The Difference of Zinc And Matrix Levels of Metalloproteinase-9 Serum Between Premature Rupture Of Membrane Aterm And Normal Pregnancy

Lisa Ernita; Ellyza Nasrul; Andi Friadi

doi:10.25077/jom.4.1.40-50.2019

The Difference of Zinc And Matrix Levels of Metalloproteinase-9 Serum Between Premature Rupture Of Membrane Aterm And Normal Pregnancy

Journal of Midwifery ◽

10.25077/jom.4.1.40-50.2019 ◽

2019 ◽

Vol 4 (1) ◽

pp. 40

Author(s):

Lisa Ernita ◽

Ellyza Nasrul ◽

Andi Friadi

Keyword(s):

Serum Zinc ◽

Normal Pregnancy ◽

Zinc Level ◽

Independent Practice ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Cross Sectional ◽

Membrane Rupture ◽

The Difference ◽

Zinc Levels

Premature rupture of membranes (PROM) is one of the common problems in the obstetric field, ranging from 8-10% of term pregnancies will experience PROM. The increase in MMP-9 also has an impact on the degradation of the extracellular matrix and the apoptotic process of amniotic epithelial cells which ultimately leads to membrane rupture. The purpose of this study was to determine the differences in serum zinc and MMP-9 levels between premature rupture of membranes and normal pregnancies.This research is quantitative observational with the cross-sectional design carried out in Independent Practice Midwives for research samples of term premature rupture of normal and amniotic pregnancies, and Biomedical Laboratory of the Medical Faculty of Andalas University in March 2018 to March 2019. The research sample amounted to 35 respondents using consecutive sampling. Zinc and MMP-9 levels were examined by the Human ELISA Kit. Data analysis using the unpaired t-test.The results showed a mean serum zinc level of 13608 ± 1128.976µg / ml in Aterm KPD and 13799,111 ± 1254,335 µg / ml in normal pregnancies with p> 0.05. The mean serum MMP-9 levels were 1682.412 ± 320,398 ng / ml in Aterm PROM and 1807,667 ± 484,735 ng / ml in normal pregnancies with p <0.05.This study concludes that there is no difference in serum zinc levels in premature rupture of membranes and normal pregnancies; there is a difference in MMP-9 levels in premature rupture of membranes and normal pregnancy.

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Decreasing Zinc Levels in Stunting Toddlers in Lampung Province, Indonesia

Biomedical & Pharmacology Journal ◽

10.13005/bpj/1633 ◽

2019 ◽

Vol 12 (1) ◽

pp. 239-243

Author(s):

Khairun Nisa Berawi ◽

Maya Nurul Hidayati ◽

Susianti Susianti ◽

Roro Rukmi W. Perdami ◽

Tiwuk Susantiningsih ◽

...

Keyword(s):

Univariate Analysis ◽

Serum Zinc ◽

Zinc Content ◽

Zinc Level ◽

Bivariate Analysis ◽

Cross Sectional ◽

The Mean ◽

The Difference ◽

Zinc Levels ◽

Serum Zinc Levels

Stunting is a condition of chronic malnutrition in children that causes the posture is not optimal and triggers other disorders such as deacreasing of immunity and intelligence. The level of adequacy of zinc is one of the factors that influence the incidence of stunting. Zinc is needed to activate and begin the synthesis of Growth Hormone (GH) so that children with zinc deficiency cause GH receptors to be disrupted and GH production to be resistant. This study aims to examine the decrease in zinc levels by looking at the difference in mean zinc levels in stunting and non-stunting toddlers. The research method was carried out observational analytic with a cross sectional approach used in this study. The study sample was 40 toddlers aged 24-60 months with 18 stunting toddlers and 22 non-stunting toddlers in Gunung Sugih District, Central Lampung Regency. The results of univariate analysis revealed that the average zinc level of toddlers serum was 52.60 ug / dl with the largest value of 76 ug / dl and the lowest value was 24 ug / dl. The results of bivariate analysis showed that there were significant differences in the mean zinc levels of stunting and non-stunting children (p = 0.01). The mean zinc content of stunting infants was 45.06 ± 12.21 lower than the mean zinc level of non-stunting infants 58.77 ± 12.98. There is a decrease in serum zinc levels in stunting toddlers compared to non stunting toddlers.

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The association between hypozincemia and aortic stenosis prevalence in hemodialysis patients: a single-center cross-sectional study

Renal Replacement Therapy ◽

10.1186/s41100-020-00299-4 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Satoshi Matsui ◽

Tomonaga Ameku ◽

Daisuke Takada ◽

Shinji Ono

Keyword(s):

Aortic Stenosis ◽

Serum Zinc ◽

Cross Sectional Study ◽

Zinc Level ◽

Sectional Study ◽

Single Center ◽

Cross Sectional ◽

Dialysis Vintage ◽

Zinc Levels ◽

Serum Zinc Levels

Abstract Background Hypozincemia contributes to phosphate-induced vascular calcification in model animals of renal failure, but the association between hypozincemia and aortic stenosis (AS) prevalence in patients with end-stage kidney disease remains unreported in clinical settings. Methods To investigate the association between hypozincemia and AS prevalence in patients undergoing hemodialysis, we designed a single-center cross-sectional study. Our outcome “AS” was defined as prevalence of moderate or severe AS or surgical history for AS. Depending on serum zinc levels, we divided patients undergoing hemodialysis into deciles. The association between hypozincemia and AS prevalence was analyzed via logistic regression adjusted for age, sex, dialysis vintage, diabetes history, serum albumin, and history of taking calcium-containing phosphate binder. Results Ninety-three patients undergoing hemodialysis were eligible. The mean serum zinc level was 61.3 ± 13.9 μg/dL. Twelve patients who belonged to 1st decile had serum zinc levels ≤ 48 μg/dL. Of these twelve patients, six patients (50 %) had AS. On the other hand, of eighty one patients who belonged to 2nd–10th deciles (serum zinc levels > 48 μg/dL), thirteen patients (16 %) had AS. Hypozincemia (serum zinc levels ≤ 48 μg/dL) was associated with AS prevalence (P = 0.038; odds ratio 4.43; 95% confidence interval 1.09–18.0). Conclusions AS was more prevalent in patients undergoing hemodialysis with severe hypozincemia in our cross-sectional study, although interventional studies are required to elucidate the benefit of zinc supplementation for AS progression.

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Estimation of serum zinc levels in children with febrile convulsions

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20182556 ◽

2018 ◽

Vol 5 (4) ◽

pp. 1518 ◽

Cited By ~ 1

Author(s):

Ubaidur Rehman H. ◽

Shamshad Ahmed Khan ◽

Prakash R. Saldanha

Keyword(s):

Serum Zinc ◽

Febrile Seizures ◽

Cross Sectional Study ◽

Zinc Level ◽

Sectional Study ◽

Serum Zinc Level ◽

Cross Sectional ◽

Significant Difference ◽

Zinc Levels ◽

Serum Zinc Levels

Background: Febrile seizures are the most common form of convulsion in children with the aged between 6 months to 6 years. Diﬀerent studies have shown that reduction of zinc leads to the incidence of febrile seizures in children. This study was conducted with the goal of examination of the zinc level in the patients with Febrile Seizures.Methods: This cross sectional study was conducted on 50 children in two equal groups of children with febrile seizures, febrile children without seizures. In order to examine the zinc level blood samples were taken of all subjects and the zinc level of these patients was determined. The data was analyzed using the SPSS-16 statistical software and by descriptive statistical tests.Results: 31 males (47.2%) and 19 female children (52.8%) with the average age of 27.23±15.3 months were examined. The two groups had no signiﬁcant diﬀerence in terms of age and sex. The average of zinc level in the patients with Febrile Seizures was 57.4 µg/dL and it was 116 µg/dL in the febrile children without FS there was a signiﬁcant diﬀerence between the two groups in terms of the zinc level (P=0.01).Conclusions: The low serum zinc level in the group of patients with Febrile Seizures compared with children without febrile seizures indicate the existence of a relationship between the serum zinc level and development of FS in children aged between 6 months and 6 years.

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A study of zinc level in cord blood of neonates and its relationship with antropometric measurements in the neonates: a descriptive cross-sectional study

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20190718 ◽

2019 ◽

Vol 6 (2) ◽

pp. 722

Author(s):

Syed Mohamed ◽

Santosh Kumar ◽

J. Kumutha

Keyword(s):

Cord Blood ◽

Growth Parameters ◽

Serum Zinc ◽

Cross Sectional Study ◽

Zinc Level ◽

Cross Sectional ◽

Medical College ◽

The Mean ◽

Zinc Levels ◽

Serum Zinc Levels

Background: During pregnancy, fast growth and cell differentiation takes place in both mother and foetus. Maternal nutritional factors play an important role in the growth of the neonate. Among the micronutrient zinc is an important micronutrient whose deficiency is associated with poor pregnancy outcomes. The objective the current study was to evaluate the relationship of serum zinc concentration of the maternal blood and the neonatal cord blood with that of the infant’s anthropometric measurements.Methods: A descriptive cross-sectional study was performed under the Department of Neonatology, Saveetha medical college. Duration of the study was from April 2017 to June 2018. The study included 82 singleton mother baby dyads born in Saveetha medical college. Anthropometric measurements such as birth weight, head circumference, neonate length apart from other clinical features of both the mother and neonates were recorded for statistical analysis. Serum zinc levels were estimated using 2-(5-bromo-2-pyridylazo)-5-(N-Propyl-N-sulfopropylamino)-phenol (5-Br-PAPS) protocol.Results: The mean maternal age of the study population is 25.3±2.3 years. Majority of the mother had natural mode of delivery (57%). The mean cord serum zinc level was found to be 94.0±1.6microgram /dl and the mother’s serum zinc level was 93.8±30.7microgram /dl (range from 49 to 171microgram /dl) which was not found to be statistically significant. Serum zinc levels of the cord was compared with the child anthropometrics and mother’s serum zinc levels to assess for the significance, but there was no correlation observed between the umbilical cord, and the birth weight (r=0.03), length of the child (r=-0.02), head circumference (r=-0.07) and mothers serum zinc levels (r=-0.002).Conclusions: According to our results authors were unable to establish a relationship between Neonates growth parameters and zinc levels in neonates cord blood and zinc levels in the mother. Further studies with a larger sample size and prospective design would establish a causal relationship between zinc and growth parameters in the neonate.

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Perbedaan Kadar Zink ASI pada Ibu Postpartum dengan Anemia dan Tidak Anemia

Jurnal Kesehatan Terpadu (Integrated Health Journal) ◽

10.32695/jkt.v12i2.151 ◽

2021 ◽

Vol 12 (2) ◽

pp. 62-68

Author(s):

Rini Mustikasari Kurnia Pratama

Keyword(s):

Data Analysis ◽

Breast Milk ◽

Zinc Concentration ◽

Zinc Level ◽

P Value ◽

Test Results ◽

Cross Sectional ◽

The Difference ◽

Zinc Levels ◽

Postpartum Mothers

Zinc is one of the substances needed in breast milk for baby growth. Zinc deficiency is a common health problem that affects the development of children and contributes to diseases such as diarrhea, pneumonia, and malaria. The purpose of this study was to determine the difference in zinc levels in the first week postpartum mothers with anemia compared to postpartum mothers who were not anemic. The research design used observational analytic with a cross-sectional approach, with purposive sampling. Examination of zinc levels in breast milk using spectrophotometry. Data analysis used an unpaired t-test. The test results obtained that the average zinc level in the first week postpartum mothers who were not anemic was 0.40±0.350 mg/L while the average zinc level in the first week postpartum mothers with anemia was 0.42±0.439 mg/L with p-value=0.92 (p>0.05). There was no difference between zinc levels in the first week postpartum mothers with anemia and not anemia. The zinc concentration in breast milk is highest during colostrum, while the lowest value is between 7-12 months of lactation and increases during weaning.

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PERBANDINGAN KADAR ZINC PADA PERSALINAN PRETERM DAN KEHAMILAN NORMAL

Jurnal IPTEKS Terapan ◽

10.22216/jit.2018.v12i3.3827 ◽

2018 ◽

Vol 12 (3) ◽

pp. 212

Author(s):

Visti Delvina ◽

Arni Amir ◽

Ermawati Ermawati

Keyword(s):

Preterm Labor ◽

Normal Pregnancy ◽

Cross Sectional Study ◽

Zinc Level ◽

T Test ◽

Cross Sectional ◽

Consecutive Sampling ◽

Significant Difference ◽

The Mean ◽

Zinc Levels

The Comparative Zinc Levels in Preterm Labor and Normal Pregnancy<h1 align="center">ABSTRACT</h1> Preterm labor occurs between 20 weeks and before 37 weeks of pregnancy. It is indicated by regular contractions of the uterus and it may cause the thinning and flattening of the cervix. Preterm labor also causes the high rates of perinatal morbidity and mortality. Deficiency zinc during pregnancy can stimulate the preterm labor. The design of this reseacrh was a comparative cross sectional study. It was conducted in Rasidin District Hospital, Siti Rahmah Hospital and Biomedical Laboratory, Faculty of Medicine, Andalas University, Padang on Februari 2017 to June 2018. There were 50 samples in this reseach. It was selected by consecutive sampling. The samples were divided into two groups: preterm labor and normal pregnancy. Zinc levels are examined by the ELISA method. Then, the data were analyzed by using the t test. The results of this reseach showed that the mean zinc level in the preterm labor group was 12.22 ± 0.41 μmol / L and 13.96 ± 0.64 μmol / L of the mean zinc level in the normal pregnancy group with P= 0.000. Moreover, statistical test inffered that there was significant difference between zinc levels in preterm labor and normal pregnancy. In short, it can be concluded that zinc levels group in the preterm labor were lower than the normal pregnancy group. Keywords: Zinc, Preterm Labor Perbandingan Kadar Zinc Pada Persalinan Preterm dan Kehamilan Normal<h1 align="center">ABSTRAK</h1> Persalinan preterm adalah persalinan yang terjadi antara 20 minggu dan sebelum 37 minggu kehamilan yang ditandai adanya kontraksi teratur dari uterus yang dapat menyebabkan penipisan dan pendataran serviks. Persalinan preterm menyebabkan tingginya angka morbiditas dan mortalitas perinatal. Defiseiensi zinc selama kehamilan dapat menstimulasi terjadinya persalinan preterm. Desain penelitian ini adalah cross sectional komparatif, penelitian dilakukan di RSUD Rasidin, RSI Siti Rahmah dan Laboratorium Biomedik Fakultas Kedokteran Universitas Andalas Padang pada bulan Februari 2017 – Juni 2018. Jumlah sampel sebanyak 50 yang dipilih secara consecutive sampling, yang dibagi menjadi dua kelompok yaitu persalinan preterm dan kehamilan normal. Kadar zinc diperiksa dengan metode ELISA. Data dianalisa menggunakan uji t test. Hasil penelitian rerata kadar zinc pada kelompok persalinan preterm 12,22 ± 0,41 µmol/L dan rerata kadar zinc pada kelompok kehamilan normal adalah 13,96 ± 0,64 µmol/L dengan nilai p 0,000. Secara statistik terdapat perbedaan yang bermakna antara kadar zinc pada persalinan preterm dan kehamilan normal. Kesimpulan, kadar zinc pada kelompok persalinan preterm lebih rendah daripada kelompok kehamilan normal. Kata Kunci : Zinc, Persalinan Preterm

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Implication of serum zinc level with duration and clinical type of vitiligo

Bangabandhu Sheikh Mujib Medical University Journal ◽

10.3329/bsmmuj.v6i2.29123 ◽

2016 ◽

Vol 6 (2) ◽

pp. 99

Author(s):

Sohail Mirza ◽

Mohammad Eakub Ali ◽

Lubna Khondker ◽

Md. Shirajul Islam Khan ◽

Nadia Islam ◽

...

Keyword(s):

Large Scale ◽

Serum Zinc ◽

Cross Sectional Study ◽

Zinc Level ◽

Serum Zinc Level ◽

Cross Sectional ◽

The Mean ◽

The Difference ◽

Medical University ◽

The Relationship

Background: Vitiligo is a common dermatological disorder characterized by acquired, idiopathic, progressive, hypomelanosis of the skin and hair, with total absence of melanocytes microscopically. Objective: The study was conducted to find out the relationship between serum zinc level and clinical spectrum of vitiligo. Methods: A cross sectional study conducted in the departmenl of Dermatology and Venereology and department of Biochemistry, Bangabandbu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh and the period of study was from May 2010 to October 2011. Results: The mean difference of sernm zinc level in male and female of both groups were significant (p<0.05) but the mean serum zinc level was not significantly different (p>0.05) among various clinical types ofvitiligo. ln case oflocalized vitiligo mean serum zinc level was 755.3 ± 288.6, in case of acrofacial viriligo mean serum zinc level was 821.4 ± 259.6 and in case of generalized vitiligo mean sernm zinc level was 771.6 ± 222.2. The difference of mean sernm zinc level observed between family history positive and negative group were not statistically significant (p>0.05). The difference of mean senun zinc level was also not statistically significant (p>0.05) among <1 year, 1-10 years and 11-20 years duration groups of vitiligo patients. A negative correlation (r = -0.227) was observed between duration of symptom with senun zinc level in this study. Conclusion: This study showed low level of serum zinc in vitiligo patients. Large-scale studies are needed to confirm these findings and multicenter study should be carried out to reveal the accurate pattern of zinc status in vitiligo.

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Difference of Serum MMP9 and TNF 􀁃 Level in Preterm and Term Premature Rupture of Membranes

Indonesian Journal of Obstetrics and Gynecology ◽

10.32771/inajog.v3i1.20 ◽

2016 ◽

Author(s):

Aji P Wibowo ◽

Sri Sulistyowati ◽

Supriyadi H Respati

Keyword(s):

Gestational Age ◽

Serum Levels ◽

Premature Rupture Of Membranes ◽

Term Pregnancy ◽

Premature Rupture ◽

Cross Sectional ◽

The Difference ◽

Average Serum ◽

Metalloproteinase 9 ◽

Necrosis Factor

Objective: To examine the difference between matrix metalloproteinase‐ 9 (MMP‐9) and Tumor Necrosis Factor 􀁃 (TNF‐􀁃) serum levels in preterm and term premature rupture of membranes (PROM). Method: Our study employed an observational cross sectional approach. Seventy samples were divided into two groups, 35 samples with preterm PROM (28‐36 weeks gestational age) and 35 samples with PROM at term pregnancy (37‐42 weeks gestational age). Both groups underwent examination for serum MMP‐9 and TNF‐􀁃 concentration using ELISA method. Statistical analysis was done using ttest. Result: Serum levels of MMP‐9 in the preterm PROM group was 2860.68K627.32 ng/ml, which was significantly higher than in the PROM at term pregnancy group 2549.74K657.15 ng/ml (p=0.04). Likewise, the average serum level of TNF‐􀁃 in subjects with preterm PROM was 12,086.60K5384.51 ng/ml, significantly higher in comparison to PROM at term pregnancy, which was 6422.51K2645.32 ng/ml (p=0.00). Conclusion: Serum levels of MMP‐9 and TNF‐􀁃 in preterm PROM is significantly higher than that in PROM at term pregnancy. Keywords: MMP‐9, premature rupture of membranes, preterm, term, TNF‐􀁃

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Perbedaan Kadar Zinc Rambut pada Anak Stunting dan Non Stunting Usia 12-24 Bulan di Kelurahan Tambak Wedi Kenjeran, Surabaya

Amerta Nutrition ◽

10.20473/amnt.v1i2.2017.133-142 ◽

2017 ◽

Vol 1 (2) ◽

pp. 133

Author(s):

Brigita Rainy Oktiva ◽

Merryana Adriani

Keyword(s):

Random Sampling ◽

Simple Random Sampling ◽

Atomic Absorption Spectrophotometry ◽

Zinc Level ◽

The Body ◽

Hair Zinc ◽

Cross Sectional ◽

Food Recall ◽

The Difference ◽

Zinc Levels

Background: Stunted is still a health problem in Indonesia. The prevalence of stunted in Surabaya has continued to increase for 3 years, while the prevalence of stunted in Tambak Wedi Kenjeran in 2017 shows high percentage (43.8%). Stunted are associated with zinc levels of the body due to zinc as a role in synthesis of growth hormone. Measurement of zinc levels can be done through the hair in describing chronic stunted incident. Measurement of zinc levels through the hair is easier to implement than other measurements of zinc levels, such as blood serum.Objectives: The purpose of this study was to analyze the difference of hair zinc level in children of stunted and non stunted age 12-24 months in Tambak Wedi village, Kenjeran district, Surabaya. Methods: This research was an observational analytic with cross sectional design. The population of this study were all children aged 12-24 months in Tambak Wedi Kenjeran, Surabaya in the amount of 267 children. The samples of this study were 36 children that divided into 18 children stunted and 18 children non-stunted, taken by simple random sampling. Data were collected by measuring height, questionnaire interview, food recall 2x24 hour, and hair zinc level measurement using Atomic Absorption Spectrophotometry (AAS). Data were analyzed using Mann-Whitney Test to find the difference in two variables with data not distributed normally. Results: The results of this study showed no differences of hair zinc levels in stunted and non stunted children (p = 0.517). Conclusion: Hair zinc levels in stunted and non stunted children aged 12-24 months in Tambak Wedi Kenjeran, Surabaya showed no differences. Required continue research by measuring the body's zinc levels simultaneously through blood serum and hair to get more accurate results. ABSTRAK Latar Belakang: Permasalahan stunting masih menjadi permasalahan kesehatan di Indonesia. Prevalensi stunting di Surabaya terus mengalami peningkatan selama 3 tahun, sedangkan di Kelurahan Tambak Wedi Kenjeran prevalensi stunting pada tahun 2017 masih sangat tinggi (43,8%). Kejadian stunting berkaitan dengan kadar zinc tubuh dikarenakan zinc berperan dalam sintesis hormon pertumbuhan. Pengukuran kadar zinc dapat dilakukan melalui rambut dalam menggambarkan kejadian stunting secara kronis. Pengukuran kadar zinc melalui rambut lebih mudah dilaksanakan dibandingkan pengukuran kadar zinc lainnya karena pengukuran kadar zinc rambut lebih sensitif dan stabil.Tujuan: Mengetahui perbedaan kadar zinc rambut pada balita stunting dan non stunting usia 12-24 bulan di Kelurahan Tambak Wedi Kecamatan Kenjeran Surabaya.Metode: Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional. Populasi penelitian ini adalah seluruh balita berusia 12-24 bulan di Kelurahan Tambak Wedi Kenjeran, Surabaya dengan jumlah 267 balita. Sampel penelitian ini sebesar 36 orang dengan 18 orang mengalami stunting dan 18 orang tidak stunting, diambil secara acak menggunakan teknik simple random sampling. Penentuan sampel menggunakan uji hipotesis dua proporsi. Pengumpulan data meliputi pengukuran tinggi badan, wawancara kuesioner, food recall 2x24 jam, dan pengambilan sampel rambut untuk pengukuran kadar zinc rambut dengan alat Spektofotometer Serapan Atom (SSA). Data dianalisis menggunakan uji Mann-Whitney untuk mengetahui perbedaan pada dua variabel dengan data tidak berdistribusi normal.Hasil: Tidak terdapat perbedaan kadar zinc rambut pada balita stunting dan non stunting (p=0,517).Kesimpulan: Kadar zinc rambut pada anak stunting dan non stunting dengan usia 12-24 bulan di Kelurahan Tambak Wedi Kenjeran, Surabaya tidak berbeda. Diperlukan penelitian lanjutan dengan mengukur kadar zinc tubuh secara bersamaan melalui serum darah dan rambut untuk mendapatkan hasil lebih akurat.

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A Study of Serum Zinc level in Cirrhosis of Liver

Bangladesh Journal of Medical Biochemistry ◽

10.3329/bjmb.v5i2.13340 ◽

2013 ◽

Vol 5 (2) ◽

pp. 44-47

Author(s):

F Atia ◽

N Sultana ◽

S Ahmed ◽

S Ferdousi ◽

R Sultana ◽

...

Keyword(s):

Serum Zinc ◽

Cross Sectional Study ◽

Zinc Level ◽

Serum Zinc Level ◽

Cross Sectional ◽

Medical College ◽

Cirrhotic Patients ◽

Cirrhosis Of Liver ◽

Zinc Levels ◽

Age Range

Cirrhosis is a consequence of chronic liver diseases. Zinc is a micronutrient that plays an important role in the function of liver. This cross-sectional study was carried out in the Department of Biochemistry, Dhaka Medical College, from July 2010 to June 2011 to observe the association of serum zinc level with liver cirrhosis. A total of 100 adults, both males and females with age range of 18-60 years, of which 50 were healthy subjects and 50 adult hospitalised cirrhotic patients were selected purposively for the study according to selection crieteria. Fasting serum zinc level was measured with atomic absorption spectrophotometer. Serum zinc level was found to be low in 72% patients. Mean ±SD of serum zinc levels (?g/L) were 610.32 ± 169.60 and 827.66 ± 267.32 in cases and controls respectively. In cirrhotic patients serum zinc level was significantly lower than that of healthy controls (P<0.001). Though, it is difficult to draw any definite conclusion from this study, because of reduced level serum of zinc found in cirrhotics, Zn may be supplemented to them with a hope of better treatment response. DOI: http://dx.doi.org/10.3329/bjmb.v5i2.13340 Bangladesh J Med Biochem 2012; 5(2): 44-47

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