Hematological Characteristics During the Third Trimester of Pregnancy in a Population of Low and High Socio-Economic Levels in Lubumbashi

Background: During pregnancy, many hematologic changes occur to meet the demands of the developing fetus. The objective of this study was to describe the hematological characteristics in the third trimester in a population of low and high socioeconomic levels in Lubumbashi, in relation to the WHO and China reference values. Methodology: A descriptive cross-sectional observational study was carried out in Lubumbashi, among pregnant women received during the third trimester antenatal consultations in apparent good health. A total of 128 pregnant women with a monofetal pregnancy of at least 27 weeks of amenorrhea in apparent good health were selected and divided into two groups of low and high socioeconomic levels. Blood was drawn and analyzed on the CYANHEMATO machine. Results: Hemoglobin (HB) averages were 9.63 ± 1.52 and 11.19 ± 1.07 g / dl respectively in the low and high socioeconomic levels population. The majority of patients in the two populations were in the reference range for red blood cell (RBC) count from 2.75 to 4.64 1012 / l. The average values of hematocrit (HCT), mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) in Lubumbashi were lower than in the China population : 28.39 ± 4.21 versus 32.47 ± 3.46% ; 67.34 ± 9.50 versus 74.38 ± 8.15 fl and 22.96 ± 3.56 versus 25.71 ± 3.23 pg for reference values of 36% ; 90.8 fl and 30.5 pg, respectively. As for the red blood cell distribution width (RDW), it was higher in the low socio-economic level population (16.86 ± 3.40%) than in the high socio-economic level population (14.90 ± 2.25%) with a difference highly significant (p <0.0001). Conclusion: The RBC and RDW were significantly increased in Lubumbashi, while HB. HCT, MCV and MCH were decreased. The mean corpuscular hemoglobin concentration (MCHC) did not present any particularity

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Comparative effect of probiotic (Saccharomyces cerevisiae), prebiotic (Fructooligosaccharide) and their combination on some blood indices in young common carp (Cyprinus carpio L.)

The Iraqi Journal of Veterinary Medicine ◽

10.30539/iraqijvm.v40i1.131 ◽

2016 ◽

Vol 40 (1) ◽

pp. 9-15 ◽

Cited By ~ 1

Author(s):

Nasreen M. Abdulrahman

Keyword(s):

Saccharomyces Cerevisiae ◽

Blood Cell ◽

Common Carp ◽

Red Blood Cell ◽

Blood Parameters ◽

Average Weight ◽

Mean Corpuscular Hemoglobin ◽

Corpuscular Hemoglobin ◽

Yeast Saccharomyces Cerevisiae ◽

Blood Indices

This study was carried out to examine the effect of Fructooligosaccharide as a source of prebiotic, and commercial dry yeast (Saccharomyces cerevisiae) as a source of probiotic and their combination in different level as a source of synbiotic. The experiment was conducted in the fish laboratory of Animal Production Department, Faculty of Agricultural Sciences of Sulaimani University. The trials lasted for three months after 21 days of adapting period 120 common carp fingerlings with an average weight of 20 ±2 gm, were used to test the effect of different levels of the Fructooligosaccharide, yeast and their combination. In T1 fish were fed a diet with 2.5 gm/kg Fructooligosaccharide, in T2, fish were fed a diet 2.5 gm/kg yeast, T3 represents the third treatment, in which fish were fed on a diet 5 gm/kg Fructooligosaccharide. While, in T4 fish were fed a diet 5 gm/kg yeast, and T5 2.5 Fructooligosaccharide: 2.5 Yeast (gm/kg), T6 was 5 Fructooligosaccharide: 5 yeast (gm/kg), T7 2.5 Fructooligosaccharide: 5 Yeast gm/kg), while T8 5 Fructooligosaccharide, 2.5 (gm/kg) Yeast. Each treatment in three replicates in which five fingerlings common carp were stocked in plastic tanks, which fed the experimental diets twice daily. Blood parameters of tested fish showed significant differences in Red blood cell count (1012 cells/l) in T5 and T7 by 1.235 and 1.260, respectively. Hemoglobin (g/dl) data were 117.000 in the fifth treatment. The mean corpuscular hemoglobin (pg/cell) was 121.400 in T2, 137.850 in T3, 121.050 in T4, and 135.300 in T6; mean corpuscular hemoglobin concentration (g/l) was 924.000, in the seventh treatment, mean corpuscular volume were (fL) 232.500 and 233.050 in T4 and T8 respectively. There were different effects of the treatment in the studied blood parameters in which the level of 2.5 g/kg in both Fructooligosaccharide and dry yeast affect significantly the Red blood cell, White blood cell and Hemoglobin.

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Association of haplotypes for SNPs in the LTR regions of bovine leukemia virus with hematological indices of cattle

Vavilov Journal of Genetics and Breeding ◽

10.18699/vj19.491 ◽

2019 ◽

Vol 23 (3) ◽

pp. 262-269 ◽

Cited By ~ 2

Author(s):

N. V. Blazhko ◽

S. Kh. Vyshegurov ◽

A. S. Donchenko ◽

K. S. Shatokhin ◽

T. I. Krytsyna ◽

...

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Leukemia Virus ◽

White Blood Cells ◽

Biological Species ◽

Mean Corpuscular Hemoglobin ◽

Corpuscular Hemoglobin ◽

Distribution Width ◽

Hematological Indices ◽

Blood Indices

Molecular typing of BLV samples isolated from Holsteinized Russian Black Pied cattle was carried out, and various cytofluorometric and morphological blood indices were examined. We performed the total count of white blood cells (WBC), lymphocyte (lymf), granulocyte (gran), monocyte (mon), red blood cell (RBC), hemoglobin (HGB), hematocrit (HTC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet crit count (PCT). The LTR-region of BLV was haplotyped. Only viruses of haplotypes I (0.33±0.03) and III (0.67±0.03) of the eight possible were detected. The ratio of hematologically sick, healthy, and suspected carriers of BLV of haplotypes I and II was comparable with the results of other researchers. The numbers of leukocytes, erythrocytes and platelets in the blood of carriers of haplotype III exceeded the corresponding parameters of cattle affected by the virus of haplotype I. It is interesting to note that the difference in the hemolytic status of animals was manifested not only by the concentration of leukocytes as direct immune agents but also by the count of erythrocytes and platelets, which are not directly involved in the immune response. The number of particles of haplotype III of the BLV circulating in the blood of infected individuals exceeded that of the carriers of haplotype I. In this connection, an assumption was made about the evolutionary advantage of the more virulent haplotype III. However, the results of our own research in conjunction with the data of other scientists indicate that the high virulence of individual virus strains is a consequence of the tendency to implement the maximum possible intensity of the synthesis of virus particles but not of the high damaging effect alone. It is shown that high lethality is evolutionarily disadvantageous for viruses, since the extinction of the carrier as a biological species is fraught with the disappearance of the virus itself.

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Abstract 25: Epigenome-Wide DNA Methylation Analysis Reveals Novel Hematologic Trait Associations for African Americans in The Jackson Heart Study

Circulation ◽

10.1161/circ.141.suppl_1.25 ◽

2020 ◽

Vol 141 (Suppl_1) ◽

Cited By ~ 1

Author(s):

Mindy D Szeto ◽

Laura M Raffield ◽

Deborah A Nickerson ◽

Neil A Zakai ◽

Dwight J Klemm ◽

...

Keyword(s):

Dna Methylation ◽

African Americans ◽

Blood Cell ◽

Red Blood Cell ◽

Mean Corpuscular Hemoglobin ◽

Red Cell ◽

Corpuscular Hemoglobin ◽

Cpg Sites ◽

Heart Study ◽

Trait Associations

Cardiovascular disease (CVD) is the leading cause of death in the U.S. and disproportionately affects African Americans (AAs). Routinely measured circulating red blood cell traits, which are highly heritable and differ by ethnicity, are independent predictors for CVD-related traits including hypertension, stroke, coronary heart disease, and CVD mortality. Many genetic loci associated with red blood cell count (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red cell distribution width (RDW) have been identified. However, identified genetic variants do not fully explain the heritability of these traits. Epigenetic alterations in DNA methylation likely also explain a portion of red cell trait variance, and detecting methylation quantitative trait loci (meQTLs) can provide critical insight into the development of CVD and CVD health disparities. We performed an epigenome-wide association analysis to identify CpG sites at which DNA methylation levels are associated with red blood cell traits in 1753 participants from the Jackson Heart Study, a population-based cohort of AAs. DNA methylation was measured by the Illumina MethylationEPIC array, interrogating approximately 850,000 CpG sites in peripheral blood mononuclear cells at the baseline exam. Associations were assessed using linear mixed models adjusted for age, sex, cell proportions, genetic ancestry, and experimental batch effects. A Bonferroni-corrected p-value of 9x10 -8 was used to assess statistical significance. We identified many significant differentially methylated CpG sites associated with red blood cell traits. Analysis of RBC, HGB, MCV, MCH, and MCHC revealed a novel highly significant association with a CpG annotated to a non-coding RNA (cg11703701; RBC P = 5.19x10 -22 , HGB P = 1.19x10 -11 , MCV P = 4.69x10 -59 , MCH P = 2.68x10 -67 , MCHC P = 2.32x10 -31 ), as well as a strong signal for a reprogramming-specific differentially methylated region (cg04321267; RBC P = 1.67x10 -16 , HGB P = 3.58x10 -12 , MCV P = 2.12x10 -49 , MCH P = 1.74x10 -57 , MCHC P = 5.91x10 -30 ). Multiple CpGs annotated to genes HBA1 and HBA2 were associated with RBC, MCV, MCH, and MCHC, while ITPKB (cg23740281; HGB P = 4.88x10 -10 , HCT P = 6.20x10 -11 ) and ALDH2 (cg17969951; HGB P = 3.03x10 -11 , HCT P = 8.31x10 -9 ) were significantly associated with both HGB and HCT. Additional CpG sites were significantly associated with HCT ( PLXND1 cg22902177; P = 7.54x10 -11 and ARL1 cg23903357; P = 9.86x10 -11 ) and RDW ( CPNE2 cg09018739; P = 3.03x10 -22 ). These findings shed light on potential hematologic and CVD mechanisms in understudied populations. Future work will explore the role of neighboring SNPs in mediating observed methylation-trait associations, and replicate results in an additional multi-ethnic cohort.

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Characteristics of red blood cell populations fractionated with a combination of counterflow centrifugation and Percoll separation

Blood ◽

10.1182/blood.v79.1.254.254 ◽

1992 ◽

Vol 79 (1) ◽

pp. 254-260 ◽

Cited By ~ 60

Author(s):

FH Bosch ◽

JM Werre ◽

B Roerdinkholder-Stoelwinder ◽

TH Huls ◽

FL Willekens ◽

...

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Hemoglobin A1c ◽

Hemoglobin Concentration ◽

Mean Corpuscular Hemoglobin ◽

Mean Corpuscular Hemoglobin Concentration ◽

Corpuscular Hemoglobin ◽

Cell Age ◽

Cellular Water ◽

Hba1c Concentration

Abstract Red blood cell (RBC) fractions were studied after separation of whole blood by means of counterflow centrifugation, Percoll column (Pharmacia, Uppsala, Sweden), and a combination of both separation techniques. Mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), and hemoglobin A1c (HbA1c) were measured in each fraction. From the results it was obvious that the combination of both techniques was the best separation technique of these three. MCV had a good correlation with cell age as measured with HbA1c concentration gradient; MCH and MCHC less so. MCV and MCH decreased in parallel to an increase in HbA1c. MCHC increased with increasing HbA1c. From these data it is concluded that there is a steadily ongoing loss of cellular hemoglobin and proportionally more cellular water during the life of the RBC.

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Complete Blood Count Peculiarities in Pregnant SARS-CoV-2-Infected Patients at Term: A Cohort Study

Diagnostics ◽

10.3390/diagnostics12010080 ◽

2021 ◽

Vol 12 (1) ◽

pp. 80

Author(s):

Roxana Covali ◽

Demetra Socolov ◽

Razvan Socolov ◽

Ioana Pavaleanu ◽

Alexandru Carauleanu ◽

...

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Blood Count ◽

Complete Blood Count ◽

Hemoglobin Concentration ◽

Mean Corpuscular Hemoglobin ◽

Mean Corpuscular Hemoglobin Concentration ◽

Blood Cell Count ◽

Corpuscular Hemoglobin ◽

Distribution Width

Background: During viral outbreaks, pregnancy poses an increased risk of infection for women. Methods: In a prospective study, all patients admitted for delivery at term to Elena Doamna Obstetrics and Gynecology University Hospital in Iasi, Romania, between 1 April 2020 and 31 December 2020 were included. There were 457 patients, divided into two groups: group 1, SARS-CoV-2-positive patients (n = 46) and group 2, SARS-CoV-2-negative patients (n = 411). Among other tests, complete blood count was determined upon admittance, and the following values were studied: white blood cell count, lymphocytes, neutrophils, red blood cell count, hemoglobin, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, mean corpuscular volume, red blood cell distribution width, hematocrit, platelet count, mean platelet volume, platelet distribution width, plateletcrit, and platelet large cell ratio. Results: in pregnant SARS-CoV-2-infected patients at term, there was a significant decrease in white blood cell, neutrophil, and lymphocyte count, and an increase in mean corpuscular hemoglobin concentration, compared to healthy pregnant women at term, although all still within normal limits. None of the other components of the complete blood count or fetal outcomes studied was significantly influenced by SARS-CoV-2 infection in pregnant patients at term.

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The influence of pistia powder (Pistia stratiotes L.) in ration on the performance index and red blood cell profile of male Magelang duck

Jurnal Ilmu-Ilmu Peternakan ◽

10.21776/ub.jiip.2021.031.01.02 ◽

2021 ◽

Vol 31 (1) ◽

pp. 10-17

Author(s):

Eka Rizky Fatmawati ◽

Teysar Adi Sarjana ◽

Edjeng Suprijatna ◽

Siswanto Imam Santoso ◽

Agus Setiadi

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Performance Index ◽

Hemoglobin Concentration ◽

Pistia Stratiotes ◽

Mean Corpuscular Hemoglobin ◽

Hematocrit Level ◽

Corpuscular Hemoglobin ◽

Materials Used ◽

Cell Profile

The research aims at studying the influence of pistia powder (Pistia stratiotes L.) as feed material on the performance index and red blood cell profile of male Magelang duck. The materials used were 100 heads of 4-week old male Magelang duck. The treatments were: T0 (basal), pistia powder in T1, T2 and T3 of ration for male Magelang duck at 6%, 12% and 18%. The parameters observed were Performance Index (PI), number of erythrocytes, amount of hemoglobin, hematocrit level, MCV (Mean Corpuscular Volume), MCH (Mean Corpuscular Hemoglobin) and MCHC (Mean Corpuscular Hemoglobin Concentration). The research results showed that using pistia powder up to 18% significantly (P≤0.05) increased performance index (PI) and generally insignificantly (P>0.05) influenced the number of erythrocytes, amount of hemoglobin, hematocrit level, MCV and MCHC, but significantly decreased (P<0.05) MCH. The research concludes that pistia powder may be used up to 18% in ration to increase the performance index without influencing the red blood cell profile of male Magelang duck.

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Evaluation of Red Blood Cell Parameters as a Biomarker for Long-Term Glycemic Control Monitoring Among Type 2 Diabetic Patients in Southwest Ethiopia: A Cross-Sectional Study

10.21203/rs.3.rs-504669/v1 ◽

2021 ◽

Author(s):

Misganaw Asmamaw ◽

Tariku Sime ◽

Kumsa Kene ◽

Minale Fekadie ◽

Muluken Teshome ◽

...

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Red Cell Distribution Width ◽

Mean Corpuscular Hemoglobin ◽

Red Cell ◽

Cell Distribution ◽

Corpuscular Hemoglobin ◽

Distribution Width ◽

Cell Parameters

Abstract Background: Type 2 Diabetes Mellitus (T2 DM) is a common type of DM characterized by hyperglycemia. Glycation of hemoglobin and related proteins in DM can affect the physiological and structural properties of red blood cells. Although glycated hemoglobin (HbA1c) test continues to be the gold standard for the assessment of long-term glycemic control accessibility and affordability of the test in routine diagnosing service are still limited in developing countries. Hence, this study was aimed to assess red blood cell parameters as a biomarker for long-term glycemic monitoring among T2 DM patients.Methods: Facility-based cross-sectional study through a consecutive sampling technique was conducted among 124 T2 DM patients at the chronic illness follow-up clinic of Jimma Medical Center (JMC) from July 27 to August 31, 2020. A structured questionnaire was used to collect socio-demographic and clinical-related data. Five milliliters of the blood specimen was collected from each eligible T2 DM patient. HbA1c and red blood cell parameters were determined by Cobas 6000 and DxH 800 fully automated analyzers respectively. Data were entered into Epi-data software version 3.1 and exported to SPSS 25 version for analysis. Independent t-test and Pearson’s correlation coefficient were used to address the research questions. A P-value < 0.05 was considered statistically significant. Results: The mean age of study participants was 51.84± 11.6 years. 60.5% of T2 DM patients were in poor glycemic control. There was a significant mean difference between good and poor glycemic controlled T2 DM patients in red blood cell count (4.79±0.5 vs 4.38±0.8), hemoglobin (14.13±1.4 vs 13.60±1.6), mean corpuscular volume (89.52±4.7 vs 92.62±7.5), mean corpuscular hemoglobin (29.63±1.6 vs 30.77±2.9), and red cell distribution width (13.68±1.1 vs 14.63±1.2) respectively. Red blood cell count was inversely correlated (r=-0.280, p=0.002) with HbA1c while mean corpuscular volume (r=0.267, p=0.003), mean corpuscular hemoglobin (r=0.231, p=0.010), and red cell distribution width (r= 0.496, p=0.000) were positively correlated with level of HbA1c. Conclusion: Red cell count, mean corpuscular volume, mean corpuscular hemoglobin, and red cell distribution width could be useful indicators to monitor the glycemic status of T2 DM patients instead of HbA1c, though large prospective studies should be considered.

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Increased vitamin B12 levels in children with zinc deficiency

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000444 ◽

2017 ◽

Vol 87 (5-6) ◽

pp. 247-252

Author(s):

Ayse Betul Ergul ◽

Cem Turanoglu ◽

Cigdem Karakukcu ◽

Elif Guler Kazanci ◽

Yasemin Altuner Torun

Keyword(s):

Blood Cell ◽

Zinc Deficiency ◽

Red Blood Cell ◽

Zn Deficiency ◽

Vitamin B ◽

Mean Corpuscular Hemoglobin ◽

Corpuscular Hemoglobin ◽

Hair Samples ◽

Significant Difference ◽

Deficient Group

Abstract. Additional nutritional deficiencies may accompany zinc deficiency. We determined the vitamin B12 levels in patients with zinc (Zn) deficiency. This retrospective study enrolled 256 patients age 6 months to 16 years (176 females and 80 males) in whom Zn levels in hair samples were measured concurrently with serum vitamin B12 and ferritin levels. For all patients, we retrospectively assessed the hair Zn levels, serum ferritin and vitamin B12 levels, red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and red cell distribution levels. Data were analyzed to determine whether there was a significant difference between any of these parameters and the presence of vitamin B12 deficiency between patients with and without Zn deficiency. In all 118 patients had Zn levels < 100 μg/g and 138 patients had levels > 100 μg/g. No significant differences were observed in ferritin levels, red blood cell parameters, or presence of iron deficiency or anemia between the two groups (p > 0.05). The median vitamin B12 level was 323 (range 238–440) pg/mL in the Zn-deficient group and 276 (range 208–382) pg/mL in those with normal Zn levels. Vitamin B12 levels were significantly higher in the Zn-deficient group (p = 0.02). A significant negative correlation was detected between vitamin B12 levels and Zn levels (r = –0.17, p = 0.004). Vitamin B12 levels are higher in patients with Zn deficiency; thus, Zn may have a negative effect on vitamin B12 levels.

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Impact of weight loss on inflammation and red blood cell biomarkers after laparoscopic gastric banding surgery

Journal of Investigative Medicine ◽

10.1136/jim-2017-000528 ◽

2017 ◽

Vol 66 (2) ◽

pp. 304-308 ◽

Cited By ~ 5

Author(s):

Susana Coimbra ◽

Cátia Ferreira ◽

Luís Belo ◽

Petronila Rocha-Pereira ◽

Alice Catarino ◽

...

Keyword(s):

Weight Loss ◽

Blood Cell ◽

Gastric Banding ◽

Iron Metabolism ◽

Red Blood Cell ◽

Hemoglobin Concentration ◽

Mean Corpuscular Hemoglobin ◽

Obese Patients ◽

Corpuscular Hemoglobin ◽

Distribution Width

Adipose tissue produces several adipokines that are enrolled in different metabolic and inflammatory pathways that may disturb iron metabolism and erythropoiesis. Considering that laparoscopic adjustable gastric banding (LAGB) has not been associated with a long-term risk of malabsorption, we performed a 13-month follow-up study in severe obese patients submitted to LAGB in order to clarify its impact on inflammation, iron metabolism and on red blood cell (RBC) biomarkers. Twenty obese patients were enrolled in the study, being clinical and analytically assessed before (T0) and 13 months after LAGB intervention (T1). Inflammation, iron bioavailability and RBC biomarkers were evaluated at T0 and T1. At T1, weight and anthropometric indices decreased significantly; patients showed a significant increase in mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration (MCHC), and a reduction in red cell distribution width, ferritin, hepcidin, tumor necrosis factor-α, interleukin-6 (IL-6) and C-reactive protein. Before LAGB, IL-6 correlated negatively with iron, hemoglobin concentration and MCHC; hepcidin correlated inversely with transferrin. Our data show that 13 months after LAGB, the weight loss is associated with an improvement in inflammation, namely a reduction in IL-6 that may reduce hepcidin production, improving iron availability for erythropoiesis, as shown by more adequate erythrocyte hemoglobinization.

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Genotype Spectrum and Hematological Features of β–Thalassemia with or without Different Forms of α-Thalassemia in Shenzhen

10.21203/rs.3.rs-28803/v1 ◽

2020 ◽

Author(s):

Mingyue Luo ◽

Likuan Xiong ◽

Xu Chen ◽

Zehao Yan ◽

Guangxing Mai ◽

...

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Mean Corpuscular Volume ◽

Globin Gene ◽

Mean Corpuscular Hemoglobin ◽

Molecular Heterogeneity ◽

Corpuscular Volume ◽

Corpuscular Hemoglobin ◽

Alpha Globin

Abstract Background: The effects of different forms of α–thalassemia on β-thalassemia phenotype has not been clearly described thus far. Methods: Genotype spectrum and hematological features of 873 female diagnosed as β-thalassemia carriers with or without different forms of α-thalassemia was retrospectively analyzed. Results: Thirteen kinds of genotypes were found in the 755 β-thalassemia carriers, including four kinds of β+-thalassemia, eight kinds of β0 -thalassemia and one kind of βE-thalassemia. The values of hemoglobin (Hb), mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) decreased and red blood cell (RBC) increased in the order of βE, β+- and β0 group (p＜0.05). Nine genotypes were determined from the 43 carriers with concurrent α- and β+-thalassemia and seventeen genotypes were determined from the 75 carriers with concurrent α- and β0 -thalassemia. Significant higher Hb, MCV and MCH values were noted in β+–thalassemia or β0–thalassemia co-inherited with α+-thalassemia or α0-thalassemia as compared to the only β+–thalassemia or β0–thalassemia heterozygosity with normal alpha globin gene (p＜0.05). Moreover, the values of Hb, MCV and MCH increased much more when β0–thalassemia co-inheritance of α0-thalassemia than that of α+-thalassemia (p＜0.05). Conclusion: The β-thalassemia presented diverse molecular heterogeneity and hypochromic microcytosis at various degrees. Co-inherited with α–thalassemia could alleviate phenotype of anemic in β+- or β0-thalassemia, and β0-thalassemia demonstrated milder phenotype with two deletion or mutation in α-globin gene than one.

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