scholarly journals Study of the phenolic compounds of the dry extract of Thymus crebrifoli ususing a combined HPLC–UV and HPLC-ESI-MS/MS method

2021 ◽  
Vol 102 (2) ◽  
pp. 18-23
Author(s):  
S.A. Ivasenko ◽  
◽  
K.K. Shakarimova ◽  
A.B. Bokayeva ◽  
A.B. Marchenko ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Wide Spectrum ◽  
Herbal Medicines ◽  
Point Of View ◽  
Endemic Plant ◽  
Plant Materials ◽  
Dry Extract ◽  
Raw Plant Materials ◽  
Double Extraction ◽  
First Time

In world practice interest in herbal medicines is noticeably increasing every year. From this point of view, plants of the ThymusL. genus of the Lamiaceaefamily are of undoubted interest. Previously we have obtained a dry extract from the aerial part of an endemic plant of the flora of Kazakhstan Thymus crebrifoliusKlokovfor the first time by double extraction of raw plant materials with 70% ethanol using ultrasound. Dry extract of Thymus crebrifoliushas a wide spectrum of antimicrobial activity, including against Helicobacter pylori, while it is not toxic, and can be used as an antimicrobial agent. The article presents the results of a study of the composition of phenolic compounds of dry extract of Thymus crebrifoliususing a combined HPLC-UV and HPLC-MS/MS method. 12 phenolic compounds have been identified and quantified in the dry extract of Thy-mus crebrifolius. Four of them are phenolic acids, and eight are flavonoids. The dominant phenolic compounds are luteolin-7-O-glucoside (109.00mg g−1),rosmarinic acid (30.98mg g−1), naringenin (24.84 mg g−1), epicat-echin (9.98mg g−1),myricetin (6.15mg g−1) and gallic acid (3.41mg g−1). The results of chromatographic analysis will be used to standardize drugs based on dry extract of Thymus crebrifolius.

scholarly journals Phenolic Compounds from An Algerian Endemic Species of Hypochaeris laevigata var. hipponensis and Investigation of Antioxidant Activities

Plants ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 514 ◽  
Author(s):  
Nabila Souilah ◽  
Zain Ullah ◽  
Hamdi Bendif ◽  
Kamel Medjroubi ◽  
Tahar Hazmoune ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Antioxidant Activities ◽  
Quinic Acid ◽  
Total Phenolic ◽  
Antioxidant Action ◽  
Endemic Plant ◽  
Aerial Parts ◽  
Phenolic Constituents ◽  
First Time ◽  
Phenolic And Flavonoid

Hypochaeris laevigata var. hipponensis (Asteraceae) is an endemic plant from Algeria. In the current study, we analyzed for the first time its chemical composition, especially phenolic constituents of dichloromethane (DCM), ethyl acetate (EA), and n-butanol (BuOH) fractionsof the aerial parts of Hypochaeris laevigata var. hipponensis by liquid chromatography-mass spectrometry (LC-MS/MS). The number of phenolic compounds detected in DCM, EA, and BuOH fractions were found to be 9, 20, and 15, respectively. More specifically, 12 phenolic acids were detected. Among them, quinic acid, chlorogenic acid, and caffeic acid were the most abundant ones. Meanwhile, only seven flavonoids were detected. Among them, rutin, apigetrin, and isoquercitrin were the major ones. We also determined the total phenolic and flavonoid contents, and fraction EA showed the highest values, followed by BuOH, and DCM fractions. Furthermore, the antioxidant action was dictated by five methods and the tested plant fractions demonstrated a noteworthy antioxidant action.

scholarly journals Analysis of the Essential Oils of Chamaemelum fuscatum (Brot.) Vasc. from Spain as a Contribution to Reinforce Its Ethnobotanical Use

Forests ◽  
2019 ◽  
Vol 10 (7) ◽  
pp. 539 ◽  
Author(s):  
Marcos Fernández-Cervantes ◽  
María José Pérez-Alonso ◽  
José Blanco-Salas ◽  
Ana Cristina Soria ◽  
Trinidad Ruiz-Téllez
Keyword(s):  
Essential Oils ◽  
Biological Activities ◽  
Folk Medicine ◽  
Gas Chromatography Mass Spectrometry ◽  
Distribution Area ◽  
Endemic Plant ◽  
Plant Materials ◽  
Whole Plant ◽  
First Time ◽  
Scientific Validation

Chamaemelum fuscatum (Brot.) Vasc. is a south west Iberian chamomile that has been traditionally used as folk medicine in its natural distribution area but currently it is underestimated regarding its biological activities. For this reason, it is proposed in this paper to get insight into the scientific validation of the traditional knowledge of this plant with the aim of taking advantage of its anti-inflammatory, gastroprotective and antinociceptive activities, among others. To this aim, the chemical composition of the essential oil from the whole plant, the flowers and the green parts of this plant has been evaluated by gas chromatography–mass spectrometry (GC–MS). Plant materials were collected in Badajoz (Spain). A total of 61 components including monoterpenoids, sesquiterpenoids and aliphatic esters were identified. (E)-2-Methyl-2-butenyl methacrylate (27.57%–18.53%) and 2-methylallyl isobutyrate (9.79%–7.51%) were the most abundant compounds in the essential oils of flowers and of the whole plant, whereas α-curcumene, trans-pinocarveol, α-bergamotene and pinocarvone were the major terpenoids irrespective of the plant part considered. Certain compounds showing a relative high abundance as isobutyl methacrylate, isoamyl butyrate, α-bergamotene and pinocarvone were identified for the first time in this species. Finally, we have reviewed the bioactivity of several compounds to relate the ethnobotanical use of this plant in Spain with its volatile profile. This work is a preliminary contribution to reinforce the use to this Mediterranean endemic plant as a natural source of bioactives.

scholarly journals Heterocyclic Compounds of some Natural Products as Anti-Covid-19: Iranian Plants and Natural Drugs of Ardabil Province

2020 ◽  
Vol 11 (3) ◽  
pp. 10940-10954
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Herbal Medicines ◽  
Medicinal And Aromatic Plants ◽  
The Caspian Sea ◽  
Plant Materials ◽  
Heterocyclic Molecules ◽  
The North ◽  
Raw Plant Materials ◽  
Natural Drugs

Natural products make amazing opportunities for novel drugs via extracting of some heterocyclic compounds. These extracted molecules are used as anti-corona virus diseases. Herbal heterocyclic drugs are included in various forms, such as tablets, capsules, tinctures, and syrups. In Iran, with around 1.65 million km2 areas, the climate is diverse, ranging from arid and semi-arid to subtropical along the Caspian coast and the northern forests. The Moghan plain is located to the north of Ardabil province and west of the Caspian Sea. Due to its mild winters and humid summers, it is considered an important pole for Iran's agriculture and natural plant drugs. To date, scientists in Iran identified 10000 plant species; out of these, approximately 1000 are medicinal and aromatic plants, and around 100 species are in Ardabil province. Therefore, this province has rich medicinal plants and raw plant materials and processed herbal medicines to produce natural drug products as anti-COVID-19. This work simulated the heterocyclic molecules extracted from those plants for anti-COVID -19 drugs.

scholarly journals THE INFLUENCE OF SOIL-CLIMATIC CONDITIONS OF GROWTH ON THE CONTENT OF PHENOLIC COMPOUNDS IN TRIFOLIUM L. PLANTS

2020 ◽  
Vol 8 (Spl-2-AABAS) ◽  
pp. S327-S335
Author(s):  
Alexander Loenidovich Mikhailov ◽  
◽  
Olga Arnoldovna Timofeeva ◽  
UlianaAleksandrovna Ogorodnova ◽  
Nikita Sergeevich Stepanov ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Plant Growth ◽  
Growth Conditions ◽  
Climatic Conditions ◽  
Biologically Active ◽  
Plant Materials ◽  
Remarkable Effect ◽  
Raw Plant Materials ◽  
Growing Conditions ◽  
The Impact

The current study was carried out to study the effect of growing conditions on the pharmaceutically promising biologically active phenolic compounds on the meadow clover plants. The impact of the plant development site on the contemplated mixes was additionally explored. The estimation of phenolic compounds in raw plant materials was carried out with the help of a spectrophotometer and photocolorimeter. Results of the study revealed that the place of plant growth conditions have remarkable effect on the content of the phenolic compounds. Further, the most ideal conditions available for clover plant growth and higher phenolic compounds were reported from the broad-leaved forests. Furthermore, the results also suggested that the most important elements which affecting the aggregation of phenolic compounds are soil nitrogen.

scholarly journals The study of the cytotoxic activity of the dry extract and the anthocyanin complex of Gebu Dahlia variety flowers

2021 ◽  
pp. 16-22
Author(s):  
L. Maloshtan ◽  
L. Shakina ◽  
T. Gontova ◽  
S. Romanova ◽  
M. Yaremenko
Keyword(s):  
Cytotoxic Activity ◽  
High Performance ◽  
Herbal Medicines ◽  
Modern Science ◽  
Spectrophotometric Study ◽  
Urgent Problem ◽  
Potential Toxicity ◽  
Red Bone Marrow ◽  
Dry Extract ◽  
First Time

Topicality. For today, the search for promising plants with a high content of anthocyanins to create safe herbal medicines is an urgent problem of modern science. Aim. To study the presence and severity of the cytotoxic activity of the dry extract of Gebu Dahlia variety flowers, the qualitative analysis and quantify the amount of anthocyanins in flowers of this variety. Materials and methods. For the study, the dry extract of Gebu flowers was obtained. The cytotoxicity analysis of 1 %; 0.5 %; 0.25 %; 0.125 %; 0.0625 % solutions of the extract were performed by microscopy on red bone marrow (RBM) cells of rats at an exposure of 15, 45, 90 minutes. The spectrophotometric study and high-performance liquid chromatography were used to assess the quantitative and qualitative content of the amount of anthocyanins. Results and discussion. The results obtained indicate that the viability of RBM cells is affected by the concentration of the extract and exposure: in the concentrations of 0.063-0.125 % no toxic effect of the extract was detected, while 0.25-1 % solutions were able to show cytostatic properties. The content of anthocyanin amount in the flowers was determined (1.8 % ± 0.02); 18 substances were identified, among them substances from the groups of cyanidin (54.7 %) and delphinidin (28 %) predominated. Conclusions. The first stage of testing of the dry extract from Gebu Dahlia variety flowers for potential toxicity has been carried out: the extract is potentially non-toxic in the lowest of the concentrations studied. For the first time, the content of anthocyanins in flowers of Gebu Dahlia variety has been determined, 18 substances from the groups of delphinidin, cyanidin, petunidine, peonidine, malvidin have been identified.

scholarly journals Antirheumatoid Arthritis Activities and Chemical Compositions of Phenolic Compounds-Rich Fraction fromUrtica atrichocaulis, an Endemic Plant to China

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Mengyue Wang ◽  
Ke Li ◽  
Yuxiao Nie ◽  
Yingfang Wei ◽  
Xiaobo Li
Keyword(s):  
Phenolic Compounds ◽  
Chemical Constituents ◽  
Biological Evaluation ◽  
Chemical Compositions ◽  
Endemic Plant ◽  
Isolation And Identification ◽  
Phenolic Components ◽  
Phenolic Constituents ◽  
Cotton Pellet ◽  
First Time

Urtica atrichocaulis, an endemic plant to China, is commonly used to treat rheumatoid arthritis even though its pharmaceutical activities and chemical constituents were not studied. Herein, we reported our investigations on the chemical compositions of the phenolic compounds-rich fraction fromU. atrichocaulis(TFUA) and their antirheumatoid arthritis activities. We found that the TFUA significantly inhibited the adjuvant-induced rats arthritis, carrageenin-induced rats paw edema, cotton pellet-induced mice granuloma, and the acetic acid-induced mice writhing response. Our phytochemical investigations on the TFUA resulted in the first-time isolation and identification of 17 phenolic constituents and a bis (5-formylfurfuryl) ether. The extensive HPLC analysis also revealed the chemical compositions of TFUA. Our further biological evaluation of the main phenolic components, individually and collectively, indicated that the antirheumatoid arthritis activities of TFUA were the combined effect of multiple phenolic constituents.

Mikroalgák mint természetes hatóanyagforrások

2018 ◽  
Vol 159 (18) ◽  
pp. 703-708
Author(s):  
Gábor Vasas
Keyword(s):  
Mass Production ◽  
Higher Plants ◽  
Herbal Medicines ◽  
Point Of View ◽  
Historical Background ◽  
Herbal Products ◽  
Chlorella Sp ◽  
Economic Significance ◽  
Preclinical And Clinical Studies ◽  
Microalgal Species

Abstract: More than 90% of herbal products and herbal medicines have been derived from higher plants recently, but due to independent circumstances, several photosynthetic microalgal species are in focus in this point of view. In the last 50 years, many carbohydrate-, peptide-, terpenoid-, alkaloid- and phenol-type components were described from algae because of the developing structural determination and analytical methods, algae mass production and also artificial algae technologies. At the same time, based partly on traditional causes and partly on the clinical and preclinical data of today, some dried products of algae are directly used as food supplements. Hereinafter, the historical background, economic significance and metabolic background of the mostly used microalgal species will be reviewed. The diverse metabolite production of these organisms will be demonstrated by some molecules with special bioactivity. Several preclinical and clinical studies will be described relating to the microalgal species Spirulina sp., Chlorella sp., Haematococcus sp. and Dunaliella sp. Orv Hetil. 2018; 159(18): 703–708.

Thanato-Laboratorien. Theorien von Tod und Sterben und Elias Canettis Buch gegen den Tod

2020 ◽  
Vol 4 (1) ◽  
pp. 67-86
Author(s):  
Elisabeth Heyne
Keyword(s):  
Human Life ◽  
Death And Dying ◽  
Point Of View ◽  
Visual Images ◽  
Elias Canetti ◽  
History Of ◽  
Series Of Experiments ◽  
First Time ◽  
Textual Form ◽  
Or History

AbstractAlthough visual culture of the 21th century increasingly focuses on representation of death and dying, contemporary discourses still lack a language of death adequate to the event shown by pictures and visual images from an outside point of view. Following this observation, this article suggests a re-reading of 20th century author Elias Canetti. His lifelong notes have been edited and published posthumously for the first time in 2014. Thanks to this edition Canetti's short texts and aphorisms can be focused as a textual laboratory in which he tries to model a language of death on experimental practices of natural sciences. The miniature series of experiments address the problem of death, not representable in discourses of cultural studies, system theory or history of knowledge, and in doing so, Canetti creates liminal texts at the margins of western concepts of (human) life, science and established textual form.

A Nabatean port on the Red Sea: note on the pottery finds from al-Qusayr (al-Wajh, Saudi Arabia)

2020 ◽  
Author(s):  
Caroline Durand
Keyword(s):  
Saudi Arabia ◽  
19Th Century ◽  
Red Sea ◽  
Point Of View ◽  
The Other ◽  
Trade Routes ◽  
Other Hand ◽  
Roman Egypt ◽  
Pottery Sherds ◽  
First Time

Al-Qusayr is located 40 km south of modern al-Wajh, roughly 7 km from the eastern Red Sea shore. This site is known since the mid-19th century, when the explorer R. Burton described it for the first time, in particular the remains of a monumental building so-called al-Qasr. In March 2016, a new survey of the site was undertaken by the al-‘Ula–al-Wajh Survey Project. This survey focused not only on al-Qasr but also on the surrounding site corresponding to the ancient settlement. A surface collection of pottery sherds revealed a striking combination of Mediterranean and Egyptian imports on one hand, and of Nabataean productions on the other hand. This material is particularly homogeneous on the chronological point of view, suggesting a rather limited occupation period for the site. Attesting contacts between Mediterranean merchants, Roman Egypt and the Nabataean kingdom, these new data allow a complete reassessment of the importance of this locality in the Red Sea trade routes during antiquity.

Ferula hermonis: A Review of Current Use and Pharmacological Studies of its Sesquiterpene Ester Ferutinin

2020 ◽  
Vol 21 (5) ◽  
pp. 499-508 ◽  
Author(s):  
Rémi Safi ◽  
Marwan El-Sabban ◽  
Fadia Najjar
Keyword(s):  
Wide Spectrum ◽  
Endemic Plant ◽  
Anti Cancer ◽  
Pharmacological Studies ◽  
Sexual Impotence ◽  
Novel Applications ◽  
Anti Fungal ◽  
Sesquiterpene Ester

Ferula hermonis Boiss, is an endemic plant of Lebanon, locally known as “shilsh Elzallouh”. It has been extensively used in the traditional medicine as an aphrodisiac and for the treatment of sexual impotence. Crude extracts and isolated compounds of ferula hermonis contain phytoestrogenic substances having a wide spectrum of in vitro and in vivo pharmacological properties including anti-osteoporosis, anti-inflammatory, anti-microbial and anti-fungal, anti-cancer and as sexual activity enhancer. The aim of this mini-review is to highlight the traditional and novel applications of this plant’s extracts and its major sesquiterpene ester, ferutinin. The phytochemical constituents and the pharmacological uses of ferula hermonis crude extract and ferutinin specifically will be discussed.

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