG) or heterozygous (CG) individuals are more inclined to have high triglycerides and low HDL cholesterol levels, which are associated with an increased risk of developing cardiovascular disease.

scholarly journals The Relationship Between Lipoprotein (A) And Lipid Profile In Patients Treated With Bay Leaf Extract [Syzygium Polyanthum (Wight) Walp] In Patients Dyslipidemia

2020 ◽  
Vol 2 (4) ◽  
pp. 183-188
Author(s):  
Catur Prianwari ◽  
Santi Syafril
Keyword(s):  
Cardiovascular Risk ◽  
Lipid Profile ◽  
Leaf Extract ◽  
Treatment Method ◽  
Extraction Process ◽  
Double Blind ◽  
Group I ◽  
Before And After ◽  
Relationship Of ◽  
The Relationship

Background: Increased Lp(a) accelerates atherosclerosis by means of cholesterol deposits in tunica. The purpose of the study was to assess the relationship of decreased Lp(a) with lipid profile in patients with dyslipidemia given bay leaf extract [syzygium polyanthum (Wight) Walp] treatment. Method: Thirty subjects were divided into 2 groups: group I received salam leaf extract therapy 2 x 200 mg and group II received salam leaf extract therapy 2 x 300 mg per day capsules for 30 days randomly selected and double blind. Examination of Lp(a), total cholesterol, LDL-C, HDL-C and TG before and after research. The manufacture of bay leaf extract is done by maseration, the extraction process using ethanol 70%, then the extract is inserted in the capsule. Result: In groups I and II there were significant differences in variable Lp(a) and lipid profiles after treatment except HDL-C. There is a significant correlation between Lp(a) and LDL at salam leaf extract therapy doses of 2x200 mg per day. Conclusion: Decrease in Lp(a) is significantly correlated with decreased LDL-C. Salam leaf extract therapy can predict decreased cardiovascular risk in patients with dyslipidemia.

Abstract P111: Comparative Efficacy Of Bisoprolol Compared To Other Selective Beta-1 Blockers In Patients With Hypertension - A Systematic Review And Meta-analysis Of Observational Studies

Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Uday M Jadhav ◽  
Tiny Nair ◽  
SANDEEP BANSAL ◽  
Saumitra Ray
Keyword(s):  
Lipid Profile ◽  
Observational Studies ◽  
Clinical Decision Making ◽  
Meta Analysis ◽  
Hdl Cholesterol ◽  
Clinical Decision ◽  
Cochrane Library ◽  
Favourable Effect ◽  
Pooled Data ◽  
Cholesterol Levels

Introduction: Selective beta-1 blockers (s-BBs) are used in the management of hypertension (HT) in specific subsets. Studies comparing the potency of blood pressure (BP) lowering with different s-BBs are sparse. The objective of this meta-analysis was to evaluate the efficacy of bisoprolol compared to other s-BBs (Atenolol, Betaxolol, Esmolol, Acebutolol, Metoprolol, Nebivolol) in HT patients by examining their effect on BP, heart rate (HR) and metabolic derangements, by examining the evidences reported in observational studies. Methods: Electronic databases like PubMed, EMBASE, Cochrane Library, Clinicaltrials.gov, Surveillance, Epidemiology and End Results Program and 12 PV databases were systematically searched from inception to October 2019. Observational studies that compared bisoprolol with other s-BBs in patients with HT were evaluated in accordance with the PRISMA guidelines. Pooled data were calculated using random-effects model for meta-analysis in terms of mean difference (MD) and 95% confidence interval (95% CI) for each outcome. Outcomes of interest were BP, HR and lipid profile. Results: Four observational studies which compared bisoprolol with other s-BBs (nebivolol and atenolol) were included in this meta-analysis. Significant reduction was observed in office diastolic BP [MD: -1.70; 95% CI: -2.68,-0.72; P <0.01] among arterial HT patients treated with bisoprolol for 26 weeks (w) compared to those treated with other s-BBs. HT patients treated with bisoprolol for 26 w showed significant reduction in HR [MD: -2.20; 95% CI: -3.57,-0.65; P <0.01] and office HR [MD: -2.55; 95% CI: -3.57,-1.53; P <0.01] than other s-BBs. HDL cholesterol levels increased significantly in essential HT patients treated with bisoprolol at 26 w [MD: 7.17; 95% CI: 1.90,12.45; P <0.01], 78 w [MD: 11.70; 95% CI: 4.49,18.91; P <0.01] and 104 w [MD: 10.20, 95% CI: 4.49,18.91; P <0.01] compared to other s-BBs. Conclusion: Our results suggests that bisoprolol is superior to other s-BBs in reducing BP and HR. Bisoprolol also had a favourable effect on lipid profile shown by increase in HDL cholesterol. This meta-analysis emphasizes the efficacy of bisoprolol over other s-BBs, which aids clinical decision making in treatment of patients with HT.

scholarly journals Effects of Red Pitaya (Hylocereus polyrhizus) on Lipid Profile of Male White Rats (Rattus norvegicus) Receiving High Fat Diet

2018 ◽  
Vol 54 (1) ◽  
pp. 16 ◽  
Author(s):  
Wiwik Werdiningsih ◽  
Suhartati Suhartati
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Fruit Peel ◽  
Cholesterol Levels ◽  
White Rats ◽  
Wistar Strain ◽  
Dragon Fruit ◽  
Pap Method

Red dragon fruit (Hylocereus polyrhizus) peel contains anthocyanin, fiber and vitamin C, so it can be used to improve lipid profile in dyslipidemia. The peel of the dragon fruit is not durable, so in this study we used freeze-dried dragon fruit peel. The aim of this study was to prove that the administration of the red dragon fruit peel in a dose of 0.72 g/200 g BW, 1.08 g/200 g BW, and 1.44 g/200 g BW of rat per day for 28 days may improve lipid profile in male wistar strain white rats with high-fat diet. Lipid profiles were studied by examining of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides. This was a pure experimental study using randomized post test only control group design. This study used experimental animal of 30 male wistar strain white rats which were divided into five groups. Measurements of total, LDL, and HDL cholesterol levels were done by CHOD-PAP method, while triglyceride level was measured with GPO-PAP method. Data were analyzed statistically by One Way Anova test. The results of this study indicated that giving the peel of red dragon fruit as much as 0.72 g lowered total cholesterol levels, 1.08 g lowered total and LDL cholesterol levels, and 1.44 g lowered total cholesterol, LDL cholesterol, triglyceride levels, and raised HDL cholesterol level. Red dragon fruit peel can be used alternatively to improve lipid profile in dyslipidemia.

scholarly journals ANALISIS HUBUNGAN KADAR GULA DARAH PUASA DENGAN KADAR KOLESTEROL HIGH DENSITY LIPOPROTEIN (HDL) PADA PASIEN DIABETES MELLITUS TIPE 2 DI RSUP SANGLAH

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Nyoman Jirna
Keyword(s):  
Blood Sugar ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Fasting Blood Sugar ◽  
Cholesterol Levels ◽  
Sugar Levels ◽  
Dm Type 2 ◽  
The Relationship

Abstract Diabetes mellitus (DM) is a group of metabolic diseases with characteristic hyperglycemia that happen by abnormal secretions of insulin, insulin action, or both. The condition of insulin resistance in DM type 2 cause abnormal lipid metabolism that indicated by increase or decrease levels of lipid fraction in plasma, include increase levels of Very Low Density Lipoprotein (VLDL) or triglycerides, decrease levels of High Density Lipoprotein (HDL), and formed small dense Low Density Lipoprotein (LDL). The purpose of this study is to determine the relationship between the fasting blood sugar levels with HDL cholesterol levels in patients with DM type 2. The method use an analytical study with cross sectional design. Sampling examined as many as 35 samples by purposive sampling. The relationship between fasting blood sugar levels with HDL cholesterol levels is analyzed by Pearson Product Moment Correlation test. Based on the result concluded that there is a relationship between fasting blood sugar levels with HDL cholesterol levels in patients with DM type 2 in RSUP Sanglah with significant value sig=0,030 (sig

Abstract 5108: Microalbuminuria is Associated with Progression of Coronary Atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA)

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Andrew P DeFilippis ◽  
Holly J Kramer ◽  
Ronit Katz ◽  
Nathan Wong ◽  
Alain Bertoni ◽  
...  
Keyword(s):  
Lipid Lowering ◽  
Albumin Creatinine Ratio ◽  
Ethnic Study ◽  
Median Increase ◽  
Increased Risk ◽  
History Of ◽  
Relationship Of ◽  
The Relationship ◽  
Progression Of Atherosclerosis

Background: Microalbuminuria (MA) is associated with an increased risk of cardiovascular disease (CVD) but the mechanism by which microalbuminuria imparts this increased risk is not known. In this study we assessed the relationship between MA and the development and progression of atherosclerosis by measuring the incidence of new CAC and the progression of existing CAC in individuals free of clinical CVD. Methods : The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective cohort study of 6,814 participants free of clinical CVD at entry who underwent assessment of coronary artery calcification (CAC) by computerized tomography at baseline. Overall, 6,775 individuals had data available on urinary albumin creatinine ratio (UACR); 1,109 individuals were excluded for missing data or macroalbuminuria (UACR≥300 mg/g). Incident CAC was defined as detectable CAC at follow-up among those with CAC=0 at baseline, and absolute CAC score change among those with CAC>0 at baseline. Relative risk (RR) regression adjusted for covariates; and multivariable adjusted median regression was employed to assess the independent relationship of MA with CAC incidence and progression. Results : Of the 5,666 subjects (mean age 62±10 years, 48% males), baseline MA was seen in 424 (7%) participants, who were more likely to have CAC compared to those with normal UACR (62% vs. 48%, p<0.0001). During a mean follow-up of 2.4±0.8 years, those with MA were more likely to develop CAC (28% vs. 15%, p<0.0001) and they had a higher absolute median increase in CAC (47 vs. 29 Agatston Units, p<0.0001). After adjustment for age, gender, ethnicity, site, follow-up duration, diabetes, hypertension, smoking, family history of heart attack, total cholesterol, lipid lowering medications and body mass index; MA was associated with incident CAC (RR 1.65; 95%CI 1.41–2.48) among those with CAC=0 at baseline. Among those with CAC>0 at baseline, MA was associated with a median increase in CAC of 7.93 (95%CI 0.38 –15.47) Agatston Units in multivariable adjusted analyses (variables noted above). Conclusion : MA is independently associated with development of incident CAC and progression of CAC in an asymptomatic multi-ethnic population, and may in part explain its associated increased risk of CVD.

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