scholarly journals The Role of Tumor Necrosis Factor  (TNF ) and Matrix Metalloproteinase9 (MMP9) Serum in Preterm Premature Rupture of Membranes

2017 ◽  
pp. 199
Author(s):  
Ardiles Ardiles ◽  
Desmiwarti Desmiwarti ◽  
Hafni Bachtiar
Keyword(s):  
Serum Levels ◽  
Cross Sectional Study ◽  
P Value ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Preterm Premature Rupture ◽  
The Mean ◽  
Necrosis Factor

Objective: To investigate the role of TNF- and MMP-9 serum in preterm premature rupture of membranes (PPROM). Methods: We used cross-sectional study design. Subjects were all pregnant women with and without PPROM who underwent checkup at Obstetrics and Gynecology Functional Medical Staff General Hospital Dr. M. Djamil and networking hospital. Results: A total of 48 subjects were enrolled in this study. The mean serum levels of TNF- in patients with PPROM 17.43 ng/ml  12.4 ng/ml and without PPROM 8.45 ng/ml  6.86 ng/ml. The mean serum levels of MMP-9 in patients with PPROM 8.77 ng/ml  4.41 ng/ml, and without PPROM 4.46 ng/ml  3.04 ng/ml. Statistical test result p value <0.05, it can be conclude there are differences in the levels of TNF- and MMP-9 serum in premature rupture of membranes and without premature rupture of membranes pregnancy of preterm. Conclusion: There are differences in the levels of TNF- and MMP-9 serum in PPROM and without PPROM.Keywords: MMP-9, premature rupture of membranes, TNF-

scholarly journals KARAKTERISTIK KEHAMILAN DENGAN KETUBAN PECAH DINI PRETERM DI RSUD ULIN BANJARMASIN

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Hermin Sabaruddin ◽  
Chalid Muthaher ◽  
M. Robyanoor AR
Keyword(s):  
Gestational Age ◽  
Medical Records ◽  
Maternal Age ◽  
Education Level ◽  
P Value ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Preterm Premature Rupture ◽  
Low Education

ABSTRAKKetuban pecah dini (KPD) didefinisikan sebagai pecahnya selaput ketuban sebelum terjadinya persalinan yang terjadi pada atau setelah usia gestasi 37 minggu disebut KPD aterm atau premature rupture of membranes (PROM) dan sebelum usia gestasi 37 minggu atau KPD preterm atau preterm premature rupture of membranes (PPROM). Insiden ketuban pecah dini di Indonesia berkisar 4,5% sampai 7,6 % dari seluruh kehamilan. KPD Preterm terjadi pada terjadi pada sekitar 2-3% dari semua kehamilan tunggal dan 7,4% dari kehamilan kembar. Penelitian ini merupakan penelitian observasional analitik secara retrospektif deskriptif cross sectional. Pengambilan data diambil dari rekam medis pasien rawat inap kamar bersalin di RSUD.Ulin Banjarmasin pada periode januari– desember 2017. Pada penelitian ini menunjukkan bahwa sebagian besar variabel faktor risiko yaitu usia, pendidikan, usia kehamilan dan paritas menunjukkan hubungan terhadap kejadian KPD preterm. Hasil analisis menunjukkan terdapat hubungan yang signifikan pada usia ibu 18-20 tahun sebesar 63.6% dengan OR (95%CI)= 7.56 (6.206-7.687). Faktor risiko pada sampel pendidikan paling banyak pada tingkat pendidikan rendah sebesar 65,1% dengan OR (95% CI) = 7.244 (6.172-7.343) dibandingkan dengan ibu tingkat pendidikan tinggi sebesar 37.3%. Pada variable usia kehamilan sampel terbanyak ditemukan pada usia kehamilan 28-34 minggu sebanyak 100% dengan OR (95%CI) = 94.0 (78.2-130.3). Pada variabel paritas terbanyak pada multigravida yaitu 45.9% dengan OR (95%CI) = 2.26-2.32) namun hasil ini tidak signifikan dikarenakan p value >0.005. Ditemukan hubungan faktor risiko pada usia ibu 18-20 tahun, pendidikan rendah, dengan usia kehamilan 28-34 minggu, namun tidak signifikan pada paritas multigravida.Kata-kata kunci : Ketuban pecah dini preterm, kehamilan ABSTRACTPremature rupture of membranes (PROM) are defined as rupture of the membranes before the onset of labor and which occur at or after 37 weeks gestational age is called premature rupture of membranes (PROM) and before 37 weeks gestational age is called preterm premature rupture of membranes (PPROM). The incidence of premature rupture of membranes in Indonesia is from 4.5% to 7.6% of all pregnancies. Preterm KPD occurs at 2-3% of all single pregnancy and 7.4% of twin pregnancy. This study was a cross sectional descriptive observational analytic study. The data was taken from the medical records of Delivery Room in RSUD Ulin Banjarmasin at January-December 2017. In this study, the majority of risk factor, age, education, gestational age and parity showed a relationship to Insidence of PPROM. The results of the analysis showed that there was a significant relationship between the age of 18-20 years percentage was 63.6% with OR (95% CI) = 7.56 (6,206-7,687). The most sample at low education level was 65,1% with OR (95% CI) = 7.244 (6.172-7.343) compared to the high education level was 37.3%. Criteria for gestational age, the most samples were found at 28-34 weeks gestational age with percentage of PPROM was 100% with OR (95% CI) = 94.0 (78.2-130.3). Then at parity most Insidece in multigravida was 45.9% with OR (95% CI) = 2.26-2.32) but this result is not significant because p value> 0.005. We found a correlation between risk factors at maternal age 18-20 years, the low education and gestational age of 28-34 weeks, but not significant in multigravida parity.Keywords : Preterm premature rupture of membranes (PPROM), pregnancy

scholarly journals Analysis of risk factors, maternal and fetal outcome of spontaneous preterm premature rupture of membranes: a cross sectional study

2017 ◽  
Vol 6 (9) ◽  
pp. 3781
Author(s):  
Surekha S. Mohan ◽  
Chamaraja Thippeveeranna ◽  
Naorem N. Singh ◽  
Laiphrakpam R. Singh
Keyword(s):  
Fetal Outcome ◽  
Cross Sectional Study ◽  
Perinatal Morbidity ◽  
Sectional Study ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Membrane Rupture ◽  
Preterm Premature Rupture ◽  
History Of

Background: Preterm premature rupture of membranes (PPROM) is one of the most common complications of pregnancy. It is an important cause of perinatal morbidity and mortality. Objective of present study was to determine incidence, risk factors, maternal, fetal outcome of PPROM occurring in patients attending a tertiary hospital in North Eastern India.Methods: This descriptive cross- sectional study was carried out in the department of Obstetrics and Gynecology, Regional Institute of Medical Sciences, Imphal, India. Out of 15,969 deliveries between July 2010 to December 2011, 358 pregnant patients with spontaneous preterm premature rupture of membranes from 28-0 to 36-6weeks gestation were reviewed. After excluding patients with uterine anomalies, intrauterine deaths and congenital anomalies 293 patients were included and evaluated in this study.Results: The incidence of PPROM was 2.2%. Out of 293 patients 86% were singleton pregnancies, 12.9% were twins and 1.02% were triplets. 48.4% had previous history of termination of pregnancy, 28.6% history of previous PPROM and 16.3% had urinary tract infection. The mean gestational age at the onset of membrane rupture was 34.1+2.4 weeks and the latency from the membrane rupture to delivery interval ranged from 0-72 days with a mean of 48.4 hours. There were 7stillbirths (2.38%) and 4 neonatal deaths (1.02%) resulting in perinatal deaths of 3.29% and perinatal mortality rate of 0.329 per 1000 births due to PPROM. Maternal morbidity was minimal with postpartum haemorrhage in 11 patients (4.1%), abruptio placentae in 7 patients (2.3%) and sepsis in 43patients (14.6%). 66 patients (22.5%) underwent caesarean section for which malpresentations were the major cause.Conclusions: Despite remarkable advances in perinatal care, preterm premature rupture of membranes continues to cause perinatal morbidity and mortality. Strategies should be developed for its prevention. Management protocol should be improved in regard to vaginal swab culture and use of specific antibiotics.

scholarly journals Vaginal flora in preterm premature rupture of membranes and their sensitivity to commonly used antibiotics

2014 ◽  
Vol 5 (4) ◽  
pp. 58-60 ◽  
Author(s):  
Shikha Rani ◽  
Reeti Mehra ◽  
Varsha Gupta ◽  
Anju Huria ◽  
Jagdish Chander
Keyword(s):  
Pregnant Women ◽  
Cross Sectional Study ◽  
Vaginal Flora ◽  
Gram Negative Bacteria ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Gram Negative ◽  
Preterm Premature Rupture ◽  
Ascending Infection

Background: Ascending infection is one of the most common etiologies in preterm premature rupture of membranes (PPROM). Antibiotics are used in PPROM to prolong the pregnancy and to prevent infection. But to prevent drug overuse and resistance, microorganism directed antibiotics should be used. So, this study was planned to evaluate vaginal flora in pregnant women with PPROM and their sensitivity to commonly used antibiotics. Methods: In this prospective cross-sectional study, 50 pregnant women (cases) preterm premature rupture of membranes and 28 pregnant women (controls) without complication were assessed for the type of vaginal flora and its sensitivity to commonly used antibiotics. Results: Among cases 18 (36%) women showed bacteria on Gram’s staining of vaginal swabs with Gram?negative bacteria (10/18) being the most common. Among controls, 16 (57%) women showed bacteria on Gram’s staining with Gram?positive bacteria being most common. Among cases Escherichia coli and Staphylococcus aureus were the commonest isolates. Of 8 (16%) positive bacterial cultures in cases, 6 (10%) were sensitive to Gentamicin and 2 (4%) to Ampicillin. Conclusion: Lower genital tract flora of pregnant women with PPROM predominantly consists of Gram?negative bacteria, which are sensitive to Gentamicin. DOI: http://dx.doi.org/10.3126/ajms.v5i4.9889 Asian Journal of Medical Sciences 2014 Vol.5(4); 58-60

scholarly journals Difference of Serum MMP9 and TNF 􀁃 Level in Preterm and Term Premature Rupture of Membranes

2016 ◽  
Author(s):  
Aji P Wibowo ◽  
Sri Sulistyowati ◽  
Supriyadi H Respati
Keyword(s):  
Gestational Age ◽  
Serum Levels ◽  
Premature Rupture Of Membranes ◽  
Term Pregnancy ◽  
Premature Rupture ◽  
Cross Sectional ◽  
The Difference ◽  
Average Serum ◽  
Metalloproteinase 9 ◽  
Necrosis Factor

Objective: To examine the difference between matrix metalloproteinase‐ 9 (MMP‐9) and Tumor Necrosis Factor 􀁃 (TNF‐􀁃) serum levels in preterm and term premature rupture of membranes (PROM). Method: Our study employed an observational cross sectional approach. Seventy samples were divided into two groups, 35 samples with preterm PROM (28‐36 weeks gestational age) and 35 samples with PROM at term pregnancy (37‐42 weeks gestational age). Both groups underwent examination for serum MMP‐9 and TNF‐􀁃 concentration using ELISA method. Statistical analysis was done using ttest. Result: Serum levels of MMP‐9 in the preterm PROM group was 2860.68K627.32 ng/ml, which was significantly higher than in the PROM at term pregnancy group 2549.74K657.15 ng/ml (p=0.04). Likewise, the average serum level of TNF‐􀁃 in subjects with preterm PROM was 12,086.60K5384.51 ng/ml, significantly higher in comparison to PROM at term pregnancy, which was 6422.51K2645.32 ng/ml (p=0.00). Conclusion: Serum levels of MMP‐9 and TNF‐􀁃 in preterm PROM is significantly higher than that in PROM at term pregnancy. Keywords: MMP‐9, premature rupture of membranes, preterm, term, TNF‐􀁃

Brief Overview and Experience of Visual Evoked Potential of First 67 cases at Referral Neuroscience Hospital in Bangladesh

2020 ◽  
Vol 6 (2) ◽  
pp. 74-77
Author(s):  
Mohammad Enayet Hussain ◽  
Bithi Debnath ◽  
AFM Al Masum Khan ◽  
Md Ferdous Mian ◽  
Md Nahidul Islam ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Clinical Diagnosis ◽  
Optic Neuropathy ◽  
Cross Sectional Study ◽  
P Value ◽  
Pattern Reversal ◽  
Cross Sectional ◽  
The Mean ◽  
Visual Evoked

Background: The visual evoked potentials (VEP) is a valuable tool to document occult lesions of the central visual channels especially within the optic nerve. Objectives: The purpose of the present study was to observe the findings of first few cases of VEP done in the neurophysiology department of the National Institute of Neurosciences (NINS), Dhaka, Bangladesh. Methodology: This cross-sectional study was conducted in the Department of Neurophysiology at the National Institute of Neurosciences and Hospital, Dhaka, Bangladesh from September 2017 to March 2020. All patients referred to the Neurophysiology Department of NINS for VEP were included. Pattern reversal VEPs were done using standard protocol set by International Federation of Clinical Neurophysiology (IFCN). Results: The mean age of the study population was 30.70 (±12.11) years (6-68 years) with 31 (46.3%) male and 36 (53.7%) female patients. The mean duration of illness was 8.71 (±1.78) months (3 days- 120 months). Most common presenting symptom was blurring of vision (37.3%) and dimness of vision (32.8%). Patterned VEP revealed mixed type (both demyelinating and axonal) of abnormality in most cases [29(43.35)]. The most common clinical diagnosis was multiple sclerosis (29.85%) and optic neuropathy (26.87%). In the clinically suspected cases of multiple sclerosis, optic neuropathy and optic neuritis most of the cases of VEP were abnormal and the p value is 0.04 in optic neuropathy and optic neuritis. Conclusion: The commonest presentation of the patients in this series were blurring of vision and dimness of vision. The most common clinical diagnosis for which VEP was asked for, was optic neuritis and multiple sclerosis. Most abnormalities were of mixed pattern (demyelinating and axonal). Journal of National Institute of Neurosciences Bangladesh, 2020;6(2): 74-77

scholarly journals POS0548 OPTIMAL ASSESSMENT OF THE RHEUMATOID ARTHRITIS ANKLE AND HINDFOOT: A COMPARATIVE STUDY BETWEEN CLINICAL EXAMINATION AND ULTRASONOGRAPHY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 508.2-509
Author(s):  
K. Maatallah ◽  
H. Boussaa ◽  
H. Riahi ◽  
H. Ferjani ◽  
M. Habechi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Examination ◽  
Demographic Data ◽  
Power Doppler ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Therapeutic Decisions ◽  
The Mean ◽  
Foot Disease

Background:Foot disease is a common problem in rheumatoid arthritis (RA). Therapeutic decisions are often based on clinical examination (CE) alone, which can be adversely affected by factors such as deformity, obesity, and peripheral edema. Ultrasonography (US) has previously been shown to be more sensitive than CE for detecting synovitis and tenosynovitis in RA forefeet, but few data exist for the hindfoot and ankle.Objectives:The aim of this study was to compare CE and US for the detection of hindfoot and ankle synovitis and tenosynovitis in patients with established RA.Methods:We conducted a cross-sectional study including patients with RA (ACR/EULAR 2010). Demographic data and disease parameters were collected. CE was performed by a rheumatologist for the presence or absence of tenderness, swelling, and mobility restriction of both ankles. The following tendons were examined for tenosynovitis: tibialis anterior (TA) and posterior (TP), fibularis longus (FL), and brevis (FB) (assessed together). In a second time, US examination of the tibiotalar, talonavicular, and subtalar joints and the same tendons as CE was performed by a blinded radiologist experienced in musculoskeletal imaging using a Philips HD11 device with a high-frequency linear transducer. The presence or absence of synovitis and tenosynovitis was recorded, and the composite synovitis score (power doppler / grayscale ultrasound (PDUS)) was measured for each joint. The US score of each patient was defined by the sum of the composite scores of the joints studied (0-30). A p-value <0.05 was considered significant.Results:Sixty-two feet were examined in 31 RA patients (25 women and six men) with a mean age of 54.8±10.8 years old [32-70]. The mean disease duration was 8.5±7.2 years [1-37]. Rheumatoid Factor (RF) and Anti-Citrullinated Peptides Antibodies (ACPA) were positive in 61.3% and 83.8% of cases. The mean DAS28 ESR was 3.8±1.5 [0.6-7].Clinical examination of ankles revealed tenderness in 57.4% of cases, swelling in 38.8% of cases, and restriction in the range of motion in 11.1% of cases. TA tenosynovitis was noted in 14.8% of cases, TP tenosynovitis in 22.2% of cases, and FL and FB tenosynovitis in 31.5% of cases.US showed tibiotalar synovitis in 59.3% of cases, talonavicular synovitis in 64.8% of cases, and subtalar synovitis in 46.3% of cases. TA tenosynovitis was noted in 5.6% of cases, TP tenosynovitis in 22.2% of cases, and FB and FL tenosynovitis in 25% and 11.1% of cases respectively.An association was found between clinical tenderness and US synovitis of the tibiotalar joint (p=0.013) and the talonavicular joint (p=0.027). No association was noted between clinical swelling and US synovitis in these joints.No association was noted between clinical and US tenosynovitis of TA (p=0.279), TP (p=0.436), FB (p=0.495) and FL (p=0.315).Conclusion:Clinical examination of RA ankles may be challenging and needs to be coupled with US, which is more sensitive and accurate in the detection of synovitis and tenosynovitis.Disclosure of Interests:None declared

Satisfaction and Adherence to Biological Treatment in Patients with Rheumatic Diseases

2021 ◽  
Vol 18 ◽  
Author(s):  
Marwa Hammad ◽  
Huny Bakry
Keyword(s):  
Rheumatic Diseases ◽  
Biological Treatment ◽  
Formal Education ◽  
Biological Therapy ◽  
Cross Sectional Study ◽  
P Value ◽  
Inflammatory Rheumatic Diseases ◽  
Cross Sectional ◽  
New Era ◽  
The Mean

Background: Autoimmune inflammatory rheumatic diseases have long been treated by conventional disease-modifying anti-rheumatic drugs. Biological therapy is a new era in the treatment of rheumatic diseases, but satisfaction and adherence to it is still not well tested. Aim: To assess the satisfaction and adherence to biological treatment among patients with autoimmune inflammatory rheumatic diseases. Methods: A cross sectional study was conducted among 56 patients suffering from inflammatory rheumatic diseases using Morisky 8 questionnaire and Treatment Satisfaction Questionnaire for Medication (TSQM) over a period of one month Results: About 76.8% of the patients had medium adherence and the underlying cause of missing doses was the unavailability of the drugs. The mean satisfaction with biological treatment was 62.7±6.9. Patients who did not receive formal education had significantly higher satisfaction with the biological treatment than others 64.94±5.01 at a P value 0.04 (<0.05). Conclusion: Patients with inflammatory rheumatic diseases in our study showed medium adherence and satisfaction. Authorities in the medical field are providing great help to these patients in need of biological therapy, but ensuring the availability of all doses of the biological treatment regimen is still necessary. Patient, family and nurse education programs are also necessary to maximize adherence and satisfaction.

scholarly journals Tooth Loss and Its Association With Frequency of Pregnancy: A Cross-Sectional Study Among Yemeni Women

2021 ◽  
Author(s):  
Anas Shamala ◽  
Ebtesam Al-Maimooni ◽  
Salsbeel Al-Matari ◽  
Ryhana Hiyat ◽  
Mohammed Al-wesabi ◽  
...  
Keyword(s):  
Oral Hygiene ◽  
Tooth Loss ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Khat Chewing ◽  
Number Of Children ◽  
Hygiene Practices ◽  
The Mean

Abstract Backgrounds: The present study sought to assess tooth loss and oral hygiene practices among a sample of Yemeni women in association with giving births (parity).Subjects and Methods: This cross-sectional study included a sample of 644 Yemeni women. They were interviewed to gather socio-demographic (age, education, number of children) and behavioral data (oral hygiene practices, khat chewing and smoking). Additionally, they were examined clinically to assess number of tooth loss. Data were analyzed using SPSS with a P-value < 0.05 was considered statistically significant. Results: The participating women aged between 16 and 51 years. Only one fifth of the sample reported brushing their teeth regularly (i.e, at least once a day), and around 36.8% reported using dental aids occasionally. Additionally, 52% and 21% of the sample reported they were khat chewers and smokers, respectively. The mean number of tooth loss was 4.7. The mean number of children was 4.15, with approximately 54% of the participating women had more than 3 children. The results of the logistic regression revealed a significant association between number of children and tooth loss. Conclusion: Yemeni women had poor oral hygiene practices and high prevalence of tooth loss increased proportionally with the increased number of children. This emphasizes the importance of an effective oral hygiene motivation and health education among female patients during pregnancy periods.

scholarly journals Cross-sectional study to compare the biochemical parameters in low normal versus high normal plasma glucose levels in euglycemic individuals

2020 ◽  
Vol 7 (6) ◽  
pp. 997
Author(s):  
Dharmendra Jhavar ◽  
Neha Kirti ◽  
Sumit Kumar Vishwakarma ◽  
Umesh Kumar Chandra ◽  
Vinod Verma
Keyword(s):  
Uric Acid ◽  
Total Cholesterol ◽  
General Medicine ◽  
Cross Sectional Study ◽  
Normal Group ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Mean ◽  
The Difference

Background: Since a long time ago, the experts have realized that determination of cut-off point for diagnosing diabetes will be revised over time with the lower blood glucose level as the more sensitive diagnosis for detecting the occurring complication and biochemical changes.Methods: This cross sectional study was carried out in the department of medicine, M.G.M. Medical College and M.Y. Hospital Indore from July, 2016 to August, 2017 in 200 individuals and patients having euglycemic status attending General Medicine OPD.Results: In the low and high normal group 2 (2.0%) and 8 (8.0%) were having abnormal total cholesterol (TC) level respectively. The mean total cholesterol in the low normal group was 117.16±26.94mg/dl and it was 154.74±28.38mg/dl in the high normal group. The difference was found to be statistically significant (p value 0.000). In the low and high normal group, 4 (4.0%) and 17 (17.0%) were having abnormal triglyceride (TG) levels respectively. The mean TG levels in the low and high normal group were 96.93±22.64mg/dl and 110.55±32.37mg/dl respectively. The difference was found to be statistically significant (p value 0.001). In the low and high normal group, 6 (6.0%) and 14 (14.0%) patient was having abnormal uric acid levels respectively. The mean uric acid levels in the low and high normal group was 4.88±1.10mg/dl and 5.31±1.31mg/dl respectively. The difference was found to be statistically significant (p value 0.013).Conclusions: Higher levels of Cholesterol and Triglycerides were found more commonly in high normal euglycemic group compared to low normal euglycemic group. Mean cholesterol and mean triglyceride levels were higher in high normal euglycemic group.

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