scholarly journals Classic Galactosemia Neurological Complications: An Overview

2018 ◽  
Vol 1 (1) ◽  

Classic galactosemia is an autosomic recessive disorder that leads to increasegalactose 1 phosphate and galactitol intracellular levels; with clinical manifestations that arise from the ingestion of galactose from the diet but can be reverted when restricted. Yet about 90% of the patients develop neurological complications. Because of that we evaluate the impact of the diet on the generation of such complications, like the strict galactose restriction and the glycosilation impairment, galactosemia and social interactions as factors that influence neurodevelopment, oxidative stress secondary to galactosemia and its influence on neuroinflamation, epigenetics modifications secondary to the diet and the social interactions and other causes that can affect neurodevelopment on galactosemia.

2014 ◽  
Vol 29 (3) ◽  
pp. 288-300
Author(s):  
Naoki Ohshima ◽  
Yuta Yamaguchi ◽  
P. Ravindra S. De Silva ◽  
Michio Okada

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Speranza Rubattu ◽  
Maurizio Forte ◽  
Salvatore Raffa

Increased oxidative stress from both mitochondrial and cytosolic sources contributes to the development and the progression of cardiovascular diseases (CVDs), and it is a target of therapeutic interventions. The numerous efforts made over the last decades in order to develop tools able to monitor the oxidative stress level in patients affected by CVDs rely on the need to gain information on the disease state. However, this goal has not been satisfactorily accomplished until now. Among others, the isolation of circulating leukocytes to measure their oxidant level offers a valid, noninvasive challenge that has been tested in few pathological contexts, including hypertension, atherosclerosis and its clinical manifestations, and heart failure. Since leukocytes circulate in the blood stream, it is expected that they might reflect quite closely both systemic and cardiovascular oxidative stress and provide useful information on the pathological condition. The results of the studies discussed in the present review article are promising. They highlight the importance of measuring oxidative stress level in circulating mononuclear cells in different CVDs with a consistent correlation between degree of oxidative stress and severity of CVD and of its complications. Importantly, they also point to a double role of leukocytes, both as a marker of disease condition and as a direct contributor to disease progression. Finally, they show that the oxidative stress level of leukocytes reflects the impact of therapeutic interventions. It is likely that the isolation of leukocytes and the measurement of oxidative stress, once adequately developed, may represent an eligible tool for both research and clinical purposes to monitor the role of oxidative stress on the promotion and progression of CVDs, as well as the impact of therapies.


2019 ◽  
Vol 40 (6) ◽  
pp. 743-751
Author(s):  
Charlene Pell

Abstract Facial disfigurement due to any congenital or acquired condition is a social disability that can impede communication, contribute to awkward social interactions, and cause individuals with differences to be isolated and rejected. Yet, few interventions have been developed to address the psychosocial consequences of living with a visible difference, despite research indicating that the more visible the disfigurement is to others, the greater the social implication and challenge for the affected individual. This article reviews the impact of the “What to Do When People Stare” social and communication workshop, including its theoretical basis (drawn from anthropological research and theory pertaining to disfigurement), the phenomenon of staring, and the experience of being the target of a stare. The review highlights feedback from 46 individuals with disfiguring conditions caused by burns, dermatological conditions, and craniofacial conditions who completed a Workshop Evaluation Survey. The instructor, who has a facial difference, reviewed the science of staring, the role and influence of the media and beauty in society, myths associated with disfigurement, social and communication skills, and asked specific questions to elicit feelings and beliefs about why people stare, and how it feels to be the object of a stare. After completing the workshop, 80% of participants reported that they felt better prepared to cope with staring, and 83% reported a better understanding about the motives of staring. The workshop demonstrates the need to increase awareness of visible differences and to teach individuals with visible differences and the general public appropriate social skills for engaging with one another. The workshop’s success to date highlights the need for similar programs addressing the psychosocial communicative dimensions related to staring. Collaborations with burn centers and other nonprofit organizations that treat and assist individuals with psychosocial issues related to visible difference could strengthen content and assessment data.


2021 ◽  
Vol 4 (3) ◽  
pp. 53-64
Author(s):  
M. P. Sukharkova

The article is devoted to the community of Olympic volunteers after the event through the study of their online activity in social network “Vkontakte”. Olympic volunteering refers to the event-oriented direction of volunteering, which is characterized by a limited period of time for the implementation of volunteering practices, but a long period of training volunteers and the opportunity for volunteers to acquire unique work experience during the organization and holding of a major sports event. At the moment, there is a lack of research on the impact of events such as the Olympic and Paralympic Games on the volunteer community.The legacy of the 2014 Olympic and Paralympic Games for the volunteer community is studied in the article. In the course of the study, an attempt was made to find answers to the following research questions: do volunteers maintain social online interactions five or more years after the event; if volunteers continue online interactions, what topics are the most popular for discussion in the volunteer community. It is proved that volunteering at major sporting events contributes to the development of the social capital of volunteers, including by expanding the circle of acquaintances, that is, social interactions. At the same time, social networks have a great influence on the reproduction of social capital, so the indicators of online interactions of volunteers can indicate whether the volunteers support the circles of social interactions acquired while working at the games, and, thus, whether the volunteers support and use the social capital acquired while working at the event. During the entire period of time considered by us, the highest indicators of volunteer activity in the online community were noted from 2014 to 2016. The most relevant topics among the participants of the online community are the topics of volunteering: both memories of working at the games, as well as information about other volunteer programs and other topics, for example, tourism, etc.


2017 ◽  
Vol 9 (1) ◽  
pp. 47
Author(s):  
Siti Djazimah ◽  
Ihab Habudin

Islam has expressly regulate the division of tasks and roles between husbands and wives fairly. Although the husband is obliged to provide sustenance for his wife and children, but the family law of Islam does not forbid a wife from helping her husband in making a living with her husband's consent and does not interfere with her obligations as a housewife. There is a wife in a family of craftsmen in the village of Tegal Kembang, Imogiri, Yogyakarta, which acts as the main breadwinners for their families. This article examines the wives who work as the wage earners by using the concept of maqa> s} id ash-shari'ah < 'ah. The impact that emerges of the role of the kapok craftsmen woman is more on the impacts that are in positive traits and it is associated with the hajjiy and daruriy needs. The wife who has an income has the economic independence power that can even sustain the needs of the family. Social interactions that occur in kapok craftsmen community, make a strong emotional connection between kapok craftsmen. While the social interaction with the "outside world" (consumers) clearly provides insight of the Kapok Craftsmen. As for the negative impact of the mother's role of Kapok craftsman towards parenting does not seem significant.[Islam secara tegas telah mengatur tentang pembagian tugas dan peran antara suami dan istri secara adil. Walaupun suami berkewajiban memberi nafkah kepada isteri dan anak-anaknya, tetapi hukum keluarga islam tidak melarang istri membantu suaminya dalam mencari nafkah dengan persetujuan suaminya dan tidak mengganggu kewajibannya sebagai seorang ibu rumah tangga. Ada istri pada keluarga perajin kapuk di dusun Tegal Kembang, Imogiri, Bantul,  Yogyakarta, yang berperan sebagai pencari nafkah utama bagi keluarganya. Tulisan ini mengkaji para isteri yang bekerja sebagai pencari nafkah dengan menggunakan konsep maqa>s}id asy-syari<‘ah. Dampak yang ditimbulkan dari peran yang dijalankan para ibu perajin kapuk adalah lebih pada dampak yang sifatnya positif dan hal ini terkait dengan kebutuhan yang sifatnya daruriy dan hajjiy. Para isteri yang mempunya penghasilan tersebut memiliki kemandirian dalam ekonomi bahkan dapat menopang kebutuhan keluarga. Interaksi sosial yang terjadi dalam komuitas perajin kapuk, menjadikan kuatnya hubungan emosional di antara perajin kapuk. Sementara  interaksi sosial dengan “dunia luar” (konsumen) jelas memberikan wawasan perajin kapuk semakin bertambah. Adapun dampak negatif peran ibu sebagai perajin kapuk terhadap pengasuhan anak tidak nampak secara signifikan.]


Author(s):  
Binyu Liu ◽  
Ye Chen ◽  
Meng Xiao

As China’s population rapidly ages, research and discussion on how to better optimize public spaces for the elderly’s health and benefit continue to deepen. This study uses observational surveys and questionnaires to investigate the elderly visitors of Nanjing’s urban parks and explore the impact the parks’ amenity buildings (structures built to provide visitors with conveniences, e.g., shelters and pavilions) has on their health and associated socialization tendencies. Data were collected from ten amenity buildings in ten separate parks to compose a total dataset of 728 activity statistics and 270 valid questionnaires. The study’s results indicate that amenity buildings significantly increase opportunities for older adults to socialize and thereby can increase this demographic’s associated health benefits. The social activities formed around amenity buildings are found to improve social interactions and connectedness among older adults more compared to other age groups. Elderly participation in social activities is also found to positively correlate with environmental characteristics. High-quality landscapes ensure healthy development of social activities within amenity buildings and promote the occurrence and continuation of social interactions. In order of highest to lowest impact on elderly activities, the following factors were identified and scored: amenity building scale, lighting, comprehensive surrounding environment, surrounding amenities, water features, and vegetation. This research also reveals that among existing amenity buildings, there is insufficient support for certain activities and therefore, parks need to be improved to address this deficiency. Overall, this study indicates that under China’s current aging trends, amenity buildings have become an especially important infrastructure within urban public space, and their design trend is to incorporate the dual characteristics of “recreation + society”.


2021 ◽  
Vol 10 (9) ◽  
pp. 1947
Author(s):  
Domenico Nuzzo ◽  
Sonya Vasto ◽  
Luca Scalisi ◽  
Salvatore Cottone ◽  
Gaetano Cambula ◽  
...  

In December 2019, in Wuhan (China), a highly pathogenic coronavirus, named SARS-CoV-2, dramatically emerged. This new virus, which causes severe pneumonia, is rapidly spreading around the world, hence it provoked the COVID-19 pandemic. This emergency launched by SARS-CoV-2 also had, and still has, devastating socio-economic aspects. Assessing the impact of COVID-19 on vulnerable groups of people is crucial for the adaptation of governments’ responses. Growing scientific evidence suggests that it is essential to keep the attention on people after acute SARS-CoV-2 infection; indeed, some clinical manifestations are frequently present even after recovery. There is consensus on the need to define which symptoms persist after the infection and which disabilities may arise after COVID-19. Recent reviews, case reports, and original contributions suggest that various organs may be affected, and neurological symptoms are present in about one third of patients with COVID-19. Neurological complications after severe COVID-19 infection might include delirium, brain inflammation, stroke, and nerve damage. In the recent pandemic, neurologists and neurobiologists have a chance to study key features of infection neurology. Furthermore, the psychological impact of the pandemic should not be underestimated, although there is currently no definition for this condition.


2021 ◽  
Vol 13 (21) ◽  
pp. 11985
Author(s):  
Iris Vilnai-Yavetz ◽  
Anat Rafaeli

Our goal in this paper is to connect workspace design to employee wellbeing and social sustainability. Toward this connection, we introduce and empirically test a new concept of “workspace integration”. This concept refers to the continuum of integration of an employee’s workspace with the organizational, physical space. We further define three workspace affordances that predict the social sustainability of workspace arrangements by influencing employee wellbeing. The three affordances are perceptions of symbolism of the organization and of symbolism of the self, and opportunities for social interactions. We evaluate our theory using data collected from an online survey of British employees (n = 392) working in offices at home and/or in the organization in various industries. As predicted, workspace integration positively influences wellbeing directly as well as indirectly via mediation of symbolism of the organization and opportunities for social interactions. The third affordance—symbolism of the self—positively influences wellbeing, but is not affected by workspace integration. Our findings confirm the impact of workspace affordances on employee wellbeing, and thus their utility for the analysis of social sustainability. The findings also contribute to understanding of the differences between workspace symbolism of the organization and of the self, their impact on wellbeing, and thus their implications for social sustainability.


2021 ◽  
Author(s):  
Larissa Lauren Meijer ◽  
Birgit Hasenack ◽  
Jonas Kamps ◽  
Andy Mahon ◽  
Guilia Titone ◽  
...  

Interpersonal touch and affective touch play a crucial role in social interactions and have a positive influence on mental health. The social distancing regulations related to the COVID-19 pandemic have reduced the ability to engage in interpersonal touch. This could cause touch deprivation, and it might alter the way in which affective touch is perceived. To investigate this, we conducted an online survey with 2348 participants, which contained questions regarding the COVID-19 regulations, touch deprivation and the perceived pleasantness of affective and non-affective touch. Results showed that participants reported feelings of touch deprivation. This significantly increased with the duration and severity of the COVID-19 regulations. Participants who experienced more touch deprivation rated videos of affective and non-affective touch as more pleasant. Current results provide insight in the impact of sudden and prolonged COVID-19 regulations and show that increasing the duration and severity of these regulations is associated with a higher desire for touch, which leads to increased perceived pleasantness of touch.


2021 ◽  
Author(s):  
Jean-Francois Mathiot ◽  
Laurent Gerbaud ◽  
Vincent J Breton

We develop a site-bond percolation model, called PERCOVID, in order to describe the time evolution of COVID epidemics and more generally all epidemics propagating through respiratory tract in human populations. This model is based on a network of social relationships representing interconnected households experiencing governmental non-pharmaceutical interventions. The model successfully accounts for the COVID-19 epidemiological data in metropolitan France from December 2019 up to July 2021. Our model shows the impact of lockdowns and curfews, as well as the influence of the progressive vaccination campaign in order to keep COVID-19 pandemic under the percolation threshold. We illustrate the role played by the social interactions by comparing a typical scenario for the epidemic evolution in France, Germany and Italy during the first wave from January to May 2020. We investigate finally the role played by the alpha and delta variants in the evolution of the epidemic in France till autumn 2021, paying particular attention to the essential role played by the vaccination. Our model predicts that the rise of the epidemic observed in July 2021 will not result in a fourth major epidemic wave in France.


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