Introduction. The article discusses the essence and main new trends of the regional foreign policy of Uzbekistan in modern conditions. New trends in regional cooperation in the foreign policy of Uzbekistan revealed from the second half of 2016. Based on the analysis of the works of Uzbek political scientists, researchers, as well as specialists, the continuity of forms, methods, and mechanisms for ensuring stability in the Central Asian region is analyzed. The President of the Republic of Uzbekistan Shavkat Mirziyoyev in his Address to the Oliy Majlis on December 29, 2020, noted that in the face of today's complex geopolitical processes, the coronavirus pandemic and the global economic crisis, Uzbekistan is actively pursuing an open and pragmatic foreign policy. He noted that as a result of our efforts, the prestige of the country is growing, and priorities for the implementation of foreign policy for 2021 have been outlined. Research methods. The article uses systematization, comparative, problem-chronological scientific research. Results and discussions.