scholarly journals Costs per DALYs Averted of Quadrivalent Influenza Vaccine versus Trivalent Influenza Vaccine in Elderly Population in Thailand

2021 ◽  
Vol 73 (4) ◽  
pp. 259-267
Author(s):  
Jadesada Lertsirimunkong ◽  
Wiwat Thavornwattanayong ◽  
Panasorn Hirunkanakorn ◽  
Rujipas Buranapatanapong ◽  
Sukanya Jermtienchai ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Cost Effective ◽  
Economic Effects ◽  
Total Cost ◽  
Trivalent Influenza Vaccine ◽  
Incident Rate ◽  
One Year ◽  
The Cost ◽  
Age Over 60 ◽  
Quadrivalent Influenza Vaccine

Objective: Influenza is an infection of the respiratory system with a high annual incident rate. Influenza vaccinecan reduce the severity of influenza and prevent transmission of the virus. Influenza vaccines in Thailand are theTrivalent Influenza Vaccine (TIV) and the Quadrivalent Influenza Vaccine (QIV). The cost and the effectiveness ofthe QIV in preventing transmission of the virus are greater than the TIV. Until now, no studies have been conductedto compare the economic impact of using QIV or TIV. This study aimed to evaluate the economic effects of usingQIV versus TIV in Thai populations age 60 years and over.Materials and Methods: The study was carried out from a societal perspective for cost per DALYs averted. A decisiontree model was used to analyse the costs and DALYs averted of Thais after they received the vaccine.Results: In a period of one year, it was found that in Thais age 60 years and over, the total cost of TIV was 2,445.19baht with 0.0094 DALYs and total cost of the QIV was 2,629.28 baht with 0.0082 DALYs and the incremental costeffectivenessratio (ICER) of the QIV was 158,489.24 baht per DALYs averted. The acceptability curves demonstratedthat the probability of QIV being cost-effective was 95% of the willingness to pay, being 1.2 times the Thai grossnational income per capita.Conclusion: Therefore, in Thai people age over 60 years and over, QIV is more cost-effective than TIV. The resultsof this study can be used by policymakers to help inform their decisions about which influenza vaccine is morecost-effective.

Sonographically guided, transcatheter foam sclerotherapy of the great saphenous vein

Phlebologie ◽  
2007 ◽  
Vol 36 (06) ◽  
pp. 309-312 ◽  
Author(s):  
T. Schulz ◽  
M. Jünger ◽  
M. Hahn
Keyword(s):  
Saphenous Vein ◽  
Great Saphenous Vein ◽  
Clinical Stage ◽  
Clinical Signs ◽  
Cost Effective ◽  
Duplex Sonography ◽  
Foam Sclerotherapy ◽  
Average Loss ◽  
One Year ◽  
The Cost

Summary Objective: The goal of the study was to assess the effectiveness and patient tolerability of single-session, sonographically guided, transcatheter foam sclerotherapy and to evaluate its economic impact. Patients, methods: We treated 20 patients with a total of 22 varicoses of the great saphenous vein (GSV) in Hach stage III-IV, clinical stage C2-C5 and a mean GSV diameter of 9 mm (range: 7 to 13 mm). We used 10 ml 3% Aethoxysklerol®. Additional varicoses of the auxiliary veins of the GSV were sclerosed immediately afterwards. Results: The occlusion rate in the treated GSVs was 100% one week after therapy as demonstrated with duplex sonography. The cost of the procedure was 207.91 E including follow-up visit, with an average loss of working time of 0.6 days. After one year one patient showed clinical signs of recurrent varicosis in the GSV; duplex sonography showed reflux in the region of the saphenofemoral junction in a total of seven patients (32% of the treated GSVs). Conclusion: Transcatheter foam sclerotherapy of the GSV is a cost-effective, safe method of treating varicoses of GSV and broadens the spectrum of therapeutic options. Relapses can be re-treated inexpensively with sclerotherapy.

Enterprise Inventory Management and Simulation

2014 ◽  
Vol 933 ◽  
pp. 874-878
Author(s):  
Yun Rui Wang
Keyword(s):  
Computer Simulation ◽  
Supply Chain ◽  
Inventory Management ◽  
Simulation Software ◽  
Total Cost ◽  
The Third ◽  
Inventory Strategy ◽  
One Year ◽  
The Cost ◽  
Operation Cost

Inventory is an important link in supply chain, according to characteristics and objectives of inventory control, the reasonable safety inventory, order point, the highest inventory and inventory strategy were determined based on historical sales data. Using Witness simulation software, the optimal strategy was selected from nine inventory strategies by running simulation model for one year. If goods shortage was allowing, the seventh schemes (72000,158100) was better ,the minimum total cost was 888158 yuan ; considering allowing a small amount of shortage, the cost of eighth schemes ( 82000,158100) was least of 1095167; the third scenarios (92000,138100) was selected if without shortage, and the minimum total cost was 1254909 yuan. This shows, the application of computer simulation to assist in the management of inventory is scientific and feasible, it can help enterprises to save the order and operation cost.

A Model for Estimating the Savings from Dimensional vs. Keyword Search

2009 ◽  
pp. 146-157
Author(s):  
Karen Corral ◽  
David Schuff ◽  
Robert D. St. Louis ◽  
Ozgur Turetken
Keyword(s):  
Search Engine ◽  
Search Strategy ◽  
Keyword Search ◽  
Cost Effective ◽  
Quantitative Model ◽  
Total Cost ◽  
Search Approach ◽  
The Cost ◽  
Keyword Searches ◽  
A Company

Inefficient and ineffective search is widely recognized as a problem for businesses. The shortcomings of keyword searches have been elaborated upon by many authors, and many enhancements to keyword searches have been proposed. To date, however, no one has provided a quantitative model or systematic process for evaluating the savings that accrue from enhanced search procedures. This paper presents a model for estimating the total cost to a company of relying on keyword searches versus a dimensional search approach. The model is based on the Zipf-Mandelbrot law in quantitative linguistics. Our analysis of the model shows that a surprisingly small number of searches are required to justify the cost associated with encoding the metadata necessary to support a dimensional search engine. The results imply that it is cost effective for almost any business organization to implement a dimensional search strategy.

scholarly journals Economic evaluation of the Good School Toolkit: an intervention for reducing violence in primary schools in Uganda

2018 ◽  
Vol 3 (2) ◽  
pp. e000526 ◽  
Author(s):  
Giulia Greco ◽  
Louise Knight ◽  
Willington Ssekadde ◽  
Sophie Namy ◽  
Dipak Naker ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Primary Schools ◽  
Physical Violence ◽  
Controlled Trial ◽  
Cost Effective ◽  
Cluster Randomised Controlled Trial ◽  
Total Cost ◽  
Good School ◽  
Randomised Controlled ◽  
The Cost

IntroductionThis paper presents the cost and cost-effectiveness of the Good School Toolkit (GST), a programme aimed at reducing physical violence perpetrated by school staff to students in Uganda.MethodsThe effectiveness of the Toolkit was tested with a cluster randomised controlled trial in 42 primary schools in Luwero District, Uganda. A full economic costing evaluation and cost-effectiveness analysis were conducted alongside the trial. Both financial and economic costs were collected retrospectively from the provider’s perspective to estimate total and unit costs.ResultsThe total cost of setting up and running the Toolkit over the 18-month trial period is estimated at US$397 233, excluding process monitor (M&E) activities. The cost to run the intervention is US$7429 per school annually, or US$15 per primary school pupil annually, in the trial intervention schools. It is estimated that the intervention has averted 1620 cases of past-week physical violence during the 18-month implementation period. The total cost per case of violence averted is US$244, and the annual implementation cost is US$96 per case averted during the trial.ConclusionsThe GST is a cost-effective intervention for reducing violence against pupils in primary schools in Uganda. It compares favourably against other violence reduction interventions in the region.

The effect of cutting technique on the mortality and re-sprouting vigor of poplar stumps in short-rotation plantations

2020 ◽  
Author(s):  
Raffaele Spinelli ◽  
Natascia Magagnotti ◽  
Carolina Lombardini ◽  
Elaine Cristina Leonello
Keyword(s):  
Cost Effective ◽  
Populus Nigra ◽  
Effective Solution ◽  
Shoot Height ◽  
Hybrid Poplars ◽  
Short Rotation ◽  
Preliminary Study ◽  
Poplar Plantations ◽  
One Year ◽  
The Cost

Mechanical felling is the cost-effective solution for harvesting short-rotation poplar plantations, but the damage inflicted by conventional shear cutting devices on tree stumps has raised concerns about stump mortality and re-sprouting vigor - both crucial to coppice regeneration. In order to determine if such concerns are justified, the experiment monitored the survival and resprouting vigor of eleven sample blocks, composed of two 10-stump row segments cut according to either of two methods: 1) lternately with a chainsaw (control) or 2) and with an excavator-mounted shear. The sample blocks were located within the same plantation, established 7 years earlier with hybrid poplars (Populus nigra x P. deltoides), belonging to the "AF8" clone. One year after cutting, no differences were found between treatments in terms of stump mortality, number of shoots per stump, shoot diameter at 30 cm from the insertion and shoot height. These results support the use of mechanical shears to fell short-rotation poplar coppice. However, further studies should be conducted on multiple fields and clones for a safe generalization of this preliminary study.

Antibody persistence and response to 2010–2011 trivalent influenza vaccine one year after a single dose of 2009 AS03-adjuvanted pandemic H1N1 vaccine in children

Vaccine ◽  
2011 ◽  
Vol 30 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Vladimir Gilca ◽  
Gaston De Serres ◽  
Marie-Eve Hamelin ◽  
Guy Boivin ◽  
Manale Ouakki ◽  
...  
Keyword(s):  
Single Dose ◽  
Influenza Vaccine ◽  
Pandemic H1n1 ◽  
H1n1 Vaccine ◽  
Antibody Persistence ◽  
Trivalent Influenza Vaccine ◽  
One Year

Cost-effectiveness analysis of first-line treatment for metastatic renal cell carcinoma (mRCC) in Colombia (ONCOLGroup study)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e16150-e16150
Author(s):  
J. Godoy ◽  
A. F. Cardona ◽  
H. Cáceres ◽  
J. M. Otero ◽  
M. Lujan ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cost Effectiveness ◽  
Renal Cell ◽  
Cost Effective ◽  
Average Total Cost ◽  
Line Treatment ◽  
First Line ◽  
Total Cost ◽  
The Cost ◽  
First Line Treatment

e16150 Background: Renal cell carcinoma has increased its incidence by 126% since 1950. A local study developed a complete economic evaluation of sunitinib versus IFN in first-line treatment of mRCC in Colombia, finding that sunitinib was more cost-useful and cost-effective. Methods: A Markov model was developed using 6-week cycles for evaluating the cost-effectiveness of four interventions (IFN, sunitinib, bevacizumab+IFN, sorafenib) approved as first-line treatment for mRCC in Colombia. The model used the third-party payer perspective and a 5-year time-line; it also presumed that all the patients (pts) continued with active treatment until progression when it became acceptable to continue with a second-line treatment or BSC. Overall survival (OS) and progression-free survival (PFS) curves of IFN were used as reference framework; they were obtained form a published clinical trial. The hazard ratios (HR) for PFS and OS were estimated for comparing new generation medicaments with IFN. The information about frequency of use and health service cost units consumed in Colombia was taken from a series of 24 pts treated in Manizales, Pereira, Medellín and Bogotá. Service costs were requested from an external consultant and corresponded to the average value billed by the EPSs, calculated from 33 sources of information which were representative of the country's market. The cost of the medicaments was obtained from LCLC. The costs and benefits were discounted annually at 3%. (all cost are presented in Colombian pesos Col$ 2008 with an exchange rate 1 USD = 1836.20 Col$). Results: Incremental analysis indicated a difference of 41.1 million Col$ in the average total cost of treatment when Sunitinib was compared to IFN; in contrast, comparing sorafenib and Bevacizumab+INF to sunitinib demonstrated that the average total cost was less for the sunitinib by 8.3 and 104.2 million Col$, respectively. Additionally, the ratios of incremental cost-effectiveness by life years (LY) gained demonstrated sunitinib's simple dominance over sorafenib and the combination of bevacizumab+IFN, and an average by LY gained of 100.5 million Col$ compared to IFN. Conclusions: Sunitinib is the most cost-effective option as first-line treatment for mRCC pts in Colombia. [Table: see text]

Sign in / Sign up

Export Citation Format

Share Document