scholarly journals Hubungan Paparan Asap Rokok Dengan Kejadian Ispa Pada Balita Di Wilayah Kerja Puskesmas Bandar Agung Kecamatan Terusan Nunyai Kabupaten Lampung Tengah

2021 ◽  
Vol 3 (1) ◽  
pp. 82-91
Author(s):  
Wahid Tri Wahyudi ◽  
M. Arifki Zainaro ◽  
Muhamad Kurniawan
Keyword(s):  
Cigarette Smoke ◽  
Quantitative Research ◽  
Health Centre ◽  
Statistical Test ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
P Value ◽  
Cross Sectional ◽  
Health Centres ◽  
Research Type

INTISARI : HUBUNGAN PAPARAN ASAP ROKOK DENGAN KEJADIAN  ISPA PADA BALITA DI WILAYAH KERJA PUSKESMAS BANDAR AGUNG KECAMATAN TERUSAN NUNYAI  KABUPATEN LAMPUNG TENGAH TAHUN 2019 Pendahuluan :ISPA atau pneumonia  merupakan penyakit yang paling sering diderita oleh balita yaitu sebanyak 78% balita datang berkunjung ke pelayanan kesehatan dengan kejadian ISPA. Berdasarkan hasil Riskesdas 2018 diketahui bahwa prevalensi ISPA menurut diagnosa Nakes mencapai 4,4%.Puskesmas Bandar agung merupakan wilayah kerja Puskesmas dengan kasus ISPA tertinggi di Kabupaten Lampung Tengah yaitu sebanyak 2.141 kasus. Kebiasaan merokok orang tua di dalam rumah menjadikan balita sebagai perokok  pasif yang selalu terpapar asap rokok. Rumah yang orang tuanya mempunyai kebiasaan merokok berpeluang meningkatkan kejadian ISPA.Tujuan: Untuk mengetahui hubungan paparan asap rokok dengan kejadian ISPA pada balita di Wilayah Kerja Puskesmas Bandar Agung Kecamatan Terusan Nunyai Kabupaten Lampung Tengah Tahun 2019.Metode: Jenis penelitian kuantitatif, menggunakan pendekatan cross sectional. Populasi pada penelitian ini adalah seluruh ibu yang memiliki balita dan berkunjung ke Puskesmas Bandar Agung Kecamatan Terusan Nunyai Kabupaten Lampung Tengah berjumlah  135 orang. Sampel 101 responden. Tehnik pengumpulan data dilakukan dengan  menggunakan kuesioner. Uji statistik yang digunakan adalah uji Chi Square.Hasil: Ada hubungan paparan asap rokok dengan kejadian ISPA pada balita di Wilayah Kerja Puskesmas Bandar Agung Kecamatan Terusan Nunyai Kabupaten Lampung Tengah Tahun 2019 (p  value 0,001. OR 4,2).Kesimpulan: Ada hubungan paparan asap rokok dengan kejadian ISPA pada balita(p  value 0,001. OR 4,2). Diharapkan kepada pihak Puskesmas Bandar Agung untuk melakukan promosi kesehatan pada masyarakat khususnya promosi tentang bahaya rokok, kandungan-kandungan yang terdapat pada rokok yang dapat membahayakan kesehatan, efek yang ditimbulkan oleh asap rokok, bahaya rokok bagi perokok aktif maupun pasi, dalam hal ini yang lebih dirugikan adalah perokok pasif teruatama balita. Sebab, balita dengan anggota keluarga perokok mempunyai frekuensi terserang ISPA lebih besar Kata Kunci    :Paparan Asap Rokok,Kejadian ISPA     ABSTRAK : THE CORRELATION OF CIGARETTE SMOKE EXPOSURE WITH URI CASE ON TODDLERS AT THE WORKING AREA OF BANDAR AGUNG HEALTH CENTRE TERUSAN NUNYAI SUBDISTRICT CENTRAL LAMPUNG REGENCY YEAR OF 2019 Introduction: URI or pneumonia is the disease most often suffered by toddlers, as many as 78% of toddlers come to visit health services with URI. Based on basic health research in 2018 it is known that the prevalence of URI according to Nakes diagnosis reaches 4.4%. Bandar Agung health centre is the working area of health centres with the highest URI cases in central Lampung regency as many as 2141 cases. Smoking habits of parents in the house make toddlers as passive smokers who are always exposed to cigarette smoke. Homes where parents have the habit of smoking are likely to increase the incidence of URI.Purpose: to know the correlation of cigarette smoke exposure with URI case on toddlers at the working area of Bandar Agung health centre Terusan Nunyai subdistrict Central Lampung regency year of 2019.Method: Quantitative research type, by using cross sectional approach. The population in this research was all mothers who had toddlers and visited to Bandar Agung Health Centre Terusan Nunyai subdistrict Central Lampung regency as many 135 people. 101 sample respondents. Collecting data technique was by using questionnaire. Statistical test was by using chi square.Result: There was the correlation of cigarette smoke exposure with URI case on toddlers at the working area of Bandar Agung health centre Terusan Nunyai subdistrict Central Lampung regency year of 2019 (p value 0,001. OR 4.2)Conclusion: There was the correlation of cigarette smoke exposure with URI case on toddlers. It is expected that the Bandar Agung Health Center to conduct health promotion to the community, especially the promotion of the dangers of cigarettes, the contents contained in cigarettes that can endanger health, the effects caused by cigarette smoke, the dangers of cigarettes for active and passive smokers, in this case more disadvantaged are passive smokers especially toddlers. Because toddlers with smoker family members have a greater frequency of ARI Keywords      : cigarette smoke exposure, URI incident.

The Relationship Between The Level Of Knowledge On The Use Of Penicillin Antibiotics In Patients With Ari In Outpatient Installations At The Kesesi Health Center In 2021

2021 ◽  
Vol 1 ◽  
pp. 977-983
Author(s):  
Anissa Salsabil ◽  
Yulian Wahyu Permadi ◽  
Ainun Muthoharoh ◽  
Wulan Agustin Ningrum
Keyword(s):  
Health Center ◽  
Quantitative Research ◽  
Antibiotic Consumption ◽  
P Value ◽  
Cross Sectional ◽  
Probability Sampling ◽  
Purposive Sampling ◽  
Level Of Knowledge ◽  
The Relationship ◽  
Research Type

AbstractInappropriate use of antibiotics has resulted in antibiotic resistance. One of the phenomena that supports this phenomenon is the lack of knowledge about patient compliance in the use of antibiotics. This study aims to determine the relationship between the level of knowledge and adherence to the use of penicillin antibiotics in patients with ARI in the Outpatient Installation at the Kesesi Health Center in 2021. Analytic research method with cross sectional approach with quantitative research type with non-probability sampling using purposive sampling method. a sample of 136 adult respondents diagnosed with ARI with antibiotic therapy. Data collection by questionnaire. Correlation data using Spearman Rho test. The results showed that the data was not significant between the use of antibiotics and adherence to taking medication with a P value of 0.286 (<0.05). The results of high antibiotic consumption compliance with sufficient knowledge results are expected for respondents and pharmaceutical staff to improve communication, information and education (KIE) to respondents who receive antibiotic prescriptions.Keywords: Penicillin Antibiotics, ARI, Compliance, Knowledge, Public Health Center AbstrakPenggunaan antibiotik yang tidak tepat telah mengakibatkan terjadinya resistensi terhadap antibiotik. Salah satu fenomena yang mendukung fenomena ini adalah kurangnya tingkat pengetahuan terhadap kepatuhan pasien dalam penggunaan antibiotik. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat pengetahuan terhadap kepatuhan dalam penggunaan antibiotik penisilin pada pasien ISPA Instalasi Rawat Jalan di Puskesmas Kesesi Tahun 2021. Metode penelitian analytic dengan pendekatan cross sectional dengan jenis penelitian kuantitatif dengan pengambilan sampel non-probability sampling menggunakan cara purposive sampling dengan sampel sebanyak 136 responden dewasa yang terdiagnosa ISPA dengan terapi antibiotik. Pengumpulan data dengan kuesioner. Data korelasi menggunakan uji spearman rho. Hasil penelitian menunjukan data tidak signifikan antara penggunaan antibiotic dengan kepatuhan konsumsi minum obat dengan nilai P value 0,286 (<0,05). Hasil kepatuhan konsumsi antibiotik yang tinggi dengan hasil pengtahuan yang cukup diharapkan kepada responden dan tenaga kefarmasian harus ditingkatkan mengenai komunikasi, informasi dan edukasi (KIE) kepada responden yang menerima resep antibiotik.Kata kunci: Antibiotik Penisilin; ISPA; kepatuhan; pengetahuan; puskesmas

scholarly journals Analysis of COVID-19 Prevention Behaviour among Diabetes Mellitus Comorbidity Patients in Palembang

2021 ◽  
Vol 9 (2) ◽  
pp. 168
Author(s):  
Giszka Putri ◽  
Hamzah Hasyim ◽  
Nur Alam Fajar
Keyword(s):  
Diabetes Mellitus ◽  
Community Health ◽  
Statistical Significance ◽  
Health Centre ◽  
P Value ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Community Health Centres ◽  
Health Centres ◽  
Preventive Behaviour

Background: COVID-19 in Diabetes Mellitus (DM) patients are at higher risk for severe complications than people without DM. Preventive behaviour is the best way to avoid COVID-19 infection for DM patients due to its bad impact, such as severe symptoms requiring intensive care, leading to death. Objective: This study aims to analyse the COVID-19 preventive behaviour among DM comorbidity patients in Palembang. Method: The cross-sectional study was conducted from April 2021 to May 2021 using a questionnaire to diabetic patients at six community health centres in Palembang. The questionnaire has four sections: patient characteristics, knowledge, attitude, and COVID-19 prevention behaviour. A proportional random sampling technique was used to determine the number of samples according to the data on diabetic patients in each health centre. The total sample was 183 respondents from 1.266 total population diabetic patients in six community health centres. Respondents were diabetic patients aged ³ 18 years old and willing to fill out the questionnaire. Univariate, bivariate, and multivariate statistical analyses were used to analyse the data. Results: More respondents have good knowledge (50.3%), negative attitude (57.3%), and poor COVID-19 preventive behaviour (53.0%). The findings revealed a statistical significance between knowledge (P-value = 0.0001), attitude (P-value = 0.0001), and educational status (P-value = 0.0001) with COVID-19 preventive behaviour. Furthermore, knowledge is the most determinant factor of COVID-19 preventive behaviour (PR= 7.597, 95% CI: 3.701 – 15.597). Conclusion: According to this study, diabetic patients with poor knowledge are at greater risk of having poor COVID-19 prevention behaviours. COVID-19 prevention programs, especially health education programs at the community health centre, need to be improved to ensure that diabetic patients adopt reasonable and appropriate COVID-19 prevention practices.

scholarly journals The Relationship Between Levels Of Spiritual Welfare and Anxiety in Elderly

2018 ◽  
Vol 4 (2) ◽  
Author(s):  
Khrisna Wisnusakti
Keyword(s):  
Quantitative Research ◽  
Data Retrieval ◽  
The Elderly ◽  
Emotional Reaction ◽  
Statistical Test ◽  
P Value ◽  
Test Results ◽  
Chi Square ◽  
Cross Sectional ◽  
The Relationship

ABSTRACTAnxiety is a normal emotional reaction to stress and perceptions of danger, feelings are not calm and unclear because of helplessness, isolation and spiritual insecurity are the beliefs of our relationship with God Almighty and Creator, it permeates the lives of people who we are and our purpose. The purpose of this study was to determine the relationship between the spiritual level of anxiety in elderly. Quantitative research method with cross sectional approach. The sample in this study were 98 respondents by using total sampling. Data processing with Chi-Square technique. The instrument used in data retrieval was a questionnaire. The results showed that the elderly had a high spiritual level of 76 people (77.6%), the elderly did not worry as many as 85 people (86.7%). Statistical test results showed there was a relationship between spiritual levels against anxiety (p value = 0.01 <α = 0.05) in the elderly. Suggestions for nurses to maintain the spiritual activities that are in place to prevent anxiety in the Elderly. ABSTRAKKecemasan merupakan reaksi emosional yang normal terhadap stress & persepsi adanya bahaya, perasaan yang tidak tenang dan tidak jelas karena ketidakberdayaan, isolasi dan ketidakamanan. Spiritual adalah keyakinan hubungan kita dengan Tuhan Yang Maha Kuasa dan Maha Pencipta, hal itu meresap kedalam kehidupan manusia akan sadarnya siapa diri kita dan tujuan kita. Tujuan penelitian untuk mengetahui hubungan tingkat spiritual terhadap kecemasan pada lansia. Metode penelitian kuantitatif  dengan pendekatan cross sectional. Sampel dalam penelitian ini sebanyak 98 responden dengan cara menggunakan total sampling. Pengolahan data dengan teknik Chi-Square. Instrumen yang digunakan dalam pengambilan data adalah kuesioner. Hasil penelitian menunjukkan lansia memiliki tingkat spiritual yang tinggi sebanyak 76 orang (77,6%), lansia tidak cemas sebanyak 85 orang (86,7%). Analisa dari hasil uji statistik tersebut adalah terdapatnya hubungan antara tingkat spiritual terhadap kecemasan (p value = 0,01 < α = 0,05) jadi semakin tinggi tingkat spiritual lansia maka semakin rendah angka kejadian kecemasan pada lansia. Saran bagi perawat mempertahankan kegiatan spiritual yang ada dipanti untuk mencegah terjadinya kecemasan pada Lansia.

scholarly journals Parenting Styles as a Function of Academic Achievement

2019 ◽  
pp. 1069-1076
Author(s):  
Bisrat Tekle Woldearegai ◽  
Dr. Babita Das
Keyword(s):  
Academic Achievement ◽  
Parenting Styles ◽  
Quantitative Research ◽  
Secondary Data ◽  
Statistical Test ◽  
Survey Questionnaire ◽  
Cross Sectional ◽  
Likert Scales ◽  
Research Type ◽  
One Way Anova

The study investigated the relationionship between parenting behaviors and academic achievement. The objective of the study was to inquire the functions of parenting on academic achievement. The study was conducted in Tulu Yombo Junior School, Oromia regional state, Ethiopia. The study was conducted from January 2018 up to September 2018. The study employed a cross-sectional research design. The population of the study was 200 students of grade 7 and 8. Subsequently, 50(25%) samples were selected using stratified random sampling. The study was a pure quantitative research type. For this reason, it used a survey questionnaire which is close-ended to identify the styles of parenting the parents of the students employed. The questions were prepared to be responded in “Likert Scales”. On the other hand, record scores of academic achievement were used as secondary data. The data were analyzed and interpreted using One-way ANOVA and Honestly Significance Difference (HSD) statistical test. The result of the study revealed that children of Authoritative (democratic) parents scored (x̅ =80.75) significantly higher in their academic achievement than did children from Non-authoritative. However, no substantial difference was observed in the academic achievement of students from authoritarian (x̅ =61.3), indulgent (x̅ =53.8) and neglectful parents (x̅ =52.4).

scholarly journals Parenting Styles as a Function of Academic Achievement.

2019 ◽  
pp. 780-787
Author(s):  
Bisrat Tekle Woldearegai ◽  
Dr. Babita Das
Keyword(s):  
Academic Achievement ◽  
Parenting Styles ◽  
Quantitative Research ◽  
Secondary Data ◽  
Statistical Test ◽  
Survey Questionnaire ◽  
Cross Sectional ◽  
Likert Scales ◽  
Research Type ◽  
One Way Anova

The study investigated the relationionship between parenting behaviors and academic achievement. The objective of the study was to inquire the functions of parenting on academic achievement. The study was conducted in Tulu Yombo Junior School, Oromia regional state, Ethiopia. The study was conducted from January 2018 up to September 2018. The study employed a cross-sectional research design. The population of the study was 200 students of grade 7 and 8. Subsequently, 50(25%) samples were selected using stratified random sampling. The study was a pure quantitative research type. For this reason, it used a survey questionnaire which is close-ended to identify the styles of parenting the parents of the students employed. The questions were prepared to be responded in “Likert Scales”. On the other hand, record scores of academic achievement were used as secondary data. The data were analyzed and interpreted using One-way ANOVA and Honestly Significance Difference (HSD) statistical test. The result of the study revealed that children of Authoritative (democratic) parents scored (x̅ =80.75) significantly higher in their academic achievement than did children from Non-authoritative. However, no substantial difference was observed in the academic achievement of students from authoritarian (x̅ =61.3), indulgent (x̅ =53.8) and neglectful parents (x̅ =52.4).

PENGETAHUAN, SIKAP DAN DUKUNGAN KELUARGA TENTANG PEMANFAATAN POSBINDU PENYAKIT TIDAK MENULAR DI KRETEK BANTUL

2019 ◽  
Vol 13 (2) ◽  
Author(s):  
Pipit Novita Sandra ◽  
Istika Dwi Kusumaningrum
Keyword(s):  
Risk Factors ◽  
Chronic Disease ◽  
Family Support ◽  
Quantitative Research ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test ◽  
Research Type ◽  
Test Result

Background: PTM is a disease that is not caused by bacterial infection including degenerative chronic disease. Integrated Guidance Post (Posbindu) is one of the empowerment program that aims to increase community participation in controlling risk factors for non-communicable diseases. Based on data obtained in Dusun Tegalsari, Donotirto village, Posbindu PTM activity was attended by 30 participants from 478 people aged > 15 years and still low in its utilization and participation. Objective: The purpose of this research is to know the correlation of knowledge, attitude and family support with the utilization of Posbindu PTM in Degotary Tegalsari Donotirto Village Kretek District, Bantul Regency. Method: This research type is descriptive quantitative research with cross-sectional research design. The population in this study as many as 30 people in which researchers took from the population of Degotary Tegalsari village Donotirto > 15 years old and actively participate in the activities posbindu PTM. Sampling using samples saturated as many as 30 people.Instrument in this research is questionnaire by using Chi Square test. Result: The result of Chi Square test shows that there is no correlation between knowledge with the utilization of Posbindu PTM with the result of significant value (P value) the correlation between knowledge with PTM Posbindu utilization is 0.778 (P value >a ). The existence of correlationbetween attitude with utilization of Posbindu PTM with result of significant value (Pvalue) equal to 0,003 (Pvalue <a). The existence of correlationbetween family support with utilization of posbindu PTM with result of significant value (P value) equal to 0,001 (P value <a). Conclusion: There is not significant correlation between knowledge with the utilization of Posbindu PTM, the correlation between attitude with the utilization of Posbindu PTM and family support with utilization of posbindu PTM.

scholarly journals Low birthweight of children is positively associated with mother’s prenatal tobacco smoke exposure in Shanghai: a cross-sectional study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ruiping Wang ◽  
Ting Sun ◽  
Qiong Yang ◽  
Qing Yang ◽  
Jian Wang ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Smoking Prevalence ◽  
Low Birthweight ◽  
Cross Sectional Study ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Cross Sectional ◽  
Shs Exposure ◽  
The Mean

Abstract Introduction Low birthweight (LBW) is a significant public health issue, and maternal smoking is the most prevalent preventable cause of LBW. But there is limited evidence on association of LBW among children and cigarette smoke exposure in mothers in China. In this cross-sectional study, we try to explore if the LBW in children is positively associated with mothers’ prenatal cigarette smoke exposure. Methods We selected 8, 586 mothers and their singleton children in 2018 in Songjiang district, Shanghai. Birthweight of children and gestational weeks of mother was identified by birth records in the hospital, we classified mothers’ prenatal cigarette smoke status into the first-hand smoke (FHS) exposure and the second-hand smoke (SHS) exposure. We use SAS 9.1.3 software to calculate the prevalence of children’s LBW and the prevalence of mothers’ prenatal cigarette smoke exposure including FHS and SHS. Chi-square test and logistic regression were used to analyze the difference. Results In 8, 586 women, The prenatal FHS and SHS exposure prevalence was 0.9 and 20.8%, respectively. The mean birthweight of children was 3315.5 g with a standard deviation of 497.2 g, the mean birthweight was 167.7 g and 66.1 g lower in children born to mothers with prenatally FHS and SHS exposure compared with those children whose mother were not exposed, respectively. The children’s LBW prevalence was 4.7% in this study. By comparing with children whose mother were not exposed, the LBW prevalence was higher among children whose mother were prenatally exposed to FHS [OR (Odds Ratios) = 2.91, 95% confidence interval (CI) (1.49, 5.68)], and SHS [OR = 2.35, 95% CI (1.90, 2.89)]. Conclusions Children’s LBW is positively associated with mothers’ prenatal tobacco smoke exposure both for FHS and SHS. So implementing tobacco control measures is crucial to lower smoking prevalence among women, and decrease smoking prevalence of their family members as well as work fellows.

scholarly journals Cigarette Smoke or Cigarette Condensate Exposure Enhances Growth of FLT3-ITD AML Models and Alters DNA Methylation and Leukemic Gene Expression

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 29-30
Author(s):  
Mary Figueroa ◽  
Maninder Khosla ◽  
Yue Lu ◽  
Marcos Estecio ◽  
Seyed Javad Moghaddam ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cigarette Smoke ◽  
Research Funding ◽  
Smoke Exposure ◽  
Scid Mice ◽  
Cigarette Smoke Exposure ◽  
P Value ◽  
The Impact ◽  
Advisory Role

Current and former smoker AML patients have worse survival outcomes compared to never smokers. This worsened prognosis of smokers with AML can also be seen in patients who carry activating mutations of the Fms-like tyrosine kinase 3 (FLT3) and are treated with regimens that include newly approved kinase inhibitors. While the impact of genetic mutations on survival in AML have been studied, and some have been therapeutically targeted, the role of cigarette smoking or cigarette smoke exposure (which is potentially modifiable) on leukemia progression or treatment response is understudied. In order to elucidate molecular effects of cigarette smoke exposure (CSE) that contribute to the poor prognosis of AML patients, we developed a cigarette smoke exposure model for mice to mimic the current and former smoking habits of AML patients. NOD-SCID mice were exposed to CSE in a smoking robot for 2 hours, 5 days/week, for 2 weeks or to air alone as a control. Mice were then injected with luciferase-tagged human AML cell lines, and leukemic burden was monitored through non-invasive bioluminescent imaging. Control "non-smoking" mice were only subject to AML cell injection. Enhanced early leukemic-burden was observed two distinct FLT3-ITD AML models, MOLM13 and MOLM14, within one week post AML introduction (p-value &lt;0.0001 and &lt;0.001 respectively). Although the latter model showed slightly longer latency of disease with increased leukemic burden apparent 24 days post leukemic introduction (p-value &lt;0.05). In order to address if the early increase in leukemic burden may have arisen from extrinsic factors in the tumor microenvironment, we utilized non-leukemia bearing immunocompetent mice exposed to CSE using the 2 week exposure scheme and saw enhanced myeloid progenitor growth, indicating evidence of microenvironment priming of myeloid cells by CSE. One month of CSE increased the MPP1 and MPP2 populations in the bone marrow of NOD-SCID mice. C57BL/6J mice had increased myeloid and hematopoietic stem cell populations after a month of CSE (p-value &lt;0.05). We also modeled the effect of smoking cessation upon leukemia engraftment by halting smoke exposure compared to mice that continued smoking. Cessation significantly slowed leukemic growth in MOLM13 bearing mice (N=10, p-value&lt;0.01). Cigarette smoke exposure globally alters DNA methylation in blood cells and these changes can persist for decades. Independent of mutations, DNA methylation patterns in AML patients have prognostic significance. To understand how CSE accelerated leukemic growth in vivo, DNA methylation was evaluated using reduced representative bisulfite sequencing. More than two hundred significant alterations in DNA methylation across the promoter region of genes were found AML cells from spleen samples of CSE MOLM13-bearing mice as compared to non-smoking mice. Among the genes with the most significantly altered DNA methylation were GATA-2, an important protein for hematopoietic differentiation, and aryl-hydrocarbon receptor repressor (AHRR), a gene whose hypomethylation is a hallmark of cigarette smoke exposure. To identify the impact of cigarette smoke exposure on the leukemia cells in the absence of the tumor microenvironment we treated AML cells directly using a cigarette smoke condensate (CSC) that contains the chemicals in cigarette smoke used in the previously described CSE model. MOLM13 cells either treated with DMSO or 10ug/ml CSC every passage for two weeks were injected into NOD-SCID mice. This model resulted in enhanced leukemic burden 3, 10, and 17 days after leukemic introduction (p-value &lt;0.0001, &lt;0.0001, and &lt;0.001) indicating strong pro-leukemic effects of CSC. Evaluation of in vitro CSC treated AML cells was conducted to identify causes for the enhanced leukemic burden. While CSC treatment yielded no changes in proliferation or survival of the cells over the course of two months, within one week there was increased expression of DNMT1 in several cells lines. Increased basal and maximal oxygen consumption, and modulation of the antioxidant gene, HO-1, was also observed along with modulation of AHRR and GATA-2, reinforcing roles for methylation data gained from in vivo CSE experiments. Discovering the mechanisms promoting AML progression from cigarette smoke exposure will lead to improved, tailored treatment for AML patients with smoking histories and our further studies of these gene changes will aid in that endeavor. Disclosures Jabbour: Takeda: Other: Advisory role, Research Funding; AbbVie: Other: Advisory role, Research Funding; Amgen: Other: Advisory role, Research Funding; Pfizer: Other: Advisory role, Research Funding; Genentech: Other: Advisory role, Research Funding; BMS: Other: Advisory role, Research Funding; Adaptive Biotechnologies: Other: Advisory role, Research Funding. Konopleva:Genentech: Consultancy, Research Funding; Ascentage: Research Funding; Forty-Seven: Consultancy, Research Funding; Calithera: Research Funding; F. Hoffmann La-Roche: Consultancy, Research Funding; Reata Pharmaceutical Inc.;: Patents & Royalties: patents and royalties with patent US 7,795,305 B2 on CDDO-compounds and combination therapies, licensed to Reata Pharmaceutical; Ablynx: Research Funding; Agios: Research Funding; Amgen: Consultancy; AstraZeneca: Research Funding; Eli Lilly: Research Funding; Kisoji: Consultancy; Cellectis: Research Funding; Rafael Pharmaceutical: Research Funding; AbbVie: Consultancy, Research Funding; Stemline Therapeutics: Consultancy, Research Funding; Sanofi: Research Funding. DiNardo:Agios: Consultancy, Honoraria, Research Funding; Syros: Honoraria; AbbVie: Consultancy, Honoraria, Research Funding; Celgene: Consultancy, Honoraria, Research Funding; Takeda: Honoraria; Calithera: Research Funding; Daiichi Sankyo: Consultancy, Honoraria, Research Funding; Notable Labs: Membership on an entity's Board of Directors or advisory committees; Novartis: Consultancy; MedImmune: Honoraria; ImmuneOnc: Honoraria; Jazz: Honoraria.

scholarly journals RELATIONSHIP BETWEEN HUSBAND SUPPORT AND MIDWIFE ROLE WITH POST PARTUM CONTRACEPTION IN KONAWE KEPULAUAN DISTRICT

2021 ◽  
Vol 3 (1) ◽  
pp. 182-187
Author(s):  
Dian Wulandari ◽  
Sunarsih Sunarsih ◽  
Akbar Torontju
Keyword(s):  
Quantitative Research ◽  
Post Partum ◽  
Health Centre ◽  
P Value ◽  
Cluster Sampling ◽  
District Health ◽  
Postpartum Contraception ◽  
Cross Sectional ◽  
Husband Support

Background: Postpartum contraceptive coverage in Konawe Kepulauan Regency in 2018, through data obtained at the Konawe Kepualaun District Health Office, Southeast Sulawesi Province as much as 8.4% and data in 2019 decreased to 1.26%. Methods:This quantitative research is observational with a cross sectional study design. The population in this study was 96 people with the determination of the sample using stratified cluster sampling, totaling 77 all post-partum mothers in the working area of the health centre in Konawe Kepulauan Regency. Results:The significance value (p) value of husband support and the role of midwife is 0.000 which means that p <0.05 so that Ha is accepted and Ho is rejected, which means that there is a significant correlation or relationship between husband's support and the role of midwives on the use of postpartum contraception. Both have a value of phi C which is 0.100 which meansvery weak relationship. Conclusion: There is a relationship between husband's support and the role of the midwife against the use of postpartum contraceptives in the Konawe Islands district.

scholarly journals Hubungan Stress Dengan Kejadian Insomnia Pada Lansia Di UPTD PSLU Tresna Werdha Natar Lampung Selatan

2020 ◽  
Vol 2 (4) ◽  
pp. 649-658
Author(s):  
Rahma Elliya ◽  
Prima Dian Furqoni ◽  
Mutiara Arini Ariska
Keyword(s):  
Survey Design ◽  
Design Method ◽  
Statistical Test ◽  
P Value ◽  
Projection Data ◽  
Chi Square ◽  
Cross Sectional ◽  
Purposive Sampling ◽  
Keywords Stress ◽  
Research Type

ABSTRACT : CORRELATION OF STRESS WITH INSOMNIA AN ELDERLY AT UPTD PSLU TRESNA WERDHA NATAR SOUTH LAMPUNG Background : Based on population projection data, in 2017 there were about 23.66 million elderly in Indonesia (9.03%). It was predicted that the number of elderlies in 2020 (27.08 million), in 2025 (33.9 million), in 2030 (40.95 million) and in 2035 (48.19 million). The number of elderly in Lampung Province based on Health Office of Lampung Province in 2016 was 516.246, and the number of elderly in Bandar Lampung city according to Health office of Lampung Province in 2016 was 118.316 people. The number of elderly in UPTD PSLU Tresna Werda as many 85 people. Most of them are elderly who suffered from stress of insomnia. Stress suffered by elderly could influence the time to sleep. Purpose : To know the correlation of stress with insomnia on elderly at UPTD PSLU Tresna Werda Natar South Lampung Year of 2019.Methods : This research type is Quantitative. The research design was Analytical Survey design method with cross sectional approach. The population as many 80 respondents, with 54 respondents, sampling in research was purposive sampling. Statistical test was by using chi square test.Result : There was the correlation of stress with insomnia on elderly at UPTD PSLU Tresna Werda Natar South Lampung Year of 2019 (p value 0.010. OR 5.6).Conclusion: There was the correlation of stress with insomnia on elderly at UPTD PSLU Tresna Werda Natar South Lampung Year of 2019.  Keywords: stress, insomnia, elderly  INTISARI : HUBUNGAN STRESS DENGAN KEJADIAN INSOMNIA DI UPTD PSLU TRESNA WERDHA NATAR LAMPUNG SELATAN Pendahuluan : Saat ini banyak masalah yang terjadi pada lansia baik secara fisik maupun psikologis, salah satunya adalah insomnia.Stres yang dialami oleh lansia dapatmempengaruhi kebutuhan waktu untuktidur.Jumlah lansia di UPTD PSLU Tresna Werda sebanyak 85 orang. Hasil presurvey menunjukkan sebanyak 70% mengalami kesulitan tidur.Tujuan : Diketahui hubungan stress dengan kejadian insomnia pada lansia di UPTD PSLU Tresna Werda Natar Lampung Selatan Tahun 2019.Metode : Jenis penelitian ini adalah Kuantitatif. Desain penelitian metode desainSurvei Analitik dengan pendekatan cross sectional Populasi sebanyak 80 responden, dengan sampel sejumlah 54 responden, pengambilan sampel pada penelitian purposive sampling Uji statistik menggunakan uji chi square.Hasil penelitian: Adahubungan stress dengan kejadian insomnia pada lansia di UPTD PSLU Tresna Werda Natar Lampung Selatan Tahun 2019 (p value 0,010. OR 5,6).Kesimpulan: Adahubungan stress dengan kejadian insomnia pada lansia di UPTD PSLU Tresna Werda Natar Lampung Selatan Tahun 2019. Lansia mengalami stres dikarenakan tidak adanya dukungan keluarga dan kurangnya aktivitas fisik.  Kata Kunci          : Stress, Insomnia, Lansia

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