scholarly journals ENVIRONMENT-FRIENDLY GREEN APPROACHES FOR AN EFFICIENT SYNTHESIS OF 2H-INDAZOLO [2,1-b] PHTHALAZINE-1,6,11 (13H)-TRIONES CATALYZED BY TANNIC ACID

2019 ◽  
Vol 64 (8) ◽  
pp. 645-650
Author(s):  
Davood SHEIKH ◽  
◽  
Ali VARASTEH MORADI ◽  
Zahra HEKMATIAN ◽  
◽  
...  
Keyword(s):  
Tannic Acid ◽  
Efficient Synthesis ◽  
Environment Friendly

Environment-friendly and efficient synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles catalyzed by Vitreoscilla hemoglobin incorporating a cobalt porphyrin cofactor

2021 ◽  
Author(s):  
Yaning Xu ◽  
Fengxi Li ◽  
Nan Zhao ◽  
Jiali Su ◽  
Chunyu Wang ◽  
...  
Keyword(s):  
Vitreoscilla Hemoglobin ◽  
Efficient Synthesis ◽  
Environment Friendly ◽  
Cobalt Porphyrin

In this work, an environment-friendly and efficient artificial Vitreoscilla hemoglobin (VHb) for the synthesis of 2-aminobenzoxazoles and 2-aminobenzothiazoles has been reported. We demonstrate an expression-based porphyrin substitution strategy to produce...

scholarly journals An Efficient Synthesis of 4-Aminomethyl-1-(2-Phenylethyl)-Piperidin-4-ol: A Key Intermediate in Fenspiride HCl Synthesis

2021 ◽  
pp. 139-146
Author(s):  
Prasad Panchabhai ◽  
Neelakandan Kaliaperumal ◽  
Gopalakrishnan Mannathusamy ◽  
Anbuselvan Chinnadurai
Keyword(s):  
Green Chemistry ◽  
Hazardous Waste ◽  
Building Block ◽  
Manufacturing Process ◽  
Good Yield ◽  
Aqueous Ammonia ◽  
Scale Production ◽  
Efficient Synthesis ◽  
Environment Friendly ◽  
Bulk Scale

The article confers a scalable manufacturing process of Fenspiride HCl. 4-aminomethyl-1-(2-phenylethyl)-piperidin-4-ol is the main building block in Fenspiride HCl synthesis. The reported reagents for 4-aminomethyl-1-(2-phenylethyl)-piperidin-4-ol synthesis are costly, explosive, highly toxic, produce hazardous waste, and also need to be handled with most care. The paper introduces aqueous ammonia as an alternate reagent in Fenspiride HCl and used in 4-aminomethyl-1-(2-phenylethyl)-piperidin-4-ol synthesis. The new green chemistry aspect makes the process environment-friendly and cheaper. It also eliminates toxic, sensitive, and hazardous reagents and makes the process safe on uncomplicated on bulk scale production. The high pure Fenspiride HCl is obtained by following this process and meets the ICH limits with good yield.

Synthesis of Medicinally Relevant Scaffolds-Triazoles and Pyrazoles in Green Solvent Ionic Liquids

2021 ◽  
Vol 25 ◽  
Author(s):  
Parmita Phukan ◽  
Diganta Sarma
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Public Sector ◽  
Chemical Industry ◽  
Constant Pressure ◽  
Energy Sources ◽  
Green Solvent ◽  
Efficient Synthesis ◽  
Environment Friendly ◽  
Tremendous Importance

: The use of natural and environment friendly energy sources for betterment of the living society has become an active concern in both government and public sector. Due to this, responsible use of global resources has become a growing concern among people. Similarly, in chemical industry especially in pharmaceutical fields, there is constant pressure in reducing hazardous organic solvents and environmentally detrimental laboratory materials. The use of ionic liquids in efficient synthesis of a wide array of fundamentally important structural motifs has gained tremendous importance in the scientific era. In this review, synthesis of two such medicinally relevant moieties, namely, triazole and pyrazole, in green and sustainable ionic liquid have been discussed.

High-Performance Rust Converter with a Formula Based on Polyphosphoric Acid and Tannic Acid

2010 ◽  
Vol 150-151 ◽  
pp. 1277-1281 ◽  
Author(s):  
Xi Qiu Fan ◽  
Xiao Dong Zhao
Keyword(s):  
Corrosion Inhibitor ◽  
Tannic Acid ◽  
High Performance ◽  
Polyphosphoric Acid ◽  
Active Agent ◽  
Wetting Agent ◽  
Environment Friendly

This paper presents a high-performance rust converter whose formulation is based on polyphosphoric acid and tannic acid. In order to improve the performance of the product, active agent, catalytic agent, corrosion inhibitor, penetrating agent and wetting agent, etc., are added. Some results of accelerating experiment such as the A. C. impedance experiment are also presented, which demonstrate the high performance of the product. All ingredients in the product are cheap, easily accessible, and environment-friendly.

Synthesis of Novel Drug Benvitimod

2011 ◽  
Vol 236-238 ◽  
pp. 2378-2382 ◽  
Author(s):  
Jun Gang Gao ◽  
Yue Zhang ◽  
He Tang Zheng ◽  
Chun Fang Wang ◽  
Hui Xian Liu ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Total Yield ◽  
Synthesis Method ◽  
Efficient Synthesis ◽  
Improved Method ◽  
Environment Friendly ◽  
Mild Conditions ◽  
Common Skin ◽  
Novel Drug ◽  
The Ideal

Benvitimod (3,5-dihydroxy-4-i-propylstilbene) is a novel drug developed for common skin disorders such as atopic dermatitis by Welichem Biotech Inc. in Canada and Celestial Pharmaceuticals (Shenzhen) Co. Ltd. in China. But the ideal synthesis method is not reported so far. Herein an efficient synthesis method which is operated under the mild conditions is reported. According this route, the total yield will reach 40.3 - 48.1% and the benefits of the improved method are easily operating and environment friendly.

A New Approach to the Demonstration of Oxidase-Localization Using Tannic Acid Or Catechin

1973 ◽  
Vol 31 ◽  
pp. 698-699
Author(s):  
V. Mizuhira ◽  
Y. Futaesaku
Keyword(s):  
Cross Section ◽  
Tannic Acid ◽  
Elastic Fiber ◽  
The Other ◽  
New Approach ◽  
Tissue Block ◽  
Active Reaction ◽  
The Cross

Previously we reported that tannic acid is a very effective fixative for proteins including polypeptides. Especially, in the cross section of microtubules, thirteen submits in A-tubule and eleven in B-tubule could be observed very clearly. An elastic fiber could be demonstrated very clearly, as an electron opaque, homogeneous fiber. However, tannic acid did not penetrate into the deep portion of the tissue-block. So we tried Catechin. This shows almost the same chemical natures as that of proteins, as tannic acid. Moreover, we thought that catechin should have two active-reaction sites, one is phenol,and the other is catechole. Catechole site should react with osmium, to make Os- black. Phenol-site should react with peroxidase existing perhydroxide.

Structural preservation and absolute contrast of catalase crystal sections prepared with tannic acid

1983 ◽  
Vol 41 ◽  
pp. 448-449
Author(s):  
C.W. Akey ◽  
M. Szalay ◽  
S.J. Edelstein
Keyword(s):  
Tannic Acid ◽  
Beef Heart ◽  
X Rays ◽  
Screw Axis ◽  
General Applicability ◽  
Thin Sections ◽  
Beef Liver ◽  
3 Dimensional ◽  
Dimensional Reconstruction ◽  
Structural Preservation

Three methods of obtaining 20 Å resolution in sectioned protein crystals have recently been described. They include tannic acid fixation, low temperature embedding and grid sectioning. To be useful for 3-dimensional reconstruction thin sections must possess suitable resolution, structural fidelity and a known contrast. Tannic acid fixation appears to satisfy the above criteria based on studies of crystals of Pseudomonas cytochrome oxidase, orthorhombic beef liver catalase and beef heart F1-ATPase. In order to develop methods with general applicability, we have concentrated our efforts on a trigonal modification of catalase which routinely demonstrated a resolution of 40 Å. The catalase system is particularly useful since a comparison with the structure recently solved with x-rays will permit evaluation of the accuracy of 3-D reconstructions of sectioned crystals.Initially, we re-evaluated the packing of trigonal catalase crystals studied by Longley. Images of the (001) plane are of particular interest since they give a projection down the 31-screw axis in space group P3121. Images obtained by the method of Longley or by tannic acid fixation are negatively contrasted since control experiments with orthorhombic catalase plates yield negatively stained specimens with conditions used for the larger trigonal crystals.

Cell Fine Structure as Revealed in Dessicator-Dried Resinless Sections

1981 ◽  
Vol 39 ◽  
pp. 622-623
Author(s):  
R. P. Becker ◽  
J. J. Wolosewick ◽  
J. Ross-Stanton
Keyword(s):  
Fine Structure ◽  
Tannic Acid ◽  
Three Dimensional ◽  
Albino Rats ◽  
Cell Organelles ◽  
Vascular Perfusion ◽  
Thin Sections ◽  
Carbon Coated ◽  
Embedding Medium ◽  
Polyethylene Glycol 6000

Methodology has been introduced recently which allows transmission and scanning electron microscopy of cell fine structure in semi-thin sections unencumbered by an embedding medium. Images obtained from these “resinless” sections show a three-dimensional lattice of microtrabeculfee contiguous with cytoskeletal structures and membrane-bounded cell organelles. Visualization of these structures, especially of the matiiDra-nous components, can be facilitated by employing tannic acid in the fixation step and dessicator drying, as reported here.Albino rats were fixed by vascular perfusion with 2% glutaraldehyde or 1.5% depolymerized paraformaldehyde plus 2.5% glutaraldehyde in 0.1M sodium cacodylate (pH 7.4). Tissues were removed and minced in the fixative and stored overnight in fixative containing 4% tannic acid. The tissues were rinsed in buffer (0.2M cacodylate), exposed to 1% buffered osmium tetroxide, dehydrated in ethyl alcohol, and embedded in pure polyethylene glycol-6000 (PEG). Sections were cut on glass knives with a Sorvall MT-1 microtome and mounted onto poly-L-lysine, formvar-carbon coated grids while submerged in a solution of 95% ethanol containing 5% PEG.

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