scholarly journals Heterocyclic Compounds of some Natural Products as Anti-Covid-19: Iranian Plants and Natural Drugs of Ardabil Province

2020 ◽  
Vol 11 (3) ◽  
pp. 10940-10954
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Herbal Medicines ◽  
Medicinal And Aromatic Plants ◽  
The Caspian Sea ◽  
Plant Materials ◽  
Heterocyclic Molecules ◽  
The North ◽  
Raw Plant Materials ◽  
Natural Drugs

Natural products make amazing opportunities for novel drugs via extracting of some heterocyclic compounds. These extracted molecules are used as anti-corona virus diseases. Herbal heterocyclic drugs are included in various forms, such as tablets, capsules, tinctures, and syrups. In Iran, with around 1.65 million km2 areas, the climate is diverse, ranging from arid and semi-arid to subtropical along the Caspian coast and the northern forests. The Moghan plain is located to the north of Ardabil province and west of the Caspian Sea. Due to its mild winters and humid summers, it is considered an important pole for Iran's agriculture and natural plant drugs. To date, scientists in Iran identified 10000 plant species; out of these, approximately 1000 are medicinal and aromatic plants, and around 100 species are in Ardabil province. Therefore, this province has rich medicinal plants and raw plant materials and processed herbal medicines to produce natural drug products as anti-COVID-19. This work simulated the heterocyclic molecules extracted from those plants for anti-COVID -19 drugs.

scholarly journals Study of the phenolic compounds of the dry extract of Thymus crebrifoli ususing a combined HPLC–UV and HPLC-ESI-MS/MS method

2021 ◽  
Vol 102 (2) ◽  
pp. 18-23
Author(s):  
S.A. Ivasenko ◽  
◽  
K.K. Shakarimova ◽  
A.B. Bokayeva ◽  
A.B. Marchenko ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Wide Spectrum ◽  
Herbal Medicines ◽  
Point Of View ◽  
Endemic Plant ◽  
Plant Materials ◽  
Dry Extract ◽  
Raw Plant Materials ◽  
Double Extraction ◽  
First Time

In world practice interest in herbal medicines is noticeably increasing every year. From this point of view, plants of the ThymusL. genus of the Lamiaceaefamily are of undoubted interest. Previously we have obtained a dry extract from the aerial part of an endemic plant of the flora of Kazakhstan Thymus crebrifoliusKlokovfor the first time by double extraction of raw plant materials with 70% ethanol using ultrasound. Dry extract of Thymus crebrifoliushas a wide spectrum of antimicrobial activity, including against Helicobacter pylori, while it is not toxic, and can be used as an antimicrobial agent. The article presents the results of a study of the composition of phenolic compounds of dry extract of Thymus crebrifoliususing a combined HPLC-UV and HPLC-MS/MS method. 12 phenolic compounds have been identified and quantified in the dry extract of Thy-mus crebrifolius. Four of them are phenolic acids, and eight are flavonoids. The dominant phenolic compounds are luteolin-7-O-glucoside (109.00mg g−1),rosmarinic acid (30.98mg g−1), naringenin (24.84 mg g−1), epicat-echin (9.98mg g−1),myricetin (6.15mg g−1) and gallic acid (3.41mg g−1). The results of chromatographic analysis will be used to standardize drugs based on dry extract of Thymus crebrifolius.

scholarly journals Aromatic Herbs, Medicinal Plant-Derived Essential Oils, and Phytochemical Extracts as Potential Therapies for Coronaviruses: Future Perspectives

Plants ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 800 ◽  
Author(s):  
Mohamed Nadjib Boukhatem ◽  
William N. Setzer
Keyword(s):  
Natural Products ◽  
Essential Oils ◽  
Viral Entry ◽  
Chemical Constituents ◽  
Herbal Medicines ◽  
Antiviral Drugs ◽  
Medicinal And Aromatic Plants ◽  
Aromatic Herbs

After its recent discovery in patients with serious pneumonia in Wuhan (China), the 2019 novel coronavirus (2019-nCoV), named also Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has spread quickly. Unfortunately, no drug or vaccine for treating human this coronavirus infection is available yet. Numerous options for controlling or preventing emerging 2019-nCoV infections may be predicted, including vaccines, interferon therapies, and small-molecule drugs. However, new interventions are likely to require months to years to develop. In addition, most of the existing antiviral treatments frequently lead to the development of viral resistance combined with the problem of side effects, viral re-emergence, and viral dormancy. The pharmaceutical industry is progressively targeting phytochemical extracts, medicinal plants, and aromatic herbs with the aim of identifying lead compounds, focusing principally on appropriate alternative antiviral drugs. Spices, herbal medicines, essential oils (EOs), and distilled natural products provide a rich source of compounds for the discovery and production of novel antiviral drugs. The determination of the antiviral mechanisms of these natural products has revealed how they interfere with the viral life cycle, i.e., during viral entry, replication, assembly, or discharge, as well as virus-specific host targets. Presently, there are no appropriate or approved drugs against CoVs, but some potential natural treatments and cures have been proposed. Given the perseverance of the 2019-nCoV outbreak, this review paper will illustrate several of the potent antiviral chemical constituents extracted from medicinal and aromatic plants, natural products, and herbal medicines with recognized in vitro and in vivo effects, along with their structure–effect relationships. As this review shows, numerous potentially valuable aromatic herbs and phytochemicals are awaiting assessment and exploitation for therapeutic use against genetically and functionally different virus families, including coronaviruses.

scholarly journals North American species of Solidago as ornamental plants and a source of promising raw plant materials

2021 ◽  
Vol 845 (1) ◽  
pp. 012150
Author(s):  
V Shelepova ◽  
E V Tkacheva ◽  
Yu K Vinogradova
Keyword(s):  
North American ◽  
Ornamental Plants ◽  
North American Species ◽  
Lag Phase ◽  
Plant Resources ◽  
Plant Materials ◽  
Secondary Range ◽  
The North ◽  
Wide Range ◽  
Raw Plant Materials

Abstract A review of the role of ornamental horticulture as a vector of phytoinvasions is presented on the example of North American species of Solidago: S. canadensis L., S. gigantea Ait and S. graminifolia (L.) Salisb. The first two species were originally cultivated as ornamental plants. With changes in environmental conditions, their range expanded to the north and east of the Eurasian continent, and the lag phase lasted 100-150 years. At the end of the XX century, their secondary range covered all the Eurasian regions, they were transformed into invasive plants and were listed in the Top 100 most threatened and aggressive species that are introduced into natural phytocoenosis and pose a threat to the environment. The secondary range of S. graminifolia is represented by several scattered localities, its lag phase ends, this species is recognized as invasive only in Poland. It has now become evident that alien species can be used as new resource plants. The study of secondary metabolites composition of species of Solidago makes possible the disbursement of a wide range of flavonoids, triterpene saponins, organic acids, and various terpene compounds in their composition. The authors believe that a detailed study of the phytochemical properties and many other widespread invasive species is required in order to identify new plant resources.

ICE CONDITIONS IN THE NORTH-WESTERN PART OF THE CASPIAN SEA IN THE MODERN PERIOD

2020 ◽  
Vol 19 (6) ◽  
pp. 4-17
Author(s):  
Nepomenko Leonid ◽  
◽  
Popova Natalia ◽  
Zubanov Stepan ◽  
Ostrovskaya Elena ◽  
...  
Keyword(s):  
Caspian Sea ◽  
The Caspian Sea ◽  
The North ◽  
Modern Period ◽  
Ice Conditions ◽  
North Western

scholarly journals In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 216
Author(s):  
Nadia A. Rivero-Segura ◽  
Juan C. Gomez-Verjan
Keyword(s):  
Natural Products ◽  
In Silico ◽  
Herbal Medicines ◽  
In Silico Screening ◽  
Docking Analysis ◽  
Physiologically Based Pharmacokinetic ◽  
Important Challenge ◽  
Emodin Anthrone ◽  
Therapeutic Tools ◽  
Vaccine Distribution

The COVID-19 pandemic has already taken the lives of more than 2 million people worldwide, causing several political and socio-economic disturbances in our daily life. At the time of publication, there are non-effective pharmacological treatments, and vaccine distribution represents an important challenge for all countries. In this sense, research for novel molecules becomes essential to develop treatments against the SARS-CoV-2 virus. In this context, Mexican natural products have proven to be quite useful for drug development; therefore, in the present study, we perform an in silico screening of 100 compounds isolated from the most commonly used Mexican plants, against the SARS-CoV-2 virus. As results, we identify ten compounds that meet leadlikeness criteria (emodin anthrone, kaempferol, quercetin, aesculin, cichoriin, luteolin, matricin, riolozatrione, monocaffeoyl tartaric acid, aucubin). According to the docking analysis, only three compounds target the key proteins of SARS-CoV-2 (quercetin, riolozatrione and cichoriin), but only one appears to be safe (cichoriin). ADME (absorption, distribution, metabolism and excretion) properties and the physiologically based pharmacokinetic (PBPK) model show that cichoriin reaches higher lung levels (100 mg/Kg, IV); therefore, it may be considered in developing therapeutic tools.

Application of the rutin standard sample in analysis of related raw plant materials, vitamin compositions, and phytopreparations

2000 ◽  
Vol 34 (1) ◽  
pp. 28-30 ◽  
Author(s):  
L. P. Smirnova ◽  
S. S. Nikolaeva ◽  
V. A. Bykov ◽  
L. V. Yakovleva ◽  
L. B. Rebrov ◽  
...  
Keyword(s):  
Standard Sample ◽  
Plant Materials ◽  
Raw Plant Materials

scholarly journals Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-26 ◽  
Author(s):  
Chen-Yi Liao ◽  
Ching-Chang Lee ◽  
Chi-chang Tsai ◽  
Chao-Wen Hsueh ◽  
Chih-Chiang Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Natural Products ◽  
Multidrug Resistance ◽  
Intracellular Signaling ◽  
Poor Prognosis ◽  
Biological Effects ◽  
Herbal Medicines ◽  
Chemopreventive Agents ◽  
Intracellular Signaling Pathways ◽  
Anticancer Effects

We would like to highlight the application of natural products to hepatocellular carcinoma (HCC). We will focus on the natural products known as flavonoids, which target this disease at different stages of hepatocarcinogenesis. In spite of the use of chemotherapy and radiotherapy in treating HCC, patients with HCC still face poor prognosis because of the nature of multidrug resistance and toxicity derived from chemotherapy and radiotherapy. Flavonoids can be found in many vegetables, fruits, and herbal medicines that exert their different anticancer effects via different intracellular signaling pathways and serve as antioxidants. In this review, we will discuss seven common flavonoids that exert different biological effects against HCC via different pathways.

scholarly journals SOME ETHNO-MEDICINAL PLANTS AND ECO-FRIENDLY NATURAL COLORS YIELDING FLOWERING PLANTS OF B.S.N. GOVT. P.G. COLLEGE CAMPUS, SHAJAPUR (M.P.) – A SURVEY REPORT

2015 ◽  
Vol 3 (4) ◽  
pp. 1-6
Author(s):  
BodaneArun Kumar
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Herbal Medicines ◽  
Flowering Plants ◽  
College Campus ◽  
Medicinal Uses ◽  
Survey Report

The present work is attempt has been made to compile the some ethno-medicinal plants and eco-friendly natural colors yielding flowering plants their preparations used for cure of diseases and information of flowering plants with the list of plants from B.S.N. Govt. P.G. College campus Shajapur, India. The present study focused on some important plants having medicinal uses and color yielding potential. Now-a-days natural products and herbal medicines have been recommended for the treatment of various diseases. The present study of ethno-medicinal and natural colors yielding flowering plants is helpful for local peoples of Shajapur.

scholarly journals Morphology, Conductivity and Electrochemical Properties of Hydrothermal Carbonized Porous Carbon Materials

2016 ◽  
Vol 3 (1) ◽  
pp. 46-55
Author(s):  
N. Nagirna ◽  
V. Mandzyuk
Keyword(s):  
Electrochemical Properties ◽  
Porous Carbon ◽  
Carbon Materials ◽  
Specific Capacity ◽  
Carbonization Temperature ◽  
Electrochemical System ◽  
Plant Materials ◽  
Temperature Growth ◽  
Raw Plant Materials ◽  
Volume Decrease

The paper studies the morphology, conductivity and electrochemical properties ofcarbon materials, obtained from raw plant materials at different condition of hydrothermalcarbonization, using low-temperature porometry, impedance spectroscopy and galvanostaticcharge/discharge. It is set, that in porous structure of carbon materials micropores are dominant;when carbonization temperature increased the specific surface and pore volume decrease morethan 10 times. The temperature growth results in increasing the electrical conductivity of thecarbon material more than 6 orders. It is found, that the maximal value of specific capacity(1138 mА·h/g) has an electrochemical system based on porous carbon carbonized at 1023 K

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